[PDF] Top 20 Constitutive AKT activation in follicular lymphoma.
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Constitutive AKT activation in follicular lymphoma.
... pathway in MCL occurs most frequently by loss of PTEN expression and/or PIK3CA gene amplification, whereas the PIK3CA gene was found unmutated ...identified in our series of FL. Since we analyzed only hot ... Voir le document complet
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The yin and the yang of follicular lymphoma cell niches: Role of microenvironment heterogeneity and plasticity.
... cells in the microenvironment, allowing FL cells to receive antigen-independent but cell contact-dependent survival signals through their BCR ...number, activation, and/or spatial organization of ... Voir le document complet
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IL-4/CXCL12 loop is a key regulator of lymphoid stroma function in follicular lymphoma
... activated in FL patients. Whether CRCs or follicular FRCs could be considered as precursors of CXCL12 hi FL stroma remains to be ...FRC activation and expansion have been proposed to rely on the ... Voir le document complet
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Aberrant AKT activation drives well-differentiated liposarcoma
... 1. Constitutive Akt activation drives WDLPS in the zebra ...incidence in p53 wild-type, heterozygous, or p53 M214K homozygous mutant siblings injected with a rag2:myr-mAkt2 transgene at ... Voir le document complet
7
Mesenchymal stromal cells orchestrate follicular lymphoma cell niche through the CCL2-dependent recruitment and polarization of monocytes.: CCL2 AND FOLLICULAR LYMPHOMA CELL NICHE
... pinpointed in the FL-MSC ...involved in the recruitment and/or activation of immune ...approach in order to specifically assess the over-representation of the TNF/LT signature in ... Voir le document complet
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The involvement of nitric oxide in bovine follicular development and ovulation
... Abstract In rabbits and rodents, nitric oxide (NO) is generally considered to be critical for ...ovulation. In monovulatory species, however, the importance of NO has not been ...cascade in bovine ... Voir le document complet
152
Integrative Analysis of Cell Crosstalk within Follicular Lymphoma Cell Niche: Towards a Definition of the FL Supportive Synapse
... A). In agreement with this activated status, FL-Tfh expressed higher levels of HLA-DR (p < ...and activation of Tfh follow a complex process, in which IL-6 and IL-7 are mandatory [ 23 ], IL-6 by ... Voir le document complet
22
Combination lenalidomide-rituximab immunotherapy activates anti-tumour immunity and induces tumour cell death by complementary mechanisms of action in follicular lymphoma
... cereblon in the Cullin-4 RING E3 ubiquitin ligase and promotes degradation of the haematopoi- etic transcription factors IKAROS and AIOLOS (Lopez-Girona et al, 2012; Chamberlain et al, ...2014). In ... Voir le document complet
15
Increased activation of PI3 kinase-δ predisposes to B cell lymphoma.
... pathway in B cells (via an antigen-driven (B cell receptor) or EBV trigger) could directly increase cell survival and malignant ...Increased activation of the conserved serine/threonine kinase mammalian ... Voir le document complet
17
Management of Drug Resistance in Mantle Cell Lymphoma
... efficacy in R/R MCL patients including those resistant to BTZ ...present in the TME, on the TME itself by modulating inflammatory cytokines, and by indirect effects on malignant B ...cells. In ... Voir le document complet
26
Stromal cell contribution to human follicular lymphoma pathogenesis.
... ). In addition, paracrine Hh signal- ing induces the upregulation of the drug transporter ATP-binding cassette (ABC) G2 and could be involved in stroma-mediated chemotolerance in indolent lymphomas ( ... Voir le document complet
8
Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways
... effects in siHSP27-transfected HepaRG ...antibiotics in human HepaRG ...efflux in HepaRG cells either untreated or treated with 6 mM cloxacillin (CLX), nafcillin (NAF), ampicillin (AMPI) and ... Voir le document complet
18
Angioimmunoblastic T-cell lymphoma is the most common T-cell lymphoma in two distinct French information data sets
... Lymphopath in France, we used another non- overlapping set of PTCL patients to compare the distribu- tion of PTCL entities over an earlier time ...centers in France, Belgium and ...enrolled in ... Voir le document complet
4
IL-6 and Akt are involved in muscular pathogenesis in myasthenia gravis
... on Akt pathway in chronic exposure [31], it remains to be determined if the action of anti-AChR antibodies is mediated by ...impaired Akt phosphorylation caused in muscle cells by AChR anti- ... Voir le document complet
15
Activation des voies de Pl3 kinase/Akt et ERK1/2 par la ghreline et la des-acyl ghreline dans les cellules musculaires lisses vasculaires : voies potentielles de signalisation dans la modulation de l'athérosclérose
... Induction of platelet-derived growth factor A-chain and c-myc gene expression by angiotensin Il in cultured rat vascular smooth muscle cells. Nakahara K, Nishimura H, Kuro O et al[r] ... Voir le document complet
198
Cyanoacrylate skin surface / follicular stripping.
... CSSS in Cutaneous Neoplasms Some epithelial neoplasms display characteristic aspects on CSSS [ 4 , 5 ...changes in the texture of the SC are usually seen in a benign ... Voir le document complet
9
Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way
... both in mouse liver and human ...both in males and females. A slight induction of some genes in CAR -/- female livers suggests the activation of other pathways in this particular ... Voir le document complet
45
Axonal Targeting of the 5-HT1B Serotonin Receptor Relies on Structure-Specific Constitutive Activation
... assays in hippocampal neurons For surface detection of receptors, anti-Flag M2 antibody ...washed in D-PBS+, fixed with paraformaldehyde (4%) containing 4% sucrose and incubated for 1 h with Alexa-Fluor® ... Voir le document complet
21
Follicular helper T cells: implications in neoplastic hematopathology.
... -derived lymphoma. Described in the seventies as a dysimmune non neoplastic condition, it has later been recognized as a subtype of peripheral T-cell lymphoma (PTCL), given the demonstration of ... Voir le document complet
29
Simulation of dynamic orofacial movements using a constitutive law varying with muscle activation
... movements in speech and non-verbal ...Mooney-Rivlin constitutive law accounts for the non linear behaviour of facial ...the constitutive law of the tissue with the level of activation of the ... Voir le document complet
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