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Anti-angiogénèse Bevacizumab

VEGF-A

VEGF-B VEGF-C VEGF-D

VEGF-E VEGFR-1

VEGFR-2

Pazopanib

c-Kit Fit-3

Sunitinib VEGFR-3

PDGFR-α PDGFR-β

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Months Pazopanib

Sunitinib 0,0

0,2 0,4 0,6 0,8

1,0 N SSP médiane (IC 95 %)

557 8,4 m (8,3-10,9) 553

Pazopanib

Sunitinib 9,5 m (8,3-11,1) HR (IC 95 %) = 1,047 (0,898-1,220)

Proportion progression-Free

24 28 32 36 40

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Rash

Douleur des extrémités Constipation

Altération du gpût Élévalion des LDH Élévalion de la créalinine Oedème périphérique Syndrome main-pied Dyspepsie

Fièvre Leucopénie Hypothyroidie Épistaxis

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