cancer therapy
Vaccination with tumor-ganglioside glycomimetics activates a selective immunity that affords cancer therapy
... in cancer development and immune evasion, making them valuable ...many cancer types for which a therapeutic strategy could be developed ( Heimburg-Molinaro et ...after therapy at least in osteo- ...
20
Incorporation of Ru(II) Polypyridyl Complexes into Nanomaterials for Cancer Therapy and Diagnosis
... Abstract Ru(II) polypyridyl complexes are compounds of great interest in cancer therapy, due to their unique photophysical, photochemical and biological properties. For effective treatment, they must be ...
43
Synthesis of lutetium-carrying oligonucleotides for targeted cancer therapy and imaging
... In a next step, the natural lutetium will be replaced by radioactive lutetium-177, a promising beta-gamma emitter suitable for cancer therapy and imaging. Finally, preclinical evaluation of this potential ...
1
Organometallic compounds of osmium for cancer therapy
... ! Chapter!1:!Cancer!and!use!of!organometallic!compounds!in!cancer!therapy! 1.1 Cancer! Cancer'is'a'class'of'diseases'where'a'group'of'cells'grow'uncontrollably'and'do'not'die.'There'are' ...
131
Spatial competition constrains resistance to targeted cancer therapy
... Since CDK1/2 inhibitor-resistant cells are sensitised to CDK4/6 inhibitors, combining both inhibitors could be an advantaegous strategy, exploiting a double-bind whereby cells might be unable to evolve resistance to both ...
16
Antibody engineering for cancer therapy
... - Engineer and select antibody mutants for improved affinity and stability using yeast surface display - Purify soluble antibody fragments secreted from yeasts using affinity chromatogra[r] ...
144
Challenges in lung cancer therapy during the COVID-19 pandemic
... Roussy Cancer Campus, Villejuif, France (J-CS, FB); Université Paris-Saclay, Orsay, France (J-CS); Aix Marseille University, CNRS, INSERM, CRCM, Marseille, France (FB); Radiology Unit, Rugani Hospital, Siena, ...
4
Gold/Polyoxometalate Core/Shell Nanoparticles for Combined Chemotherapy–Photothermal Cancer Therapy
... gold nanoparticles (AuNPs) have been recognized as first-in-class agents in nanomedicine. 2,3 Several studies have shown that the combination of drugs with gold nanoparticles improves the drug chemotherapeutic effects ...
19
Antibody targeting of claudin-1 as a potential colorectal cancer therapy
... that cancer cells cultured in 3D spheroids are closer to in vivo models than cell cultured in 2D systems and that they might better predict the in vivo outcome ...
14
A novel multi-target cancer therapy based on destabilization of short-lived mRNAs
... Cherradi et al., 2006). Our data in vivo show that the hormone also induces a rapid phosphorylation of TIS11b which is significantly impaired in the presence of H89. We subsequently used prediction software to identify ...
323
Zebrafish xenografts as a fast screening platform for bevacizumab cancer therapy
... Fig. 6 zPDX reveal different response pro files to bevacizumab. Human breast cancer or CRC surgical resected samples were injected into the PVS of 2 dpf Tg( fli1:eGFP) zebrafish larvae. zPDXs were treated in vivo ...
14
Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy
... lung cancer cell lines LKR10 and LKR13, while the peptide DPT- C9, specific for mouse caspase-9, induced apoptosis in both cell lines upon 24 h of treatment (Fig ...
13
Design of an intraperitoneal drug-release device for advanced ovarian cancer therapy
... The degree of tumor spheroid shrinkage following continuous exposure to cisplatin was shown to correlate with the average diameter of tumor nodules, so it is important to [r] ...
121
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls.
... for cancer researchers and clinicians is how to identify those patients that are most κ likely to benefit from IKK or NF- B ...MM, cancer genetics and genomics approaches have been successful in β κ ...
11
Anti-HER2 vaccines: new prospects for breast cancer therapy.
... 29 The major goal of anti-cancer vaccines is to counteract tumor-derived immunosuppression by specifically eliminating the mediators of immunosuppression. This can be achieved by acting on enzymes that are ...
44
The sexist behaviour of immune checkpoint inhibitors in cancer therapy?
... of cancer; stage of disease; arms of treatment; number and sex of patients for each arm of treatment; PFS and OS expressed as HR for the whole population and differentiated by ...
11
Irradiation Effects on Polymer-Grafted Gold Nanoparticles for Cancer Therapy
... where they showed a significant increase in the one-year survival rate for carcinoma-bearing mice treated with gold nanoparticles prior to X-ray therapy. This in vivo study preceded several other in vitro ones to ...
42
Development of aptamer-based radiopharmaceuticals for targeted cancer imaging and therapy
... Aptamers are small (5-15 kDa, 15–60 mer), non-coding, single-stranded nucleic acids (DNA or RNA) that can fold into unique three-dimensional structures which allow the interaction with a target with high affinity and ...
1
Cell Death Pathways in Photodynamic Therapy of Cancer
... 2. PDT and Apoptosis Apoptosis is a very complex, multi-step, multi-pathway cell-death program that is genetically encoded in every cell of the body [18]. It can be initiated either through the activation of death ...
25
Photodynamic therapy for skin cancer : How to enhance drug penetration ?
... proliferation whereas at higher concentrations it inhibits proliferation. Also, whatever the concentration, cell differentiation still occurs [83]. Anand et al. [84] showed that coproporphyrinogen oxidase and ...
50