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Full factorial design optimization of anti-inflammatory drug release by PCL–PEG–PCL microspheres

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Full factorial design optimization of anti-inflammatory drug release

by PCL–PEG–PCL microspheres

Authors

Farid Dahmoune, Farouk Rezgui, Christian G'Sell

Publication date

2016/1/1

Journal

Materials Science and Engineering: C

Volume 58 Pages 412-419 Publisher Elsevier Description

A biodegradable triblock poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone) copolymer was successfully synthesized by ring-opening polymerization of ε-caprolactone, and was characterized by intrinsic viscosimetry, 1H nuclear magnetic resonance, infrared spectroscopy and X-ray diffraction.

Copolymer microparticles loaded with ibuprofen were prepared by an oil-in-water (o/w) emulsion solvent evaporation process. They were carefully weighted and characterized through their zeta potential. In this work, 4 selected process parameters (shaking speed X1, time of contact X2, poly(vinyl

alcohol) concentration X3, and ibuprofen concentration X4) were adjusted at 2 different values. For

each of the 16 experimental conditions, repeated twice, the drug encapsulation efficiency of the microspheres was determined, according to the following definition: EE (X1, X2, X3, X4) = mass of

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