Hedgehog signaling pathway
The importance of the Hedgehog signaling pathway at the level of the blood-brain barrier
... the signaling pathway 157 . Binding of Shh to Ptch-1 alleviates repression of the signal transducer Smoothened (Smo), a serpentine transmembrane protein with a topology reminiscent of Frizzled family of ...
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Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs.
... Effects of Su(fu) over-expression are enhanced in a fu mutant background It is known that Su(fu) and Fu act antagonistically in the Hh pathway as negative and positive effectors, respectively, (Alves et al., 1998; ...
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The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth.
... The inhibition of the SHH signalling pathway does not induce CRCC cells senescence. RCC cells were seeded in 24-well plates (20,000 cells/ ml), grown for 24 h, and then treated for 1 day to 5 days with 20 μ M ...
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Hedging against Neuropathic Pain: Role of Hedgehog Signaling in Pathological Nerve Healing
... morphogenetic Hedgehog signaling pathway and its main effectors, Sonic Hedgehog (SHH) and Desert Hedgehog (DHH) in the regenerative drive following nerve ...dysfunctional ...
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Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes
... Several studies have demonstrated the hypoglycemic effect of UA [15–19]. The reported mechanisms include the inhibition of protein tyrosine phosphatase 1B (PTP1B) [21], increase of liver glycogen synthesis [22], ...
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A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib
... with wild-type BMDCs, Sema4A-deficient BMDCs were im- paired in their ability to migrate toward ear lymphatic vessels (Figs. 3 a and S3 a). Given that lymphatic endothelial cells play an important role in guiding DCs to ...
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Bone morphogenetic protein signaling pathway plays multiple roles during gastrointestinal tract development.
... Human ENS disorders are fairly common and include Hirschsprung’s disease, a pediatric dysmotility disorder associated with a varying amount of colonic agangliosis (Amiel and Lyonnet, 2001). It is speculative but ...
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Thyroid-specific inactivation of Kif3a alters TSH signaling pathway and leads to hypothyroidism.
... Finally, our results in mouse embryonic fibroblasts indicate that Kif3a inactivation in the absence of any Pax8 gene alteration leads to altered GPCR plasma membrane expression, as sho[r] ...
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Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML
... downstream signaling pathways in order to i) prevent potential resistance mechanisms to inhibition of the metabolic targets and ii) nominate combination therapies that may synergize with metabolic ...relevant ...
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Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes
... mechanism mitigates the “biphasic effect” in which scaffold proteins can exhibit concentration-dependent titration effects (19). Increasing concentrations of scaffold proteins initially favor interaction of partner ...
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Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway
... Sortilin-released propeptide A B S T R A C T Deterioration of insulin secretion and pancreatic beta-cell mass by inflammatory attacks is one of the main pathophysiological features of type 2 diabetes (T2D). Therefore, ...
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UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway
... Thus, there is an urgent need to develop novel and more effective PI3K/Akt signaling pathway inhibitors for colon cancer therapy. In our present study, we studied the effects of UNBS5162, which inhibited ...
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Hippo/YAP Signaling Pathway: A Promising Therapeutic Target in Bone Paediatric Cancers?
... Hippo pathway and other factors such as chromatin remodeling or other signaling ...Other signaling pathways can interact with the Hippo/YAP/TAZ pathway [ 28 ...Hippo pathway may be ...
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Chitotetraose activates the fungal-dependent endosymbiotic signaling pathway in actinorhizal plant species
... lular or intercellular Frankia root colonization respectively. Host perception of AM fungal sig- nals was studied for both plants using a nuclear-localized Ca 2+ reporter to monitor the activation of the conserved ...
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Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in Cancers
... indicate that KCNQ1 restricts the Wnt/ b-catenin signaling pathway activity, stabilising b-catenin at the plasma membrane. These results reveal a new role for KCNQ1: in parallel with its function of ...
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Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway
... Figure 2. Type I and II IFNs promote CLL cell resistance to apoptosis through an STAT3/Mcl-1 signaling pathway. (a,b) Cell lysates from CLL cell samples cultured for 24 h in the presence or absence of IFNs ...
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The Transient Receptor Potential Channel TRPM8 Is Inhibited via the α2A Adrenoreceptor Signaling Pathway
... ing pathway is ...␣2A-AR-to-TRPM8 pathway in HEK-293 cells, employment of specific pharmacological and molecular tools combined with patch-clamp recording of the whole-cell TRPM8 currents, ...
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Hedgehog theory via Euler calculus
... intersection number of almost every oriented half-line with origin x with the hypersurface H h equipped with its transverse orientation [5]. This index is, in some sense, the corner stone of hedgehog theory. In ...
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Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration
... FGF pathway promotes the migration of the parapineal in the zebrafish ...Notch signaling in modulating FGF activity within the ...FGF pathway, global activation of Notch signaling decreases ...
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Genetic variants of TORC1 signaling pathway affect nitrogen consumption in Saccharomyces cerevisiae during alcoholic fermentation
... TORC1 signaling pathway ( Fig 2 ...TORC1 pathway on nitrogen ...TORC1 signaling pathway [ 50 ], therefore, supporting our hypothesis that allelic variants in TORC1 could be impacting ...
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