internal ribosome entry site (IRES)
A single internal ribosome entry site containing a G quartet RNA structure drives fibroblast growth factor 2 gene expression at four alternative translation initiation codons.
... Abstract SUMMARY The 484 nucleotides (nts)-long alternatively translated region (ATR) of the human fibroblast growth factor 2 (FGF-2) mRNA contains four CUG and one AUG translation initiation codons. While the 5 end ...
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Targeted inhibition of the hepatitis C internal ribosomal entry site genomic RNA with oligonucleotide conjugates.
... an Internal Ribosome Entry Site [IRES, ...with internal bulges, domain III contains five stem–loops, denoted ‘a to e’ with a four-way junction, abutting to a ...
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Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site.
... We previously demonstrated the in vivo behavior of FGF-2 IRES activity under physiological conditions, which have been tested in transgenic mice which express a bicistronic mRNA encodi[r] ...
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Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA.
... translation start sites. This is particularly striking for hnRNP A1 that is already described for its properties to control the selection of alternative splice sites (30). We have also shown that hnRNP A1 is able to ...
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Bmi1 Promotes Erythroid Development Through Regulating Ribosome Biogenesis
... including ribosome biogenesis, mitochondria function, DNA damage repair, apoptosis and hemoglobin ...the ribosome biogenesis pathway was the most altered pathway in Bmi1 null pro-E ...impaired ...
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Modelling Spatio-temporal Dynamic of Ribosome During Translation
... Carole Chevalier 1 , Jean-Charles Walter 1 , John Palmeri 1 , Frédéric Geniet 1 , Jérôme Dorignac 1 , Nils-Ole Walliser 1 , Eric Rivals 2 , Damien Paulet 2 , Alexandre David 3 1 Laboratoire Charles Coulomb (L2C) 2 ...
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Entry Preventing Locations Under Incomplete Information
... accommodate entry because she is not believed to be su±ciently strong to blockade entry even if she is indeed strong enough when properly ...demonstrates entry blockading strength, in which case the ...
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Alternative Ways to Think About Cellular Internal Ribosome Entry
... method, ribosome footprint profiling, permits quantitative measurement in vivo of translational efficiency genome-wide, and is capable of confidently distinguishing small changes in translation over a large ...
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Cholesterol uptake and hepatitis C virus entry.
... HCV entry is the first step of virus- hepatocyte interaction and is not only required to initiate infection, but is also necessary for spread and maintenance of ...Host entry factors are attractive ...
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Etude des erreurs programmées du ribosome par microscopie de fluorescence en molécule unique
... The dynamics of translation are difficult to study using tra- ditional biochemical and biophysical tools, because it is a highly stochastic process, involving multiple steps and fac- tors. Single-molecule techniques ...
212
Is ribosome synthesis controlled by pol I transcription?
... In conclusion, the recent characterization of the CARA strain strongly supports the emerging concept that Pol I activity is a key element for the coordinated synthesis of ribosome components. To dissect the ...
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Étude du mécanisme du changement programmé -1 du cadre de lecture par le ribosome
... aa-tRNA: aminoacyl-tRNA; deac-tRNA: deacylated-tRNA; EIAV: equine infectous anemia virus; EF-G: elongation factor G; EF-Tu: e1ongation factor Tu; Flue: firefly lucifer[r] ...
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Structural aspects of the ribosome evolution and function
... du ribosome bactérien a été ...du ribosome à des éléments particuliers de sa structure ...du ribosome soient vraiment utiles à la compréhension du fonctionnement du ribosome, ces données ...
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An analysis of translation heterogeneity in ribosome profiling data
... the ribosome exit tunnel. High RNA folding strength that can hamper ribosome translocation was tested by evaluating positive PARS scores (Kertesz et ...
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Comparison of AIM, Entry Standard and AlterNext
... Main Market is known for its high entry barrier, whereas AIM is acknowledged for its private regulation mechanism. As the most successful second-tier market, AIM has lived through three economic downturns and has ...
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Analytical and theoretical extensions of double entry
... DEWEY LIBRARY.. Recent analysis has revealed that double entry can be represented analytically as two separate partitionings of the same finite point set. One natural con- sequence of th[r] ...
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Advertising and entry deterrence : an exploratory model
... that in the presence of economies of scale, an established monopoly facing the threat of entry might find it possible and optimal to deter that entry credibly by Investing more in durabl[r] ...
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Endogenous Entry, Product Variety and Business Cycles
... producer entry, it is certainly unrealistic: Part of observed investment is accounted for by the need to augment the capital stock used in production of existing ...
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Dynamics of Dowstream Entry in Postal Markets
... of entry in the postal sector We will consider a situation similar to Hori and Mizuno (2006) where the mail demand faced by the entrant is growing over ...no entry, access and ...
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Ribosome biogenesis: an emerging druggable pathway for cancer therapeutics
... Nucleus Nucleolus Cyt oplasm Export Transcription Processing Assembly 40S 60S Translation 18S 5.8S 28S rDNA rRNA CX-5461 CX-3543 BMH-21 Inhibition of transcription U3/U8 silencing FBL si[r] ...
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