ل تا
و ما !
ﺍ
ةرازو
%ا !%ا ـــ
'%ا ()*%او '%
%ا ر%ا ـــ
+%
ـــــ ة,
-%ا *-%ا /ا0%ا )
(
Ministère de l'enseignement Supérieur
et de la recherche Scientifique
ECOLE NORMALE SUPERIEURE Vieux – kouba (ALGER)
يZ ذ!أ ةد^_ % ج/ ة/آ,
داإ c e) :
فا/_إ :
د ي^ - ذ!hا
/i%ا * 'آ :
-jر '%kl ج c - د -
mn%ا 0%
:
ةذ!hا - j_ c/- :
oر
ذ!hا-
)! %p زا/p :
ذ!hا- j/m /i%ا * 'آ :
0%ا o%ا :
2008 - 2009
jد ناl: 2009
ﺹﹼﺨﻠﻤﻝﺍ
ﻡﺍﺩﺨﺘﺴﺎﺒ ﺕﺎﻤﻴﺯﻨﻹﺍ لﻤﻋ ﻡﻴﻅﻨﺘﻝ ﺔﻴﻠﻤﻋ ﺹﺼﺤ ﻡﻴﻤﺼﺘ ﺓﺭﻜﺫﻤﻝﺍ ﻩﺫﻫ ﻲﻓ ﺎﻨﻝﻭﺎﻨﺘ
ﺞﻤﺎﻨﺭﺒ Rastop
، ﺔﻨﺴﻝﺍ ﺔﺒﻠﻁﻝ ﺔﻬﺠﻭﻤ ﺔﻴﻨﺎﺜﻝﺍ
ﺔﻴﻌﻴﺒﻁ ﻡﻭﻠﻋ ﻱﺭﻅﻨﻝﺍ ﺏﻨﺎﺠﻝﺍ ﺯﻴﺯﻌﺘ ﻑﺩﻬﺒ .
ﺩﻴﺠﻝﺍ ﻡﻬﻔﻝﺍ ﻭ ﺔﻴﻝﻵ
ﻡﻴﻅﻨﺘ ﺕﺎﻤﻴﺯﻨﻹﺍ
،ﺔﻐﻝﺎﺒﻝﺍ ﺎﻬﺘﻴﻤﻫﻷ ﺍﺭﻅﻨ ﻥﻴﻤﻠﻌﺘﻤﻝﺍ ﻥﹼﻜﻤﺘ ﺙﻴﺤ
ﻥﻤ
لﻀﻓﺃ لﻜﺸﺒ ﻡﺯﻴﻝﻭﺒﺎﺘﻴﻤﻝﺎﺒ ﺔﺼﺎﺨﻝﺍ ﺔﻴﺭﻅﻨﻝﺍ ﻡﻴﻫﺎﻔﻤﻝﺍ ﺏﺎﻌﻴﺘﺴﺍ ﺹﺼﺤﻝﺍ ﺝﺍﺭﺩﺇ ﻥﺃ ﺎﻤﻜ .
ﺔﻴﻌﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍ ﺔﺒﻠﻁ ﺩﻨﻋ ﺔﻴﺘﺎﻤﻭﻠﻌﻤﻭﻴﺒﻝﺍ ﺔﻴﺠﻭﻝﻭﻴﺒﻝﺍ ﻡﻭﻠﻌﻝﺍ)
ﻲﻬﻓ ،ﺔﺤﻠﻤ ﺓﺭﻭﺭﻀ ﺢﺒﺼﺃ (
ﺔﺴﺍﺭﺩ ﺽﺭﻐﻝ ﺕﺎﻨﻴﺘﻭﺭﺒﻝﺍ ﻭ ﺕﺎﻤﻴﺯﻨﻺﻝ ﺔﻴﻏﺍﺭﻔﻝﺍ ﺕﺎﻴﻨﺒﻝﺍ ﻊﻤ لﻤﺎﻌﺘﻝﺍ ﻥﻤ ﻥﻴﻤﻠﻌﺘﻤﻝﺍ ﻥﹼﻜﻤﺘ ﻭ ﺎﻬﻠﻤﻋ ﺔﻴﻝﺁ ﺎﻬﻤﻴﻅﻨﺘ
.
ﻡﺩﻫ ﺭﺎﺴﻤ ﻡﻴﻅﻨﺘ ﻲﻓ ﺔﻤﻬﻤ ﺕﺎﻤﻴﺯﻨﺇ ﺙﻼﺜ ﺭﺎﻴﺘﺨﺍ ﻡﺘ ﻑﺍﺩﻫﻷﺍ ﻩﺫﻫ ﻕﻴﻘﺤﺘ لﺠﺃ ﻥﻤ ﻭ
ﻲﻓ لﺜﻤﺘﺘ ﺕﺎﻴﺭﻜﺴﻝﺍ Hexokinase(HK),Phosphofructokinase(PFK)
ﻡﺘﻴ ﻱﺫﻝﺍ
ﻭ ،ﺎﻴﺭﻴﺘﺴﻭﻝﺃ ﺎﻤﻴﻅﻨﺘ ﺎﻤﻬﻤﻴﻅﻨﺘ Glycogen Phosphorylase(GP)
ﻪﻤﻴﻅﻨﺘ ﻡﺘﻴ ﻱﺫﻝﺍ
ﺔﻴﺴﻜﻌﻝﺍ ﺓﺭﻔﺴﻔﻝﺎﺒ .
ﺎﺴﻷﺍ ﺍﺫﻫ ﻰﻠﻋ ﻭ ﺱ
ﻲﻠﻴ ﺎﻤ ﺓﺭﻜﺫﻤﻝﺍ ﺕﻨﻤﻀﺘ :
ﺔﻤﺎﻋ ﺔﻤﺩﻘﻤ ﺔﻴﻝﺎﻜﺸﺇ ﺡﺭﻁ ﻭ ،ﻡﺯﻴﻝﻭﺒﺎﺘﻴﻤﻝﺍ ﻡﻴﻅﻨﺘ ﻲﻓ ﺕﺎﻤﻴﺯﻨﻹﺍ ﺭﻭﺩ ﺎﻬﻴﻓ ﺎﻨﺤﻀﻭ
ﻥﺎﻫﺫﺃ ﻲﻓ ﺎﻬﺘﻴﺒﺜﺘ ﻭ ﻡﻴﻫﺎﻔﻤﻝﺍ ﺏﻴﺭﻘﺘﻝ ﺔﻴﻌﻴﺒﻁﻝﺍ ﻡﻭﻠﻌﻝﺍ ﻲﻓ ﺏﻴﺭﺠﺘﻝﺍ ﺔﻴﻤﻫﺃ لﻭﺤ ﺔﻤﺎﻋ ﺞﻤﺍﺭﺒﻝﺍ لﺎﻤﻌﺘﺴﺍ ﺓﺭﻭﺭﻀ لﻭﺤ ﺔﺼﺎﺨ ﺔﻴﻝﺎﻜﺸﺇ ﻭ ،ﺔﻴﻭﺩﻴ ﺕﺍﺭﺎﻬﻤ ﻡﻬﺒﺎﺴﻜﺇ ﻭ ﻥﻴﻤﻠﻌﺘﻤﻝﺍ ﻴﺒﻝﺍ ﺔﻴﻘﻴﺒﻁﺘﻝﺍ لﺎﻤﻋﻷﺍ ﺏﺎﻴﻏ ﻥﻋ ﺞﺘﺎﻨﻝﺍ ﺹﻘﻨﻝﺍ ﻥﻤ ﺀﺯﺠ ﺽﻴﻭﻌﺘﻝ ﺔﻴﺘﺎﻤﻭﻠﻌﻤﻭ .
لﺼﻔﻝﺍ ﻱﺭﻅﻨﻝﺍ ﺀﺯﺠﻝﺍ ﻲﻓ لﺜﻤﺘﻤﻝﺍ لﻭﻷﺍ
، ﺕﺎﻤﻴﺯﻨﻹﺍ ﻥﻋ ﺔﻤﺎﻋ ﺓﺭﻅﻨ ﻥﻤﻀﺘ ﻱﺫﻝﺍ
،
ﺎﻬﻤﻴﻅﻨﺘ ﻕﺭﻁ ﻭ ﺔﻤﻅﻨﻤﻝﺍ ﺕﺎﻤﻴﺯﻨﻹﺍ .
،ﻲﻠﻤﻌﻝﺍ ﺀﺯﺠﻝﺍ ﻲﻓ لﺜﻤﺘﻤﻝﺍ ﻲﻨﺎﺜﻝﺍ لﺼﻔﻝﺍ ﻪﻴﻓ ﺎﻨﻝﻭﺎﻨﺘ
ﺔﻴﻝﺎﺘﻝﺍ ﻁﺎﻘﻨﻝﺍ :
- ﻴﻠﻤﻋ ﺹﺼﺤ ﻡﻴﻤﺼﺘ ﺕﺎﻤﻴﺯﻨﻹ ﺎﻨﺭﻭﺼﺘ ﺏﺴﺤ ﺔﻴﻝﻭﺃ ﺔ
GP,PFK,HK ﻩﺫﻫ ﺕﻨﻤﻀﺘ
ﻡﻴﻅﻨﺘﻝﺍ ﻭ لﻤﻌﻝﺍ ﺔﻴﻝﺁ ،ﻡﻴﺯﻨﻹﺍ ﺔﻴﻨﺒﻝ ﺔﻠﻤﺎﺸ ﺔﻠﺌﺴﻷﺍ ﻥﻤ ﺔﻋﻭﻤﺠﻤ ﺹﺼﺤﻝﺍ .
- ﻲﺘﺼﺤ ﻲﻓ ﺔﻠﺠﺴﻤﻝﺍ ﺹﺌﺎﻘﻨﻝﺍ ﻭ ﺕﺎﻅﺤﻼﻤﻝﺍ ﻡﻫﺃ PFK,HK
ﻰﻠﻋ ﺎﻤﻬﺒﻴﺭﺠﺘ ﺩﻌﺒ
ﺔﺒﻠﻁﻝ .
- ﺔﻴﺌﺎﻬﻨ ﺔﻴﻠﻤﻋ ﺹﺼﺤ ﺯﺎﺠﻨﺇ ﺔﻝﺩﻌﻤ)
ﻲﻤﻴﺯﻨﻹ ( PFK,HK
ﺕﺎﻅﺤﻼﻤﻝﺍ ﻰﻠﻋ ﺍﺀﺎﻨﺒ
ﻝﺍ ﺏﻴﺭﺠﺘﻝﺍ ﺀﺎﻨﺜﺃ ﺔﻠﺠﺴﻤ .
- ﺞﻤﺎﻨﺭﺒ لﺎﻤﻌﺘﺴﺎﺒ ﺔﻤﻤﺼﻤﻝﺍ ﺔﻴﻠﻤﻌﻝﺍ ﺹﺼﺤﻠﻝ ﺔﻴﺠﺫﻭﻤﻨ ﺕﺎﺒﺎﺠﺇ ﺡﺍﺭﺘﻗﺍ Rastop
.
ﻭ ﺍﺭﻴﺨﺃ ﺔﺼﻼﺨ ﺎﻬﻴﻓ ﺎﻨﺭﺸﺃ
،ﺎﻬﻴﻝﺇ لﺼﻭﺘﻤﻝﺍ ﺕﺎﺠﺎﺘﻨﺘﺴﻻﺍ ﻡﻫﺃ ﻰﻝﺇ ﻕﻴﻘﺤﺘ ﻯﺩﻤ
ﻑﺍﺩﻫﺃ ﺓﺭﻜﺫﻤﻝﺍ ﻩﺫﻫ ﻩﺫﻫ ﺭﻴﻭﻁﺘ لﺠﺃ ﻥﻤ ﺔﻴﻠﺒﻘﺘﺴﻤﻝﺍ ﻕﺎﻓﻵﺍ ﻭ ﺕﺎﺤﺍﺭﺘﻗﻻﺍ ﻰﻝﺇ ﺔﻓﺎﻀﻹﺎﺒ ،
ﺹﺼﺤﻝﺍ .
