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Individual registration form

To send via email to mailto:frederic.bringaud@u-bordeaux.fr; lkohl@mnhn.fr;

rotureau@pasteur.fr

Before November 10

th

2017

---

This free registration includes a full access to all the conference sessions, two coffee breaks, two lunches and one cocktail.

The conference diner will be organized in a Parisian restaurant and directly paid by the attendees, however registration is mandatory.

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Last name: Peylhard First name: Moana

Position

(PI, engineer, post-doc, PhD or Student)

: PhD Affiliation: CIRAD BIOS UMR INTERTRYP

Tel: 04 67 69 39 91

Email: moana.peylhard@cirad.fr

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I will attend the Conference Diner on Tuesday 5

th(price between 30 and 40 euros, to be paid on site):

 yes  no

(2)

--- I’m willing to present my recent work as a TALK (15 min. + 5 min.):

 yes  no

I’m willing to present my recent work as a POSTER:

 yes  no

Talk / Poster title: Biological Pathways Discriminating African Trypanotolerant and Trypanosusceptible Cattle Breeds?

Authors:

Moana Peylhard

1,2

, David Berthier

1,2

, Laurence Flori

3,4

, Guiguigbaza-Kossigan Dayo

5

, Isabelle Chantal

12,

, Sophie Thévenon

1,2

Affiliations:

1 CIRAD, UMR INTERTRYP, F-34398 Montpellier, France.

2 INTERTRYP, Univ Montpellier, CIRAD, IRD, France 3 CIRAD, UMR SELMET, F-34398 Montpellier, France

4 SELMET, Univ Montpellier, CIRAD, INRA, SupAgro, Montpellier, France 5 CIRDES unité URBIO Bobo-Dioulasso

Key words

(5 maximum)

:

Animal African Trypanosomosis, trypanotolerance, RNA-seq, pathways analysis, host*parasite interactions

Abstract

(250 words maximum)

:

Animal African Trypanosomosis (AAT) is a vector-borne disease caused by blood protozoan parasites of the Trypanosoma genus. It represents a major constraint to the development of cattle breeding in the humid and sub-humid zones of Africa because of the high morbidity and mortality it causes. Zebu breeds and European taurine breeds are very susceptible to AAT and they usually die in the absence treatment. On the contrary, some taurine breeds in West Africa have the capacity to tolerate the disease and are called trypanotolerant.

The trypanotolerant phenotype is known to be polygenic and multifactorial, but up to

now, its mechanisms remain unknown. In order to decipher the molecular bases of

trypanotolerance, we chose to analyse the genes expression of blood cells of

susceptible and tolerant cattle during an experimental infection, performed in Burkina

Faso, in 40 cattle from five West African breeds with T. congolense. mRNA were

extracted from blood, comprising bovine leukocytes and parasites, before and during

the infection and were sequenced using a Illumina highSeq2000. We mapped the

reads on the bovine and trypanosome genomes, counted the reads on the annotated

(3)

genes and performed a differential expression analysis. The genes identified as

differentially expressed during the infection were then analysed using the Ingenuity

Pathway Analysis software in order to identify enriched functional patterns. The

functional analyses highlighted upstream regulators and canonical pathways

associated with the immune response, the cell proliferation and signaling. Very fine

differences in the modulation of the response between trypanotolerant and

susceptible cattle were observed

.

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