adenosine monophosphate-activated protein kinase
Activation of Adenosine Monophosphate—Activated Protein Kinase Reduces the Onset of Diet‐Induced Hepatocellular Carcinoma in Mice
... Dieter Schmoll, 1 Nicole Ziegler, 1 Benoit Viollet, 2 Marc Foretz, 2 Patrick C. Even, 3 Dalila Azzout-Marniche, 3 Andreas Nygaard Madsen, 4 Martin Illemann, 4 Karen Mandrup , 4 Michael Feigh, 4 Jörg Czech, 1 Heiner ...
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Impact d’un épisode asphyxique périnatal associé à des convulsions sur le développement des interneurones corticaux : rôle de l’adenosine monophosphate-activated protein kinase (AMPK)
... striking features of this group of neurons is their morphological diversity, in particular with regard to their axonal arborization and, as a consequence, their postsynaptic targets. In fact, distinct classes of ...
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Place de l'AMP-activated protein kinase dans le preconditionnement ischemique renal.
... R E´ S U M E´ La transplantation re´nale repre´sente aujourd’hui le traitement de choix de l’insuffisance re´nale terminale. Outre l’ade´quation des antige`nes human leucocyte antigens (HLA) entre le donneur et le ...
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Cyclic adenosine 3',5'-monophosphate-elevating agents inhibit transforming growth factor-beta-induced SMAD3/4-dependent transcription via a protein kinase A-dependent mechanism.: Inhibition of SMAD-dependent transcription by cAMP
... INTRODUCTION Cellular signaling from the Transforming Growth Factor- (TGF- ) family of growth factors (e.g. activins, bone morphogenic proteins, and the TGF- ) is initiated by binding of the ligands to ...
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Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1
... phospho-AMP-activated protein kinase (pAMPK), and total AMPK (AMPKt) in low Ca 2+ conditions (S-MEM) and following Ca 2+ switch using MDCK cells or LKB1- shRNA MDCK cells, with versus without ...
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Studies of the role of MAP kinase-activated protein kinase-5 (MK5) in reactive and reparative fibrosis in the murine heart
... fibrosis, in response to pressure overload (6, 60) or infusion of ANG II, isoproterenol, or phenylephrine (6). In addition, cardiac-specific expression of constitutively active MKK3bE or MKK6bE results in cardiac ...
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Protein kinase D increases maximal Ca 2+ -activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser 315
... Several proteins have been identified to be substrates of PKD, including cardiac troponin I (TnI), telethonin, and car- diac myosin-binding protein C (cMyBP-C) (9). cMyBP-C is a component of the cardiac sarcomere ...
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AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice.
... alveolar protein tracer compared with the initial instilled tracer protein fluorescence intensity ...tracer protein and C2 is the final total tracer protein fluorescence intensity in the ...
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The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
... active adenosine triphosphate (ATP) release and subsequent ATP, adenosine diphosphate (ADP) and adenosine receptor signalling are required for inflammasome ...by adenosine degradation or ...
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Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process
... microtubule-associated protein 1 light chain 3 (LC3) to assess the autophagic flux following AMPK activation. p62 levels were significantly increased following 24 h of AICAR treatment (Fig. 5 a, d). p62 increase ...
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Beyond energy homeostasis: the expanding role of AMP-activated protein kinase in regulating metabolism
... Calabrese, M.F., Rajamohan, F., Harris, M.S., Caspers, N.L., Magyar, R., Withka, J.M., Wang, H., Borzilleri, K.A., Sahasrabudhe, P.V., Hoth, L.R., Geoghegan, K.F., Han, S., Brown, J., Subashi, T.A., Reyes, A.R., Frisbie, ...
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Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
... INTRODUCTION PPAR, and (NR1C1, NR1C2, NR1C3)(1), which are encoded by separate genes and exhibit distinct tissue-distribution, belong to the nuclear receptor superfamily (2). This family includes receptors for ...
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Implication de l'AMP-Activated Protein Kinase (AMPK) dans le mécanisme du préconditionnement anesthésique par le Sévoflurane vis-à-vis de l'ischémie-reperfusion myocardique
... Ainsi nous avons démontré pour la première fois que le sévoflurane induisait par lʼintermédiaire dʼune production dʼespèces réactives de lʼoxygène ROS, une activation de la voie de lʼAMP[r] ...
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en fr AMP-activated protein kinase : Screening for novel membrane substrates and creatine kinase phosphorylation linked to specific subcellular compartment La protéine kinase activée par AMP : Criblage de nouveaux substrats membranaires et phosphorylation de la créatine kinase liée à une compartimentation subcellulaire
... creatine kinase, identified by in vitro substrate screening of soluble brain proteins following an earlier published work (Tuerk et ...spectrometry, protein sequencing, site-directed mutagenesis, ...
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en fr Interactomics of key kinases in energy metabolism : Characterizing interactions of AMP-activated protein kinase & B-type creatine kinase Ineractomique d'enzymes clef du métabolisme énergétique : Charactérisation d'interactions de la protéine kinase activée par AMP et de la creatine kinase cytosolique du cerveau (B-type)
... the kinase is anchored to proteins providing a type of scaffolding ...Golgi protein GM130, occurring transiently during ATP-dependent mitotic defragmentation of Golgi (Burklen et ...
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AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3beta (GSK-3beta) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane.
... the kinase activities of GSK-3  and AMPK might contribute to this process, it is worth reviewing the biological program of tight junction assembly, much of which is poorly ...are activated that induce ...
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Decreased Expression of Cyclic Adenosine Monophosphate-Regulated Aldose Reductase (AKR1B1) Is Associated with Malignancy in Human Sporadic Adrenocortical Tumors
... deferens protein (MVDP), respectively (18, ...reductase-like protein showing ACTH ...regulatory protein gene (StAR) and CYP11A (25–27), or in adrenal differentiation, ...
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Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.: Crosstalks between the MAP kinase and Smad pathways
... be activated by various MAPKKKs in response to many ...be activated by TGF- family members is TGF- -activated kinase 1 (TAK1), originally identified as a MAPKKK activated by TAB1 ...
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Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology
... Masitinib pull-down. Masitinib-NH 2 was cross-linked via its amino functional group to NHS-activated Sepharose 4 Fast Flow beads according to the manu- facturer ’s instructions (GE Healthcare). Pull-down ...
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Protein kinase C and human uterine contractility.
... * Corresponding author Abstract Abnormalities in uterine contractility are thought to contribute to several clinical problems, including preterm labor. A better understanding of the mechanisms controlling uterine ...
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