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CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans

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Academic year: 2021

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Figure

Fig 1. PKHB1 selectively induces cell death in leukemic B cells, including those from patients with dysfunctional TP53
Fig 2. PKHB1 induces calreticulin exposure and caspase-independent PCD in CLL cells. (A) PCD induced by PKHB1 (200 μ M, 2 h) or etoposide (250 μ M, 12 h) was measured in B cells from 30 CLL patients with functional TP53 and 11 CLL patients with dysfunction
Fig 3. PKHB1 generates endoplasmic reticulum stress that provokes Ca 2+ -mediated PCD in the CLL cells
Fig 4. PKHB1 treatment results in sustained Ca 2+ mobilization that induces mitochondrial damage and PCD in CLL cells
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