[PDF] Top 20 Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients.
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Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients.
... terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...ABSTRACT: Patients with ... Voir le document complet
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Aberrant Chloride Intracellular Channel 4 Expression Is Associated With Adverse Outcome in Cytogenetically Normal Acute Myeloid Leukemia
... CLIC4, expression, prognostic biomarker, CN-AML, adverse outcome INTRODUCTION Acute myeloid leukemia (AML) is a genetically and clinically heterogeneous hematopoietic ...outcome of AML ... Voir le document complet
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Routine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples.
... kind of samples - either with a low leu- kemic blast load, poor quality control criteria or both - and the ability to identify favorable-risk karyotype AMLs in such situations, using ... Voir le document complet
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Identification of a 20-gene expression-based risk score as a predictor of clinical outcome in chronic lymphocytic leukemia patients.
... GE-based risk score and NRIP1 and TCF7 expression, kept prognostic ...NRIP1 gene, known as RIP140, is a nuclear receptor coregulator with important role in energy homeostasis and ... Voir le document complet
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The stem cell mobilizing capacity of patients with acute myeloid leukemia in complete remission correlates with relapse risk: results of the EORTC-GIMEMA AML-10 trial
... centage of performed autologous transplantation ...pancytopenia of the patients in whom the mob- ilization failed completely may be explained by the possibility that this group consists ... Voir le document complet
8
Outcome and impact of post-remission strategy after MIDAM regimen in patients with relapsing or refractory acute myeloid leukemia
... nature of pPCL, our patient was frequently followed-up. The first signs of relapse occurred in Feb- ruary 2018; 6 months after high dose ...elevation of FLC lambda was accompanied by the ... Voir le document complet
4
Analysis of the proteasome-autophagy crosstalk under proteotoxic stress conditions in acute myeloid leukemia
... detection of selective autophagy events Cell culture conditions are crucial to detect molecular events regulated by autophagy since this process is inhibited when cells are grown under rich nutrient conditions and ... Voir le document complet
222
Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy
... elevated in several types of tumors, and that USP7 overexpression is often predictive of a poor prognosis [ 9 , 32 , 35 , 36 ...inhibitors of this enzyme have recently been developed [ 9 , 13 ... Voir le document complet
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Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia
... Lists of DE mRNA (FC > ...loaded in the Genome Analyzer bioinformatics tool (Genom‑ atix) for further functional analyses (GO term, TFs, and small molecules) based on the Genomatix literature ... Voir le document complet
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Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells
... effect of DCA and 17-AAG on R248Q stability DCA causes metabolic stress by inhibiting PDK1 in AML cells 33, 34 ...including in the NB4 cell line, which carries p53 R248Q 29 ...activity of wt ... Voir le document complet
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CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia
... inhibition in MV4-11 and MOLM-14, two AML cell lines carrying FLT3-ITD ...inhibitors of FLT3 (FLT3 inhibitor III and the potent new generation inhibitor AC220, quizartinib) induced CDC25A down-regulation ... Voir le document complet
19
View of Specific pulmonary involvement in acute myeloid leukemia: from diagnosis to treatment
... 20 patients atteints de LAM5 et admis en réanimation pour une IRA secondaire à une leucostase pulmonaire ou une infiltration pulmonaire leu- cémique au moment du diagnostic de leucémie, dix patients sont ... Voir le document complet
8
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
... SEM of at least five independent experiments. Each point is the mean of three technical ...time of HL60 (different clones) and MOLM14 IDH1 WT and R132H treated or not with doxycycline ...SEM ... Voir le document complet
35
Intravenous busulfan for autologous stem cell transplantation in adult patients with acute myeloid leukemia: a survey of 952 patients on behalf of the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
... role of ASCT, two in good and intermediate risk AML within the Spanish CET- LAM group with a specific interest in evaluation of minimal residual disease and in vivo purging by ... Voir le document complet
8
H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations
... flex of H3K27me3 level in the RUNX1-RUNX1T1/RUNX1 mut cell lines does not result in any phenotypically alteration, we will explore the possibility that the phenotype that we observed it is due to the ... Voir le document complet
89
Transplant Outcomes for Secondary Acute Myeloid Leukemia: Acute Leukemia Working Party of the European Society for Blood and Bone Marrow Transplantation Study.
... shown in Table 3 . The 2-year cumulative incidence of NRM was ...causes of NRM were infection and GVHD, which occurred in 615 ...(15.5%) of patients, ...causes of death ... Voir le document complet
9
ABO incompatibility in mismatched unrelated donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia: A report from the acute leukemia working party of the EBMT.
... total of 1,013 AML patients who underwent HLA mismatched allo- geneic stem cell transplantation between 2005 and 2014 was identi- fied and ...most of the patients were transplanted with ... Voir le document complet
8
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
... 10% of GFP- positive ...half of the volume of each quadruplicate was pelleted and frozen down to constitute the day 0 time point, and cells were maintained in culture and split every two days ... Voir le document complet
34
Late cardiomyopathy in childhood acute myeloid leukemia survivors: a study from the LEA program
... Impairment in several domains of QoL has been described in childhood cancer survivors, but to the best of our knowledge, our study is the first to focus on the impact of late cardiac ... Voir le document complet
5
Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3‐ITD‐driven acute myeloid leukemia
... inhibition in FLT3-ITD mutant driven MOLM-14 leukemic cells To mechanistically understand the regulation of the crosstalk between UPS and ALS in leukaemia, we investigated the role of ... Voir le document complet
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