Acetylcholine receptor
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
... LETTERS A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 Rayjean J. Hung 1,2 *, James D. McKay 1 *, Valerie Gaborieau 1 , Paolo Boffetta 1 , Mia ...
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Preparation of Reconstituted Acetylcholine Receptor Membranes Suitable for AFM Imaging of Lipid-protein Interactions
... nicotinic acetylcholine receptor (nAChR) has been reconstituted in POPC vesicles at high lipid–protein (L/P) ratios for the preparation of supported lipid bilayers with a low protein density for studies of ...
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Activation of a-7 Nicotinic Acetylcholine Receptor Reduces Ischemic Stroke Injury through Reduction of Pro-Inflammatory Macrophages and Oxidative Stress
... Curie-Paris VI and UMR INSERM 1141, Paris, France, 4 Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America, 5 Department of Neurology, University ...
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The mechanisms shaping CA2 pyramidal neuron action potential bursting induced by muscarinic acetylcholine receptor activation
... of acetylcholine, allowing it to resist hydrolysis by acetylcholinesterase, and is a nonselective agonist for mus- carinic acetylcholine receptors and a weaker nonselective agonist for nAChRs in the ...
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Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex
... mM: 143 potassium gluconate, 3 NaCl, 1 MgCl 2 , 0.3 CaCl 2 , 1 EGTA, 0.2 cAMP, 0.3 NaGTP, 2 NaATP, 10 HEPES (pH 7.25), osmolarity 290–300 mol/L). Patch pipettes had a resistance between 3 and 5 MΩ. In all experiments ...
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Agrin elicits membrane lipid condensation at sites of acetylcholine receptor clusters in C2C12 myotubes.
... Materials and methods Antibodies and reagents Mouse monoclonal (mAb) anti-syntrophin (mAb 1351E; 27) anti-rapsyn (mAb 1234; 28) antibodies were provided by Pr. S. Froehner (University of Washington, Seattle, WA) or ...
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Development of pure prolactin receptor antagonists
... Prolactin Receptor Antagonists* Received for publication, May 30, 2003, and in revised form, June 23, 2003 Published, JBC Papers in Press, June 24, 2003, DOI ...
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Source-receptor matrix calculation with a Source-receptor matrix calculation with a backward mode
... ship. The length of each square is 1 ¹ . The parameter shown is the s–r relationship [s], calculated with the mode represented by green squares in Figure 2. ward calculations modes for the s–r relationship in general. In ...
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Hyperfunction of Muscarinic Receptor Maintains Long-Term Memory in 5-HT4 Receptor Knock-Out Mice
... 4 Receptor Knock-Out Mice Luis Segu 1{ , Marie-Jose´ Lecomte 2 , Mathieu Wolff 1 , Julie Santamaria 2 , Rene´ Hen 3 , Aline Dumuis 4 , Sylvie Berrard 2 , Joe¨l Bockaert 4 , Marie-Christine Buhot 1 , Vale´rie ...
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System modeling of receptor-induced apoptosis
... receptors. Receptor-induced apoptosis raised therapeutical interest as anti-cancer strategy for at least two ...its receptor CD95) were discovered first, TRAIL (and its receptors DRs) has the highest ...
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Modified Receptor Internalization upon Co-expression of 5-HT1B Receptor and 5-HT2B Receptors.
... 2B receptor antagonists is less clear, but suspected (Schmuck et ...modulate receptor responsiveness. Receptor desensitization and down- regulation are well described for various individual GPCR ...
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The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.: The Mineralocorticoid Receptor
... A brief history In the late 1960’s, evidence for the presence of specific receptors mediating corticosteroid action in the toad bladder was initially proposed by the group of Edelman [Porter and Edelman, 1964]. ...
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Progesterone receptor, obesity and prognosis in women diagnosed with estrogen receptor positive breast cancer
... its receptor can result in the repression of progesterone receptor (PR) gene transcription in ER+ cells through the phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway ...
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Aryl hydrocarbon receptor and liver fibrosis
... 1. Introduction Liver fibrosis is defined as a response to a sustained cell injury and chronic inflammation that leads to the activation of pro-fibrotic cells and the excessive deposition of extracellular matrix. While ...
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A trilogy of glucocorticoid receptor actions
... glucocorticoid receptor actions Chek Kun Tan a and Walter Wahli a,b,c,1 Glucocorticoids (GCs) belong to a class of endoge- nous, stress-stimulated steroid hormones found in vertebrates ...GC receptor (GR), ...
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NRIP1 (nuclear receptor interacting protein 1)
... nuclear receptor mediated gene expression including gene expression mediated by the estrogen receptor, liver X receptor, PPARs, steroidogenic factor 1 (SF1) and ...
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The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies
... 6 receptor antagonists would account for the pro-cognitive effects of these ...the receptor effects upon neuronal migration (Riccio et ...characterizing receptor interacting ...6 receptor ...
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Receptor-interacting protein 140 is a repressor of the androgen receptor activity.: AR repression by RIP140
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Therapeutic potential of endothelin receptor type A and bradykinin receptor B1 dual antagonism in osteoarthritis treatment
... Methods: Osteoarthritis was surgically induced in rats by transection of the right anterior cruciate ligament. Animals were subsequently treated with weekly intra- articular injections of specific peptide antagonists of ...
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Hypoglycaemia revealing heterozygous insulin receptor mutations.
... [4] Cama A, Quon MJ, de la Luz Sierra M, Taylor SI. Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine ...
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