cell homeostasis
Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity
... B cell and T cell responses in the intestine of mice with different intestinal ...T cell-dependent IgA response to these organisms and their subsequent over- growth and increased contact with the ...
13
Early and long-lasting alteration of effector CD45RA(-)Foxp3(high) regulatory T-cell homeostasis during HIV infection.: Effector Treg are persistently altered during HIV infection
... Treg cell numbers was consistently detected in all HIV patients studied, in accordance with studies demonstrating HIV infection affected both Treg and conventional CD4 T ...
14
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis
... Introduction Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency disorder characterized by opportunistic, viral, and bacterial infections due to abnormal lymphocyte function. Affected individuals also have ...
12
p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis
... Fig 4. p53-dependent necrotic cell death suppresses testicular hyperplasia in Drosophila. (A-F) Bright field images of testes from adult wild-type (wt; w 1118 , A) flies and flies lacking genes required for germ ...
22
Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation.
... corticosteroids and/or immunosuppressive agents remain associated with morbidity and mortality [2]. SLE is a T and B cell-dependent disease characterized by the appearance of a variety of autoantibodies, some of ...
11
Cytokine signaling control of naïve CD8⁺ T-cell homeostasis
... Aside from knowledge of some downstream TCR signaling activity following spMHC binding (evidenced by zeta chain phosphorylation), the exact signaling pathways critica[r] ...
209
Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses
... Vα2Vβ5 + CD4 + PD-1 + CXCR5 + T FH per spleen. (H) The number of CD45.1 + Vα2Vβ5 + CD4 + PD-1 + CXCR5 + T FH per spleen. (F–H) N = 10 mice/genotype. Each point represents an individual mouse, bars represent mean; error ...
13
Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep.
... where cell production equals cell ...peripheral cell renewal depends on the life span of peripheral ...the cell but is determined by factors such as the environment, viral infections, and the ...
10
TRPM7 is essential for Mg2+ homeostasis in mammals
... development in mouse Es cells isolated from wild-type (black circles, n = 13), TRPm7 + / ∆kinase (red circles, n = 12) and TRPm7 ∆ kinase/ ∆kinase mice (blue circles, n = 13). Data were acquired and analysed as in Figure ...
9
ILC3s control splenic cDC homeostasis via lymphotoxin signaling
... NK cell deficiency also exhibited partial deficiencies in Tbet + NKp46 + ILC1s and Rorgt + CD4 − NKp46 + ILC3s ( ...the homeostasis of Sirp α + CD4 + Esam + cDC2s as all seemed to dose-dependently influence ...
21
The effect of calcium homeostasis on HSV-1 propagation
... while it is detected at the TGN and cellular surface at later times [35, 147]. Although it is defined as a non-essential glycoprotein in culture, gM was shown to interact with the viral fusion machinery as it ...
81
Stat5 Is an Ambivalent Regulator of Neutrophil Homeostasis
... All cell nuclei in the fields are shown by hexidium iodide staining (red, b and e), and merges of frames (a) and (b), and (d) and (e), are given in (c) and (f), ...
14
A Central Role for mTOR in Lipid Homeostasis
... Clinically, inhibition of hepatic mTORC2 may promote the metabolism of excess hepatic lipids, while inhibition of mTORC2 during adipocyte differentiation could promote the gain of brown adipose tissue. Both of these ...
9
Matriptase zymogen supports epithelial development, homeostasis and regeneration.
... development, homeostasis, and regeneration, as well as a central orchestrator of pathogenic pericellular signaling in the context of inflammatory and proliferative ...
18
Intestinal Adaptations after Bariatric Surgery: Consequences on Glucose Homeostasis
... Intestinal Adaptations after Bariatric Surgery: Consequences on Glucose Homeostasis.. Jean-Baptiste Cavin, André Bado, Maude Le Gall.[r] ...
24
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis
... aneuploid cell lines we measured proliferative capacity of trisomy 1, 16 and 19 MEFs over a range of DL-PDMP ...trisomic cell lines was preferentially inhibited by the drug compared to euploid control lines ...
31
MicroRNAs, Major Players in B Cells Homeostasis and Function
... B cells start to express IgD and ter- minate their differentiation into follicular (FO) or MZ B cells ( 11 , 68 ). FO B cells are currently associated with a T dependent- response whereas MZ B cells, located in the ...
10
Virtual environment model of glucose homeostasis for diabetes patients
... VII. C ONCLUSION AND F UTURE C HALLENGES There are several existing clinical models based differential equations and higher order polynomial equations that require significant computation and a large memory for ...
8
FGF10 Signaling in Heart Development, Homeostasis, Disease and Repair
... development, homeostasis and ...cardiomyocyte cell cycle reentry and directs stem cell differentiation and cell reprogramming toward the cardiogenic lineage provide new insights into ...
12
Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis
... Cell death was quantified by terminal deoxynucleotidyl transferase-mediated tetramethylrhodamine-dUTP (TMR- dUTP) nickened labeling (TUNEL kit, Roche). Frozen sections of small intestine and colon were fixed with ...
13