[PDF] Top 20 Dendritic Spine Loss and Synaptic Alterations in Alzheimer's Disease
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Dendritic Spine Loss and Synaptic Alterations in Alzheimer's Disease
... dendritic spine loss and synaptic alterations, which ulti- mately result in cognitive ...a synaptic level. Kinases and phosphatases influence the cycling, ... Voir le document complet
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Area-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer's disease: dissociation between somatosensory cortex and hippocampus
... plasticity in hippocampal and cortical synapses was assessed by measuring paired pulse ratio in hippocampus and ...of synaptic strength, could be obtained by delivering paired stimuli ... Voir le document complet
10
Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability
... Homer and mGlu5a receptor in den- dritic ...(middle) and during 50 min in the presence of 50 nM TAT-Homer1a ...show loss of interaction between mGlu5a receptor and Homer ... Voir le document complet
14
Imaging Cerebral Oxygenation Alterations in an Alzheimer Mouse Model
... Alzheimer’s disease (AD) is a chronic neurodegenerative disease whose symptoms slowly occur and gradually worsen over time (Gaugler et ...information and statistics,” 2018), half a million ... Voir le document complet
156
Correct Laminar Positioning in the Neocortex Influences Proper Dendritic and Synaptic Development
... neurons. In humans, migration failure during corticogenesis leads to malformations of cortical development that are often associated with epilepsy and intellectual disabil- ity ( Guerrini and Parrini ... Voir le document complet
16
Loss of brain inter-frequency hubs in Alzheimer's disease.
... MPC and we showed that it led to increased classification accuracy ...(78.39%) and sensitivity ...functional alterations underlying AD and provide analytical tools for identifying ... Voir le document complet
14
Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
... dimorphism in biology is a hot topic, and AD research makes no ...higher in women ( Hebert et al., 2013 ), and women suffering from AD display specific cognitive alterations, biomarker ... Voir le document complet
21
β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network
... synapse loss in the Hi compartment within 24 h (Figure 3c-e), whereas cortical axons and soma showed no obvious sign of de- generation (Figure ...synapse loss that is followed by delayed ... Voir le document complet
10
Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor
... cognitive alterations. Materials and methods Post-mortem brain samples Post-mortem brain tissue was obtained from brain banks at university medical centres in Lille (France), Paris (France) ... Voir le document complet
20
Loss of X-linked mental retardation gene oligophrenin1 in mice impairs spatial memory and leads to ventricular enlargement and dendritic spine immaturity.: Phenotypic characterization of ophn1 knockout mice
... analyses in the CA1 hippocampus of ophn1 ⫺/y revealed little, if any, changes in the global dendrite structure of pyramidal ...quantitative and qualitative alterations were observed in ... Voir le document complet
13
Dendritic Spine Plasticity: Function and Mechanisms
... cortex in a given hemisphere receives sensory input predominantly from the contralateral eye, while the contribution of the ipsilateral eye is much ...(MD), and recording visual signals in the ... Voir le document complet
27
Synaptic Activity and (Neuro)Inflammation in Alzheimer’s Disease: Could Exosomes be an Additional Link?
... synaptic dysfunction precedes alterations in neurotransmitter release, and thus impairment of memory and cognitive functions [1] ...(amyloidosis) and clinical symptom onset are ... Voir le document complet
32
Brain Regions Showing White Matter Loss in Huntington’s Disease Are Enriched for Synaptic and Metabolic Genes
... ’s Disease Centre (PM, SG, MP, EJ, RIS, SJT), Department of Neurodegenerative Disease; and Wellcome Trust Centre for Neuroimaging (AR, GR), UCL Institute of Neurology; Developmental Imaging ... Voir le document complet
11
Heterogeneous Spine Loss in Layer 5 Cortical Neurons after Spinal Cord Injury
... the dendritic spine density from a subset of layer 5 neurons along the entire 420-lm-long apical dendrite traveling through cortical layers 5 to ...cortex in mice before and 3, 7, and ... Voir le document complet
9
Dendritic Spine Morphology Determines Membrane-Associated Protein Exchange between Dendritic Shafts and Spine Heads
... variability in the shape of dendritic spines affects protein movement within the plasma ...microscopy and the fluorescence loss in photobleaching technique in living hippocampal ... Voir le document complet
6
Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer’s disease mice
... basal synaptic transmission in all groups was not affected. In addition, we analyzed paired-pulse facilitation (PPF) of fEPSP to afferent stimulation, a form of short-term synaptic ...response ... Voir le document complet
31
Alterations of the epigenome in brain cancer: loss of 5-hydroxymethylcytosine
... sites in mammals ...development and maintains genetic stability thereafter ...reported in the 1970’s (5,6), this modification was only recognized as a novel epigenetic mark related to 5mC in ... Voir le document complet
69
Progressive hearing loss in Fabry's disease: a case report
... week later, he tried to use his hearing aids and noticed that he could not hear on the left side. The patient presented for audiological consultation the 23rd of May 2003. The clinical examination showed a normal ... Voir le document complet
4
Clinical and haematological alterations in foot and mouth disease virus naturally-infected domestic water buffaloes in Vietnam
... DAM VAN P 1,2 ., BUI TRAN ANH D 1 ., DESMECHT D 2 . 1. Department of Pathology, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, Vietnam. 2. Department of Pathology and Autopsy, ... Voir le document complet
1
Effect of chemically induced mGluR-dependent long-term depression on dendritic spine volume
... demonstrated that the temporal bidirectionality of L-LTP facilitation is asymmetric, that synaptic tag and capture is a spatially localized process favoring a dendritic branch (ra[r] ... Voir le document complet
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