Regulatory myeloid suppressor cells
Deciphering the Crosstalk Between Myeloid-Derived Suppressor Cells and Regulatory T Cells in Pancreatic Ductal Adenocarcinoma
... immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) and regulatory T cells ...immunoregulatory cells in ...Treg cells in a cell-cell dependent ...
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Early expansion of circulating granulocytic myeloid-derived suppressor cells predicts development of nosocomial infections in septic patients
... I NTRODUCTION Sepsis is one of the leading causes of admission in intensive care units (ICUs). Despite a decreased overall mortality rate during the past three decades, the prognosis remains hampered by a high long term ...
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Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation
... Abstract Myeloid cells play a pivotal role in regulating innate and adaptive immune ...transplantation, myeloid cells have contrasting roles: on the one hand they initiate the immune response, ...
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Regulatory myeloid cells: an underexplored continent in B-cell lymphomas
... the myeloid compartment. In particular, high circulating monocyte or myeloid-derived suppressor cell counts are associated with poor prognosis for patients with high- grade B-cell ...types, ...
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Deciphering myeloid-derived suppressor cells isolation and markers in humans, mice and non-human primates
... perspectives Myeloid cells show high plasticity and readily adapt to changing conditions such as those present in cancer, infec- tion and ...many myeloid cells can acquire (immune) ...
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Picturing Polarized Myeloid Phagocytes and Regulatory Cells by Mass Cytometry
... 22. Krieg C, Nowicka M, Guglietta S et al. (2018) High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy. Nat Med 9:2579–2514. 10.1038/nm.4466 23. Roussel M, Ferrell PB, Greenplate AR et al. ...
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Myeloid-Derived Suppressor Cells in Hematologic Diseases: Promising Biomarkers and Treatment Targets
... presenting cells; membrane- bound transforming growth factor b1 (TGFb1), which promotes the anergy of NK-cells and the development of regulatory T cells (Treg); IL-10, which leads to Th2 ...
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Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells
... Discussion Cells growing in low resources or under metabolic stress use autophagy to ...In cells expressing wt p53 or lacking p53 expression, DCA does not affect the autophagy ...In cells expressing ...
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Distinct intracellular trafficking of hepatitis C virus in myeloid and plasmacytoid dendritic cells.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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ASB-2 Inhibits Growth and Promotes Commitment in Myeloid Leukemia Cells*
... ASB-2 Is a Member of the SOCS Family Highly Expressed in Human Bone Marrow—We have cloned a 2396-bp cDNA (Gen- Bank 娂 accession no. AJ251238) (Fig. 2A) showing: (i) complete homology to a 1635-bp unpublished human ...
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Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site
... immune cells can reject tumor cells embedded in a tumor mass, in a connective network of stromal ...T cells kill tumor cells directly in the ...T cells can be found close to dying tumor ...
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What is the Role for Regulatory T-Cells after Nonmyeloablative conditioning
... nucleated cells express HLA class I, one would expect all single HLA class I mismatched transplanted patients to develop se- vere ...on cells of the patient is not suf- ficient to elicit an effective ...
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Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23
... pathway (8, 11). Consistent with an intermediate role for the cAMP/ PKA pathway, forskolin, a cAMP agonist, recapitulated the effect of OSCM by inducing Il23 expression by BMDCs (Fig S5B). Since Grm4 also regulates Il23 ...
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Altered innate functions of myeloid dendritic cells in ANCA-associated vasculitis
... that myeloid DC (mDC) from patients in acute phase exhibited a decreased IL-12 production after TLR3, 4 and 7/8 stimulation compared to patients in remission and healthy ...
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Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells.
... T cells [ 28 ] . Conventional and regulatory T cell activation was studied using ICOS ...and regulatory CD4 T cells, it also allows distinguishing activated conventional T ...Foxp3 ...
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Myeloid suppressor cell (MSC) deficiencies in non-obese diabetic (NOD) mice: a role in type 1 diabetes pathogenesis ?
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells.
... of myeloid leukemia (histiocytic sarcomas, HS) based on the genetic inactivation of the tumor suppressor Ink4a/Arf locus, we have recently unraveled an unsuspected function of E4F1 in the survival of ...
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Cyclophosphamide inhibits the generation and function of CD8(+) regulatory T cells
... Introduction Regulatory T cells (Treg) play a pivotal role in the maintenance of immunologic self-tolerance, downregulating the activation/pro- liferation of self-reactive T cells and thus preventing ...
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Early-life microbiota exposure restricts myeloid-derived suppressor cell-driven colonic tumorigenesis Running Title: Early-life microbiota restricts colonic tumorigenesis
... Enhanced CXCR2 ligands and granulocytic MDSCs in AOM/DSS-treated exGF mice In light of enhanced pro-inflammatory gene expression and the alteration in the expression of cytokine/chemokine signaling pathways in exGF mice ...
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T follicular helper and T follicular regulatory cells have different TCR specificity
... T cells from TCR-transgenic mice, we demonstrate that recruitment of Tfh cells into GCs is predominantly controlled by specificity for the immunizing ...Tfr cells for the same GCs was not biased ...
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