[PDF] Top 20 Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation.
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Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation.
... by insulin-mediated INSR activation 30 INSR . is also expressed in primary MMC, at the same level as that found in normal bone marrow plasma ...But a major difference between normal and ... Voir le document complet
15
Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1.
... regulation is a key process in multiple myeloma biology, we have studied the Bcl-2 family proteins that can be regulated by 3 myeloma cell survival factors: interleukin-6 (IL-6), ... Voir le document complet
31
Altered expression of type I insulin-like growth factor receptor in Crohn's disease
... promote cell proliferation, the IGF system may have a role in smooth muscle cell hyperplasia of the muscularis propria, which is a prominent feature of CD intestinal ...for ... Voir le document complet
9
Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury.
... in a pure 129/Sv genetic ...Overall, IGF-1R neo/- mice were more resistant to hyperoxic stress than littermate controls ...of IGF-1R in response to high oxygen concentration [11,14], directly ... Voir le document complet
12
Role of Insulin-Like Growth Factor Binding Proteins in Limitation of Igf-I Degradation into the N-Methyl-D-Aspartate Receptor Antagonist Gpe: Evidence from Gonadotrophin-Releasing Hormone Secretion in Vitro at Two Developmental Stages
... of IGF-I in the CNS is particularly complex. IGF-I has trophic brain effects mediated through its classical ...more potent than IGF-I due to reduced binding to the IGF- ... Voir le document complet
9
Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells.
... those growth factors inhibits apoptosis via both IGF1 and EGF receptors in NSCLC ( 11 ...IGF1 receptor exerts its anti-apoptotic effect essentially through activation of the PI K pathway ( 3 ... Voir le document complet
18
PKB mediates Insulin-Like Growth Factor 1-induced phosphorylation and nuclear export of Histone Deacetylase 5 via NADPH Oxidase 4 activation in vascular smooth muscle cells
... CVD is an increased vascular resistance due to blood vessel ...migration, growth and proliferation of VSMCs are believed to be key events that contribute to structural remodeling of blood vessels and have ... Voir le document complet
118
Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature
... (NS), a genetic disease caused in half of cases by activating mutations of the tyrosine phosphatase SHP2 (PTPN11), is characterized by congenital cardiopathies, facial dysmorphic fea- tures, and short ... Voir le document complet
6
CD200 is a new prognostic factor in multiple myeloma.
... MMC growth factors may have clinical applications in combination with other drugs 3-6 ...OX-2, is a highly conserved type I transmembrane glycoprotein that is expressed by thymocytes, ... Voir le document complet
13
Modulation of Endothelin-1 and Insulin-like Growth Factor Type 1-induced Signaling by Curcumin in A-10 Vascular Smooth Muscle Cells
... demonstrated a correlation between cardiovascular disease and an increased activation of ET-1-induced signaling in vascular smooth muscle cell (VSMC), including protein kinase B (PKB) and ... Voir le document complet
133
The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor.: IGF-1 is the major growth factor on myeloma
... and IGF-1, different techniques have been used focussing on different aspects that may yield to challenging conclusions 10,25,26 ...confirm a previous study showing that the IL-6-induced ... Voir le document complet
42
Early growth response protein 1 (Egr-1) expression by Insulin-like growth factor 1 (IGF-1) involves MAPKs and PKB pathways
... that IGF-1 has potent endothelial antioxidant effects on both basal and oxidized LDL-induced reactive oxygen species (ROS) ...activity is mainly mediated through the upregulation of ... Voir le document complet
99
Allergy reactions to insulin: effects of continuous subcutaneous insulin infusion and insulin analogues.
... long-acting insulin analogues such as insulin glargine and insulin detemir offer the potential advantage of a better basal insulin coverage over a 24-h period as compared to ... Voir le document complet
15
Genistein induces pancreatic β-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice
... in a room maintained on a 12-h light, 12-h dark cycle under constant temperature (22–25 C) with ad libitum access to food and ...fed a modified AIN-93G rodent diet with corn oil substituted for ... Voir le document complet
13
Monoacylglycerol as a metabolic coupling factor in glucose-stimulated insulin secretion
... lipolysis is also highly dependent on several important enzymes, depending on different ...lipase is adipose TG lipase (ATGL; also named desnutrin and patatin-like domain containing phospholipase A2, PNPLA2 ... Voir le document complet
133
PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons.: IGF-1 transactivates PACAP type I receptors
... in a vacuum centrifuge, solubilized in 10 μl of formic acid (2%), desalted using C18 ZipTips (Millipore, elution with 10 μl of ...to a 1-μl ...on a 384-well MALDI target using the dry droplet ... Voir le document complet
35
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.
... CXCL5 is dramatically increased in serum of human obese compared to lean ...concentration is decreased in obese subjects after a weight reduction program, or in obese non-insulin resistant, ... Voir le document complet
12
The Bcl-2 family member Bfl-1/A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells.
... Piskurich, J.F., Lin, K., Lin, Y., Wang, Y., Ting, J.P.Y. & Calame, K. (2000) BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cells. Nature Immunology, 1, ... Voir le document complet
34
Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells.
... XG-1 myeloma cell growth through an ErbB1-independent mechanism, probably via ErbB2/ErbB3 or ErbB2/ErbB4 ...This is attractive because AREG is known to be an ErbB1 ligand ... Voir le document complet
38
Vascular Endothelial Growth Factor Receptor 3 Controls Neural Stem Cell Activation in Mice and Humans
... NSC activation as well as the mechanisms regulating Vegfr3 expression in NSCs remain to be ...the cell membrane. The discon- tinuous process of NSC activation also implies that VEGF-C avail- ability ... Voir le document complet
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