HAL Id: hal-01772995
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Submitted on 23 Apr 2018
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Production in Plasmacytoid Dendritic Cells
Vaclav Janovec, Besma Aouar, Albert Font-Haro, Tomas Hofman, Katerina Trejbalova, Jan Weber, Laurence Chaperot, Joël Plumas, Daniel Olive,
Patrice Dubreuil, et al.
To cite this version:
Vaclav Janovec, Besma Aouar, Albert Font-Haro, Tomas Hofman, Katerina Trejbalova, et al.. The
MEK1/2-ERK Pathway Inhibits Type I IFN Production in Plasmacytoid Dendritic Cells. Frontiers
in Immunology, Frontiers, 2018, 9, pp.364. �10.3389/fimmu.2018.00364�. �hal-01772995�
Edited by:
Moncef Zouali, INSERM U1132, Paris Diderot University, France
Reviewed by:
Junji Xing, Houston Methodist Research Institute, United States Nadine Varin-Blank, INSERM U978, France
*Correspondence:
Ruzena Stranska ruzena.stranska@kuleuven.be;
Ivan Hirsch ivan.hirsch@inserm.fr, ivan.hirsch@natur.cuni.cz
†
Present address:
Ruzena Stranska, Rega Institute, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium
‡
These authors have contributed equally to this work.
§
Jointly directed this study.
Specialty section:
This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology Received: 20 November 2017 Accepted: 09 February 2018 Published: 26 February 2018 Citation:
Janovec V, Aouar B, Font-Haro A, Hofman T, Trejbalova K, Weber J, Chaperot L, Plumas J, Olive D, Dubreuil P, Nunès JA, Stranska R and Hirsch I (2018) The MEK1/2-ERK Pathway Inhibits Type I IFN Production in Plasmacytoid Dendritic Cells.
Front. Immunol. 9:364.
doi: 10.3389/fimmu.2018.00364
Vaclav Janovec
1,2,3‡, Besma Aouar
4‡, Albert Font-Haro
1,2,3‡, Tomas Hofman
2, Katerina Trejbalova
1, Jan Weber
3, Laurence Chaperot
5, Joel Plumas
6, Daniel Olive
4, Patrice Dubreuil
4, Jacques A. Nunès
4, Ruzena Stranska
4*
†§and Ivan Hirsch
1,2,3,4*
§1
Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia,
2Department of Genetics and Microbiology, Faculty of Sciences, Biocev, Charles University, Prague, Czechia,
3Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences & IOCB Research Centre (GSRC), Prague, Czechia,
4