L-Type Ca2+ channel
Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling.
... The pore subunit of the DHPR is tightly bound to a β subunit that modulates multiple processes ranging from the voltage-dependence of the gating current to trafficking of the Ca 2+ channel to the plasma membrane ...
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Differential somatic Ca2+ channel profile in midbrain dopaminergic neurons
... calcium channel blocker, has been shown to be neuroprotective for SNc DA neurons in animal models of Parkinson’s disease and is currently tested in a large clinical trial ( Parkinson Study Group, 2013 ...2⫹ ...
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Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity
... Voltage-gated Na + channels mediate the TTX-sensitive Na + current ( I NaTTX ), which contribute to pacemaking and intra-nodal conduction in the mouse, rabbit and human SAN [45,3,40,41] (Figure 1B). In the human SAN, the ...
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Two PEST-like motifs regulate Ca2+/calpain-mediated cleavage of the CaVbeta3 subunit and provide important determinants for neuronal Ca2+ channel activity.
... Lastly, as mentioned earlier, our data showed that the deletion of PEST like sequences decreases the degradation of Ca V β 3 subunit in ( ), we therefore aimed to reproduce these results . In order to determine whether ...
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Ca2+ influx via the platelet P2X1 ion channel contributes to collagen-induced platelet activation.
... ent receptors. 3,4 It, therefore, seems that P2Y sig- nal transduction mediated via ADP does not include ERK2 phosphorylation. Although the selective stim- ulation of P2X1 and the resulting ERK2 phosphory- lation by ...
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Proteolytic cleavage of the voltage-gated Ca2+ channel alpha2delta subunit: structural and functional features.
... 5. Bernstein GM, Jones OT. (2006) Kinetics of internalization and degradation of N-type voltage-gated calcium channels: Role of the α2/δ subunit. Cell Calcium (in press). 6. Brodbeck J, Davies A, Courtney J-M, ...
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Combining Ca2+ imaging with -glutamate photorelease.: Ca2+ Imaging and Glutamate Photorelease
... controls type I metabotropic glutamate receptor signalling via a tyrosine kinase at parallel fibre-Purkinje cell ...single channel properties of the ...
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Metabolic Inhibition Induces Transient Increase of L-type Ca2+ Current in Human and Rat Cardiac Myocytes
... thapsigargin abolished the increase of I CaL amplitude itself during increased frequency depolarization and FCCP additionally reduced I CaL amplitude. Int. J. Mol. Sci. 2019, 20, x 9 of 15 Figure 5. Effect of FCCP on ...
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Suppression of Voltage-Gated L-type Ca2+ Currents by Polyunsaturated Fatty Acids in Adult and Neonatal Rat Ventricular Myocytes
... actions result from the direct electrical consequence of their effects on ion channel proteins, not on the activity of intracellular messengers. Pepe et al. (32) confirmed that in adult rat cardiomyocytes an ...
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Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
... were observed for Grin2a +/+ control mice, whereas in Grin2a +/S Fig. 1 GluN2A(N615S) containing NMDAR expression in vitro and in vivo. a The position of N615 in the membrane segment M2 is depicted together with the ...
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GABA receptors and T-type Ca2+ channels crosstalk in thalamic networks
... 4. T-channel activity controls GABA synapses While the functional links between GABA IPSPs and LTS generation in the thalamic network have been studied for many years (Deschenes et al., 1984; Steriade et al., ...
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GABA receptors and T-type Ca2+ channels crosstalk in thalamic networks
... high frequency bursts of action potentials generated by LTSs at spindle frequency. These bursts of action potentials elicit fast rising multicomponent GABA A IPSPs in TC neurons that, if strong enough, generate an LTS ...
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Ca2+-Dependent Protein Kinase 6 Enhances KAT2 Shaker Channel Activity in Arabidopsis thaliana
... 3. Discussion KAT2 is expressed in stomatal guard cell and in leaf vascular tissues [12,13]. Its function was characterized in plant stomata guard cells allowing stomatal opening [12,42]. Our recent work has shown that ...
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Energy Efficient Resource Allocation for Type-I HARQ Under the Rician Channel
... Our objective is to allocate to each link a transmit power and a bandwidth proportion. We consider a parallel channel model, i.e., there is no multiuser interference. A. Related Works First, let us review the ...
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Hypothalamic control of hippocampal area CA2 activity
... of CA2 pyramidal neurons during SWRs, indicating that this region is contributing to hippocampal network dynamics in an unusual ...area CA2 that had opposite modulations of their firing rates during SWRs. ...
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Importance of voltage-dependent inactivation in N-type calcium channel regulation by G-proteins.
... between channel opening probability and rate of G protein dissociation ...all channel combinations are at their maximal activation (data not shown) and should produce maximal opening ...the channel ...
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Differential effects of maurocalcine on Ca2+ release events and depolarization-induced Ca2+ release in rat skeletal muscle.
... to strongly modify RyR1 Ca channel properties in vitro (El-Hayek et al. 1995b; Fajloun et al. 2000). Interestingly these two toxins display some amino acid sequence homologies and structural features with domain A ...
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Side-Channel Indistinguishability
... lives in a subset C of F n 2 . Designs featuring a leak- age as per Eqn. (1) are numerous. However, it is customary that, in addition to Z, another share leaks M (refer for instance to the setup described in [7] for ...
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Estimation of Clustered MIMO Channel Parameters exploiting Channel Statistics
... wireless channel, the channel multipath components are modeled as clusters of multirays due to scatterers distributed in the ...typical channel configuration that future multiple-input ...
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Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture.
... the channel or the SR calcium load is increased or more than a single channel was opened during the ...single channel conductance in planar lipid bilayers (Goonasekera et ...
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