corps où c'est plus ou moins épais (l'épiderme), on doit établir le rapport de nouveau.
Ce travail de validation de la technique laser devait être complété, par une étude de la cinétique de la réépidermisation ainsi que le rétablissement de la fonction barrière. Pour ce fait l'utilisation de technique de la PIE ainsi que la mesure du flux sanguin, couplées à une technique de photographie, a permis le suivi de ce phénomène et la détermination d'une courbe d'évolution en fonction du temps de ces différents paramètres.
L'utilisation de la technique de tomographie par cohérence optique, a permis la visualisation de l'apparition du nouvel épiderme (apparition d'un stratum corneum). De cette manière nous avons pu établir une corrélation entre les mesures physiologiques et les observations obtenues par imagerie (OCT).
Enfin, et à la suite de ces résultats, le laser Er:YAG comme technique de désépidermisation, présente plus d'avantages que la technique référence: la bulle de succion. Ce travail peut être compléter par une analyse biochimique comparative afin de vérifier les mécanismes intervenants, ainsi qu'une différence, probable, entre les deux techniques.
Le laser Er: YAG ainsi validé, pourra être utiliser dans d'autres études sur la cicatrisation proprement dite, en augmentant la fluence pour atteindre le derme. Ou inversement en réduisant la fluence utilisée, et par conséquent n'atteindre que le SC et induire ainsi des irritations.
B
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