MAPK signaling
The adaptor protein Ste50 directly modulates yeast MAPK signaling specificity through differential connections of its RA domain
... for signaling pathways are usually transient (Gibson, 2009), and the interfaces are typically smaller than permanent inter- faces (Perkins et ...differential MAPK signaling, indicating the ...
15
A genome-scale CRISPR knock-out screen in chronic myeloid leukemia identifies novel drug resistance mechanisms along with intrinsic apoptosis and MAPK signaling
... Understanding resistance mechanisms in cancer is of utmost importance for the dis- covery of novel “druggable” targets. Efficient genetic screening, now even more pos- sible with CRISPR-Cas9 gene-editing technology, ...
14
DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers
... by MAPK signaling (the nuclear DUSP1, DUSP2 and DUSP4; the cytosolic DUSP7 and DUSP9) [ 8 ] and are, thus, good can- didate genes to study in order to understand the compensatory increase in this ...the ...
25
Tgfbeta-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves.
... of signaling pathways in a temporal and spatial manner [1] ...Tgfβ2-Smad signaling positively regulates Scx and CSPG expression ( ...that MAPK signaling converges onto this pathway to have a ...
10
Aberrant Ras/MAPK signaling in skeletal development
... increased signaling down the Ras/MAPK pathway (Keilhack et ...pathway signaling (Roberts et ...increased signaling down the Ras/MAPK pathway either by reducing the intrinsic GAP ...
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The adaptor protein Ste50 directly modulates yeast MAPK signaling specificity through differential connections of its RA domain
... FIGURE S2: Location of the functional interfaces of Ste50-RA domain mapped in this study relative to the canonical interaction mode of RA domains with small GTPases. The image was generated by an overlay of the Ste50-RA ...
10
A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans
... inflammatory signaling through Toll Like Receptor 3 contributes to increased pathology in West Nile Virus infection in the elderly ...immune signaling activity during aging have also been observed in ...
10
Régulation du métabolisme des ARNm par les voies de signalisation MAPK et mTOR
... and MAPK signaling pathways, which are strongly implicated in cancer etiology, control mRNA translation by modulating eIF4E activity through the inhibition of the 4E-BPs and the regulation of eIF4E ...
254
Feedback regulation of Gab2-dependent signaling by the Ras/MAPK pathway
... downstream signaling cascades, such as the Ras/MAPK or Rac/JNK pathways (Nishida et ...of MAPK signaling in HEK293 cells (Chapter 2, Figure ...Kit signaling in mast ...
210
Integrative Modelling of the Influence of MAPK Network on Cancer Cell Fate Decision
... Based on specific biological questions, our dynamical logical modelling involved the abstraction of relevant information from the map and the drawing of a qualitative influence network (regulatory graph). Next, we ...
16
Analysis of MAPK and MAPKK gene families in wheat and related Triticeae species
... All Triticeae MPK17s have a single EF-hand CBP motif in their C-terminal extensions (except for TuMPK17, which appears to have a truncated C-ter- minal end) (Fig. 1 ; Additional file 7 ), a signature which is not only ...
27
Signaling in the immune response.
... elegans have been established, results from several laboratories strongly support such an idea ( Lu et al., 2005 ; Wilkins et al., 2005 ; Schott et al., 2005 ). Another area ripe for study is the cell biology of the ...
13
Microenvironment signaling driving lymphomagenesis
... BCR/NF-κB signaling pathways have been recently described in about 30% of FL patients but their biological and clinical significance remain to be elucidated ...
25
Characterization of a MAPK module involved in Arabidopsis response to wounding
... Characterization of a MAPK module involved in Arabidopsis response to wounding 57 higher in map3k14-1 plants. Studying more carefully the localization of the T-DNA insertion in the MAP3K14 locus, we realized that ...
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Retinoic acid signaling in chordates : the evolutionary history of a morphogen-dependent signaling
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Signaling in the Phytomicrobiome
... The best understood example of signaling between a plant and elements of the phytomicrobiome occurs between leguminous plants and associated nitrogen-fixing rhizobia ( Lira et al.; Nelson and Sadowsky; Smith et ...
3
Retinoic acid signaling pathways
... caudal Fgf8 in mouse. Future studies are needed to determine how some RAREs act as enhancers, whereas others act as silencers. Although many advances have been made in understanding RA signaling, a ...
8
Security Design: Signaling Versus Speculative Markets
... The essential public policy problem highlighted by the model is that securitizers fail to internalize the negative externality they impose on uninformed investors when they sell informationally-sensitive securities in ...
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On coding for Faster-Than-Nyquist signaling
... LDPC CODED FTN SIGNALING The discrete equivalent baseband channel model is given by (4) when considering a classical Forney-type receiver (ie. matched filtering followed by a whitening filter). The resulting ...
6
Macrophage signaling in HIV-1 infection.
... macrophage signaling has been recently ...with signaling pathways in infected ...the signaling pathways such as NF-kappaB, MAP kinase (MAPK) and JAK/STAT, HIV-1 proteins promote viral ...
14