[PDF] Top 20 Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors
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Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors
... ABSTRACT Histone lysine acetylation is an epigenetic mark regulated by histone acetyltransferases and histone deacetylases (HDAC) which plays an important role in ...at the mRNA ... Voir le document complet
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A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.
... mitogen and stress activated kinase cascades leads not only to the activation of a variety of transcription factors but also to phosphorylation of HMG-14 (HMGN-1) and histone H3 ... Voir le document complet
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Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases
... in the control of chromatin structure, decreased significantly after TSA ...(19), the TSA-mediated inhibition of Sp1 DNA binding may explain the decrease in expression observed in this ...TSA ... Voir le document complet
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Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines
... for the treatment of various chronic diseases including ...SIRT1 and -2 have been reported to play a key role in the development of ..., 9 Accordingly, first inhibitors comprised ... Voir le document complet
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The role of histone variant H2A.Z in the regulation of gene expression in breast cancer cells
... negative breast cancer types are generally more aggressive and prone to ...metastasize. The absence of Estrogen receptor-alpha (ERa) correlates with hormone-indepen- dent growth of ... Voir le document complet
125
Effect Of Inhibitors Of Histone Deacetylase On The Induction Of Cell Differentiation In Murine And Human Erythroleukemia Cell Lines
... Received 9 November 2004 Revised form accepted 29 March 2005 Introduction Histone deacetylase (HDAC) inhibitors are a relatively new class of potential drugs for the treatment of ... Voir le document complet
9
Targeting steroidogenic enzymes and cyclin-dependent kinases in breast cancer cells : novel attempt to control cell proliferation and cell cycle
... later, the cells were treated with individual STS inhibitors or INH80 at the desired concentrations for 4 days, in the presence of ...On the fourth day, the cells were harvested ... Voir le document complet
176
Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer
... Conclusions and Future Directions In conclusion, regardless of whether SIRT1 has a pro-survival role by repressing TSGs, upregulating the expression of oncogenes, and activating oncogeneic signaling ... Voir le document complet
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Histone deacetylase inhibitors and genomic instability.
... Sensitization to exogenous DNA damage by HDACI. Early observations indicated that the HDACI sodium butyrate enhances cell radiosensitivity in vitro ...findings and the development of ... Voir le document complet
33
Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors.
... Introduction The molecular events governing the onset and progression of malignant transformation involve oncogenic activation and inactivation of tumor suppressor genes, which help ... Voir le document complet
39
SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer
... DISCUSSION Breast cancer is the most commonly diagnosed cancer in women worldwide; it is a multifactorial genetic ...Sporadic breast tumors represent 85 to 90% of all ... Voir le document complet
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The Histone Variant MacroH2A1 Regulates Key Genes for Myogenic Cell Fusion in a Splice-Isoform Dependent Manner
... of Histone Variant MacroH2A1 Affect Gene Transcription? The initial observation that macroH2A1 is enriched on the inactive X chromosome suggested a role in gene repression [ 37 ...While the ... Voir le document complet
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Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury.
... addition to cytokine expression and microglia number, we investigated expression of the LPS-binding protein gelsolin and HSC 70, additional mechanisms by which HDACis are reported to ... Voir le document complet
17
Cytoplasmic I kappa B alpha increases NF-kappa B-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3
... in the cytoplasm of unstimulated cells. Upon stimulation, NF- B moves to the nucleus and induces the expression of a variety of genes including I ...translocates to the ... Voir le document complet
8
Role of Histone H3 Lysine 56 Acetylation in the Response to Replicative stress
... increasing the affinity of Rtt106 and CAF-1 for histones [167], as described above (see section ...DNA and completion of replication, the acetylation is removed from ...for cell ... Voir le document complet
127
Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1.
... is the objective since the combination of different classes of compounds could synergize ...than the sum of the reactivations produced by each compound individually) to reac- tivate HIV ... Voir le document complet
22
Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1
... is the objective since the combination of different classes of compounds could synergize ...than the sum of the reactivations produced by each compound individually) to reac- tivate HIV ... Voir le document complet
23
Effects of Spiro-bisheterocycles on Proliferation and Apoptosis in Human Breast Cancer Cell Lines
... proliferation assays were performed at least six times for each cell line (in replicates of six wells per concentration tested) ...treated and control cells were taken out of freezer storage at ... Voir le document complet
10
Histone H2B-R95A mutant identifies the pheromone pathway that signals cell cycle arrest during rapamycin response
... 22 1.2 La rapamycine et ses protéines ciblées 1.2.1 La découverte de la rapamycine La rapamycine est un métabolite naturel et un macrolide avec une propriété lipophile produite par une bactérie de la terre qui s’appelle ... Voir le document complet
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Arl13b regulates breast cancer cell migration and invasion by controlling integrin-mediated signaling
... Arl13b-silenced and control MDA-MB-231 cells were immunostained for Vinculin to detect ...localizes to and regulates focal adhesion size and integrin-mediated signaling in ... Voir le document complet
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