[PDF] Top 20 Regulation of the DNA replication fork: a way to fight genomic instability
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Regulation of the DNA replication fork: a way to fight genomic instability
... Abstract DNA replication is a complex mechanism that functions due to the coordinated interplay of many ...In the last few years, numerous studies have suggested that ... Voir le document complet
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Topoisomerase 1 suppresses replication stress and genomic instability by preventing interference between replication and transcription.
... Distribution of centre-to-centre distances between BrdU tracks in murine ...(d) Replication fork rate in HCT116 cells transfected with siCtrl and siTop1 ...Analysis of sister ... Voir le document complet
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Does interference between replication and transcription contribute to genomic instability in cancer cells?
... encounter DNA lesions or natural pause sites 7 ...prone to breakage and unscheduled ...represents a prominent source of replication fork arrest and genomic ... Voir le document complet
15
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
... in DNA replication fork remodeling and ...HR-mediated fork remo- deling promotes cancer chemoresistance, by as-yet elusive ...– the RAD51 paralogs RAD51B, RAD51C, RAD51D, XRCC2 and ... Voir le document complet
13
Reversible Top1 cleavage complexes are stabilized strand-specifically at the ribosomal replication fork barrier and contribute to ribosomal DNA stability
... stabilization of Top1cc would implicate some form of regulation of the re-ligation step of the of Top1 ...provide a mechanism for controlled release ... Voir le document complet
11
Aneuploidy Drives Genomic Instability in Yeast
... whether the genomic instability present in the disomic strains was caused by the presence of extra DNA or by aneuploidy-induced imbalances in protein ...human DNA ... Voir le document complet
10
Developmental control of the DNA replication and transcription programs
... in the Whitehead Institute’s Genome Core Facility for the alignment and sequence counting of the Illumina mRNA-sequencing ...in the Whitehead Institute’s Bioinformatics and Research ... Voir le document complet
10
Histone deacetylase inhibitors and genomic instability.
... Sensitization to exogenous DNA damage by ...that the HDACI sodium butyrate enhances cell radiosensitivity in vitro ...and the development of HDACIs as anticancer drugs, the ... Voir le document complet
33
The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer
... Inhibition The major effect of TGFβ, in large tumors in particular, is to resolve inflammation, to facilitate wound healing and to contribute to ...both a source and ... Voir le document complet
10
Restoration of replication fork stability in BRCA1- and BRCA2-deficient cells by inactivation of SNF2-family fork remodelers
... nascent DNA— MCF10A cells were seeded on round coverslips at a density of ...After the indicated treatment, cells were permeabilized with ...subjected to Click-iT reaction with ... Voir le document complet
43
SwiftCloud: Fault-Tolerant Geo-Replication Integrated all the Way to the Client Machine
... is to make scouts co-responsible for the recovery of missing session causal dependencies at the new ...earlier, a scout cannot keep track of all transitive dependencies, we ... Voir le document complet
28
Drosophila E2F and DP genes : their role in the regulation of G1-S progression and the activity of DNA replication origins
... In Chapter 3, mutations in dDP are presented and used to examine the relationship between E2F-dependent G1-S transcription and S phase onset in vivo; the role of dDP and dE2F in cel[r] ... Voir le document complet
168
Supercoiling, knotting and replication fork reversal in partially replicated plasmids
... ABSTRACT To study the structure of partially replicated plasmids, we cloned the Escherichia coli polar replication terminator TerE in its active orientation at different locations in ... Voir le document complet
11
Architecture of the Saccharomyces cerevisiae origin recognition complex bound to origins of DNA replication
... Protein + ATP Required For: Early Step (ATPase inhibited?) A Signal Then Triggers: 4 ATP Hydrolysis and Switch in Protein Activity + Origin Binding PreRC Assembly Origin Unwinding AD[r] ... Voir le document complet
187
A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication
... Regulation and control of DNA replication elongation Whether the loss of viability in GapR-depleted cells arises from the defects in replication or the ... Voir le document complet
49
DNA Replication Restart in Archaea
... rate of the fluorophore, temperature and pH stability or oligomeric state for instance, one has to carefully choose the variants that optimally fit the lifestyle of the ... Voir le document complet
25
A predictable conserved DNA base composition signature defines human core DNA replication origins
... modified to contain hg38 and ...intersect to generate a comprehensive list of all human DNA initiation sites (IS; Table ...by the ENCODE project (hg38, ENCSR636HFF) were ... Voir le document complet
16
Replication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell lines.
... Here, to determine the existence of a new type of replication domains presenting gradients of replication fork polarity, we establish (i) that the ... Voir le document complet
15
A new strategy to fight antimicrobial resistance: the revival of old antibiotics
... isolates of MRSA (97% of USA300 strain) from outpatients with SSTIs, 95% were susceptible to clindamycin ( Moran et ...98% of CA-MRSA iso- lates from patients with SSTI, were susceptible ... Voir le document complet
16
Screening of two agricultural genomic DNA libraries to seek new glycoside hydrolases
... Sequence analyses with the BLASTX program revealed putative enzymes showing between 25% and 72% sequence identity with known enzymes and belonging to [r] ... Voir le document complet
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