Human triple-negative breast cancer cells
CXCR4 inhibitors could benefit to HER2 but not to triple-negative breast cancer patients
... of cancer cell ...corresponding human BC in terms of stromal properties and CXCR4/CXCL12 ...quantifying human ALU sequences and detecting both macro- and micro-metastases (Figures 2c ...tumor ...
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A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer
... in Breast Cancer of morphological and immunohistochemical characteristics as well as migration/invasion patterns and MSLN expression, reflecting the heterogeneity of ...NK cells recruitment and ...NK ...
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Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response
... seven human macrophage subpopulations, three M1 types and four M2 types ...endothelial cells from the tumour microenviron- ment, in conjunction with tumour cells, intervene at different stages of the ...
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Increased macroH2A1.1 Expression Correlates with Poor Survival of Triple-Negative Breast Cancer Patients
... HMLE cells is accompanied by an increase in ...immortalized human mammary epithelial cells with inhibiting E-cadherin function either shRNA-mediated (GSE9691 [34] and E-MTAB-884 [45]) or by ...
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miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells.
... MDA-MB-231 cells were transiently transfected with siADAM8-2 or ...Array Human MicroRNA A + B cards ...(RT) Human Pool Set ...MDA-MB-231 cells with ADAM8 knock- down to cells with the ...
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A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer
... France Triple negative breast cancers (TNBC) remain a major medical challenge due to poor prognosis and limited treatment ...in breast tumors has been recently correlated with a decreased ...
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en fr Strategies of Cancer Immunotherapy : Model of Triple Negative Breast Cancer Stratégie d'immunothérapie des cancers : modèle de cancer du sein triple négatif
... as cancer vaccines have been produced almost 100 years later using immunization of mice with fetal material ( Review Brewer BG Exp Mol Path ) or antisera developed against 9-day old mouse embryos ( Stonehill et ...
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Statistical and algorithmic developments for the analysis of Triple Negative Breast Cancers
... in cells under physiologic conditions and have also been shown to contribute to various aspects of tumorigenesis including invasion of carcinoma cells ...MDA-MB-231 cells cultured on a ...
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In Vivo Assessment of VCAM-1 Expression by SPECT/CT Imaging in Mice Models of Human Triple Negative Breast Cancer
... tumor cells (human VCAM-1), or to the inflammatory and endothelial cells (mouse VCAM-1) using RT-qPCR (Figure 4 ...tumor cells was the predominant form present in MDA-MB-231 subcutaneous ...
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Human breast cancer cells educate macrophages toward the M2 activation status
... Immunohistopathological breast carcinoma studies with restricted numbers of samples (n = 53 and 120, respectively) reveal a gradual increase in the amount of infiltrating macrophages (CD68 + ) from normal ...
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TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer
... normal breast tissues ...positive cells measured by immunohistochemistry (IHC) in human breast cancer ...of cells positively stained for TTK within fractions of samples in each ...
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New Insights into the Implication of Epigenetic Alterations in the EMT of Triple Negative Breast Cancer
... Abstract: Breast cancer is the most common cancer and leading cause of cancer death among women worldwide, encompassing a wide heterogeneity of subtypes with different clinical ...the ...
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Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies
... fully human anti-cath-D IgG1 antibody isolated from a human scFv phage display ...anti-cath-D human antibody F1 is a candidate drug that could be translated into the clinic for the treatment of ...
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Role of stable free radicals in conjugated antioxidant and cytotoxicity treatment of triple negative breast cancer
... many breast cancers, including triple negative breast cancer ...are breast cancers that do not have receptors for estrogen (ER), progesterone (PR), human epidermal growth ...
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CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
... Many human cancers depend on the deregulated expression of MYC family members for their aberrant growth and proliferation, with elevated expression of these oncogenes predicting aggressive disease and a poor ...
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Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
... basal-like breast cancers (Supplementary ...stem cells, early embryonic stem cells, or epithelial cell lines submitted to EMT-inducing factor TGFB1 and mesenchymal breast cancer cell ...
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EHD2 is a Predictive Biomarker of Chemotherapy Efficacy in Triple Negative Breast Carcinoma
... several human cancers, however the significance of EHD2 transcript levels in cancer prognosis remains ...debated. Breast cancer is the most commonly occurring cancer in women and ...
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View of Triple Negative Breast Cancer: A review of common therapeutic Targets and Current Treatment options.
... CONCLUSION TNBC is a subtype of breast cancer that is associated with poor prognosis and is resistant to the main forms of breast cancer treatment. Molecular therapeutics such as platinating ...
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Transactivation of vimentin by beta-catenin in human breast cancer cells
... epithelial cells. We have also shown that the vimentin-expressing cells displayed a higher β-catenin/TCF activity than the vimentin-negative cells using the TOP-FLASH reporter ...the ...
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Modeling Heterogeneity of Triple‐Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance
... 2.5. BCL-XL Inhibition Exacerbates WEE1 Requirement in TNBC Cells While BCL-XL primarily has an anti-apoptotic function by in- hibiting cytochrome C release, WEE1 acts on multiple regulatory circuits. Besides its ...
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