RAR: Retinoic-acid Receptor
Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes
... Endogenous Retinoic Acid Re- ceptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regu- lating Retinoid-responsive Elements in Adult Human Keratinocytes.[r] ...
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Function of retinoic acid receptors during embryonic development.
... nuclear receptor; PHPV: persistent and hyperplastic vitreous body; POM: periocular mesenchyme; R1 to R7: rhombomeres 1 to 7; RA: retinoic acid; RALDH: retinaldehyde dehydrogenase; RAR: ...
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Retinoic acid improves nephrotoxic serum–induced glomerulonephritis through activation of podocyte retinoic acid receptor α
... the retinoic acid receptors (RAR) and the retinoid X receptors (RXR), which have distinct cellular functions and are expressed in a variety of tissues including the kidney 12 ...trans-retinoic ...
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en fr Nuclear retinoic acid receptor alpha (RARα) : novel unconventional non-genomic effects and novel partners Le récepteur nucléaire de l'acide rétinoïque alpha (RARa) : nouveaux effets non-génomiques et nouveaux partenaires
... 4. NEW UNCONVENTIONAL ROLE OF RARα IN CELL ADHESION (UNPUBLISHED RESULTS) - RARα KNOCKOUT CELLS ARE DEFICIENT IN ADHESION Then the challenge was to investigate the role of RARα (with profilin IIA) in the RA response. As ...
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An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist
... to receptor regulation has been greatly ad- vanced by structural studies of RAR LBDs in complex with different pharmacological classes of retinoids as well as CoA- and CoR-derived fragments [ 7 – 12 ...that ...
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Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner.
... proliferator-activated receptor, the insect edysteroid receptor, and a number of orphan receptors whose ligands are unknown (Chambon, 1996; Jetten et ...the receptor (Kumar & Thompson, 1999; ...
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Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis.
... ABSTRACT Retinoic acid (RA) is known to be required at various levels of eye patterning via Retinoic Acid Receptors (RAR); however the molecular and cellular mechanisms triggered by ...
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Retinoic acid signaling and the evolution of chordates
... RA receptor (RAR), in non-chordate deuterostomes (such as hemichordates and echinoderms), protostomes (such as insects and mollusks) and maybe even ...
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Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling
... 3-fold faster in females than in males, highlighting the role of sex hormones in this process 30 . Here we have performed a large-scale study integrating transcriptome, histological and immunohistological analyses with ...
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Collecting duct cells show differential retinoic acid responses to acute versus chronic kidney injury stimuli
... exogenous RAR agonists, if applica- ble, nor does it repress any RA-independent transcription activity of RAR mediated by the AF-2 domain of the nuclear receptor 84 ; (ii) AGN193109 is not only a ...
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All-trans retinoic acid induces oxidative phosphorylation and mitochondria biogenesis in adipocytes
... chondria fusion and fi ssion. In fact, ⵑ 60% of the genes in the OXPHOS pathway were upregulated at the mRNA level in the ATRA-treated adipocytes. Genes encoding mitochon- drial proteins capable of uncoupling OXPHOS to ...
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Mechanisms of retinoic acid signaling during cardiogenesis
... for RAR and RXR nuclear receptors, switching them from potential repressors to transcriptional ...absent, RAR/RXR heterodimers bind RAREs where they recruit repressive complexes that inhibit ...the ...
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en fr Functional and evolutionary study of retinoic acid signaling and of receptor phosphoylation in zebrafish Etude fonctionnelle et évolutive de la voie de l'acide rétinoique et de la phosphorylation des récepteurs chez le poisson zèbre
... de RAR qui est requis lors de cette différentiation, et plus particulièrement l’isoforme 2 de RARγ ...les RAR (KO) ne peuvent plus se différencier en neurones, la différenciation est restaurée lorsqu’on ...
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Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review
... 3.1. Retinoic Acid Receptor α (RARα) It has been demonstrated that ATRA is a RARα ligand, and that a specific antagonist of RARα can counteract ATRA’s effect [ 50 , 51 ] (Table 1 ...the RAR ...
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Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue
... and retinoic acid response element signaling was selectively observed in WAT of mice fed a normal–vitamin A, high-fat ...synthetic retinoic acid receptor (RAR)a- and ...
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The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation
... Although RAR itself is absent in cnidarians, the existence of RXR orthologs activated by 9cRA indicates the existence of nuclear recep- tors capable of mediating retinoid actions (38), possibly as homodimers or ...
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Retinoic acid signaling pathways
... nuclear receptor coactivators (NCOA) or nuclear receptor corepressors (NCOR), thus directly activating or repressing transcription (Cunningham and Duester, ...2015). RAR chromatin immunoprecipitation ...
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PLZF is a negative regulator of retinoic acid receptor transcriptional activity.
... Plasmids The yeast expression plasmid pLex12-RARK244A-K262A was generated by insertion of the RARK244A-K262A cDNA [26] between the Bgl2 andXba1 sites of pLex10, a LexA DBD fusion vector. pSG5-PLZF was a gift from J.D. ...
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Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering
... oestrogen receptor ERβ in the prostate, where this alternative ERβ ligand has been shown to regulate cell proliferation and hence organ growth [ 60 ...D receptor VDR, in the intestine this receptor ...
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Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression
... FIGURE S1. Figure S1, related to Figure 1 : SAXS analysis of RXR/RAR heterodimer. (A) Average disorder prediction (solid grey line) and its standard deviation computed using different computational tools along ...
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