[PDF] Top 20 Tamoxifen resistance and epigenetic modifications in breast cancer cell lines.
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Tamoxifen resistance and epigenetic modifications in breast cancer cell lines.
... treatment and epigenetic modifications Recent developments have linked epigenetic mechanisms to ER action (for recent reviews see [41, ...between epigenetic alterations (which influence ... Voir le document complet
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Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases
... Ducourouble, and Isabelle Van Seuningen 1 Inserm U837, Jean-Pierre Aubert Research Centre, Place de Verdun, Lille, France ABSTRACT The human gene MUC4 encodes a trans- membrane mucin, ligand of ErbB2, that is ... Voir le document complet
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Hormonal Therapy Resistance and Breast Cancer: Involvement of Adipocytes and Leptin
... for breast cancer in postmenopausal women, is associated with higher mortality rates regardless of menopausal status, which could in part be explained by therapeutic ...chemo- and ... Voir le document complet
17
SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer
... ABSTRACT Breast cancer is the most frequently diagnosed malignancy in women ...profound epigenetic deregulations that contribute to the tumorigenesis ...H3 and H4 acetylated histone ... Voir le document complet
19
Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines
... 3 and NH 2 /NH 2 aromatic bis-substitution are all extremely active, with IC 50 values in nanomolar region, while the monosubstituted compounds (chart 1) are approximately an order of magnitude less ... Voir le document complet
7
Effect of tamoxifen and fulvestrant long-term treatments on ROS production and (pro/anti)-oxidant enzymes mRNA levels in a MCF-7-derived breast cancer cell line
... generation and suppression of ROS in vessels [ 11 ], uterus [ 12 ], and also in breast cancer cells [ 13 ...system in females. Breast cancer adjuvant ... Voir le document complet
16
O-GlcNAcylation-Inducing Treatments Inhibit Estrogen Receptor α Expression and Confer Resistance to 4-OH-Tamoxifen in Human Breast Cancer-Derived MCF-7 Cells.
... tamoxifen induced cell ...from tamoxifen-induced cell death appear to be independent of this ...that tamoxifen can have ERα-independent anti-proliferative and pro-apotptotic ... Voir le document complet
18
Emergence of cytotoxic resistance in cancer cell populations: single-cell mechanisms and population-level consequences
... of epigenetic modifications of the DNA (methylation, histone acetylation) in relevant parts of the ...proposed in [22], using a one-dimensional, phenotype-like structure ... Voir le document complet
5
Adipocyte/breast cancer cell crosstalk in obesity interferes with the anti-proliferative efficacy of tamoxifen
... recurrence and mortality in obese patients could be related to a lesser efficacy of anti-cancer treatments probably due to plasma adipokine variations linked to over- ...obese breast ... Voir le document complet
15
Septin 9 isoform expression, localization and epigenetic changes during human and mouse breast cancer progression.
... Fluorescence in situ hybridization analysis of cell lines and tissue microarrays Nine bacterial artificial chromosome (BAC) clones map- ping to SEPT9, HER2 and CEP17 were obtained from ... Voir le document complet
18
New Insights into the Implication of Epigenetic Alterations in the EMT of Triple Negative Breast Cancer
... tools and overall knowledge, the function of lncRNAs was largely unknown until the early 1990 0 s when H19 and Xist were found to be involved in epigenetic modulations [ 9 ...genome in ... Voir le document complet
22
Hormonal Therapy Resistance and Breast Cancer: Involvement of Adipocytes and Leptin
... for breast cancer in postmenopausal women, is associated with higher mortality rates regardless of menopausal status, which could in part be explained by therapeutic ...chemo- and ... Voir le document complet
16
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
... relevant in other tumor types. It is lower in some of the more ICI- responsive tumors (kidney, skin, lung) and higher in tumor types that are less responsive and/or arise from ... Voir le document complet
49
A Gene Expression Signature that Can Predict the Recurrence of Tamoxifen-Treated Primary Breast Cancer.
... TPX2 and UBE2C) have been reported to discriminate ER+ from ER- breast cancers [8, 23, ...PNRC2 and PKIB, are possibly involved in the regulation of the ER ...ER, and it has also been ... Voir le document complet
25
A 3D model of ovarian cancer cell lines on peptide nanofiber scaffold to explore the cell–scaffold interaction and chemotherapeutic resistance of anticancer drugs
... nm in diameter with the drive of positively and negatively charged residues by complemen- tary ionic interactions and spontaneously assembled into the well-ordered nanofiber networks with the pore ... Voir le document complet
9
Bioinformatics methods for analyzing anti-hormonal treatment resistance in breast cancer
... 345 and Richard D Iggo 123 1. Institut Bergonié Comprehensive Cancer Centre, ...appeared in the copy number profile after treatment, including an amplicon on chromosome 6q containing the ER gene ... Voir le document complet
2
Cell swelling, softening and invasion in a three-dimensional breast cancer model
... culture and immunofluorescence staining. The mammary epithelial cancer organoid with invasive phenotype was cultured and induced following a previously established protocol 11,12 ...cultured ... Voir le document complet
21
Synthesis and biological assessment of organometallic tamoxifen derivatives for the diagnosis and the treatment of breast cancer
... son’s and Ruenitz’s research groups has been the only important e¢ cacious estrogen antagonist examples found so far [56, 113, ...114]. In addition to the chemical alteration from a basic amino side-chain ... Voir le document complet
166
Germline DLST Variants Promote Epigenetic Modifications in Pheochromocytoma-Paraganglioma
... Sigma) in cell lysates in 96-well ...samples and standards were run in du- ...included in the 96-well plate, with 0 (blank), ...CaCl2 and MgCl2) and homogenized ... Voir le document complet
14
HNF1α inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines
... HNF1a and HNF4a ...HNF1a and activates the expression of HNF1a ...HNF1a and HNF4a in hepatocytes ...sion and the expression of other targets of HNF4a, through interaction with HNF4a ... Voir le document complet
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