Rôle des ribosomes et de leur biogenèse dans la tumorigenèse et la réponse aux traitements chimiothérapeutiques

Texte intégral

(1)Rôle des ribosomes et de leur biogenèse dans la tumorigenèse et la réponse aux traitements chimiothérapeutiques Gabriel Therizols. To cite this version: Gabriel Therizols. Rôle des ribosomes et de leur biogenèse dans la tumorigenèse et la réponse aux traitements chimiothérapeutiques. Cancer. Université Claude Bernard - Lyon I, 2014. Français. �NNT : 2014LYO10083�. �tel-01296934�. HAL Id: tel-01296934 https://tel.archives-ouvertes.fr/tel-01296934 Submitted on 1 Apr 2016. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

(2) N° d’ordre : 83-2014. Année 2014 THÈSE DE L’UNIVERSITÉ DE LYON délivrée par. L’UNIVERSITÉ CLAUDE BERNARD LYON 1 ÉCOLE DOCTORALE de BIOLOGIE MOLÉCULAIRE, INTÉGRATIVE ET CELLULAIRE. DIPLOME DE DOCTORAT (Arrêté du 7 août 2006) Soutenue publiquement le 26 mai 2014 par M. Gabriel THERIZOLS.

(3)

(4)

(5)

(6)

(7) . Directeur de thèse : Jean-Jacques DIAZ JURY : Mme le Docteur Christiane BRANLANT, rapporteur M. le Professeur Pierre-Emmanuel GLEIZES, rapporteur M. le Professeur Charles DUMONTET M. le Docteur Théophile OHLMANN M. le Docteur Marc BILLAUD M. le Docteur Jean-Jacques DIAZ .

(8) UNIVERSITE CLAUDE BERNARD - LYON 1 Président de l’Université. M. François-Noël GILLY. Vice-président du Conseil d’Administration. M. le Professeur Hamda BEN HADID. Vice-président du Conseil des Etudes et de la Vie Universitaire. M. le Professeur Philippe LALLE. Vice-président du Conseil Scientifique. M. le Professeur Germain GILLET. Directeur Général des Services. M. Alain HELLEU. COMPOSANTES SANTE Faculté de Médecine Lyon Est – Claude Bernard Faculté de Médecine et de Maïeutique Lyon Sud – Charles érieux. Directeur : M. le Professeur J. ETIENNE Directeur : Mme la Professeure C. BURILLON Directeur : M. le Professeur D. BOURGEOIS. Faculté d’Odontologie Institut des Sciences Pharmaceutiques et Biologiques Institut des Sciences et Techniques de la Réadaptation Département de formation et Centre de Recherche en Biologie maine. Directeur : Mme la Professeure C. VINCIGUERRA Directeur : M. le Professeur Y. MATILLON Directeur : Mme. la Professeure A-M. SCHOTT. COMPOSANTES ET DEPARTEMENTS DE SCIENCES ET TECHNOLOGIE Faculté des Sciences et Technologies. Directeur : M. F. DE MARCHI. Département Biologie. Directeur : M. le Professeur F. FLEURY. Département Chimie Biochimie. Directeur : Mme Caroline FELIX. Département GEP. Directeur : M. Hassan HAMMOURI. Département Informatique. Directeur : M. le Professeur S. AKKOUCHE. Département Mathématiques. Directeur : M. Georges TOMANOV. Département Mécanique. Directeur : M. le Professeur H. BEN HADID. Département Physique. Directeur : M. Jean-Claude PLENET. UFR Sciences et Techniques des Activités Physiques et Sportives Directeur : M. Y.VANPOULLE Observatoire des Sciences de l’Univers de Lyon. Directeur : M. B. GUIDERDONI. Polytech Lyon. Directeur : M. P. FOURNIER. Ecole Supérieure de Chimie Physique Electronique. Directeur : M. G. PIGNAULT. Institut Universitaire de Technologie de Lyon 1. Directeur : M. C. VITON. Ecole Supérieure du Professorat et de l’Education. Directeur : M. A. MOUGNIOTTE. Institut de Science Financière et d'Assurances. Directeur : M. N. LEBOISNE. . . . {.

(9) % !'& &406)"*5&&913*.&3."130'0/%&3&$0//"*44"/$&"69.&.#3&4%6+63:%&$&55&5)B4&d g<.&)3*45*"/&3"/-"/5&5e-&130'&44&63*&33&g.."/6&--&*;&426*0/5 "$$&15C%kD53&3"11035&634%&."5)B4&c g<e)C01)*-&)-."//&5e"3$*--"6%26*0/5"$$&15C%kD53&&9".*/"5&634 %& ." 5)B4& &5 26* 0/5 '"*5 1"35*& %& .0/ $0.*5C %& 46*7* %& 5)B4&e & 3&.&3$*& e)"3-&46.0/5&526*"C("-&.&/5"$$&15C%&+6(&3.0/53"7"*-e /53B4(3"/%.&3$*< &"/g "$26&4*";26*.k""$$6&*--*"64&*/%&40/-"#03"50*3&b&5 (6*%C 5065 "6 -0/( %& $&4 $*/2 %&3/*B3&4 "//C&4e & 5& 3&.&3$*& 1063 -k*/&45*."#-& $0/'*"/$& &5 -" -*#&35C 26& 56 .k"4 "$$03%C&4b -&4 &/4&*(/&.&/54 26& 56 .k"4 53"/4.*4b 5"/5 463 -& 1-"/ 4$*&/5*'*26& 26& 463 -k&/4&.#-& %&4 "41&$54 %6 .C5*&3 %& $)&3$)&63e k&41B3&26k"7&$-&5&.14&5-k&91C3*&/$&b+k"33*7&3"*<"11-*26&35064-&4$0/4&*-426&56 .k"4%0//C4e &-&4("3%&3"*-0/(5&.14&/.C.0*3&e &3$*<-k&/4&.#-&%&-kC26*1&l0."*/&46$-C"*3&4&5"5)0-0(*&4m"7&$26**-"C5C &953D.&.&/5 "(3C"#-& &5 &/3*$)*44"/5 %& 53"7"*--&3e &3$* < *3(*/*&b &*/"b "3*&g -&9"/%3"b 3C%C3*$b -03*"/b *$)&. &5 &"/g)3*4501)& 1063 -&4 /0.#3&69 C$)"/(&4b %*4$644*0/4&5$0/4&*-426*.k0/5-"3(&.&/5"*%C5065"6-0/(%&."5)B4&e &3&.&3$*& C("-&.&/5"5)"-*&b:-7"*/&b"3*/&b 0)"/b"*/4*26&5065$&6926*40/51"44C4%"/4-& -"#0 &5 26* 0/5 1"35*$*1C < -k&/7*30//&.&/5 $0--"#03"5*' &5 45*.6-"/5 %& -kC26*1&e /& 1&/4C& 1063 "/%3"b 5C1)"/& &5 "#*/&b 26* .k0/5 53"/4.*4 -&4 #"4&4 5&$)/*26&4 &5 5)C03*26&4%&$&53"7"*-%&5)B4&b&526*0/5C5C%&53B4#0/4&9&.1-&4e &3$*<-" *(6&/"5*0/"-&$0/53&-&$"/$&3b<-"0/%"5*0/1063-"3&$)&3$)&.C%*$"-&b&5 &/13&.*&3-*&6<-&634%0/"5&634b26*0/5'"*5$0/'*"/$&"6130+&5&5'*/"/$C$&53"7"*-e / (3"/% .&3$* < 5064 $&69 "7&$ 26* +k"* $0--"#03C &5 26* 0/5b %& $& '"*5b "$5*7&.&/5 $0/53*#6C<$&453"7"69d g .&3$* < "53*$, &)-&/b C-*/&b "7*% &5 /%3&" 1063 .k"70*3 1&3.*4 %& 1"35*$*1&3 < 6/ 130+&5 53B4 */5C3&44"/5e & 3&.&3$*& C("-&.&/5 -k&/4&.#-& %& -kC26*1&&)-&/1063-&4/0.#3&64&4'0*40R7064.k"7&;"*%Cc g.&3$*<)C01)*-&)-."//%&.k"70*31&3.*4%&7&/*3'"*3&%&4."/*14%"/440/ -"#03"50*3&e &3&.&3$*&1"35*$6-*B3&.&/5"15*45&b+k"*C5C53B4)&63&69%&10670*3 53"7"*--&3 &5 %*4$65&3 "7&$ 50*e 13B4 0-% 13*/( "3#03 &5 &*%&-#&3(b +k&41B3& 26k0/"63"-k0$$"4*0/%&4&3&$30*4&3%"/4%k"653&4$0/(3B4h g6/(3"/%.&3$*< C3L.&6*550/b106340/"*%&463.0/130+&5&51063-&5&.14 . |.

(10) 26k*-.k"$0/4"$3C"'*/%&.k&91-*26&3-&413*/$*1&4%&-" gnc g .&3$* < "/6 04"g"-"53"7" 26* ." 1&3.*4 %& 1"35*$*1&3 < %&4 130+&54 &/ 7*30-0(*&b&5.k"%0//C%&413C$*&69$0/4&*-4463-kC56%&%&4/6$-C0-&4c g 6/& 1&/4C& 1063 03"-*& "330/b 1063 4" #0//& )6.&63 &5 1063 4&4 $0//"*44"/$&4%&-"#*0(&/B4&%&43*#040.&4c g .&3$* < "/%3*/& 0/*/g*3"6% &5 "-C3*& 03*/ %& .k"70*3 -"*44C "$$C%&3 < -k"11"3&*--"(& 1063 -&4 (3"%*&/54 %& 10-:40.& &5 %& .k"70*3 &91-*26C -& '0/$5*0//&.&/5c g 6/ (3"/% .&3$* < 5064 -&4 .&.#3&4 %&4 C26*1&4 %& *%*&3 6#0&6' &5 "5)*&6 "#65b"7&$26*/0641"35"(&0/4-kC5"(&e &4C$)"/(&4$0/45"/54&5-k&/53"*%&%"/4 -& -"#0 0/5 C5C &953D.&.&/5 45*.6-"/54e / .&3$* 1"35*$6-*&3 < -&0/03"b "/0/b 5*&//&b 644&*/b&5*.0/c g .&3$* < )3*4501)& "/#&--& &5 -*4"#&5) %6 &5 &/*4 %6 1063 -&63 "*%&%"/4-&%0."*/&%&-k*."(&3*&e &5*&/4<3&.&3$*&35065&4-&41&340//&4"7&$26*+k"*16*/5&3"(*3"6 e &4 3&-"5*0/4 26& /064 "70/4 C5"#-*&4 &/53& -&4 %0$503"/54 %6 0/5 $3CC 6/ $-*."5 53B440-*%"*3&&553B4".*$"-e k&41B3&4*/$B3&.&/526&$&43&-"5*0/470/5%63&3e&3$*< //&g "63&b )-0Cb 45&--&b -*4&b b 5*&//&b /5)0b "5)*&6b )*#"65b -C.&/5b &5 5064 -&4"653&4e &3$*<.&4".*4b$0.13C)&/4*'4&5&/$063"(&"/54b4"/426**-"63"*5C5C%*''*$*-&%&4& %C5&/%3&e&3$*<C$*-&b*&33&&5&--:b 6-*&b"5)*&6b"3*&b b&55"/5%k"653&4f5064 -&4l3&450*4mf &5*&/4<3&.&3$*&35064$&6926*b-0*/%&4:&69."*45065"644*13C4&/5%"/4.0/&413*5b .k0/5 "*%C < 3C"-*4&3 $&55& 5)B4& %"/4 -&4 .&*--&63&4 $0/%*5*0/4 "''&$5*7&4e /& 1&/4C 1063 ." 4O63 "3*& &5 .&4 '3B3&4 7"*/ &5 35)63b &5 1063 3*$e &3$* < 06$&b &"/g -"6%&b&55065&-"'".*--& &33:g ".063e /'*/b-&4%&691&340//&426&+&5*&/4-&1-64<3&.&3$*&3b1063-&634065*&/b-&4611035 &5-"45"#*-*5C26k&--&.k0/5"11035C4b-"$0/'*"/$&26k&--&4.k0/55C.0*(/C&d g<.".B3&e&3$*%&.k"70*31&3.*4%k&/"33*7&3-<e g<7&e&3$*%k"70*3C5C-<b%&.k"70*34611035Cb&/$063"(Cb3&.0/5C-&.03"-f&3$* 10635065f . . }.

(11) .&( . . &4 $&--6-&4 $"/$C3&64&4 130%6*4&/5 6/& (3"/%& 26"/5*5C %& 3*#040.&4 "'*/ %& 4:/5)C5*4&3 -&4 1305C*/&4 /C$&44"*3&4 < -&63 130-*'C3"5*0/ 3"1*%&e &4 .C$"/*4.&4 26* $0/%6*4&/5 < $&55& "6(.&/5"5*0/ %& -" 130%6$5*0/ %& 3*#040.& /& 40/5 26& 1"35*&--&.&/5 $0.13*4b ."*4 *-4 4&.#-&/5 */5*.&.&/5 -*C4 < -k"$26*4*5*0/ %6 1)C/05:1& 56.03"-e & 1-64b 6/& /067&--& 5)C03*& 130104& 26& -&4 3*#040.&4 /& 40/5 1"4 %&4 &''&$5&634/&653&4%&-"53"%6$5*0/b."*426k*-4+06&/56/3L-&%*3&$5%"/4-"3C(6-"5*0/%& -k&913&44*0/ (C/*26&e &55& 5)C03*& 4& #"4& 463 -k0#4&37"5*0/ 26& -" $0.104*5*0/ %&4 3*#040.&4 &45 )C5C30(B/& &/ '0/$5*0/ %&4 5:1&4 $&--6-"*3&4 &5 %&4 $0/%*5*0/4 &/7*30//&.&/5"-&4e "/4 $& $0/5&95&b +k"* C56%*C -&4 -*&/4 &/53& -&4 "-5C3"5*0/4 %&4 4*(/"69 26* $0/53L-&/5 -" #*0(&/B4& %&4 3*#040.&4b 5"/5 "6 /*7&"6 26"/5*5"5*' 26& 26"-*5"5*'b &5 -& %C7&-011&.&/5%61)C/05:1&56.03"-e&."/64$3*53"11035&530*4C56%&4&''&$56C&4"6 $0634 %& .0/ 53"7"*- %& 5)B4&e&4 C56%&4 0/5 1&3.*4 %k*%&/5*'*&3d *q 6/ /067&"6 3C(6-"5&63 %& -" 26"/5*5C %& 3*#040.&4b -" gC53*/&gz&5 **q %&4 .0%*'*$"5*0/4 %& -" $0.104*5*0/ &5 %& -" '0/$5*0/ %&4 3*#040.&4 */%6*5&4 1"3 %&4 "-5C3"5*0/4 (C/C5*26&4 p1&35& %k"$5*7*5C %& 1~|q &5 1"3 -k65*-*4"5*0/ %k6/& .0-C$6-& $)*.*05)C3"1&65*26&b -& ~g -603063"$*-&e&41&3563#"5*0/4%&-"26"/5*5C&5%&-"'0/$5*0/%&43*#040.&4.0%*'*&/5 -& $0/53L-& %& -" 53"%6$5*0/ %&4 $&--6-&4 &5 -" $30*44"/$&b -" 130-*'C3"5*0/ &5 -" 4637*& $&--6-"*3&e. -3&44035%&$&43C46-5"5426&-&43*#040.&440/5%&4C-C.&/5426*1"35*$*1&/5"6 $0/53L-&%&-k&913&44*0/(C/*26&&526*+06&/56/3L-&%"/4-"1"5)0-0(*&$"/$C3&64&&5-" 3C10/4&"653"*5&.&/5$)*.*05)C3"1&65*26&e 054$-C4d*#040.&c#*0(&/B4&%&43*#040.&4b$"/$&3b3C(6-"5*0/53"%6$5*0//&--&c~g '-603063"$*-& . . ~.

(12) &'%' 0-&0'3*#040.&4"/%3*#040.&#*0(&/&4*4*/56.03%&7&-01.&/5"/%3&410/4& 50$)&.05)&3"1&65*$53&"5.&/54e "/$&3 $&--4 130%6$& -"3(& ".06/54 0' 3*#040.&4 50 4:/5)&4*;& 5)& 1305&*/4 3&26*3&% '03 5)&*3 3"1*% 130-*'&3"5*0/e )& .&$)"/*4.4 -&"%*/( 50 5)*4 */$3&"4& */ 3*#040.&130%6$5*0/"3&0/-:1"35-:6/%&34500%b#655)&:"3&3&-"5&%505)&"$26*4*5*0/ 0' 5)& 56.03 1)&/05:1&e / "%%*5*0/b " /&8 5)&03: 130104&4 5)"5 3*#040.&4 "3& /05 /&653"- &''&$5034 0' 53"/4-"5*0/b #65 )"7& " %*3&$5 30-& */ 5)& 3&(6-"5*0/ 0' (&/& &913&44*0/e )*4 5)&03: *4 #"4&% 0/ 5)& 0#4&37"5*0/ 5)"5 3*#040.& $0.104*5*0/ *4 )&5&30(&/&064*/%*''&3&/5$&--5:1&4"/%"$$03%*/(50&/7*30/.&/5"-$0/%*5*0/4e. /5)*4$0/5&95b )"7&"/"-:;&%5)&3&-"5*0/4)*14#&58&&/$)"/(&4*/4*(/"-45)"5 $0/530-3*#040.&#*0(&/&4*4b#05)26"/5*5"5*7&-:"/%26"-*5"5*7&-:b"/%5)&%&7&-01.&/5 0' 5)& 56.03 1)&/05:1&e )*4 ."/64$3*15 3&10354 5)3&& 456%*&4 ."%& %63*/( 5)*4 ) 130(3".e)&4&456%*&4*%&/5*'*&%d*q"/07&-3&(6-"5030'5)&".06/50'3*#040.&4b5)& g&53*/gz "/% **q $)"/(&4 */ 5)& 3*#040.& $0.104*5*0/ "/% '6/$5*0/ */%6$&% #: (&/&5*$ "-5&3"5*0/4 p-044 0' "$5*7*5: 0' 1~|q "/% #: 5)& 64& 0' " $)&.05)&3"1&65*$ .0-&$6-&b 5)& ~g-603063"$*-e )&4& 1&3563#"5*0/4 0' 5)& ".06/5 "/% 5)& '6/$5*0/ 0' 3*#040.&4 .0%*': 5)& 53"/4-"5*0/ $0/530- "/% $&-- (3085)b $&-- 130-*'&3"5*0/ "/% $&-- 4637*7"-e 30.5)&4&3&46-54*5$"/#&$0/$-6%&5)"53*#040.&4"3&&-&.&/54*/70-7&%*/5)& 3&(6-"5*0/ 0' (&/& &913&44*0/ "/% 1-": " 30-& */ $"/$&3 1"5)0-0(: "/% 3&410/4& 50 $)&.05)&3"1:e . . . .

(13) & '-%& &.&3$*&.&/54eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee| C46.Ceeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee~ #453"$5eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee "#-&%&4."5*B3&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee *45&%&4'*(63&4&55"#-&"69eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeezy. /530%6$5*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeezz "35*& eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez{ *#040.&4&553"%6$5*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez{. e 536$563&&5'0/$5*0/%&43*#040.&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez{ ze 0.104*5*0/&503("/*4"5*0/(C/C3"-&%&43*#040.&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez| {e L-&%&4%*''C3&/54$0.104"/54%63*#040.&%"/4-"53"%6$5*0/eeeeeeeeeeeeeeeeeeeeeeez "e C$0%"(&%&-k.&44"(&3eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{z #e &/53&%&53"/4'&35%&-"-*"*40/1&15*%*26&eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{z $e 653&44*5&4*.1035"/54%63*#040.&eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{~. e 0/53L-&%&-"53"%6$5*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{ ze 0%"-*5C4%k*/*5*"5*0/%&-"53"%6$5*0/$)&;-&4&6$"3:05&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{ "e C$"/*4.&%k*/*5*"5*0/l$0*''&g%C1&/%"/5&meeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{ #e C$"/*4.&%k*/*5*"5*0/l g%C1&/%"/5&meeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee|y {e "4&4%&-"3C(6-"5*0/53"%6$5*0//&--&eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee|| |e 0/$5*0/&953"g3*#040.*26&%&1305C*/&43*#040.*26&4%"/4-"3C(6-"5*0/%& -"53"%6$5*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee|. e &3*#040.&d6/3C(6-"5&63%&-"53"%6$5*0/ieeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee| ze L-&%63*#040.&%"/4-&$0/53L-&%&-"53"%6$5*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee| "e L-&%&41305C*/&43*#040.*26&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee| #e L-&%&43*#040.*26&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee}y $e L-&%&4.0%*'*$"5*0/41045g53"/4$3*15*0//&--&4%&43*#040.*26&4eee}y {e C5C30(C/C*5C%&-"$0.104*5*0/%&43*#040.&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee} "e C5C30(C/C*5C%&41305C*/&43*#040.*26&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee} #e C5C30(C/C*5C%&43eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee} $e C5C30(C/C*5C%&4.0%*'*$"5*0/41045g53"/4$3*15*0//&--&4%&43eeeeeeeeeee} |e &43*#040.&41"5)0-0(*26&4ieeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee~z "e *#040.01"5)*&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee~z . .

(14) #e &43*#040.&441C$*"-*4C4%"/4-&$"/$&3ieeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee~| "35*&. eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee~ *0(&/B4&%&43*#040.&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee~. e 3("/*4"5*0/'0/$5*0//&--&%&4/6$-C0-&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee~. e 3"/4$3*15*0/%&43eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez "e C$"/*4.&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez #e C(6-"5*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{. e 5"1&41045g53"/4$3*15*0//&--&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee ze 06163&4%&43eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee {e 0%*'*$"5*0/41045g53"/4$3*15*0//&--&4%&43*#040.*26&4eeeeeeeeeeeeeeeeeeeeeeeeeey. e *0(&/B4&%&43*#040.&4%"/4-&$"/$&3eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee| C46-5"54eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee 35*$-&zeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeey. e 30#-C."5*26&(C/C3"-&eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez. e C46-5"54&5%*4$644*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{. e 0/$-64*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee~. e &34*0/%&-k"35*$-&16#-*Ceeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee 35*$-&{eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeezy|. e 30#-C."5*26&(C/C3"-&eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeezy}. e C46-5"54&5%*4$644*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeezy~. e 0/$-64*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeezy. e &34*0/%&-k"35*$-&16#-*Ceeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeezy 35*$-&|eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez{}. e 30#-C."5*26&(C/C3"-&eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez{~. e C46-5"54&5%*4$644*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez{. e 0/$-64*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez|y. e "/64$3*5&/13C1"3"5*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez|z *4$644*0/(C/C3"-&eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez~. e C(6-"5*0/26"/5*5"5*7&%&-"#*0(&/B4&%&43*#040.&4%"/4-&4$"/$&34eeeeeeeeez. e C(6-"5*0/26"-*5"5*7&%&-"#*0(&/B4&%&43*#040.&4%"/4-&4$"/$&34eeeeeeeeeeez C'C3&/$&4#*#-*0(3"1)*26&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez~ //&9&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez e *45&%&416#-*$"5*0/4&5$0..6/*$"5*0/4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez. . .

(15) ze 6#-*$"5*0/4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez {e 0..6/*$"5*0/403"-&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez |e 0..6/*$"5*0/41"3"''*$)&eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez e 35*$-&d /$061-*/( 3*#040.& #*0(&/&4*4 3&(6-"5*0/ '30. 10-:.&3"4& "$5*7*5:%63*/()&31&44*.1-&97*3645:1&z*/'&$5*0/pb{yzyqeeeeeeeeeeeeeeeeeeeeeeeeeeeeez . e "#-&"6 %& 4:/5)B4& %&4 .0%*'*$"5*0/4 1045g53"/4$3*15*0//&--&4 %&4 *#040.*26&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{zy . . . .

(16) &'&(%&''(* *(63&zd "4536$563&%&44064g6/*5C43*#040.*26&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez~ *(63&{d536$563&4&$0/%"*3&%&43*#040.*26&4)6."*/4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez *(63&|d3("/*4"5*0/%&4$0.104"/54%63*#040.&)6."*/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez *(63&}d3("/*4"5*0/'0/$5*0//&--&%&43*#040.&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{y *(63&~d &$&/53&%&%C$0%"(&%&-k.eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{{ *(63&d kC-0/("5*0/%&-"53"%6$5*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{} *(63&d k*/*5*"5*0/%&-"53"%6$5*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{ *(63&d &4%*''C3&/545:1&4%k 7*3"69eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee|z *(63&d3*/$*1"69C-C.&/543C(6-"5&634%&-"53"%6$5*0/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee|} *(63&zydC(6-"5*0/%&-"53"%6$5*0/%&-k.%&}1"3-&46eeeeeeeeeeeeeeeeeeeeeeeeeeeeee| *(63&zzd &4.0%*'*$"5*0/4$)*.*26&4%&-k3eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee}{ *(63&z{dC5):-"5*0/&514&6%063*%:-"5*0/%&43{&5~beeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee}| *(63&z|dC5):-"5*0/&514&6%063*%:-"5*0/%&-k3zeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee}} *(63&z}d$)C."(C/C3"-%&-"#*0(&/B4&%&43*#040.&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee~ *(63&z~d-53"4536$563&%6/6$-C0-&eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeey *(63&zd &$0.1-&9&%k*/*5*"5*0/%&-"53"/4$3*15*0/%&-k10-:.C3"4& eeeeeeeeeeeeeeeeee| *(63&zd &44*5&4%&$06163&%613Cg3}eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee *(63&zd "."563"5*0/%&43&5-k"44&.#-"(&%&41"35*$6-&413Cg3*#040.*26&4ee *(63&zd &44/0eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee{ *(63&{yd0*&4%&4*(/"-*4"5*0/&553"/4$3*15*0/1"3-"-k0-g %"/4-&$"/$&3eeeeeeee~ *(63& {zd C(6-"5*0/ %& -" 53"/4$3*15*0/ %&4 3 1"3 -&4 0/$0(B/&4 &5 -&4 46113&44&634%&56.&63eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee *(63&{{d''&5%&-"gC53*/&gz463-"."563"5*0/%&43eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee} *(63&{|d''&5%6~g463-"130-*'C3"5*0/%&4$&--6-&4 zzeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez{ *(63& {}d 0%B-& 3&13C4&/5"/5 -&4 "-5C3"5*0/4 26"/5*5"5*7&4 &5 26"-*5"5*7&4 %& -" #*0(&/B4&%&43*#040.&4.C%*C&41"3-"gC53*/&gzb1~|&5-"'*#3*--"3*/&eeeeeeeeez{ *(63&{~d0%B-&%&-k&''&5%6~g463-"130%6$5*0/&5-"'0/$5*0/%&43*#040.&4eeez} "#-&"6zd70-65*0/%&-"$0.104*5*0/%&43*#040.&4eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeeez . . . zy.

(17) . . . zz.

(18) "35*& "&" &''%('"! . 6. '%('(%'"!'"!&%"&" &. /z~~b&03(&e"-"%&%C$3*7"*51063-"13&.*B3&'0*4-k0#4&37"5*0/%&1&5*5&4 1"35*$6-&4 (3"/6-"*3&4 7*4*#-&4 1"3 .*$304$01*& "6 4&*/ %& $&--6-&4 %& 3"54b -&4 .*$3040.&4 p b z~~qe /& 4C3*& *.1035"/5& %kC56%&4 " &/46*5& 46*7* $&55& 13&.*B3& 0#4&37"5*0/ 26* 0/5 1&3.*4 %& 3C7C-&3 -" /"563& 3*#0/6$-C0g1305C*26& %& $&4 1"35*$6-&426*0/5C5C#"15*4C&43*#040.&4"6$0634%&4"//C&4zyek&45%63"/5$&55& 1C3*0%&26&-&633L-&%"/4-"4:/5)B4&1305C*26&"C5C'&3.&.&/5%C.0/53Cp

(19) * ":b zy c b z~ c $6*--&/ * ":b z~qe &16*4 $&4 "//C&4b 6/& .6-5*56%& %kC56%&4%C$3*7"/5-"$0.104*5*0/&5-"'0/$5*0/%&43*#040.&40/51&3.*4%&.&553&< +063 -& $"3"$5B3& 6/*7&34&- %&4 3*#040.&4 %"/4 -k&/4&.#-& %&4 %0."*/&4 %6 .0/%& 7*7"/5e &1&/%"/5b -" $0.13C)&/4*0/ %&4 .C$"/*4.&4 .0-C$6-"*3&4 1&3.&55"/5 "69 3*#040.&4%&%C$3:15&3-&.&44"(&(C/C5*26&1035C1"3-&4.&44"(&34p.q&5 %& 4:/5)C5*4&3 -k"44&.#-"(& %&4 "$*%&4 ".*/C4 /k" C5C 1044*#-& 26k"44&; 3C$&..&/5 /05"..&/5(3>$&<-"%C5&3.*/"5*0/%&-"4536$563&53*g%*.&/4*0//&--&%&43*#040.&4< 6/ /*7&"6 %& 3C40-65*0/ 46''*4"..&/5 C-&7Cb $0.1"3"#-& < $&-6* 26& -k0/ 1&65 0#5&/*3 1063%&41305C*/&4ek&45 "*/4* 26& -&%C7&-011&.&/5&5-k015*.*4"5*0/%&.C5)0%&4%& $3*45"--0(3"1)*& $061-C&4 < -" 41&$530.C53*& "69 3":0/4 &5 %& $3:0g.*$304$01*& C-&$530/*26&p$3:0gq"%"15C&4<-kC56%&%&(304$0.1-&9&4.0-C$6-"*3&47&34-"'*/%&4 "//C&4zyb0/51&3.*4%kC-6$*%&3-"4536$563&%&43*#040.&4%&$&--6-&4130$"3:05&4b -" #"$5C3*& : *(#%& "+) &5 -k"3$)C& : #( )#%(*+ b "7&$ 6/& 3C40-65*0/ "50.*26& pb{yyycb{yyzqeC$0.1&/4C&4&/{yy1"3-&13*90#&-%&$)*.*&"553*#6C < e ".",3*4)/"/b e e 5&*5; &5 e e 0/"5)b $&4 C56%&4 0/5 1&3.*4 %& 3C7C-&3 -" $0.1-&9*5C%&-"4536$563&%&$&55&."$)*/&3*&&/;:."5*26&&50/51&3.*46/&.&*--&63& $0.13C)&/4*0/%&4130$&4464*.1-*26C4%"/4-"4:/5)B4&1305C*26&p b{yyqe / 1"35*$6-*&3b -" %C5&3.*/"5*0/ %& -" 4536$563& %& -" (3"/%& 4064g6/*5C %6 3*#040.&130$"3:05&"1&3.*4%&.0/53&326&-k3*#040.*26&p3q&45-&4611035 %&-k"$5*7*5C$"5"-:5*26&&526&-&41305C*/&43*#040.*26&4pq1&3.&55&/5-&."*/5*&/. . z{.

(20) %& -" 4536$563& %& -k3e 30*4 C56%&4 16#-*C4 &/ {yyy %"/4 -& +063/"- $ 0/5 1&3.*4 %& %C.0/53&3 %C'*/*5*7&.&/5 -& 3L-& &/;:."5*26& %&4 3 &/ .&55"/5 &/ C7*%&/$& -k"#4&/$& %& 1305C*/&4 "6 4*5& $"5"-:5*26& %& -" -*"*40/ 1&15*%*26& &5 "*/4* %& $-"44&3 -& 3*#040.& %"/4 -" $"5C(03*& %&4 3*#0;:.&4 p b {yyy c b {yyy c b {yyyqe &5&3.&3*#0;:.&"C5C*/530%6*5&/z{1"3

(21) 36(&3&5"e1063%C'*/*3-&4 26* 1044B%&/5 6/& "$5*7*5C $"5"-:5*26& */53*/4B26& p

(22) *":b z{qe " %C$067&35& %&4 3*#0;:.&4 " C("-&.&/5 C5C 3C$0.1&/4C& 1"3 -& 13*9 0#&- %& $)*.*& &/ z "553*#6C < &$) &5 -5."/ p b zqe " 1044*#*-*5C 26& -&4 3 40*&/5 3&410/4"#-&4 %& -" 4:/5)B4& 1305C*26& "7"*5 C5C 130104C& "7"/5 -" 3C40-65*0/ %& -" 4536$563&%&43*#040.&4b463-"#"4&%&453"7"69%& ee0--&3&5ee&$)b&/53&"653&4 p *":bz{c &5 bzqe " 3C40-65*0/ %& -" 4536$563& %&4 3*#040.&4 &6$"3:05&4 " C5C 1-64 5"3%*7& C5"/5 %0//C -&63 1-64 (3"/%& 5"*--& &5 -&63 1-64 (3"/%& $0.1-&9*5Ce k&45 &/ {yzy 26& -& 3*#040.& %& -&763& " C5C $3*45"--*4C &5 "/"-:4C 1"3 41&$530.C53*& "69 3":0/4 b '063/*44"/5 -" 13&.*B3& 4536$563& < )"65& 3C40-65*0/ p}bz~ q %6 3*#040.& &6$"3:05& pg * ":b {yzyq 4&6-&.&/5 26&-26&4 .0*4 "13B4 -k0#5&/5*0/ %& -" 4536$563& %6 3*#040.& %& 1-"/5& &5 %& -&763& 1"3 $3:0g "7&$ 6/& 3C40-65*0/ %k&/7*30/ p *":b{yzyqe/{yzzb530*4/067&--&44536$563&4%&3*#040.&4$3*45"--*4C4%& -&763& &5 %k6/ 13050;0"*3& p*(/#$ *(#%& "q 0/5 1&3.*4 %k"''*/&3 -" $0.13C)&/4*0/ %&4 3&-"5*0/4 &9*45"/5 &/53& -&4 %*''C3&/54 $0.104"/54 %6 3*#040.& &5 $&35"*/4'"$5&634/0/g3*#040.*26&4*.1-*26C4%"/4-"53"%6$5*0/pg *":b{yzzc *":b{yzzc

(23) *":b{yzzqe "4536$563&-"1-6413C$*4&%63*#040.&)6."*/ %*410/*#-& < $& +063 " C5C 0#5&/6& &/ {yz| 1"3 $3:0gb 4*.6-5"/C.&/5 < $&--& %6 3*#040.&%&%30401)*-&b"7&$6/&3C40-65*0/$0.13*4&&/53&~b}&5bp*":b {yz|qe / $0.#*/"/5 -&4 %&/4*5C4 C-&$530/*26&4 "7&$ -&4 4536$563&4 $3*45"--*/&4 %&4 3*#040.&4%&-&763&&5%&*(/#$9&5%&413C%*$5*0/4%&4536$563&44&$0/%"*3&4%& -k3b-&4"65&6340/516130104&36/.0%B-&.0-C$6-"*3&$0.1-&5%&-"4536$563&%&4 3*#040.&4)6."*/&5%&%30401)*-&e =6 " #"&'"!'"%!&'"!.!.%&%"&" & "/45065&4-&4$&--6-&4b-&43*#040.&440/53&410/4"#-&4%&-"4:/5)B4&1305C*26&e "-(3C$&55&&953D.&$0/4&37"5*0/%&-"/"563&1):4*$0g$)*.*26&&5%&-"'0/$5*0/%&4. . z|.

(24) 3*#040.&4b 0/ $0/45"5& 26& -&63 $0.104*5*0/ &45 /&55&.&/5 %*''C3&/5& &/53& -&4 3*#040.&4 "11"35&/"/5 "69 %*''C3&/54 %0."*/&4 %6 .0/%& 7*7"/5e &4 $0.104"/54 p3&5q4k03("/*4&/5%&."/*B3&"4:.C53*26&&/%&694064g6/*5C4d-"(3"/%&4064g 6/*5C p b 1063 l-"3(& 46#6/*5mq %k6/ $0&''*$*&/5 %& 4C%*.&/5"5*0/ %& y p~y $)&; -&4130$"3:05&4q&5-"1&5*5&40646/*5Cpb1063l4."--46#6/*5mq%k6/$0&''*$*&/5%& 4C%*.&/5"5*0/}yp|y$)&;-&4130$"3:05&4qb%0/5-k"44&.#-"(&%0//&-&3*#040.&y py$)&;-&4130$"3:05&4qr*(63&zse " $0.104*5*0/ %&4 3*#040.&4 4k&45 $0.1-&9*'*C& "6 $0634 %& -kC70-65*0/ "7&$b %k6/&1"35%&4"%%*5*0/4%&&5%&4&95&/4*0/410-:1&15*%*26&4463%&4$0/4&37C&4 &5b %k"653& 1"35b %&4 &95&/4*0/4 /6$-C05*%*26&4 pl&95&/4*0/ 4&(.&/54d mqe / $0/4C26&/$&b-"."44&%&43*#040.&4&45%k&/7*30/{b~"1063-&yb|b{"1063 -&4y%k&6$"3:05&46/*$&--6-"*3&4&5&/7*30/}b|"1063-&3*#040.&%&."..*'B3&e &4 $0.104"/54 %&4 3*#040.&4 %& 26"53& 03("/*4.&4 .0%B-&4b #"$5C3*&b "3$)C&b &6$"3:05&4 6/*$&--6-"*3& &5 ."..*'B3& 40/5 C/6.C3C4 %"/4 -& "#-&"6 z r0*3 "644* -" *(63&zse &4313C4&/5&/5%&44536$563&4$0.1-&9&426*'03.&/5%&/0.#3&64&4)C-*$&4 &5 #06$-&4e )&; -&4 #"$5C3*&4b -k3 {| $0/5*&/5 zyz )C-*$&4 p z < zyzq 26* 4k03("/*4&/5&/%0."*/&4p < q&5-k3zb}~)C-*$&4p)z<)}~q03("/*4C&4&/} %0."*/&4p~kb$&/53"-b|k."+&63&5|k.*/&63qr*(63&{sp *":bzzc * ":b zzqe &4 3 %&4 &6$"3:05&4 1044B%&/5 %&4 4536$563&4 4*.*-"*3&4b "7&$ 6/& (3"/%&$0/4&37"5*0/%&4)C-*$&4&5%0."*/&4b1&3.&55"/56/&/0.&/$-"563&$0..6/&e k&/4&.#-& %& $&4 %0//C&4 4536$563"-&4 " 1&3.*4 %& %C'*/*3 %&4 C-C.&/54 %& -" 4536$563& %&4 3*#040.&4e &4 |y &5 }y 0/5 %&4 '03.&4 $0.1"3"#-&4b %C'*/*44"/5 %&44536$563&43&1C3"#-&45&--&426&-"5D5&b-&$061b-kC1"6-&b-&$0314b-"1-"5&'03.&&5-&4 1*&%4 %30*5 &5 ("6$)& r*(63& zse - &/ &45 %& .D.& 1063 -&4 ~y &5 yb 26* 13C4&/5&/5530*43&1B3&4d-"13056#C3"/$&$&/53"-&b-"5*(& z&5-"5*(&p n z{$)&; -&4 130$"3:05&4q r*(63& zse & ."/*B3& (C/C3"-&b -&4 &5 41C$*'*26&4 %&4 &6$"3:05&4 '03.&/5 %&4 $06$)&4 &95&3/&4 "65063 %6 $O63 %6 3*#040.& 26*b &--&b 3&13C4&/5& 6/& 3C(*0/ %6 3*#040.& 26* " C5C &953D.&.&/5 $0/4&37C& "6 $0634 %& -kC70-65*0/p*":b{yz|qr*(63&zb&5se&$O63$0..6/<5064-&43*#040.&4 $0.13&/%|}pz1063-" &5z~1063-"q&5}e}{{/6$-C05*%&4p{e}1063-" &5 z}~ 1063 -" q &5 $0/5*&/5 -&4 13*/$*1"69 4*5&4 '0/$5*0//&-4 1&3.&55"/5 -& %C$0%"(&%&-k.&5-"'03."5*0/%&-"-*"*40/1&15*%*26&p

(25) *":b{yz{qe. . z}.

(26) *(63&zd#$"%$%"##%#/%$*#"#!%#. . d536$563&%&-"4064g6/*5C}yb76&%6$05C%&-k*/5&3'"$&@1+A&5%&-"463'"$&&9104C&"640-7"/5 @1(% *A: "463'"$&0$$61C1"3-k3&45$0-03C&&/03"/(&&5$&--&%&1305C*/&43*#040.*26&4&/(3*4e d536$563&%&-"4064g6/*5Cyb76&%6$05C%&-k*/5&3'"$&@1+A&5%&-"463'"$&&9104C&"640-7"/5@1 (% *A: &5 d &4 ;0/&4 (3*4&4 &5 #-&6 $-"*3&4 3&13C4&/5&/5 3&41&$5*7&.&/5 -k3 &5 -&4 1305C*/&4 $0/4&37C&4"6$0634%&-kC70-65*0/e &4;0/&4304&4&5#-&6'0/$C&43&41&$5*7&.&/5-k3&5-&41305C*/&4 41C$*'*26&4 %&4 &6$"3:05&4e d 0%B-& %&4 $06$)&4 46$$&44*7&.&/5 "+065C&4 "6 $0634 %& -kC70-65*0/e & /0:"6(3*43&13C4&/5&-&3*#040.&#"$5C3*&/b&/#-&640/53&13C4&/5C&4-&4"%%*5*0/4$)&;-&4&6$"3:05&4 6/*$&--6-"*3&4b&5&/03"/(&&5306(&40/53&13C4&/5C&4-&4$06$)&441C$*'*26&4%&4&6$"3:05&4461C3*&634e &4 *."(&4 &5 0/5 C5C 0#5&/6&4 < 1"35*3 %&4 4536$563&4 %6 3*#040.& %& (%#/)(, ) &/ 65*-*4"/5 -&4 '*$)*&34 |~b |~b |~ &5 |~ &5 -& -0(*$*&- : e &5 d *#040.& %& *(/#$ *(#%& "b { &5 }zb &5 p &5 b {yz{qe d ."(& *446& %& p*":b{yz|qe. . . . z~.

(27) *(63&{d$"%$%"#"# "#!%#%#. . d536$563&4%&43%&-"4064g6/*5Cyd{b~b&5~ed536$563&%&-k%&-"4064g6/*5C}yd ze &4 )C-*$&4 %&4 3 {b ~b &5 ~ 40/5 */%*26C&4 1"3 6/ &5 -&4 )C-*$&4 %& -k3 z 40/5 */%*26C&4 1"3 6/ )e &4 ;0/&4 463-*(/C&4 &/ (3*4 3&13C4&/5&/5 -&4 pl&95&/4*0/ 4&(.&/54d mqe *(63& *446&%&p*":b{yz|qe. . z.

(28) k"%%*5*0/*.1035"/5&%&$0.104"/54/6$-C05*%*26&4&51305C*26&4<-"463'"$&%&4 3*#040.&4 &6$"3:05&4 $033&410/% "6 .0%& 3"%*$"-&.&/5 %*''C3&/5 %& 3&$365&.&/5 %&4 3*#040.&4463-&4."6$0634%&-k*/*5*"5*0/%&-"53"%6$5*0/$)&;-&4130$"3:05&4&5 -&4 &6$"3:05&4e " 3C40-65*0/ 3C$&/5& %& -" 4536$563& %&4 3*#040.&4 %& %30401)*-& &5 )6."*/1"3$3:0g"3C7C-C-"13C4&/$&%&$06$)&4&9$-64*7&.&/5$0/45*56C&4%k 26*&/5063&/56/&$06$)&gb13C4&/5&$)&;-"-&763&b&95&3/&"6/0:"6$0..6/ r*(63& zse *&/ 26& -" '0/$5*0/ %&4 $0.104"/54 3*#040.*26&4 41C$*'*26&4 %&4 &6$"3:05&4 3&45& ."- $0.13*4&b *-4 '03.&/5 6/& 7C3*5"#-& 1-"5&'03.& 1&3.&55"/5 -k*/5C(3"5*0/ %& 4*(/"69 %& 3C(6-"5*0/ %& -" 53"%6$5*0/ &5 %& -" .0%*'*$"5*0/ $0g 53"%6$5*0//&--&%&41305C*/&4p *":b{yzzc

(29) *":b{yyqe "#-&"6zd&%$ #$#"## 0."*/& 41B$&. 30$"3:05&4. 6$"3:05&4. "$5C3*&. 3$)C&. :%" . :#( )#%(*+ . :(, ) . y. :)& $). *#0g. 0C'ee. y. 40.&. "44&. {b}". {b". |b|". }b|". #. ~}. ~. . y. 1305C*/&4 3 . |3d}~/5 |3d}~z/5 }3d~}{/5 }3d{{|/5. 0C'ee #. ~y. y. ||. ||. }. }. {|d{y}/5. {|d{{|/5. {~d||/5. {d~y/5. ~dz{y/5. ~dz{{/5. ~dzz/5. ~dz{z. ~bdz~/5. ~bdz~/5. 1305C*/&4 3. g . 0C'ee #. |y. }y. {z. {}. ||. ||. zdz~}{/5. zdz}{/5. zdzyy/5. zdz/5. 1305C*/&4 3 . . . z.

(30) >6 /&.%!'&" #"&!'&(%"&" !&'%('"! &3L-&%&4$0.104"/54%63*#040.&b1305C*26&4&5/6$-C*26&4b&453&45C1&/%"/5 -0/(5&.146/&26&45*0/%C#"556&"64&*/%k6/&1"35*&%&-"$0..6/"65C4$*&/5*'*26&e& -" '*/ %&4 "//C&4 zy +6426x"69 "//C&4 {yyyb %&4 &''0354 $0/4*%C3"#-&4 0/5 C5C '"*54 1063*40-&3&53b3&$0/45*56&3-&4"$5*7*5C4&/;:."5*26&4%&43*#040.&4&5%C'*/*3 -&6344*5&4'0/$5*0//&-4e&1&/%"/5b"6$6/&"$5*7*5C&/;:."5*26&/k"C5C.*4&<+063463 -&4$0.104"/54*40-C4b%C.0/53"/5-&3L-&&44&/5*&-%&-"4536$563&%63*#040.&%"/440/ "$5*7*5Ce B4 -&4 "//C&4 zyb "7"/5 -" %C$067&35& %&4 3*#0;:.&4b 6/ $&35"*/ /0.#3& %kC56%&4 0/5 46((C3C 26& -k3 -6* .D.& 1067"*5 +06&3 6/ 3L-& '0/$5*0//&- %"/4 -" 53"%6$5*0/b /05"..&/5 %"/4 -k"$5*7*5C 1&15*%:-g53"/4'C3"4&b ."*4 $&55& *%C& &45 3&45C& -0/(5&.14$0/5307&34C&p *":bz}c *":bzzc*":bz}c b z|qe k&45 '*/"-&.&/5 -k"7B/&.&/5 %& -" $3*45"--0(3"1)*& "440$*C& < -k"/"-:4& 1"341&$530.C53*&"693":0/4&5-"3C40-65*0/%&-"4536$563&"6/*7&"6"50.*26&%&4 3*#040.&4 26* " 1&3.*4 %& 3C10/%3& < $&4 26&45*0/4b &5 %k"/"-:4&3 -&4 3&-"5*0/4 4536$563&g'0/$5*0/ 26* 3C(*44&/5 -k"$5*7*5C %&4 3*#040.&4 p b {yyyqe " *(63& | 13C4&/5&-k03("/*4"5*0/%&4&53463-"4536$563&%63*#040.&y)6."*/e /& 7*4*0/ 4*.1-*'*C& %6 .C$"/*4.& %& 53"%6$5*0/ .0/53& -k*.1035"/$& %& 530*4 130$&4464 '0/%".&/5"69d -" 3&$0//"*44"/$& %6 $0%0/ %& -k. 1"3 -k"/5*$0%0/ %& -k5b-"'03."5*0/%&-"-*"*40/1&15*%*26&&5-&.067&.&/5%&45&5%&-k."6 4&*/%63*#040.&e &3*#040.&1044B%&530*44*5&4%&-*"*40/%&45d-&4*5&b%"/4-&26&-4&-0(& -k".*/0"$:-g5b-&4*5&0R4&1-"$&-&1&15*%:-g5&5-&4*5&p9*5qb%"/4-&26&-4& 1-"$& -k5 %C$)"3(C 13D5 < 26*55&3 -& 3*#040.& r*(63& }se &4 5 40/5 45"#*-*4C4 %"/4 -& 3*#040.& 1"3 %& /0.#3&69 $0/5"$54 "7&$ %&4 &5 -&4 3b "4463"/5 -&63 104*5*0//&.&/5$033&$57*4<7*4%&-k."6/*7&"6%&-"b&5%6$&/53&%&$"5"-:4& %& -" -*"*40/ 1&15*%*26& pld &15*%:- 3"/4'&3"4& &/5&3mq %"/4 -" e 6 /*7&"6 %64*5&b-k5&45104*5*0//C%&."/*B3&<$&26&-"#06$-&%&-k"/5*$0%0/7*&//&"6 $0/5"$5%6$0%0/%&-k.b%"/46/&;0/&%&-""11&-C&-&$&/53&%&%C$0%"(&%& -k. pld &$0%*/( &/5&3mqe k5 &45 $)"3(C "6 4*5& &/ $0.1-&9& "7&$ -& '"$5&63&z"pg6$)&;-&4#"$5C3*&4q&56/&.0-C$6-&%&e/4$)C."(C/C3"-%& -" 53"%6$5*0/ 13C4&/5"/5 -&4 13*/$*1"-&4 3C"$5*0/4 &5 -&4 '"$5&634 3&26*4 "69 %*''C3&/5&4 C5"1&4&4513C4&/5C%"/4-"*(63&e . z.

(31) *(63&|d "#$# #$#%"#%. . d04*5*0/%&41305C*/&43*#040.*26&4463-"4064g6/*5C}y76&%6$05C%&-k*/5&3'"$&@+A&5%&-" 463'"$&&9104C&"640-7"/5@(% *A: d04*5*0/%&41305C*/&43*#040.*26&4463-"4064g6/*5Cy76&%6 $05C %& -k*/5&3'"$& @+A &5 %& -" 463'"$& &9104C& "6 40-7"/5 @(% *A: d 3("/*4"5*0/ %&4 3 zb {b ~b &5 ~ %"/4 -& 3*#040.& y )6."*/e d *#040.& y )6."*/ $0.1-&5e &4 *."(&4 0/5 C5C (C/C3C&4"7&$-&-0(*$*&-:0-&5-&4'*$)*&34| |b| |b| |&5| |p*":b{yz|q. . z.

(32) . . . *(63&}d "#$$#"## d&13C4&/5"5*0/4$)C."5*26&%&4%*''C3&/544*5&4'0/$5*0//&-4%63*#040.&e &$&/53&%&%C$0%"(&%& -k. pq &45 3&13C4&/5C 1"3 6/ 3&$5"/(-& 7&35 &5 4& 4*56& < -" #"4& %6 4*5& e &4 4*5&4 b &5 0R 7*&//&/54&-0(&3-&4540/5*/%*26C41"3-&43&$5"/(-&4%&%*''C3&/5&4$06-&634e &$&/53&%&53"/4'&35 %& -" -*"*40/ 1&15*%*26& pq &45 */%*26C 1"3 6/ 07"-& 306(&e k.b 26* 1"44& &/53& -&4 %&69 4064g 6/*5C4%63*#040.&b&453&13C4&/5C&/304&ed61&3104*5*0/%&-"4536$563&%63*#040.&)6."*/p | |b | |b | | &5 | |q &5 %&4 5 %&4 4*5&4 pg5qb pg5q &5 pg5q %& (#+) *(#%& "+)p{

(33) qe &4$06-&63440/53&41&$5C&41"33"11035"64$)C."&/e &&45*/%*26C &/306(&&5-&4/6$-C05*%&4%&-k3z26*40/54*56C4-&-0/(%61"44"(&%&-k.40/5*/%*26C4&/ 7&35e. . . . {y.

(34) : 3%"=#))( 6/*7&"6%6b-&3*#040.&1&3.&5-&$0/53L-&%&-k"11"3*&.&/5&/53&-&$0%0/ &5-k"/5*$0%0/e"/4-&.0%B-&130104C46*5&"6913&.*B3&44536$563&4%&-"4064g6/*5C |y %& : *(#%& "+)b $&55& "$5*7*5C %& 4637&*--"/$& pl1300'3&"%*/(mq &45 13*/$*1"-&.&/5 1035C& 1"3 530*4 /6$-C05*%&4 6/*7&34&--&.&/5 $0/4&37C4 %& -k3 znzd~|ybz}{&5z}|p0.&/$-"563&%&:%" qp *":b{yyyc b {yyz c

(35) b {yy{qe " *(63& ~ .0/53& -k03("/*4"5*0/ %6 %6 3*#040.& %& -&763&e k"11"3*&.&/5 $033&$5 %&4 %&69 13&.*&34 /6$-C05*%&4 %& -k. "7&$ -k"/5*$0%0/&45$0/53L-C%&'"A0/453*$5&1"3-&4#"4&4z}{bz}|&5~|y%&-k3 zb 26* 1&3.&55&/5 %& %*4$3*.*/&3 -&4 "/5*$0%0/4 ":"/5 -&4 %&69 #"4&4 "11"3*C&4 %& $&69/k&/":"/526k6/&e k"11"3*&.&/5%6530*4*B.&/6$-C05*%&%6$0%0/&45$0/53L-C%& '"A0/ .0*/4 453*$5& 1"3 -&4 #"4& ~|y &5 zy~}b "6503*4"/5 6/ "11"3*&.&/5 /0/g $"/0/*26& 5&- 26& ge & .0%B-& &91-*26& -" 1044*#*-*5C %& %C(C/C3&4$&/$& %6 $0%& (C/C5*26& &5 -k):105)B4& 4&-0/ -"26&--& 6/ .D.& 5 1&65 3&$0//"G53& 1-64*&634 $0%0/426*%*''B3&/5<-"530*4*B.&104*5*0/b-"104*5*0/%*5&l800#-&mp

(36) bzqe /{yz{b6-/"646107"&54&4$0--"#03"5&6340/5130104C6//067&"6.0%B-&%6 .C$"/*4.& %& 4637&*--"/$& %& -k*/5&3"$5*0/ $0%0/g"/5*$0%0/b &/ 4& #"4"/5 463 %& /067&--&44536$563&4<)"65&3C40-65*0/%63*#040.&y%&:*(#%& "+)p

(37) * ":b {yz{qe &4 4536$563&4 $0.1"3C&4 %& 1-64*&634 $0.#*/"*40/4 %& $0%0/4 &5 "/5*$0%0/4 "11"3*C4 06 /0/b $0/'*3.&/5 -" 50-C3"/$& "6 /*7&"6 %& -" #"4& l80##-&mb ."*4.0%B3&/5-k*.1-*$"5*0/%&4#"4&4~|ybz}{&5z}|%&-kze &4"65&634 130104&/526&-&4$0/53"*/5&4*.104C&41"3-&4)C-*$&4z&5}}%&-k3zb-"zb &51"3-" , -k)C-*$&%&-k3{|%"/4-&b'03$&/5-&4%&6913&.*B3&4#"4&4 %6$0%0/&5%&-k"/5*$0%0/<"%015&36/&$0/'03."5*0/%C'*/*&e"/4-&$"40R-k6/&%&4 %&69 104*5*0/4 /k&45 1"4 "11"3*C&b -kC/&3(*& %& 3C16-4*0/ 3C46-5"/5 %6 ."67"*4 "11"3*&.&/546''*3"*5<*/%6*3&-&3&+&5%&-k5e : $*(*($)(*"" )%$&&* '+ k"11"3*&.&/5 &/53& -& $0%0/ &5 -k"/5*$0%0/ %C$-&/$)& -" -*#C3"5*0/ %6 '"$5&63 &z" "13B4 -k):%30-:4& %6 b "*/4* 26& %&4 $)"/(&.&/54 4536$563"69 "6 4&*/ %6 3*#040.& &5 %&4 5b 1&3.&55"/5 -& 3"1130$)&.&/5 410/5"/C %&4 &953C.*5C4 %& -k".*/0"$:-g5%64*5&&5-&1&15*%:-g5%64*5&"6/*7&"6%6e . . {z.

(38) . *(63&~d$"*0 61&3104*5*0/%&-"4536$563&%&-"40646/*5C}y%63*#040.&%&(%#/)(, ) p|~&5 |~q&5%&45%&44*5&4pg5qbpg5q&5pg5q&5%&-k.%&(#+)*(#%& "+) p {

(39) qe &4 /6$-C05*%&4 6/*7&34&--&.&/5 $0/4&37C4 %6 4*5& 40/5 */%*26C4 &/ 306(& &5 "7&$ -" /0.&/$-"563&%&:%" e. . . . {{.

(40) " %C5&3.*/"5*0/ %& -" 4536$563& %& -" ~y %& : ."3*4.0356** " 1&3.*4 %& .0/53&3 26& -& 53"/4'&35 %& -" -*"*40/ 1&15*%*26& "7"*5 -*&6 %"/4 6/ &/7*30//&.&/5 $0.104C &9$-64*7&.&/5 %k3b 7"-*%"/5 -&4 /0.#3&64&4 0#4&37"5*0/4 (C/C5*26&4 &5 #*0$)*.*26&446((C3"/526&-&3*#040.&&456/3*#0;:.&p &5 bzc b {yyyqe 0.104C %& /6$-C05*%&4 $0/4&37C4b -& */5&3"(*5 "7&$ -&4 &953C.*5C4 |k %&4 5"694*5&4&5b'"703*4&-&63104*5*0//&.&/5b&5$3C&6/&/7*30//&.&/5'"703"#-& "6 53"/4'&35 1&15*%*26& p

(41) b {yy{qe &4 5*(&4 &5 b $0.104C&4 3&41&$5*7&.&/5 %& /6$-C05*%&4 %&4 )C-*$&4 { &5 y %6 {|n{b */5&3"(*44&/5 "7&$ -&4 &953C.*5C4%&45%&44*5&4&5e*&/26k"6$6/&1305C*/&/&40*5%*3&$5&.&/5 *.1-*26C&%"/4-"3C"$5*0/$"5"-:5*26&%653"/4'&35%&-"-*"*40/1&15*%*26&b$&35"*/&4 40/5 */%*41&/4"#-&4 1063 26& -" 3C"$5*0/ "*5 -*&6e 05"..&/5b -&4 z &5 { %& : *(#%& "+) 4kC5&/%&/5 13B4 %6 &5 */5&3"(*44&/5 "7&$ -&4 5b '"703*4"/5 "*/4* -" 3C"$5*0/ $"5"-:5*26& p * ":b {yyqe &4 4536$563&4 %& 3*#040.&4 &6$"3:05&4 0#5&/6&43C$&..&/50/53C7C-C&426&-"4536$563&%6C5"*5505"-&.&/5*%&/5*26&< $&--& %&4 3*#040.&4 130$"3:05&4b 46((C3"/5 26& -& 130$&4464 %& 53"/4'&35 %& -" -*"*40/ 1&15*%*26& &5 -& 3L-& %& -k3 40/5 *%&/5*26&4e " 3C40-65*0/ %& -" 4536$563& %6 #"$5C3*&/"C("-&.&/51&3.*4%&$0.13&/%3&-&.C$"/*4.&%&/0.#3&69"/5*#*05*26&4 26* */)*#&/5 -k"$5*7*5C %6 3*#040.& 5&-4 26& -" 1630.:$*/&b -k"/*40.:$*/& 06 &/$03& -& $)-03".1)&/*$0- p &5 b {yzzqe k&45 "*/4* 26k*- " 16 D53& .0/53C 26& -" 1-64 (3"/%& 3C4*45"/$& %&4 3*#040.&4 &6$"3:05&4 < $&4 "/5*#*05*26&4 4&3"*5 %6& < %&4 %*''C3&/$&4 4536$563"-&4 &95&3/&4 "6 b ."*4 26* .0%*'*&3"*&/5 -k"$$B4 &5 -&4 */5&3"$5*0/4 %& $&4 .0-C$6-&4 "6 p$0..6/*$"5*0/ 1&340//&--& %& *$0-"4 "33&"6 %& 06#3&44&b$0/'C3&/$&b4&15&.#3&{yz|qe 13B4 -& 53"/4'&35 %& -" -*"*40/ 1&15*%*26&b -" $0/'03."5*0/ %&4 5 $)"/(& 410/5"/C.&/5&5$3C&6/C5"5):#3*%&"7&$-k5%C"$C5:-C%"/4-&4*5&%&-" &5-& 4*5& %& -" b &5 -& 1&15*%:-g5 %"/4 -& 4*5& %& -" &5 -& 4*5& %& -" e &4 C7B/&.&/54 1307026&/5 &/46*5&b "7&$ -& '"$5&63 "4& g p&{ $)&; -&4 &6$"3:05&4qb 6/ .067&.&/5 %& -" 3&-"5*' < -" b "11&-C 53"/4-0$"5*0/e " 53"/4-0$"5*0/ 1&3.&5 -" -*#C3"5*0/ %6 4*5& b -& 4*5& $0.1035"/5 -& /067&"6 1&15*%:-g 5&5-&4*5&6/5%C"$C5:-Cr70*3-"*(63&1063-k*--6453"5*0/%6.C$"/*4.&se . . . {|.

(42) . . *(63&d0*$$"%$ & 4$)C." .0/53& -&4 %*''C3&/5&4 C5"1&4 %k6/ $:$-& %& -kC-0/("5*0/ %& -" 53"%6$5*0/ "6 $0634 %626&- 6/ 3*#040.&3&$365&6/".*/0"$:-g5b7C3*'*&-k"11"3*&.&/55g."6/*7&"6%&-k*/5&3"$5*0/$0%0/g "/5*$0/%0/b4:/5)C5*4&-&53"/4'B3&%&-"-*"*40/1&15*%*26&16*43&13&/%6/&$0/'03."5*0/"%"15C&<6/ /067&"6$:$-&(3>$&<-"53"/4-0$"5*0/e &$0%&$06-&6365*-*4C&45-&.D.&26&%"/4-"'*(63&|e . . . . {}.

(43) : +*()) *) #&%(*$*)+( %)%# " $)"G/& 10-:1&15*%*26& /"*44"/5& &.136/5& 6/ 56//&- %& 4035*& 53"7&34"/5 -" %6 +6426k< -" 463'"$&e & 10-:1&15*%& C5"#-*5 %& /0.#3&69 $0/5"$54 "7&$ -& 3*#040.& %"/4 $&55& 3C(*0/b /05"..&/5 "7&$ -&4 3C4*%64 %&4 |b zb } &5 -&4 )C-*$&4|~b~y&5}%&-k3{p *":b{yzyqe "'03.&&5-"$0.104*5*0/%6 56//&- %& 4035*& &9&3$&/5 %&4 $0/53"*/5&4 463 -& 10-:1&15*%& $& 26* */'-6&/$& -& 3&1-*&.&/5 1305C*26& %"/4 -& 3*#040.& &5 '"703*4& %"/4 $&35"*/4 $"4 -" '03."5*0/ %k)C-*$&u%&-"1305C*/&/"*44"/5&p*":b{yyqe k*/5&3"$5*0/ &/53& -&4 %&69 4064g6/*5C4 &45 C("-&.&/5 6/& $"3"$5C3*45*26& *.1035"/5&%&-"'0/$5*0/%&43*#040.&4e&4*/5&3"$5*0/4+06&/56/3L-&*.1035"/5%"/4 -"53"/4-0$"5*0/%&44064g6/*5C4&5-034%63&$365&.&/5%&43*#040.&4463-k.e)&; -" -&763&b*- : "z 10*/54 %& $0/5"$5 &/53& -&4 4064g6/*5C4}y&5y p&/g)&.*":b {yzyqe&410/5440/5'03.C41"3%&4*/5&3"$5*0/41-6406.0*/4'035&4%&5:1&3gb g&53g3e&691305C*/&4%&-" 41C$*'*26&.&/5&6$"3:05&4b {}&5 zb 13C4&/5&/5%&4&95&/4*0/4<-"463'"$&%&-"e k&953C.*5Cg5&3.*/"-&%& {}'03.& 6/$0/5"$5"7&$-"b&5-"-0/(6&)C-*$&u%& z7*&/54&1-"$&3<1309*.*5C%64*5& %& -*"*40/ "6 '"$5&63 %k*/*5*"5*0/ %& -" 53"%6$5*0/ & } p&/g)&. * ":b {yzzqe &4 */5&3"$5*0/4 26* 1&3.&55&/5 6/ -*&/ &/53& %&4 C-C.&/54 C-0*(/C4 %&4 %&69 4064 6/*5C4 +06&/5$&35"*/&.&/56/3L-&'0/$5*0//&-%"/4-"53"%6$5*0/b."*4-&4.C$"/*4.&413C$*4 /&40/51"4&/$03&C-6$*%C4ek"653&410/544*56C4<-k*/5&3'"$&%&4%&694064g6/*5C440/5 6/*7&34&--&.&/5 $0/4&37C4e k&45 /05"..&/5 -& $"4 %& -k)C-*$& %& -k3 { 26* C5"#-*5%&/0.#3&69$0/5"$54"7&$-&463-"&51"35*$*1&"6$0/53L-&%&-"'*%C-*5C %&53"%6$5*0/e & ."/*B3& (-0#"-&b $)"26& C5"1& %& -" 53"%6$5*0/ &/(&/%3& %&4 .0%*'*$"5*0/4 4536$563"-&4 %6 3*#040.&e & 3C4&"6 $0.1-&9& %k*/5&3"$5*0/4 26& '03.&/5 &5 3 1&3.&5-"53"/4.*44*0/%&4*(/"69%k6/4*5&%63*#040.&<6/"653&b$003%0//"/5"*/4* -&4 %*''C3&/54 .067&.&/54 %&4 4064g6/*5C4 3*#040.*26&4b 5 &5 '"$5&634 %& 53"%6$5*0/e kC56%&%&-"4536$563&%&43*#040.&4/&3&/%$0.15&26&%kC5"54'*(C4&5-" $0.13C)&/4*0/ %& -" %:/".*26& %&4 .067&.&/54 &5 3C"33"/(&.&/54 */5&3/&4 "6 3*#040.& 7*&/5 %& -" $0/'30/5"5*0/ %&4 /0.#3&64&4 C56%&4 4536$563"-&4b (C/C5*26&4 &5 #*0$)*.*26&43&-"5"/5-"104*5*0/&5-"3C"$5*7*5C%&4%*''C3&/54C-C.&/54%63*#040.&< %*''C3&/5&4 1)"4&4 %& -" 53"%6$5*0/e &4 .C5)0%&4 1&3.&55"/5 %& .&463&3 -& $0.1035&.&/5 %& .0-C$6-&4 6/*26&4 1"3 %&4 "1130$)&4 %& pl-603&4&/$&. . {~.