[PDF] Top 20 Acid-sensing ion channels in postoperative pain.
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Acid-sensing ion channels in postoperative pain.
... ASIC3-containing channels are particularly well suited to de- tect local changes in pH associated with postoperative pain and to contribute to nociceptor sensitization: (1) they exhibit the ... Voir le document complet
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Acid-Sensing Ion Channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis
... Chronic pain is associated with anxiety and depression ...role in the relationship between emotional responses and chronic ...of Acid- Sensing Ion Channels 1a within the ... Voir le document complet
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en fr Involvement of nerve growth factor (NGF) and acid-sensing ion channels (ASIC) in colonic hypersensitivity induced by butyrate in the rat Étude de l'implication du Nerve Growth Factor et des Acid-Sensing Ion Channels dans l'hypersensibilité colique induite par le butyrate chez le rat
... sensitization in CHS We have used the Fos method, a marker for neuronal activity, in order to evaluate the spinal excitability in rats treated with ...protein in rats challenged with repeated ... Voir le document complet
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en fr Involvement of nerve growth factor (NGF) and acid-sensing ion channels (ASIC) in colonic hypersensitivity induced by butyrate in the rat Étude de l'implication du nerve growth factor (NGF) et des acid-sensing ion channels (ASIC) dans l'hyper-sensibilité colique induite par le butyrate chez le rat
... Canaux sodiques dépendants du voltage Les canaux VGSC (voltage-gated sodium channels) sont présents dans le SNC et le SNP (Amir et al., 2006) où ils assurent la phase dépolarisante du PA en augmentant la ... Voir le document complet
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Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels
... putative in vivo effects of ASIC-targeting toxins In an in vivo model of kainate-induced epilepsy, an ...amiloride in rats and mice (Ali et ...ASIC channels, and ASIC1a-containing ... Voir le document complet
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Anti-allodynic effects of systemic inhibitors of Acid-Sensing Ion Channels 1 (ASIC1) against acute and chronic migraine in rodents
... For Peer Review technical replicates (replicates were used to calculate a mean individual value). Control (or vehicle treated) animals and test animals were randomized within experimental days. Data are presented as ... Voir le document complet
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Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain
... hyperalgesia in the CCI model of neuropathic pain determined using the paw-immersion test (46°C) in wild-type (WT) and ASIC1a-knockout mice ...difference in paw withdrawal latency compared ... Voir le document complet
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TACAN is an essential component of the mechanosensitive ion channel responsible for pain sensing
... found in small diameter nociceptors (Cho et ...of ion channels that appears specialized to transduce mechanical forces into electrical ...involved in touch (Ranade et ...expressed in ... Voir le document complet
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Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat Acid-Sensing Ion Channel 1a
... Abstract Acid-sensing ion channels (ASICs) are proton-gated cationic channels involved in pain and other processes, underscoring the potential therapeutic value of ... Voir le document complet
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Specific ion channels control sensory gain, sensitivity, and kinetics in a tonic thermonociceptor
... many ion channels involved in no- ciceptor ...of channels in pain pathways are TRP channels ( Ramsey et ...transduction channels for noxious temperatures ...other ... Voir le document complet
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Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives
... development in a variety of neurological and psychiatric disorders including pain, stroke, epilepsy, anxiety, depression or traumatic ...(e.g., in hepatic fibrosis or ...discovered in animal ... Voir le document complet
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Zn 2+ and H + Are Coactivators of Acid-sensing Ion Channels
... preparation. F IG . 7. The H72A mutation modifies the pH dependence of homomeric ASIC2a current. A, the G430T mutation is associated with a basal amiloride-sensitive current (5), but the mutated channel is still ... Voir le document complet
8
From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
... [4]. In addition to their usage as analgesics [79], they are now evaluated as potential treatment for many pathologies ...used in clinic or that entered clinical trials (clinical trials were monitored using ... Voir le document complet
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Autism throughout genetics: Perusal of the implication of ion channels
... found in ASD prov- ing that additional epigenetic factors or environmental condi- tions may contribute to the clinical manifestation of this ...involved in neurogenesis and synaptogenesis, suggesting that ... Voir le document complet
19
Voltage- and cold-dependent gating of single TRPM8 ion channels
... gates in a minimum of five closed and two open states To examine TRPM8 gating kinetics, large numbers of open and closed intervals (55,000–380,000) were col- lected from each of eight single channels at ... Voir le document complet
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Role of ion channels in programmed cell death induced by hyperosmotic stresses in plant cells
... the sensing of the perturbation of the volume to the rearrangement of the cytoskeleton have not been completely ...elucidated. In plants there is a strong and transient response of microtubules to ... Voir le document complet
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From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
... Gated Ion Channels LGIC are allosteric proteins (for a recent review on the allosteric nature of nicotinic receptors, see ...are in equilibrium between a few states, switching from the resting state ... Voir le document complet
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Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in Cancers
... Wood, L. D., Parsons, D. W., Jones, S., Lin, J., Sjöblom, T., Leary, R. J., et al. (2007). The genomic landscapes of human breast and colorectal cancers. Science 318, 1108–1113. doi: 10.1126/science.1145720 Wu, J., Jiao, ... Voir le document complet
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VNS in pain
... implanted in humans for epilepsy treatment and pain studies have been conducted in such ...on pain thresholds. Indeed, in one study, VNS induced a significant decrease of thermal ... Voir le document complet
1
Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels
... PIEZO CHANNELS Role of Piezo1/2 in mechanosensory physiology and disease states Opening of Piezo1/2 channels is involved in a variety of key physiological functions and disease states ... Voir le document complet
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