[PDF] Top 20 Polymorphisms in Toll-like receptor 4 ( TLR4 ) are associated with protection against leprosy
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Polymorphisms in Toll-like receptor 4 ( TLR4 ) are associated with protection against leprosy
... effect against some infections and an increased risk for others is ...pressures in hosts and ...ined in functional and genetic epidemiological studies. 896A was associated with LPS ... Voir le document complet
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CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults.
... genetic polymorphisms and asthma The genotypic distribution of CD14, TLR2, TLR4, and TLR9 SNPs and the associations between these polymorphisms and asthma in the 825 unrelated subjects are ... Voir le document complet
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Toll-Like Receptor 9 Deficiency Protects Mice against Pseudomonas aeruginosa Lung Infection
... France, 4 Unite´ d’histopathologie humaine et mode`les animaux, Institut Pasteur, Paris, France Abstract Pseudomonas aeruginosa is an opportunistic pathogen involved in nosocomial ...TLR5 in host ... Voir le document complet
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Rôle du toll-like receptor 4 (TLR4) immun dans le développement de la fibrose du tissu adipeux
... observed in humans between WAT lipolysis and insulin sensitivity (Figure 1), we next investigated peripheral insulin tolerance in HSL +/2 ...tolerance in vivo with no difference in body ... Voir le document complet
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Dysregulated Responsiveness of Circulating Dendritic Cells to Toll-Like Receptors in ANCA-Associated Vasculitis
... TLRs are now available, it would be interesting to assess TLR expression by FACS on cDCs in future ...monocytes in AAV patients but no difference in TLR expression between patients in ... Voir le document complet
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Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies
... TLR4 in LPS signaling is indisputable and molecular mechanisms of LPS binding were very well described in human and/or mouse (Kim et ...LPSs are present in the outer membrane of Gram-negative ... Voir le document complet
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Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway
... role in the humoral innate immunity during complement activation and patho- gen recognition, in flammatory responses, and tissue repair [ 13 , 14 ...]. In contrast, its function in tumor ... Voir le document complet
18
Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models
... autoantibodies against the acetylcholine receptor (AChR) at the neuromuscular ...symptoms are characterized by muscle ...mice with polyinosinic–polycytidylic acid [Poly(I:C)], a synthetic ... Voir le document complet
15
Toll-like receptor 4 knockout mice are protected against endoplasmic reticulum stress induced by a high-fat diet.
... Activation in Adipose Tissue TLR4 appears to mediate the signal linking obesity to insulin ...mechanisms are unclear and seem to be organ-dependent [66]. In the present study, we found that TLR4 was ... Voir le document complet
11
Adiponectin protects against Toll-like receptor 4-mediated cardiac inflammation and injury
... APN in a TLR4-dependent manner might in part explain the observed attenu- ation of cardiac inflammation in EAM following APN ...role in cardiovascular in- flammation by removing cell ... Voir le document complet
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Signatures of positive selection in Toll-like receptor (TLR) genes in mammals.
... 4, 5, 6, 10) and viral TLRs (TLR3, 7, 8, 9) with respect to their ligand recognition ...interleukin-1 receptor (IL1R) and human IL-18 receptor (IL-18R) and designated TIR domain ...“pathogen ... Voir le document complet
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Common CX3CR1 alleles are associated with a reduced risk of headaches.: CX3CR1 gene polymorphisms and headaches.
... vessels with activation of the trigeminal system ...inflammation in response to proinflammatory cytokines are known to play a role in leukocyte activation and recruitment but there is growing ... Voir le document complet
12
Species-Specific Recognition of Aspergillus fumigatus by Toll-like Receptor 1 and Toll-like Receptor 6
... compared with other families [ 41 ]. Human TLR1 and TLR6 are closely located on chromosome 4 [ 39 ], suggesting a gene duplication ...(96% in paralogs and 80% in orthologs) than the ... Voir le document complet
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Mold allergen sensitization in adult asthma according to integrin β3 polymorphisms and Toll-like receptor 2/+596 genotype.
... and Toll-like receptor 2 (TLR2) are candidate genes for asthma and sensitization to mold ...complex with TLR2, and this biological interaction is required for the response of monocytes ... Voir le document complet
12
Caractérisation des propriétés anti-infectieuses de la flagelline, agoniste du Toll-like receptor 5
... protect against pathogenic microbes (1, ...(IL-22) in innate host defense, and tissue protective and regenerative functions in the gastro-intestinal tract (3, ...However, in the gut mucosa the ... Voir le document complet
125
Single nucleotide polymorphisms in the promoter regions of Foxp3 and ICOSLG genes are associated with Alopecia areata.
... Gene sequencing DNA was extracted from the peripheral blood cells by the DNA blood extraction kit (Qiagen, Valencia, CA.). The promoter regions of the FOXP3 and ICOSLG genes, con- taining the rs2294020 (A-3675G) and ... Voir le document complet
7
Toll-Like Receptor 2-Deficient Mice Are Highly Susceptible to Streptococcus pneumoniae Meningitis because of Reduced Bacterial Clearing and Enhanced Inflammation
... mortality in TLR2 ⫺/⫺ mice was not due to defective bacterial clearance in the ...bacteria in the brains, but not in the CSF, of TLR2 ⫺/⫺ ...was associated with a protracted ... Voir le document complet
9
Protein level expression of Toll-like receptors 2, 4 and 9 in renal disease
... diseases are shown in Table 1. Any unspe- cific staining seen with the isotype control was taken into account for the final ...seen in Table 1, TLR-2 and -4 were only seen on ... Voir le document complet
4
Hepatitis C Virus Nonstructural 5A Protein Inhibits Lipopolysaccharide-Mediated Apoptosis of Hepatocytes by Decreasing Expression of Toll-Like Receptor 4
... apoptosis in hu- man hepatocytes, suggesting that it plays an additional Figure ...of Toll-like receptor (TLR) 4 reduces lipopoly- saccharide (LPS)–stimulated HepG2-NS5A cell ... Voir le document complet
9
CD14 Works with Toll-Like Receptor 2 to Contribute to Recognition and Control of Listeria monocytogenes Infection
... washing with PBS that contained ...cells in the liver, mice were euthanized and the organs perfused with ...minced with scissors, pressed through a nylon filter, resuspended in Percoll ... Voir le document complet
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