T-cell receptor (TCR) repertoire
Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire
... peptide repertoire presented by MHC class II molecules in the ...T cell receptor (TCR) repertoire, the development of CD4 T cells expressing the OTII and Marilyn transgenic TCRs is impaired in ...
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Comment on “Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination”
... T-cell receptor (TCR) repertoire analysis has clearly gained the status of a major tool to profile the immune response in health and ...immunological repertoire studies, their application also ...
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FB5P-seq: FACS-Based 5-Prime End Single-Cell RNA-seq for Integrative Analysis of Transcriptome and Antigen Receptor Repertoire in B and T Cells
... B cell receptor (BCR) and T cell receptor (TCR) repertoires, enabling the recognition of an infinite range of antigens by B and T cells, ...T cell clone can differentiate into multiple ...
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Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients
... stem cell transplantation (aHSCT) in systemic sclerosis (SSc) are still ...T cell receptor (TCR) repertoire diversity in 10 SSc patients, with at least 6 years simultaneous clinical and ...
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A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire
... T cell antigen receptor (TCR) signals and therefore plays a critical role in the development and activation of T cells ( 18 – 22 ...T cell activation ( 25 , 26 ...T cell development and for ...
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T cell repertoire analysis and comparison between different compartments in two MS patients
... T cell responses in MS is to investigate the T cell receptor (TCR) structure in ...T cell repertoire in circulating lymphocytes are more pro- nounced in MS patients than in healthy ...
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Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance
... antigen receptor (TCR) on conventional αβT cells recognizes peptide fragments bound to class I or class II major histocompatibility complexes (pMHCI or ...T cell expresses a unique TCR and generation of a ...
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RhoB Mediates Phosphoantigen Recognition by Vg9Vd2 T Cell Receptor
... of cell lines from the Centre d’Etude du Polymorphisme Humain (CEPH), which contains a large collection of EBV-transformed B cell lines (EBV-LCLs) obtained from several family pedigrees ( Dausset et ...
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The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate
... non-T cell lineage capacity of the progenitors and eventually establish the T-cell ...T-cell receptor (TCR) αβ heterodimer on their cell surface that can recognize foreign or ...
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The V$_\beta$ 17$^+$ T cell repertoire: skewed J$\beta$ usage after thymic selection; dissimilar CDR3s in CD4$^+$ versus CD8$^+$ cells.
... Consequently, one side of the loop (and in particular, positions (3, 4, and 5) would seem to be much more variable than the other; perhaps the two sides interact with distinct[r] ...
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A model of apoptosis receptor reactions to study cell fate decision
... programmed cell death, a mechanism to ensure organism homeostasis and the elimination of tumor ...of cell decision remain unclear, with no accurate prediction for when a given cell commits to ...
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Trimeric structure of the mouse Kupffer cell C‐type lectin receptor Clec4f
... distinct cell surfaces and represent dif- ferent cell surface markers with potentially diverse bio- logical functions, both mouse Clec4f and Langerin consist of an N-terminal cytoplasmic signaling domain, a ...
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Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling.
... per cell could be directly associated with surface expression of CD79B, we first measured α-IgM-induced signaling in an IgM + MCL cell line, Granta 519, with highly heterogeneous expression of ...
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Characterization of pattern recognition receptor responses against materials for cell encapsulation
... SEAP activity with adhering RAW-Blue T " cells seeded on alginate hydrogels. (b) Quantification of SEAP activity with non- adhering THP1-XBlue T "-MD2-CD14 cells on both [r] ...
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CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment
... T-cell receptor; T-cell triggering; spreading; 2D binding kinetics; laminar flow chamber; interference reflection microscopy; reflection interference contrast microscopy ...target cell, or ...
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Autotaxin promotes cancer cell invasion via the lysophosphatidic acid receptor 4
... Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cell migration in tumors[r] ...
145
Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells.
... this cell type and by the existence of specialised mechanisms and factors that control their expression ...specialised cell type with a unique gene expres- sion programme, haploid cells clearly provide a ...
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Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses
... In vivo models of immunization and in vitro secondary challenge LEW.1W heart allografts were transplanted to WT and CLEC-1 –deficient recipients as previously described 9 and were rejected in 7 days. 10 Spleens and ...
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IL-23 receptor and IL-12 receptor expression is restricted to distinct cell types in the IL-23R-GFP reporter mouse
... Following the identification of this polymorphism, multiple studies have tried to identify the biological impact of the amino acid substitution. One of them took CD4+CD45RO+ T-cells from patients with either WT or R381Q ...
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Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.
... the cell line and on the levels of FLIP expression, all three proteins can be found within the Fas DISC due to their N-terminal domain which contains two DED repeats similar to caspase-8 or caspase-10 ...induced ...
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