[PDF] Top 20 Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies.
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Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies.
... Germany Bispecific antibodies (BsAbs) are designed to recognize and bind to two different antigens or ...epitopes. In the last few decades, BsAbs have been developed within the context of cancer ... Voir le document complet
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Efficiency of T Cell Triggering by Anti-Cd3 Monoclonal Antibodies (Mab) with Potential Usefulness in Bispecific Mab Generation
... T cell triggering by anti-CD3 monoclonal antibodies (mAb) with potential usefulness in bispecific mAb generation Received: 2 January 1997 / Accepted: 6 February 1997 Abstract m T cell ... Voir le document complet
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Single-domain antibody-based and linker-free bispecific antibodies targeting FcγRIII induce potent antitumor activity without recruiting regulatory T cells.
... of antibodies targeting activating receptors is the activation of effector cells in the absence of target cells, potentially leading to a systemic inflammatory response (cytokine ...cultured in the ... Voir le document complet
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Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice
... anti-CD43 antibodies ( Figures 2 F and ...junctions in five of six mice tested. Splenic B cells from three DKO mice showed monoclonal Ig ...monomorphic B cell expansions/infiltra- tions ... Voir le document complet
15
Asymmetric Fc engineering for bispecific antibodies with reduced effector function
... delivered in dry shipper and stored at −20 ◦ C before ...target cell number was adjusted to 4× cell stock (10,000 cells in 50 µL assay ...target cell stock were seeded to 96-well assay ... Voir le document complet
17
Monitoring NK cell activity in patients with hematological malignancies
... anti-CD20 antibodies prior to use would hence be helpful to identify those patients that have the high- est chances to respond to therapy (an example of personalized ...ADCC in patients receiving ... Voir le document complet
7
Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers
... counts). In clinical settings, reduced myelosuppression may translate into lower rates of infection, fewer bleeding complications and improved ...secondary malignancies, including myelodysplastic syndrome, ... Voir le document complet
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Bispecific antibodies for cancer therapy: the light at the end of the tunnel?
... indications. In a phase I study for the treatment of non-small cell lung cancer patients, it was established that the maximum tolerated dose for multiple catumaxomab ...considered in the future and ... Voir le document complet
11
The Immune Microenvironment in Clear Cell Renal Cell Carcinoma : The heterogeneous immune contextures accompanying CD8+ T cell infiltration in clear cell Renal Cell Carcinoma
... axis in RCC PD-1 PD-1 is an inhibitory receptor of the CD28/B7 superfamily, upregulated on lymphocytes upon TCR or BCR engagement or γ-chain cytokine-mediated activation (353) (354) ...elevated in ... Voir le document complet
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The therapeutic effectiveness of 177Lu-lilotomab in B-cell non- Hodgkin lymphoma involves modulation of G2/M cell cycle arrest
... for cell cycle progression ...assessed in clinical trials [ 43 , 44 ...inhibitors in BL [ 45 ], and the combination of CHK1 and WEE-1 inhibitors is synergistic in mantle cell lymphoma [ ... Voir le document complet
15
HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation
... by cell sorting based on the expression of CXCR5 and PD-1 ...PCR in a microfluidic dynamic ...interest in 100 ...implicated in T cell functions ( S1 Table ... Voir le document complet
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Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation.
... metabolized in the liver to 25-hydroxyvitamin D (25(OH)D), which is used to determine a patient’s vitamin D status; 25(OH)D is metabolized in the kidneys by the enzyme 25-hydroxyvi- tamin D-1a-hydroxylase ... Voir le document complet
11
Identification and Characterization of TspA, a Major CD4+ T-Cell- and B-Cell-StimulatingNeisseria-Specific Antigen
... rescued in vivo into pBlue- script SKII plasmids (within XB) and designated pSKC1, pSKC13, pSKC14, and ...grown in the presence of isopropyl-b- D-thiogalac- toside (IPTG) and analyzed by Western ... Voir le document complet
9
Gene expression-based risk score in diffuse large B-cell lymphoma.
... apoptosis in tumor cells of patients within high risk GERS group (supplementary Figure S1 and supplementary Tables S1, S2 and ...S3). In particular, enrichment for genes encoding for nucleotide excision DNA ... Voir le document complet
12
CD4-positive T-helper cell responses to the PASD1 protein in patients with diffuse large B-cell lymphoma
... limitations in using short peptide sequences from tumor-associated antigens to elicit long-lasting CTL responses to the target ...peptides in a vac- cine should increase the efficacy of the resulting immune ... Voir le document complet
9
GZMB+ B cells, a key factor of cell immunity in human?
... specific B cell population with suppressive regulatory functions in the blood of transplanted patients with long- term graft ...These B cells inhibit an effector T cell response through ... Voir le document complet
2
BOB.1 controls memory B-cell fate in the germinal center reaction
... B cells to enter Bmem pool. Activated B cell factor-1, ABF1, was reported to be induced by T follicular helper cell-mediated signals and facilitate Bmem in vitro and in vivo by ... Voir le document complet
15
Mass cytometry defines distinct immune profile in germinal center B-cell lymphomas
... conjugation, cell labeling, and mass cytometry analysis steps were performed as previously published [ 22 ...puriied antibodies were purchased from Biolegend (San Diego, CA, USA) or Immunotech (Marseille, ... Voir le document complet
15
Origin of public mMemory B cell clones in fish after antiviral vaccination
... exist in the clonotypes that emerge from the recombination process, before any ...an in- frame premature stop codon) junctions of our dataset (see Supporting methods), which were not subjected to selection ... Voir le document complet
16
Bistability of a coupled Aurora B kinase-phosphatase system in cell division
... Aurora B kinase activity in ...Aurora B localization at the centromere and along chromosome arms to define the spatial distribution of Aurora B binding sites on chromatin ( Figure 6—figure ... Voir le document complet
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