[PDF] Top 20 Cisplatin in yeast--repair of DNA adducts and binding of HMG domain proteins
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Cisplatin in yeast--repair of DNA adducts and binding of HMG domain proteins
... Cisplatin cytotoxicity assays performed on the excision repair deficient strains rad4 IXR1, rad14 IXR1, rad4 ixrl, and radl4.. ixrl ...[r] ... Voir le document complet
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Consequences of Cisplatin Binding on Nucleosome Structure and Dynamics
... DNA adducts of cisplatin have been thoroughly characterized by a variety of biochemical and biophysical methods, including X-ray crystallography and NMR spectroscopy, as ... Voir le document complet
11
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer
... arrest and apoptosis profiles in response to cisplatin compared to controls (Supp ...that cisplatin response in vivo is not dependent on the p53-p21 ...kinetics of ... Voir le document complet
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C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair.
... effect of threading, one can imagine that translocation of Ku inside a broken chromosome could affect the genome integrity by displacing useful DNA repair proteins or by creating road- ... Voir le document complet
23
Binding Interaction of HMGB4 with Cisplatin-Modified DNA
... roles in the mechanism of the action of cisplatin ...platinated DNA (7). SSRP1 contains a highly charged DNA-binding motif termed the high mobility group box, presents ... Voir le document complet
24
Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites
... B-cells and dendritic cells. T-bet is a member of the Tbox family of transcription factors; however, T-bet coordinately regu- lates the expression of many more genes than other Tbox pro- ... Voir le document complet
11
Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA
... housed in individual cages and were kept under the same conditions as mice fed OTA by ...period of one week, 5 mice per group were given feed containing increasing amount of OTA ...presence ... Voir le document complet
18
Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
... crosslinking and immunoprecipitation (eCLIP) peaks and with similar expression levels as UPF1 targets (within +/−30% of ...Fraction of ASB SNVs located in expression quantitative trait ... Voir le document complet
16
Analysis of NusA's roles in DNA repair and damage tolerance pathways in Escherichia coli
... Further studies on NusA showed that both AnusA and nusA 1] (G 181 D, temperature sensitive) were highly sensitive to NFZ at the permissive temperature, more so than AdinB, s[r] ... Voir le document complet
29
Method for identification of heme-binding proteins and quantification of their interactions
... consists of smaller peptides, obtained by hydrolysis of 300 kDa protein collagen, hence reducing the possibility for non-specific ...groups of heme require chemical activation in order to be ... Voir le document complet
12
DNA replication in budding yeast : link between chromatin conformation and kinetics of replication
... (Woolford and Baserga 2013) but its kinetics during the cell cycle is less ...production of ribosomes is increasing with the size of the cell and therefore the quantity of ribosomes ... Voir le document complet
285
Crystal structure of the anticancer drug cisplatin bound to duplex DNA
... The crystal structure described in this thesis is the first X-ray determination of a segment of duplex DNA containing the major adduct of the anticancer drug cisp[r] ... Voir le document complet
159
Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site
... difference and the rate of exchange between the free and bound ...shift of the free and bound ...form and one for the bound. In the intermediate case (the exchange rate is ... Voir le document complet
9
New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity
... radioresistance, DNA damage repair, EGFRvIII Received: June 16, 2016 Accepted: August 05, 2016 Published: August 22, 2016 ABSTRACT Glioblastoma (GBM) represents the most aggressive and common solid ... Voir le document complet
15
Design, Synthesis, and Evaluation of Enhanced DNA Binding New Lipopolythioureas
... shown in Figure 4. In the absence of Chol-PEG-RGD, we only observed extracellular binding of lipoplexes to the cell ...However, in its presence, we clearly saw intracellular ... Voir le document complet
10
Balancing repair and tolerance of DNA damage caused by alkylating agents
... inhibition of BER initiation (as observed in Aag -/- mice) protects against alkylation-mediated cell death in numerous tissues, it is important to note that BER inhibition does not confer protection ... Voir le document complet
33
Impact of nanoparticles on DNA repair processes: current knowledge and working hypotheses
... global DNA repair activities, some studies reported impact of NPs on the activity of isolated DNA repair proteins, especially ...impact of Ag- NPs on this enzyme ... Voir le document complet
39
Role of Conformational Heterogeneity in Domain Swapping and Adapter Function of the Cks Proteins
... residues of the -sheet in free Cks1 on a microsecond to millisecond timescale, indicating the presence of more than one conformation, and this dynamic property is modified upon binding ... Voir le document complet
42
SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coli.
... DedD and DamX both have a small but significant stimulatory effect on the GTase and TPase activities of ...overproduction of DamX leads to cell filamentation and death ...deletion ... Voir le document complet
16
Discordance between immunochemistry of mismatch repair proteins and molecular testing of microsatellite instability in colorectal cancer
... strengths of our study are its multicentric nature and, to our knowledge, the largest series with both MMR IHC and MSI testing up until ...impact of MMR IHC test with two or four MMR ... Voir le document complet
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