[PDF] Top 20 The role of GSK-3 in synaptic plasticity.
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The role of GSK-3 in synaptic plasticity.
... isoforms of GSK-3 in mammals that are encoded by different genes (GSK-3α and GSK-3β) (Woodgett, 1990), the latter of which has two splice ...homologous in ... Voir le document complet
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Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment
... elaborate the mechanisms that lead to p25 generation, we first used calpeptin to inhibit calpain, which cleaves p35 to p25 following neurotoxic ...treatment of acute hippocampal slices in the ... Voir le document complet
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Muscarinic M1 Receptor Modulation of Synaptic Plasticity in Nucleus Accumbens of Wild-Type and Fragile X Mice
... mRNAs in the brain and especially in synapses. 26 − 28 In humans with FXS, the loss of FMRP results in a variety of neurological symptoms widely associated with ... Voir le document complet
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Ca²+ mechanisms of synaptic integration and plasticity in inhibitory interneurons
... number of social and cognitive deficits as well as manifestations of ...beyond the scope of this work), but many pieces of evidence point to interneuron dysfunction as an important part ... Voir le document complet
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Differential role of pre-and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites
... Induction of plasticity normalizes presynaptic strengths in the stimulated axon Our experiments thus far examined the relative contribution of the presynaptic cell and ... Voir le document complet
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Role of the actomyosin cytoskeleton on the synaptic effects of the type-1 cannabinoid receptor (CB1R)
... 4 of 23 Research article Figure 1. CB1R activation induces retraction of actin-rich growth ...retraction of the F-actin- rich domain ...Progression of individual growth cones in ... Voir le document complet
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Role of vascular plasticity in muscle remodeling in the child
... Changes in the microenvironment in aging muscle could impede the physiological angiogenesis and myogenesis and thus alter muscle capacities to ...regenerate. In parallel, the ... Voir le document complet
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LTP inhibits LTD in the hippocampus via regulation of GSK3beta.: A role for GSK3beta in synaptic plasticity
... surrounding the stimulating electrode was then dissected and ...activity in hippocampal slices following electrode induced LTD (900 stimuli delivered at 3 Hz) microdissected areas of slices ... Voir le document complet
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Regulation of glutamatergic neurotransmission, synaptic plasticity, sleep and behavior by D2-GSK3B-FXR1
... One of the best described GSK3 incorporating pathways is the regulation of β- catenin downstream of Wnt ...activation of the canonical Wnt pathway, ligands bind to seven ... Voir le document complet
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Sushi domain-containing protein 4 controls synaptic plasticity and motor learning
... SUSD4 and GluA2 interaction is affected by SUSD4 binding to NEDD4 ubiquitin ligases, co- 356.. immunoprecipitation experiments were performed on extracts from heterologous HEK293 cells [r] ... Voir le document complet
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Consequences of synaptic plasticity at inhibitory synapses in mouse hippocampal area CA2 under normal and pathological conditions
... broader role for area CA2? Recent reports investigating place cell dynamics indicate this region likely does not encode spatial information but rather displays marked instability over time in the ... Voir le document complet
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Area-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer's disease: dissociation between somatosensory cortex and hippocampus
... applied in this superfusion. MEA was positioned on the platform of a Leica inverted microscope equipped with a CCD camera (CoolSnap, Roper Scientific, ...Images of the ... Voir le document complet
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Chronic Sodium Selenate Treatment Restores Deficits in Cognition and Synaptic Plasticity in a Murine Model of Tauopathy
... ). The spatiotemporal progression of NFTs from the entorhinal cortex and the hippocampus to the isocortical areas has been reported to correlate well with cognitive deficits and disease ... Voir le document complet
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Role of synaptic variability in spike-based neuromorphic circuits with unsupervised learning
... robustness. In this paper, we fully characterize a 4kbit RRAM array under different pro- gramming ...conditions. The impact of the electrical characteristics of RRAM (resistance ... Voir le document complet
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Role of synaptic variability in resistive memory-based spiking neural networks with unsupervised learning
... Role of synaptic variability in Resistive Memory-based Spiking Neural Networks with unsupervised learning 2 ...adaptive synaptic elements in artificial bio-inspired Spiking ... Voir le document complet
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The role of frameshifting and transcriptional dysregulation in spinocerebellar ataxia type-3
... transcriptional impairment could be responsible for the degeneration observed in affected fleurons, and since we have shown that in SCA3 this impairment seems to be independent of RNAPII[r] ... Voir le document complet
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Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)—hydrogen sulfide (H2S) pathway in cancer cells
... roles in mammalian cells in health and ...emerged in the field of H 2 S biology, showing that various cancer cells upregulate their endogenous H 2 S production, and utilize this mediator ... Voir le document complet
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CD8 + T cells are essential for the effects of enriched environment on hippocampus-dependent behavior, hippocampal neurogenesis and synaptic plasticity
... floating in an upright position with only slight movements to keep its head above water (Pechnick et ...test The social testing apparatus was a rectangular, three-chambered box with clear Plexiglas walls, ... Voir le document complet
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CD4 + T Cells Have a Permissive Effect on Enriched Environment-Induced Hippocampus Synaptic Plasticity
... assistance in the animal care facility; Iris Grosjean, Sophie Abelanet, and Frederic Brau from the imaging platform of IPMC; Delphine Debayle and Anne Sophie Gay from the proteomic ... Voir le document complet
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The yin and the yang of follicular lymphoma cell niches: Role of microenvironment heterogeneity and plasticity.
... display in vitro a greater phagocytic capacity towards Rituximab-opsonized B cells from chronic lymphocytic leukemia (CLL), when compared to M1 proinflammatory macrophages ...regulation of FcγR expression ... Voir le document complet
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