Up-Regulation
Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases
... VEGF regulation, we found that the activation of MAPK/ERK kinase, p38 MAPK, or phosphatidylinositol 3-kinase pathways is not required for VEGF up- regulation in our experimental ...VEGF ...
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Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression.
... development, up-regulation of ATX occurred only 3 weeks after emergence of hyper- insulinemia, and was concomitant to emergence of ...was up-regulated by treatment with TNFα (insulin ...
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Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor
... Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor.. Supplementary Figures.[r] ...
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Infrared optical imaging of matrix metalloproteinases (MMPs) up regulation following ischemia reperfusion is ameliorated by hypothermia
... Discussion This study reports a novel early up-regulation of MMP- 9 in ischemic reperfusion. The acute in-vivo detection of MMP upregulation following ischemic stroke has not been reported previously. ...
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Transcriptional analysis of PRRSV-infected porcine dendritic cell response to Streptococcus suis infection reveals up-regulation of inflammatory-related genes expression
... clearly up-regulated IFN-β and, to a lesser extent, IFN-α, confirming previous pub- lished data [ 52 , 53 ...also up-regulated IFN- β and, to a lesser extent, IFN-α. Although the up-regulation ...
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Global gene expression in muscle from fasted/refed trout reveals up-regulation of genes promoting myofibre hypertrophy but not myofibre production
... the up-regulation of a large number of genes involved in this process, notably HSP90 and ...the up-regulation of genes promoting myofibre hypertrophy was not associated with an activation of ...
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Transcriptional Activation and Cell Cycle Block Are the Keys for 5-Fluorouracil Induced Up-Regulation of Human Thymidylate Synthase Expression
... Moreover, the presence of the inactive ternary complex 3– 6 hours posteriori of 5-FU addition (figure 6) supports the notion that the steady-state expression level of hTS reflects increased stability of hTS in the ...
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Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression.
... Several recent reports have implicated FLCN in the energy and nutrient signaling pathway through its inter- actions with FNIP1 and FNIP2 and its indirect interac- tion with AMPK (Figure 4A). These studies have also ...
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Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3β-HSD inhibition
... Significant up-regulations in gene expression of both 3β-HSD and 17β-HSD were observed at PMZ concentration of ...pronounced up-regulation in 3β-HSD gene expression was also observed for ...This ...
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RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity.
... In the present study we developed a more selective approach to identify truly kinase involved in EROD regulation. We first considered a kinase as a potential hit when at least 2 out of 3 siRNA were found into the ...
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Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure
... [3H]PK 11195 autoradiography PTBR binding sites were determined by autoradiography using the specific PTBR/IBP ligand [3H]PK 11195 as described before [18]. 20 μM thick sagittal brain sections were cut using a cryostat ...
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Model-based investigation of the circadian clock and cell cycle coupling in mouse embryonic fibroblasts: Prediction of RevErb-α up-regulation during mitosis
... a regulation of the cell division cycle by the circadian clock [2, 3, 4], in particular in mammalian cells with possible applications to cancer chronotherapies [5, ...this regulation. In particular the ...
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The coordinated up-regulation of the ubiquitin-proteasome and autophagy-lysosomal pathways strongly alters the Human muscle proteome during ultra-endurance exercise
... Alice Decourt, Cécile Coudy-Gandilhon, Guillaume Millet, Cécile Polge, Lydie Combaret, Daniel Taillandier, Didier Attaix, Christophe Chambon, Léonard. Féasson, Daniel Bechet[r] ...
5
Plant virus infection influences bottom-up regulation of a plant-aphid-parasitoid system
... control through a reduction in their abundance and between-field movement. However, while negative effects of virus infection on parasitoid fitness are likely the result of bottom-up effects they may also be due ...
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Angiogenesis by Fibroblast Growth Factor 4 Is Mediated through an Autocrine Up-regulation of Vascular Endothelial Growth Factor Expression
... This result was confirmed by Northern blot analysis of total RNA extracted from the three cell types; the steady-state level of VEGF mRNA was low and equivalent in EF43.C and EF43.Fgf-3,[r] ...
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Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism
... Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give ...
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DeltaNp63 isoform-mediated beta-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma.
... GLIIHUHQFH LQ WHUPV RI +ȕ' H[SUHVVLRQ ZDV REVHUYHG EHWZHHQǻ1SSRVLWLYHDQGQHJDWLYHFHOOV,QRUGHUWR GHPRQVWUDWH WKLV UHODWLRQVKLS EHWZHHQ S DQG +ȕ'V ...
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Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation.
... Using a whole-cell patch-clamp configuration, we further determined both total I Na and TTX-R Na v 1.8 currents in large-soma dorsal root ganglia (DRG) neurons isolated from sham or CFA-[r] ...
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Concerted Up-regulation of Aldehyde/Alcohol Dehydrogenase (ADHE) and Starch in Chlamydomonas reinhardtii Increases Survival under Dark Anoxia
... 6 profiles of mutant strain 10-6C appeared stable through the 24 h-period. To gain insights into the respective acclimation of the two strains to dark anoxia, selected proteins were followed by immunoblotting ...
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Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor
... Increasing evidence has revealed that miRNAs may play a central role in chronic drug exposure-triggered neuroadap- tive processes [for review see ( Pietrzykowski, 2010 )]. miR- NAs were profiled, using miRNA array ...
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