Glucocorticoid-induced muscle atrophy
Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy
... glucocorticoid-induced stimulation of the ...ticoid-induced muscle atrophy partially at least by inhibition of the ubiquitin-proteasome ...
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Obestatin signalling counteracts glucocorticoid‐induced skeletal muscle atrophy via NEDD4/KLF15 axis
... and muscle regeneration, obestatin participates in the speci fication of muscle fibre identity by inducing skeletal muscle remodelling towards an oxidative phenotype and en- hancing muscle ...
14
Physiological role of receptor activator nuclear factor-κB (RANK) in denervation-induced muscle atrophy and dysfunction
... skeletal muscle contractile ...denervation, muscle diseases, or glucocorticoid treatments affect all four muscle fiber phenotypes to different ...favor muscle atrophy and a ...
6
REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy
... skeletal muscle in vivo has been poorly ...skeletal muscle mass, protein synthesis, proteolysis, and mTORC1 signaling pathway under basal conditions and after glucocorticoid ...skeletal muscle ...
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Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy
... the muscle secretome elicited by mus- cle atrophy should allow us to better understand the cellular mechanisms involved in this process and might lead to iden- tify circulating biomarkers of this condition, ...
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Effects of leucine supplementation and resistance exercise on dexamethasone-induced muscle atrophy and insulin resistance in rats
... skeletal muscle atrophy [23 –26] of fast-twitch fibers [27] ...skeletal muscle loss [26] ...through glucocorticoid receptor translocation, and/or indirectly by the impairment of signaling ...
7
Inhibition of Atrogin-1/MAFbx Mediated MyoD Proteolysis Prevents Skeletal Muscle Atrophy In Vivo
... lateral muscle. An electrical field was then applied to muscle with calliper rule electrodes coated with ultrasound transmission gel (Aquasonic 100, Parker) and placed on each side of the ...
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Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old Wistar rats
... efficiently induced vitamin D deficiency in old ...skeletal muscle atrophy in old rats through a reduction in the proliferative ability and in Notch pathway activity in skeletal ...of muscle ...
2
Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old wistar rats
... the muscle atrophy in old rats as the expressions of key markers modulating muscle cell proliferation are down- ...was induced in our model, discrete episodes of repair and regeneration occur ...
14
Role of the UPS proteolytic pathway during muscle atrophy: from animal models to human diseases
... on muscle wasting following chronic kidney disease in humans: the PROMETHE cohort CT (n=13) Cancer (n=14) Hemodialysis (n=7) Men / Women 7 / 6 9 / 5 6 / 1 ...
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Grape polyphenols supplementation reduces muscle atrophy in a mouse model of chronic inflammation
... Methods: We used a transgenic mice model (transforming growth factor [TGF] mice) to develop a high T cell –dependent inflammation and C57 BL/6 control (CTL) mice model. Skeletal muscles of TGF and CTL mice were ...
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Skeletal muscle disuse atrophy : implications on intracellular signaling pathways and mitochondrial permeability transition pore function
... The three original studies presented in this thesis have provided information regarding the cellular processes regulating disuse muscle atrophy with respect to: 1) the understanding of i[r] ...
209
Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress
... skeletal muscle after intensive endurance exercise (assessed by mitochondrial DNA content, and BNIP3 and ULK S317 levels; Additional file 2 : Figure S11) as well as after hypoxia (BNIP3, Gabarapl and LAMP2A mRNA ...
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Nutritional strategies to counteract muscle atrophy caused by disuse and to improve recovery
... prandial muscle protein synthesis (148 – 150) ...reduces muscle protein breakdown and further stimulates muscle protein syn- thesis (159 – 161) ...limit muscle atrophy during ...
18
During early recovery the worsening of immobilization-induced rat tibialis anterior muscle atrophy is associated with sustained activation of proteolytic and apoptotic pathways
... Depot modulation of interferon- γ in rat white adipose tissue by cancer-associated cachexia Alex S. Yamashita, José C. Rosa Neto, Rodrigo X. Neves, Miguel L Batista Junior, Marília C Seelaender (Department of Cell and ...
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Adaptive β-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance
... Figure 3: The beta-cell mass adaptation is reversible and can be re-induced (A) Scheme of the protocol. During 4 weeks, mice were treated with CORT or VEH (I). Mice were then submitted to a 4-weeks washout (II). ...
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Unilateral hindlimb casting induced a delayed generalized muscle atrophy during rehabilitation that is prevented by a whey or a high protein diet but not a free leucine-enriched diet
... maintain muscle mass ...of muscle leucine-associated protein metabolism pathways and the delayed availability of amino acids as substrates can explain that protein anabolism was only stimulated for a very ...
11
Assessing atrophy measurement techniques in dementia: Results from the MIRIAD atrophy challenge
... brain atrophy in many neurodegenerative disorders, with several research groups developing and publishing techniques to provide quantitative assessments of this longitudinal ...MIRIAD atrophy challenge in ...
17
Role of p38MAPK in palmitate-induced inflammation in C2C12 muscle cells
... Institute of Cardiometabolisme and Nutrition (ICAN), INSERM, Sorbonne University Fibrosis occurs in many organs including the white adipose tissue (WAT) as a result of prolonged tissue injury with exaggerated extra- ...
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Role of P38MAPK in palmitate-induced inflammation in C2C12 muscle cells
... Introduction: Objectives: 100 nM Insulin The aim of the study was to investigate the n-3PUFA effects on PAL-induced inflammation and the potential link between inflammation, p38 mitogen-activated protein kinase ...
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