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[PDF] Top 20 The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate

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The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate

The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate

... In the first manuscript presented in this thesis, we demonstrate that compared to MHC- I-restricted thymocytes, TCR signaling in MHC-II-restricted thymocytes is more potent in ... Voir le document complet

230

Blockade of Interleukin 27 Signaling Attenuates Graft Versus Host Disease By Augmenting CD4+ and CD8+ Regulatory T Cell Reconstitution

Blockade of Interleukin 27 Signaling Attenuates Graft Versus Host Disease By Augmenting CD4+ and CD8+ Regulatory T Cell Reconstitution

... IL-12, and IL-23) plays a major role in the modulation of inflammatory and regulatory pathways during graft versus host disease ...member of this family, is a ... Voir le document complet

1

Blockade of Interleukin 27 Signaling Attenuates Graft Versus Host Disease By Augmenting CD4+ and CD8+ Regulatory T Cell Reconstitution

Blockade of Interleukin 27 Signaling Attenuates Graft Versus Host Disease By Augmenting CD4+ and CD8+ Regulatory T Cell Reconstitution

... College of Wisconsin, Milwaukee, WI; 2 Indiana University School of Medicine, Indianapolis, IN; 3 Genentech, Inc, South San Francisco, CA; 4 Ludwig Cancer Institute, Brussels, Belgium The ... Voir le document complet

1

Pivotal role of receptor-interacting protein kinase 1 and mixed lineage kinase domain-like in neuronal cell death induced by the human neuroinvasive coronavirus OC43

Pivotal role of receptor-interacting protein kinase 1 and mixed lineage kinase domain-like in neuronal cell death induced by the human neuroinvasive coronavirus OC43

... process and whether the mutations in the viral S protein engage other pathways in infected ...cells. The current study demonstrates that two point mutations located in ... Voir le document complet

20

Role of Cytokines in Thymus- Versus Peripherally Derived-Regulatory T Cell Differentiation and Function

Role of Cytokines in Thymus- Versus Peripherally Derived-Regulatory T Cell Differentiation and Function

... T cell pre- cursors under particular conditions of stimulation, present great similarities, and ...by the expres- sion of the transcription factor Foxp3, widely recognized as ... Voir le document complet

11

Homeostatic interplay between bacterial cell-cell signaling and iron in virulence

Homeostatic interplay between bacterial cell-cell signaling and iron in virulence

... Schematic of the positive and negative homeostatic interplay among the MvfR regulon components PqsE, and PQS and HHQ with RhlR and ...HHQ and PQS (blue) and ... Voir le document complet

14

Effet différentiel de la costimulation par la molécule B7.2 sur les lymphocytes T CD4+ versus T CD8+

Effet différentiel de la costimulation par la molécule B7.2 sur les lymphocytes T CD4+ versus T CD8+

... Toutes ces informations nous démontrent qu'il existe une similitude entre les lymphocytes T CD8+ des différentes lignées de souris B7.2Tg déficientes au niveau du CM[r] ... Voir le document complet

128

Control of larval hematopoiesis in Drosophila; microenvironment, precursors and cell lineage

Control of larval hematopoiesis in Drosophila; microenvironment, precursors and cell lineage

... Lamellocytes The lamellocytes of Drosophila are flat, large, adhesive cells only produced in the larval hematopoietic organ – the lymph ...observed in healthy larvae but ... Voir le document complet

166

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

... School of Pathology, University of Oxford, Oxford OX1 3RE, UK * Correspondence: ...Abstract: The scanning of surrounding tissues by T lymphocytes to detect cognate antigens requires high ... Voir le document complet

17

Cell interactions and cell signaling during hematopoietic development

Cell interactions and cell signaling during hematopoietic development

... In the embryo proper, production of IAHC is restricted to the ventral part of the fused dorsal aorta, whose origin is splanchnopleural ...[34]. The avian embryo model has ... Voir le document complet

12

Targeting CD8 T-Cell Metabolism in Transplantation

Targeting CD8 T-Cell Metabolism in Transplantation

... through the β-oxidation of fatty acids and espe- cially quiescent memory subsets (Figure ...to the development of memory T cells, and when FAO is impeded, the memory ... Voir le document complet

9

Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification.

Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification.

... Microradiography The technique of digitized microradiography was used to measure the degree of mineralization of bone (DMB) and its heterogeneity index ...maximum of 8 W, ... Voir le document complet

39

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

... mRNAs and proteins were highly expressed in NPCs (VZ), with Rbfox1/2/3 specifically expressed in neurons (CP, Figures 6B and S6C), consistent with the positional enrichment around ... Voir le document complet

32

Importance of AJ and cell polarity in the regulation of Fas signaling

Importance of AJ and cell polarity in the regulation of Fas signaling

... &90;alpha 33 50,5 84,659 323,31 1304300000 252 0,0 1 ;0,2 RPL7 P18124 P18124 60S&ribosomal&protein&L7 6 29,4 29,225 36,437 161560000 69 0,1 1 ;0,2 RPL37A P61513;A6NKH3 P61513 ... Voir le document complet

226

Role of receptor and non-receptor protein tyrosine kinases in vasoactive peptide-induced signaling

Role of receptor and non-receptor protein tyrosine kinases in vasoactive peptide-induced signaling

... EDTA and plated in 60mm dished. Cells were grown to 90% confluence and incubated in serum-free DMEM 18h prior to the ...aorta of eight week old Sprague Dawley rats were isolated ... Voir le document complet

218

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

... fluctuations in intracellular phosphorylation events after the perturbation of signaling ...studies of large-scale phosphorylation dynamics, and studies have successfully applied ... Voir le document complet

31

Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset

Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset

... factor in the development of chronic diseases, especially car‐ diovascular ...with the accumulation of senescent ...part of the microenvironment, modulate cardiac ... Voir le document complet

16

Prognostic role of CD4 T-cell depletion after frontline fludarabine, cyclophosphamide and rituximab in chronic lymphocytic leukaemia

Prognostic role of CD4 T-cell depletion after frontline fludarabine, cyclophosphamide and rituximab in chronic lymphocytic leukaemia

... MRD and normal immune cell levels at the end of treatment, in 162 first-line FCR patients, and analysed survival and adverse ...0.043), the level of MRD ... Voir le document complet

12

Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire

Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire

... differences in the J segment usage between V6 chains found in HEL 12–27 -responsive CD4 T cells from WT or Tssp  / ...Analysis of all the V6 CDR3 sequences points to several ... Voir le document complet

10

The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate

The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate

... functions of the testis include production of gametes and male ...by the Leydig cells influences male fertility through its involve- ment in testis development, attainment ... Voir le document complet

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