Population pharmacokinetics
Target-Mediated Drug Disposition Population Pharmacokinetics Model of Alirocumab in Healthy Volunteers and Patients: Pooled Analysis of Randomized Phase I/II/III Studies
... a population pharmacokinetics (PopPK) model for alirocumab in heal- thy subjects and patients, taking into account the mecha- nistic target-mediated drug disposition (TMDD) ...
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Population pharmacokinetics of oxcarbazepine and its monohydroxy derivative in epileptic children
... 42. Yukawa E, Higuchi S, Aoyama T. Phenobarbitone population pharmacokinetics from routine clinical data: role of patient characteristics for estimating dosing regimens. J Pharm Pharmacol. ...
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Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonates.
... Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonates. Déborah Hirt, Saik Urien, Elisabeth Rey, Elise Arrivé, Didier Ekouévi, Patrick ...
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Powers of the likelihood ratio test and the correlation test using empirical bayes estimates for various shrinkages in population pharmacokinetics.
... Population pharmacokinetics (PK) is increasingly used in drug development and is based on nonlinear mixed-effect models (NLMEMs). 1 Several software algorithms developed to estimate the parameters of these ...
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Population pharmacokinetics of nalbuphine after surgery in children
... a population pharmacokinetic study carried out in neo- ...on pharmacokinetics of nalbuphine in a paediatric population aged 1 –11 yr ...accurate population pharmacokinetic parameters by using ...
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A mechanism-based model for the population pharmacokinetics of free and bound aflibercept in healthy subjects.
... versus population predictions and observations versus individual predictions indicated that the model adequately described the observations over the dose ...
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Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide.
... biological functions, and the pharmacokinetics in patients may show a number of modifications. All the evaluation methods we presented aim at providing one or a small set of metrics to assess model adequacy. As ...
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Evaluation of bootstrap methods for estimating uncertainty of parameters in nonlinear mixed-effects models: a simulation study in population pharmacokinetics
... · Pharmacokinetics · Uncertainty of parameters · MONOLIX 1 Introduction Nonlinear mixed-effects models (NLMEM) have been widely used in the field of pharmacokinetics (PK) and pharmacodynamics (PD) to ...
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Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies.: Softwares for design evaluation in population PKPD
... D-criterion predicted by the different software tools for the warfarin PK model compared to simulated D-criterion calculated from the inverse of the empirical covariance matrix. NM FOC[r] ...
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Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm.
... * Correspondence should be adressed to: Julie Bertrand <julie.bertrand@inserm.fr > Abstract Pharmacogenetics is now widely investigated and health institutions acknowledge its place in clinical ...
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Population pharmacokinetics and pharmacodynamics of cysteamine in nephropathic cystinosis patients
... and population pharmacokinetic- pharmacodynamic model Data were analysed using the nonlinear mixed effect modelling software program Monolix version 31s http:// ...the population model estimate of the BSV ...
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Methods and software tools for design evaluation in population pharmacokinetics-pharmacodynamics
... Answer to Referees' comments Referee 1 Comments to the Author The authors describe how one experimental design can be evaluated by the set of existing optimal design software tools (that all are based on calculation of ...
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Population pharmacokinetics of levobupivacaine during a transversus abdominis plane block in children
... 7. Sola C, Menace C, Rochette A, Raux O, Bringuier S, Molinari N, et al. Ultrasound-guided tranversus abdominis plane block for herniorrhaphy in children: what is the optimal dose of levobupivacaine? Eur J Anaesthesiol. ...
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Pharmacokinetics of intramuscular alfaxalone and its echocardiographic, cardiopulmonary and sedative effects in healthy dogs.
... 13.8 ± 4.6 minutes; 31.4 ± 6.9 minutes; 75.1 ± 28.9 minutes at 2, 3, 6 and 20 mg kg -1 , respec- tively) [ 4 , 6 ]. Most studies report that the quality of recovery from alfaxalone anaesthesia alone in dogs is “quite ...
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Influence of alpha-1 glycoprotein acid concentrations and variants on atazanavir pharmacokinetics in HIV-infected patients included in the ANRS 107 trial.: alpha 1 glycoprotein acid polymorphism and atazanavir pharmacokinetics
... Influence of alpha-1 glycoprotein acid concentrations and variants on atazanavir pharmacokinetics in HIV-infected patients included in the ANRS 107 trial.: alpha 1 glycoprotein acid poly[r] ...
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Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers.
... drugs. Pharmacokinetics of clopidogrel, its inactive carboxylic acid metabolite as well as the active metabolite was determined from blood samples taken before (H0) and at various times after administration of the ...
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In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles.
... Anne-Laure Bailly 1,2 , florian correard 1,3 , Anton popov 4,5 , Gleb tselikov 4 , florence chaspoul 6 , Romain Appay 1,7 , Ahmed Al-Kattan 4 , Andrei V. Kabashin 4,5 , Diane Braguer 1,3 & Marie-Anne esteve 1,3 ...
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La population autochtone
... Qui plus est, les esti ma tions de popu la tion de l’ère pré sta tis ti que que l’on tro uve dans les sour ces sont notoi re ment impré ci ses et sou vent repri ses d’un auteur[r] ...
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Population et habitat
... Le résul tat de tout ce pro ces sus est visi ble à la fois dans l’espace et dans la topo ny mie locale (rang des Caron, rang des Matte, etc.), et laisse l’impres sion d’une orga ni[r] ...
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Population et territoire
... Les regis tres qué bé cois sont d’une grande qua lité. D’une part, le calme rela tif de l’his toire qué bé coise et le res pect de l’ordon nance de 1678, exi geant que les regis tres[r] ...
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