HAL Id: inserm-00926577
https://www.hal.inserm.fr/inserm-00926577
Submitted on 23 Apr 2014
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PRR repeats in the intracellular domain of KISS1R are important for its export to cell membrane.
Lucie Chevrier, Alexandre de Brevern, Eva Hernandez, Jérome Leprince, Hubert Vaudry, Anne Marie Guedj, Nicolas de Roux
To cite this version:
Lucie Chevrier, Alexandre de Brevern, Eva Hernandez, Jérome Leprince, Hubert Vaudry, et al.. PRR
repeats in the intracellular domain of KISS1R are important for its export to cell membrane.: PRR re-
peats in intracellular domain of KISSIR. Mol Endocrinol, 2013, 27 (6), pp.1004-14. �10.1210/me.2012-
1386�. �inserm-00926577�
✁ ✂ ✂ ✄ ☎ ✆ ☎ ✝ ✞ ✟ ✠✡ ✞☛ ☎ ✠✡ ✞ ✄ ✝ ☞ ☎ ✌✌✍ ✌ ✝ ✄ ✎ ✏ ✑ ✝ ✠✡ ✏ ✒ ✓ ✔ ✕ ✕ ✖ ✂ ✝ ✄ ☎ ✠✑ ✆ ✏ ✄ ✞ ✝ ✡ ✞ ✒ ✏ ✄ ✠✞ ✟ ☎ ✗ ✆ ✏ ✄ ✞ ✞ ✏ ☞ ☎ ✌✌
✑ ☎✑ ✘ ✄ ✝ ✡ ☎
✙ ✚ ✛ ✜ ✜ ✢✜ ✣ ✤✢✤✥✦ ✧ ★ ✚ ✚ ✩ ✦✪ ✦ ✫ ✤✬ ✢✜ ✢✜ ✤✩ ✫ ✭ ✦ ✥✥✛ ✥✫ ✩ ✮ ✯ ✰ ✫ ✢✜ ✯✱ ✲ ✳ ✴ ✴ ✵ ✚
✶ ✷ ✸ ✹ ✺✻ ✼ ✽ ✻✾ ✿ ✺✻ ✿ ❀❁ ❂ ❃✻ ❄ ❅ ❆ ❇ ✿ ✻ ❇ ✻ ❈ ✿ ✻ ✾ ✻ ✿❆ ❉ ❁ ❊ ✾ ❅ ❋ ✻ ✿ ❆ ❅ ❆ ❇ ✻ ● ❀❁ ❍ ■ ✿ ❏ ❑ ✻ ✷ ✻ ▲ ✿ ✺❆ ✹ ✻ ▼ ❁ ❋ ✸ ◆ ✻ ✿ ❖ P ❅ ✸ ❇ ✿ ◗ ▼ ❁ ❂ ❆ ❆ ✻
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❪❫ ❀ ❴❲ ❵ ❊ ❨ ❙ ❛ ❙ ❨ ❜ ❝ ❜ ❁ ❛ ❆ ✺✾ ❞ ❅ ✿ ✺❳ ❡ ✺❇ ✻ ✿ ❏ ❖ ❁ ❵ ❏ ✿◆ ❏ ❆ ❆ ✻ ❞ ❅ ✿ ✺❳ ✼ ✺❖ ■ ❁ ❢ ❣ ❝ ❤ ❝ ✐ ❥ ❞ ❅ ✿ ✺❳ ❁ ❢ ✿ ❅ ❆ ✹ ✻
❉ ❴❲ ❵ ❊ ❨ ❙ ❛ ❙ ❨ ❣❵ ❜ ❜ ❤ ❦ ❛ ❆ ✺✾ ❞ ❅ ✿ ✺❳ ❡ ✺❇ ✻ ✿ ❏ ❖ ❦ ❵ ❏ ✿ ◆ ❏ ❆ ❆ ✻ ❞ ❅ ✿ ✺❳ ✼ ✺❖ ■ ❦ ❴❲ ❧ ❵ ❦ ✷ ❅ ◆ ❏ ✿ ❅❖ ❏ ✺✿ ✻ ❇ ♠❊ ❄ ✹ ✻ ❃❃✻❆ ✹ ✻
♥ ❚ ❨ ❣❊ ❄ ❁ ❝ ❤ ♦ ♣ ❤ ❞ ❅ ✿ ✺❳ ❁ ❢ ✿ ❅ ❆ ✹ ✻ ❭
q ▼ ❴❲ ❵ ❊ ❨ ❙ ❛ ❙ ❨ ❥ r s ❁ ❛ ❆ ✺✾ ❨ ❏ ✸ ✻ ❆ ❁ ❙ ❏ ❆ ❖ ❣❵ ❅ ✺❆ ❖ ❣❂ ✺t ❆ ❅ ❆ ❁ ❢ ✿ ❅❆ ✹ ✻
✉ ❱ ❵ ✻ ✿✾ ✺✹ ✻ ❇ ✻ ❳ ❙ ❅ ❃❅ ❇ ✺✻ ❳ ❙ ■ ❖ ❅ ◆ ❏ ❃✺✈ ✸ ✻ ❳ ✻ ❖ ❊ ❆ ❇ ❏ ✹ ✿ ✺❆ ✺✻❆ ❆ ✻ ❳ ❁ ❋ ✇ ▲ ✺❖ ❅ ❃ ✼ ❅ ✿ ■ ❑ ✻ ❅ ✸ ❁ ❲ ①❑ ✻ ❳
② ❬ ✷ ❅ ◆ ❏ ✿ ❅ ❖ ❏ ✺✿ ✻ ❇ ✻ ❈ ✺❏ ✹ ✽ ✺❑ ✺✻ ❭ ❋ ✇ ▲ ✺❖ ❅ ❃ ❨ ❏ ◆ ✻✿ ❖ ❡ ✻ ◆ ✿ ■ ❭ ❝ ❤ ♦ ♣ ❥ ❞ ❅ ✿ ✺❳ ❭
✙ ✼ ❏ ✿ ✿ ✻ ❳▲ ❏ ❆ ❇ ✺❆ t ❅ ✸ ❖✽ ❏ ✿ ③ ❲ ✺✹ ❏ ❃❅ ❳ ❇ ✻ ❨ ❏ ✸ ❄ ❁ ❴ ❲ ❵ ❊ ❨ ❙ ❛ ❜ ❝ ❜ ❁ ❋ ✇ ▲ ✺❖ ❅ ❃ ❨ ❏ ◆ ✻ ✿❖ ❡ ✻ ◆ ✿ ■ ❁ ④ r ❈ ❇ ❵ ■ ✿✸ ✿ ✺✻ ✿ ❁
✶ ❝ ❤ ♦ ♣ ❥ ❞ ❅✿ ✺❳ ❁ ❢ ✿ ❅ ❆ ✹ ✻ ❁ ❖ ✻ ❃❭③ ⑤ ✐ ✐ ⑥ ♦ ⑦ ♣ ④ ♦ ♦ ✐ ♣ ❥ r ❤ ❦ ❢ ❅ ❄ ③ ⑤ ✐ ✐ ⑥♦ ⑦ ♣ ④ ♦ ♦ ✐ ♣ ❥ ❥ ❤ ❦ ❊ ❣❑ ❅ ✺❃③
❘ ❆ ✺✹ ❏ ❃❅ ❳ ❭❇ ✻ ✿ ❏ ✸ ❄ ⑧ ✺❆ ❳ ✻ ✿❑ ❭⑨✿ ❭
❪❫ ❧ ❏ ⑩ ✽ ❏ ❑ ✹ ❏ ✿ ✿ ✻ ❳▲ ❏ ❆ ❇ ✻ ❆ ✹ ✻ ❳✽ ❏ ✸ ❃❇ ◆ ✻ ❅ ❇ ❇ ✿ ✻ ❳ ❳ ✻ ❇ ③ ❲ ✺✹ ❏ ❃❅ ❳ ❇ ✻ ❨ ❏ ✸ ❄ ❁ ❴❲ ❵ ❊ ❨ ❙ ❛ ❜ ❝ ❜ ❁ ❋ ✇ ▲ ✺❖ ❅ ❃ ❨ ❏ ◆ ✻ ✿❖
♥ ❡ ✻ ◆ ✿ ■ ❁ ④ r ❈ ❇ ❵ ■ ✿ ✸ ✿ ✺✻ ✿ ❁ ❝ ❤ ♦ ♣ ❥ ❞ ❅ ✿ ✺❳ ❁ ❢ ✿ ❅ ❆ ✹ ✻ ❁ ❖ ✻ ❃❭③ ⑤ ✐ ✐ ⑥♦ ⑦ ♣ ④ ♦ ♦ ✐ ♣ ❥ r ❤ ❦ ❢ ❅ ❄ ③ ⑤ ✐ ✐ ⑥♦ ⑦ ♣ ④ ♦ ♦ ✐ ♣ ❥ ❥ ❤ ❦
q ❊ ❣❑ ❅ ✺❃③ ❆ ✺✹ ❏ ❃❅ ❳ ❭❇ ✻ ✿ ❏ ✸ ❄ ⑧ ✺❆ ❳ ✻ ✿ ❑ ❭⑨✿ ❭
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✙✙ ✙ ❹ ✠ ✟☞ ✌✏ ✟✍ ✄ ☎ ✟✞ ✝ ✞ ☎ ✑ ☎ ✡ ✞ ❺ ❧ ✽ ✻ ❅ ✸ ❖✽ ❏ ✿ ❳ ✽ ❅ ✾ ✻ ❆ ❏ ❖✽ ✺❆ t ❖ ❏ ❇ ✺❳ ✹ ❃❏ ❳ ✻ ❭
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❼ ❽ ❾ ❿ ➀ ❼ ➁ ❿
➃➄ ➅ ➆ ➇ ➈➉ ➅ ➇ ➈➄ ➊ ➋ ➌ ➇ ➅ ➇ ➈➍ ➄ ➎ ➍ ➏ ➐ ➃ ➑ ➑ ➒➓ ➔ ➅ ➉ → ➣ → → ➄ ↔ → ➆ → ➄ ➇ ↕➙ ➛ → ➎ ➆ ↔ ➈➣ → ➛ ➅ ➎ ➅ ↔ ➅ ↔ → ➆ ➅ ➌ ➎ → ➍ ➏ ➈➎ ➍ ↕➅ ➇ → ➛
❻ ➜ ➔ ➙ ➝ ➍ ➊ ➍ ➄ ➅ ➛ ➍ ➇↔ ➍ ➝ ➈➆ ➔ ➙ ➝ ➍ ➊ ➍ ➄ ➅ ➛ ➈➎➋ ➞➃➟ ➟ ➠ ➇↔ ➅ ➄ ➎ ➋ ➈➇➇ → ➛ ➅ ➎ ➅ ↔ → ➆ → ➎ ➎ ➈➉ → ➇↔ ➅ ➈➇ ➡ ➢ → ➤ ➋ ➌ ➇ ➅ ➇ ➈➍ ➄ ➎ ➔ ➅ ➉ → ➣ → → ➄
➥ ➦ ➛ → ➎ ➆↔ ➈➣ → ➛ ➅ ➄ ➛ ➇➔ → ➎➇↔ ➌ ➆ ➇➌ ↔ → ➧ ➏➌ ➄ ➆ ➇ ➈➍ ➄ ↔ → ↕➅ ➇ ➈➍ ➄ ➎➔ ➈➝ ➍ ➏ ➐ ➃ ➑ ➑ ➒ ➓ ↔ → ➋ ➅ ➈➄ ➎ ➝ ➍ ➍ ↔ ↕➙ ➌ ➄ ➛ → ↔ ➎➇ ➍ ➍ ➛ ➡ ➟ → ↔ → ➨ ➤ →
➥ ➩ ➔ ➅ ➉ → ➇ ➅ ➫ → ➄ ➅ ➛ ➉ ➅ ➄ ➇ ➅ ➊ → ➍ ➏ ➇➔ → ➛ ➈➎ ➆ ➍ ➉ → ↔➙ ➍ ➏ ➅ ➄ ➍ ➉ → ↕ ➋ ➌ ➇ ➅ ➇ ➈➍ ➄ ➍ ➏ ➐ ➃ ➑ ➑ ➒➓ ➇ ➍ ➆ ➔ ➅ ↔ ➅ ➆ ➇ → ↔ ➈➭ → ➇➔ → ➎➇↔➌ ➆➇➌ ↔ →
➥ ❻ ➅➄ ➛ ➏➌ ➄ ➆➇ ➈➍ ➄ ➍ ➏ ➅ ➄ ➌ ➄ ➆ ➍ ➋ ➋ ➍ ➄ ➝ ↔ ➍ ➇ → ➈➄ ➋ ➍ ➇ ➈➏ ➆ ➍ ➋ ➝ ➍ ➎ → ➛ ➍ ➏ ➇➔ ↔ → → ➝ ↔ ➍ ↕➈➄ → ➧➅ ↔ ➊ ➈➄ ➈➄ → ➧➅ ↔ ➊ ➈➄ ➈➄ → ➞➯ ➓ ➓ ➠
➥ ➥ ↔ → ➝ → ➅ ➇ ➎ ↕➍ ➆ ➅ ➇ → ➛ ➤ ➈➇➔ ➈➄ ➇➔ → ➈➄ ➇↔ ➅ ➆ → ↕↕➌ ↕➅↔ ➛ ➍ ➋ ➅ ➈➄ ➡ ➲ ➔ →➇ →↔ ➍ ➭ ➙ ➊ ➍ ➌ ➎ ➈➄ ➎ → ↔➇ ➈➍ ➄ ➍ ➏ ➍ ➄ → ➯ ➓ ➓ ↔ → ➝ → ➅➇ ➈➄ ➧➏↔ ➅ ➋ →
➥ ➳ ➤ ➈➇➔ ➇➔ ↔ → → ➯ ➓ ➓ ↔ → ➝ → ➅➇ ➎ ↕→ ➅ ➛ ➈➄ ➊ ➇ ➍ ➎➙ ➄ ➇➔ → ➎ ➈➎ ➍ ➏ ➅ ↔ → ➆ → ➝ ➇ ➍ ↔ ➣ → ➅ ↔ ➈➄ ➊ ➵ ➯ ➓ ➓ ↔ → ➝ → ➅ ➇ ➎ ➞➯ ➓ ➓ ➧➐ ➃ ➑ ➑ ➒➓ ➠ ➤ ➅ ➎
➥ ➸ ➏➍ ➌ ➄ ➛ ➈➄ ➇➔ → ➈➄ ➛ → ➺ ➆ ➅ ➎ → ➡ ➢ ➌ ➄ ➆ ➇ ➈➍ ➄ ➅ ↕ ➅ ➄ ➅ ↕➙ ➎ ➈➎ ➍ ➏ ➯ ➓ ➓ ➧➐ ➃ ➑ ➑ ➒➓ ➎➔ ➍ ➤ → ➛ ➅ ➛ → ➆ ↔ → ➅ ➎ → ➍ ➏ ➇➔ → ➋ ➅ ➺ ➈➋ ➅ ↕
➥ ➻ ↔ → ➎ ➝ ➍ ➄ ➎ → ➇ ➍ ➫ ➈➎ ➎➝ → ➝ ➇ ➈➄ ➎➇ ➈➋ ➌ ↕➅ ➇ ➈➍ ➄ ➨ ➅ ➎ ➎ ➍ ➆ ➈➅ ➇ → ➛ ➇ ➍ ➅ ↕➍ ➤ → ↔ ➆ → ↕↕ ➎ ➌ ↔ ➏➅ ➆ → → ➺ ➝ ↔ → ➎ ➎ ➈➍ ➄ ➤ ➈➇➔ ➍ ➌ ➇ ➋ ➍ ➛ ➈➏ ➈➆ ➅ ➇ ➈➍ ➄
➥ ➼ ➍ ➏ ➇ ➍ ➇ ➅ ↕ → ➺ ➝ ↔ → ➎ ➎ ➈➍ ➄ ➡ ➯ ➓ ➓ ➧➐ ➃ ➑ ➑ ➒ ➓ → ➺ → ↔➇ ➎ ➅ ➛ ➍ ➋ ➈➄ ➅ ➄ ➇ ➄ → ➊ ➅ ➇ ➈➉ → → ➏ ➏→ ➆ ➇ ➍ ➄ ➇➔ → ➎➙ ➄ ➇➔ → ➎ ➈➎ ➍ ➏ ➇➔ → ➤ ➈↕➛ ➇➙ ➝ →
➥ ➂ ➐ ➃ ➑ ➑ ➒➓ ➞➽ ➾ ➧➐ ➃ ➑ ➑ ➒ ➓ ➠ ➡ ➾ ➔ ➈➎ → ➏ ➏→ ➆➇ ➤ ➅ ➎ ➛ ➌ → ➇ ➍ ➇➔ → ➄ ➅ ➇➌ ↔ → ➍ ➏ ➈➄ ➎ → ↔ ➇ → ➛ ↔ → ➎ ➈➛ ➌ → ➎ ➨ ➣ ➌ ➇ ➅ ↕➎ ➍ ➇ ➍ ➇➔ →
➥ ➜ ➛ ➈➏ ➏→ ↔ → ➄ ➆ → ➍ ➏ ➇➔ → ↕→ ➄ ➊ ➇➔ ➍ ➏ ➇➔ → ➈➄ ➇↔ ➅ ➆ → ↕↕➌ ↕➅↔ ➛ ➍ ➋ ➅ ➈➄ ➣ → ➇➤ → → ➄ ➯ ➓ ➓ ➧ ➅ ➄ ➛ ➽ ➾ ➧➐ ➃ ➑ ➑ ➒➓ ➡ ➲ ➋ ➍ ↕→ ➆ ➌ ↕➅↔
➳ ➦ ➛ ➙ ➄ ➅ ➋ ➈➆ ➅ ➄ ➅ ↕➙ ➎ ➈➎ ➎➔ ➍ ➤ → ➛ ➇➔ ➅ ➇ ➇➔ → ➅ ➛ ➛ ➈➇ ➈➍ ➄ ➅ ↕ ➯ ➓ ➓ ➆ ➍ ➄ ➎➇↔ ➅ ➈➄ → ➛ ➇➔ ➈➎ ➅ ↔ ➊ ➈➄ ➈➄ → ↔ ➈➆ ➔ ↔ → ➊ ➈➍ ➄ ➈➄ ➇ ➍ ➅
➳ ➩ ➝ ➍ ↕➙ ➯ ↔ ➍ ↕➈➄ → ➇➙ ➝ → ➃➃ ➔ → ↕➈➺ ➡ ➲ ↕➇ ➍ ➊ → ➇➔ →↔ ➨ ➇➔ ➈➎ ➎➇➌ ➛ ➙ ➎➔ ➍ ➤ ➎ ➇➔ ➅ ➇ ➅ ➔ → ➇ → ↔ ➍ ➭ ➙ ➊ ➍ ➌ ➎ ➈➄ ➎ → ↔ ➇ ➈➍ ➄ ➈➄ ➐ ➃ ➑ ➑ ➒ ➓ ➋ ➅ ➙
➳ ❻ ↕→ ➅ ➛ ➇ ➍ ➃➟ ➟ ➣ ➙ ➅ ➛ ➍ ➋ ➈➄ ➅ ➄ ➇ ➄ → ➊ ➅ ➇ ➈➉ → → ➏ ➏→ ➆ ➇ ➍ ➄ ➇➔ → ➽ ➾ ↔ → ➆ → ➝ ➇ ➍ ↔ ➡ ➲ ➄ ➅ ➛ ➛ ➈➇ ➈➍ ➄ ➅ ↕ ➯ ➓ ➓ ↔ → ➝ → ➅ ➇ ➈➄ ➇ ➍ ➅
➳ ➥ ➝ ↔ ➍ ↕➈➄ → ➧➅↔ ➊ ➈➄ ➈➄ → ↔ ➈➆ ➔ ➋ ➍ ➇ ➈➏ ➆ ➅ ➄ ➛ ↔ ➅➋ ➅➇ ➈➆ ➅ ↕↕➙ ➆ ➔ ➅ ➄ ➊ → ➛ ➇➔ → ➆ ➍ ➄ ➏➍ ↔ ➋ ➅ ➇ ➈➍ ➄ ➍ ➏ ➇➔ → ➈➄ ➇↔ ➅ ➆ → ↕↕➌ ↕➅ ↔ ➛ ➍ ➋ ➅ ➈➄ ➍ ➏
➳ ➳ ➐ ➃ ➑ ➑ ➒➓ ➅➄ ➛ ➈➇ ➎ ➝ ↔ ➍ ➣ ➅➣ ↕→ ➈➄ ➇ → ↔ ➅ ➆ ➇ ➈➍ ➄ ➤ ➈➇➔ ➝ ➅ ↔ ➇➄ → ↔ ➝ ↔ ➍ ➇ → ➈➄ ➎ ➡
➳ ➸
➳ ➻
