Tel que vu précédemment, le SMet et la DDVG sont des anomalies étroitement reliées [7]. Des associations entre la réversibilité de la DDVG et des mesures d’adiposité, de résistance à l’insuline ou de tolérance à l’effort ont été rapportées par certaines études [11-15]. Par contre, ces dernières ne tenaient compte que de certaines caractéristiques de la fonction diastolique obtenues à l’échocardiographie. Au cours du projet présenté dans ce mémoire, il a été démontré que la DDVG, telle que diagnostiquée selon les recommandations [61], est réversible suite à un programme d’un an visant la modification des habitudes de vie par l’alimentation et l’activité physique. Cependant, la réversibilité de la DDVG n’est pas associée à l’amélioration des mesures d’adiposité, du profil métabolique ou de la tolérance à l’effort, malgré le fait que ces mesures se soient améliorées de façon significative pour le groupe de participants dans son ensemble.
Bien que les déterminants de la réversibilité de la DDVG n’aient pas été identifiés dans le cadre du présent projet de recherche, il a tout de même été possible d’établir un profil des participants étant en mesure d’améliorer leur fonction diastolique par une modification des habitudes de vie. Ainsi, ce profil type présenterait une bonne tolérance à l’effort accompagnée d’une légère hypertension d’effort et une tolérance au glucose diminuée. Des recherches supplémentaires seraient nécessaires pour explorer les autres déterminants possibles de la réversibilité de la DDVG, soit la durée de l’obésité, le débit cardiaque à l’effort et la lipotoxicité du myocarde.
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