Myeloid-derived suppressor cell
Early-life microbiota exposure restricts myeloid-derived suppressor cell-driven colonic tumorigenesis Running Title: Early-life microbiota restricts colonic tumorigenesis
... epithelial cell (IEC) proliferation in exGF mice were associated with augmented intratumoral chemokine expression and granulocytic myeloid-derived suppressor cell (G-MDSC) ...
28
Evaluation of the Therapeutic Potential of Bone Marrow- Derived Myeloid Suppressor Cell (MDSC) Adoptive Transfer in Mouse Models of Autoimmunity and Allograft Rejection
... decade, myeloid-derived suppressor cells (MDSC) have emerged as novel key regulatory players in the context of tumor growth, inflammation, transplantation or ...T cell proliferation in ...T ...
11
Regulatory myeloid cells: an underexplored continent in B-cell lymphomas
... the myeloid compartment. In particular, high circulating monocyte or myeloid-derived suppressor cell counts are associated with poor prognosis for patients with high- grade ...
26
en fr Myeloid-derived suppressor cells in septic patients Cellules suppressives d'origine myéloïde au cours du sepsis
... Introduction Sepsis is one of the leading causes of morbidity and mortality in intensive care units (ICUs) and affects more than one million critically ill patients each year in the United States alone (1). Although ...
279
Early expansion of circulating granulocytic myeloid-derived suppressor cells predicts development of nosocomial infections in septic patients
... TGF-ß; and induction of Tregs (14-17). Two main subsets, monocytic (M)-MDSCs and granulocytic (G)-MDSCs, have been identified, but their definition and role in humans remain elusive due to the lack of specific ...
57
Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models
... BM- derived MDSC cultures resulted in an increase in the cell content of TCA cycle ...be derived from isocitrate or L-Gln, accumulated at a rate of ...the cell specific concen- tration of ...
16
Myeloid-Derived Suppressor Cells in Hematologic Diseases: Promising Biomarkers and Treatment Targets
... prevents the accurate quantification of absolute MDSC numbers whereas markers unique for MDSCs have not been identi fied so far. Therefore, the functional characterization, and specifically the T-cell suppression ...
13
Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow
... for myeloid markers whereas T-, NK-, and B- gates expressed CD3, CD16/CD45RA, CD19, ...Left- Cell abundance in gate (Mo, DC, MDSC, M_b, M_LPS, M_IFNγ, M_IL4, M_IL10, M_IL6, and M_TPP) reported to MPS gate ...
40
Deciphering the Crosstalk Between Myeloid-Derived Suppressor Cells and Regulatory T Cells in Pancreatic Ductal Adenocarcinoma
... a cell-cell dependent manner, (ii) Treg cells affect the survival and/or the proliferation of ...Treg cell interactions to alleviate tumor-induced immunosuppression might suggest a new therapeutic ...
17
Deciphering myeloid-derived suppressor cells isolation and markers in humans, mice and non-human primates
... and morphological characteristics with monocytes, and CD11b + Ly6G + Ly6C lo PMN-MDSC, which resemble neu- trophils [ 6 , 7 , 43 , 54 ]. These markers are present on multi- ple hematopoietic cells thereby calling for a ...
12
A dynamic metabolic flux analysis of myeloid-derived suppressor cells confirms immunosuppression-related metabolic plasticity
... ơ
Ǥ Dynamic metabolic flux analysis confirms MDSCs mimick tumour cells metabolic profile. Indeed, model simulation of experimental data confirm that ...
15
Dendritic Cell Activating Receptor 1 (DCAR1) Associates With FcεRIγ and Is Expressed by Myeloid Cell Subsets in the Rat
... Dendritic cell activating receptor-1 (DCAR1) is a cell-surface receptor encoded by the Antigen Presenting Lectin-like gene Complex ...of myeloid cells in lymphoid tissue, but was uniformly expressed ...
13
Small efficient cell-penetrating peptides derived from scorpion toxin maurocalcine.
... their mode of cell penetration, some being more prone to enter cells by macropinocytosis than others. Various peptides were even insensitive to amiloride application suggesting that macropinocytosis did not ...
20
PD1/PD-L1 dependent immunosuppression by huiPS-derived cell population
... in cell therapy due to their ability to differentiate in any cell ...(patient’s derived iPS), iPS derived cells can induce rejecting immune responses ...
2
Asporin Is a Fibroblast-Derived TGF-beta1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer.
... each cell line] and GSE41445 [three replicates]) comparing the mRNA expression of MDA-MB-231 and MCF-7 cells [ 36 , 37 ...for cell-to-cell contact, we hypothesized that the effect must be mediated ...
29
Endothelial cell-derived microparticles induce plasmacytoid dendritic cell maturation: potential implications in inflammatory diseases.
... shown), excluding a role of nucleic acids packed into EMP in PDC maturation. Alternatively, EMP-induced PDC maturation may use a distinct mechanism that does not lead to IFN- α secretion. Some C-type lectin receptors, ...
12
Inferior outcome of allogeneic stem cell transplantation for secondary acute myeloid leukemia in first complete remission as compared to de novo acute myeloid leukemia
... Variables of interest were patient and donor char- acteristics (age, gender, Karnofsky performance score [KPS], cytomegalovirus [CMV] serostatus), disease- related (favorable/intermediate/adverse cytogenetics according ...
10
Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists
... Western blot analysis. For STAT5 protein analysis, K562 cells (2.5 3 10 5 ) were lysed in RIPA lysis buffer on ice. Whole-cell extracts were boiled for 5 min in Laemmli sample buffer and subjected to SDS–PAGE in ...
17
New methodological strategies in haematology using cell-derived microvesicles
... parental cell, thus constituting a disseminated dynamic pool of bioactive effectors or messengers, as do- cumented by several in vitro studies [17 25, 19 22, 20 ...
5
Comprehensive proteomic characterization of stem cell-derived extracellular matrices
... cells as compared to TCPS culture, indicating that the ECM signatures influence each cell type in 46 a differential fashion.. Materials and methods 51..[r] ...
25