DNA repair and processing
![A Chemical Genetics Analysis of the Roles of Bypass Polymerase DinB and DNA Repair Protein AlkB in Processing N[superscript 2]-Alkylguanine Lesions In Vivo](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
A Chemical Genetics Analysis of the Roles of Bypass Polymerase DinB and DNA Repair Protein AlkB in Processing N[superscript 2]-Alkylguanine Lesions In Vivo
... cellular processing of N 2 -guanine DNA ...FF and HF are replication blocks in the absence of DinB (Figure 2A and Table S1 in File ...FF and HF lesions in DinB 2 cells (Figure 2B ...
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Correlation of bistranded clustered abasic DNA lesion processing with structural and dynamic DNA helix distortion
... the DNA backbone, the damaged sites are too distant to asso- ciate together by HB as the B-helix evolves in ...T11 and T13, and A34 and ...accessed and the structural reorganization ...
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Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting
... al. DNA Repair Inhibition and Radiotherapy FIGURE 1 | DNA damage repair after radiation ...of DNA lesions are induced including single (SSB) and double-strand breaks ...
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Concerted cutting by Spo11 illuminates DNA break mechanisms and initiates gap repair during meiosis
... Figures and Legends Supplementary Figure ...endonucleolytic processing. (Related to Fig. 1) a-e, Immunoprecipitated Spo11 oligos and Spo11-DCs isolated from meiotic extracts of the indicated mutants ...
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C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.
... C and then directly used for the ex- ...mm and a wall thickness of 10 m, positioned within a vacuum ...system, and eluted directly into the SAXS flow-through capillary cell at a flow rate of ...NaCl ...
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The MRE11 complex : a versatile toolkit for the repair of broken DNA
... Conclusion and future perspectives DSB repair is of crucial importance in the maintenance of genome stability and perturbations of the underlying pathways are often asso- ciated with cancer ...to ...
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Survivin contributes to DNA repair by homologous recombination in breast cancer cells
... with DNA lesions, such as DNA double-strand breaks (DSB), is particularly challenging for cancer cells and their capacity to repair them will finally determine their fate between survival ...
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The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage
... of DNA damaging agents leading to various types of DNA le- sions. DNA damage contributes to genome instability and is associated with serious consequences for human health, including cancer, ...
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Xeroderma Pigmentosum Groups C and A in Algerian Patients with Deregulation of both Transcription and DNA Repair
... Reports and Studies 2 This genetic disease is characterized by a wide variety of clinical ...eyes and areas of skin exposed to the sun and results in a high incidence of skin cancers (more than ...
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Toxicity and DNA repair in normal human keratinocytes co-exposed to benzo[a]pyrene and sunlight
... deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...teaching and research institutions in France or abroad, or from public or private research ...
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Chromatin Regulation of DNA Damage Repair and Genome Integrity in the Central Nervous System
... damage repair in the chromatin context DNA is organized into nucleosome core particles, where 147 bp of DNA wraps in ...linker DNA to form the structure of “beads on a ...(H1) and other ...
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RAD50 promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes
... is considered a minor reaction 25 . In trypanosomes both transcriptionally active and silent 78 (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without ...
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Xrcc1-dependent and Ku-dependent DNA double-strand break repair kinetics in Arabidopsis plants.
... microhomologies and the generation of larger deletions at the ...yeast and requires the Mre11–Rad50–Xrs2 complex and the struc- ture-specific endonuclease Rad1–Rad10 (Ma et ...Zhang and Paull, ...
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Analysis of NusA's roles in DNA repair and damage tolerance pathways in Escherichia coli
... Further studies on NusA showed that both AnusA and nusA 1] (G 181 D, temperature sensitive) were highly sensitive to NFZ at the permissive temperature, more so than AdinB, s[r] ...
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Alkyl transfer to metal thiolates and models for the repair of DNA aklylation damage
... How will the rate constants for demethylation of (CH30) 3 PO by the clusters compare with those of the zinc thiolates; will the reaction rate depend on the cluster ch[r] ...
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Cisplatin in yeast--repair of DNA adducts and binding of HMG domain proteins
... Cisplatin cytotoxicity assays performed on the excision repair deficient strains rad4 IXR1, rad14 IXR1, rad4 ixrl, and radl4.. ixrl ...[r] ...
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Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice
... AZD5438 and roscovitine 21,22 , both of which inhibit CDKs 1 and 2, the principal CDKs driving progression through S and G2 phases 2 (Fig 1a,b; Supplementary ...1 and 2 (Fig. 1c; Supplementary ...
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Both base excision repair and O-6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis
... toxic and genotoxic (33), the contribution to carcinogenicity of N-methylated bases has been a matter of controversy for many ...(34) and were not tumor initiating in two-stage skin carcinogenesis, but ...
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Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation
... formation and processive enlargement of DNA loops, eventually arresting at boundary ...before and after DSB induction in DIvA cells, focusing on cis interaction frequencies around ...position ...
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Conformational dynamics control catalysis in disparate systems : structural insights from DNA repair and antibiotic biosynthetic enzymes
... We have been able to structurally characterize KtzI in several states along its reaction path, and by pairing these snapshots with the biochemical and structural dat[r] ...
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