Ovarian granulosa cell tumor
Anti-VEGFA therapy reduces tumor growth and extends survival in a murine model of ovarian granulosa cell tumor
... Abstract Ovarian granulosa cell tumors (GCTs) are potentially malignant tumors that have a tendency for late recurrence and cause death in 80% of women with advanced GCT due to recurrent ...of ...
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Functional Exploration of the Adult Ovarian Granulosa Cell Tumor-Associated Somatic FOXL2 Mutation p.Cys134Trp (c.402C>G)
... Working with over-expressed FOXL2 variants presents some shortcomings, as some fine-tuned effects, as is often the case for cancer-associated mutations, could be overlooked in this context. However, this also means that ...
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Detection of Minimal Levels of Serum Anti-Müllerian Hormone during Follow-Up of Patients with Ovarian Granulosa Cell Tumor by Means of a Highly Sensitive Enzyme-Linked Immunosorbent Assay.
... Spleen cell suspensions were fused with NS1 myeloma cells (four lym- phocytes/one NS1 cell) in the presence of polyethylene glycol 1000, according to Ko¨hler and Milstein ...
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Alteration of Interendothelial Adherens Junctions Following Tumor Cell-Endothelial Cell Interaction in Vitro
... of tumor cell contact with the endothelium and could not be reproduced when using tumor cell culture supernatant or fixed tumor ...single tumor cell within a time period ...
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Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy.
... Western blot analysis. The cells were washed with PBS and disrupted in lysis buffer containing 1% Triton X-100, 150 mM NaCl, 50 mM Tris (pH 7.5), 0.5% Nonidet P-40, 50 mM NaF, and complete protease inhibitor cocktail ...
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Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?
... and cell-cell non overlapping is supposed instan- taneously reached and gives the instantaneous configuration of the ...with cell (quasi)-incompressibility is much faster than that involved in the ...
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A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors
... During the analysis of the AKT1 gene, the agarose gel electropho- resis of exon-3 PCR amplicons revealed the coexistence of two or three bands in 9 out of the 16 JGCT samples (Fig. 1A). One band had the expected length ...
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Ascites analysis by a microfluidic chip allows tumor-cell profiling
... identifying ovarian cancer treatment failures before radiographic evidence of ...within ovarian cancers have spawned a number of novel approaches for detection and treatment monitoring; these approaches ...
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Les tumeurs de la granulosa de lovaire (10 cas)
... la granulosa, des sarcomes et des carcinomes ovariens ...la granulosa avec des rosettes ...la granulosa est ...la granulosa de l’ovaire en tumeurs adultes et juvéniles ...
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Ovarian carcinoma patient derived xenografts reproduce their tumor of origin and preserve an oligoclonal structure
... Epithelial ovarian carcinoma (EOC) is a devastating disease because of its silent ...rare ovarian cancer subtypes such as clear cell, mucinous or carcinosarcomas, our PDX collection covered the ...
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Stochastic nonlinear model for somatic cell population dynamics during ovarian follicle activation
... the cell dynamics of ovarian follicles in vivo, in a non invasive manner, would provide all needed ...first cell transitions could awake the oocyte and settle a positive feedback loop between the ...
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Lysyl oxidase is a strong determinant of tumor cell colonization in bone. Short Title: LOX triggers tumor cell colonization in bone
... that tumor-secreted LOX promotes osteolytic lesion formation in vivo, irrespective of HIF-1 α ...CRC cell lines (HT29 and LS174Tr) in which LOX expression has been overexpressed or silenced ...LOX+ ...
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Injectable Hybrid Hydrogels, with Cell-Responsive Degradation, for Tumor Resection
... To achieve a degradation that could be triggered by cells proliferating onto the material, without the need of any additional stimulus, we have incorporated a disulfide crosslinker in the polymeric network of the ...
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Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function
... the tumor compared to the adjacent healthy ...of tumor cells ( 37 – 39 ...the tumor compared to the adjacent tissue, suggesting that an immune response is occurring in the ...NK cell-driven ...
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PTPN13 induces cell junction stabilization and inhibits mammary tumor invasiveness
... and cell models we demonstrated that PTPN13 acts as a tumor suppressor in breast cancer and that it inhibits tumor aggressiveness through a SNAIL- and ZEB-independent MET-like transition, cautioning ...
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Étude de l'expression génique dans les cellules de granulosa bovines provenant de différents statuts folliculaires et dans les cellules de granulosa humaines provenant de différents protocoles de stimulation
... follicule et un impact négatif sur la lutéinisation et l’atrésie, ces dernières étant caractérisées par la sécrétion de progestérone par les cellules de granulosa (Knight et Glister 2001). Dans les ovocytes, les ...
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REG3β modifies cell tumor function by impairing extracellular vesicle uptake
... modifies cell tumor function by impairing extracellular vesicle uptake Laia Bonjoch 1 , Meritxell Gironella 2 , Juan Iovanna 3 , Daniel Closa 1 1 Department of Experimental pathology, Institut ...
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Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment
... 3D tumor cell migration within the initial 24 h of adding EGF ...individual cell speed ...the cell trajectory plots ...increased cell counts near the y-axis ...high cell motility ...
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Diversity of Tumor-Infiltrating, γδ T-Cell Abundance in Solid Cancers
... the cohort, and we found that γδ T-cell density was not impacted by the microsatellite status. However, the number of MSI samples were very low (nine MSI versus 46 MSS); thus, examination of a larger cohort might ...
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Circulating Tumor Cell Clusters: United We Stand Divided We Fall
... that tumor-specific tropism of metastasis was early observed as not being always neighboring organs of the primary tumor but can also be distant ...between tumor detached cells and macrophages can ...
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