Prostaglandin D2 (PGD2) signalling and male germ cell : differentiation in the mouse embryonic testis

HAL Id: tel-02926881

https://tel.archives-ouvertes.fr/tel-02926881

Submitted on 1 Sep 2020

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.

L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Prostaglandin D2 (PGD2) signalling and male germ

cell : differentiation in the mouse embryonic testis

Safdar Ali Ujjan

To cite this version:

Safdar Ali Ujjan. Prostaglandin D2 (PGD2) signalling and male germ cell : differentiation in the mouse embryonic testis. Human genetics. Université Montpellier II - Sciences et Techniques du Languedoc, 2014. English. �NNT : 2014MON20099�. �tel-02926881�

Délivré par UNIVERSITE MONTPELLIER 2

Préparée au sein de l’école doctorale

Sciences Chimiques et Biologiques pour la Santé

Et de l’unité de recherche

Institut de Génétique Humaine

(IGH)

Spécialité :

Biologie Cellulaire ET Moléculaire

Présentée par Mr. SAFDAR ALI UJJAN

Soutenue le 15/12/2014 devant le jury composé de

Prof. Philippe Berta Université de Nîmes Président du jury

Dr. Marie-Christine Chaboissier INSERM, Nice Rapportrice

Dr. Corinne Cotinot INRA Jouy-en-Josas Rapportrice

Dr. Eric Pailhoux INRA Jouy-en-Josas Dr. Francis Poulat INSERM, Montpellier

Examinateur Co-directeur de thèse

Dr. Brigitte Boizet-Bonhoure CNRS, Montpellier Directrice de Thèse

! !

!

TITRE DE LA THESE

Prostaglandin D2 (PGD2) Signalling and Male Germ Cell Differentiation in the Mouse Embryonic Testis

!" !"#$%!&$' "

"

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

?%*%" :%" &$.:" )$-)" (/*!,2" %+0*6.,!3" &%'" (%)%*+!,-)!.,<" @*.&)-24-,(!," AB" C@DABE" 7*.(/3%(" 06" %-3$" .5" )$%" ):." %,F6+%&G" H=@2(&" -,(" ?=@2(&" !," &.+-)!3" 3%44&" -,(" 2%*+" 3%44&" .5" )%&)!&" 7-*)!3!7-)%&" !," +-4%" 2%*+" 3%44" (!55%*%,)!-)!.," 7*.2*-+8" @DAB" &!2,-4!,2" &/77.*)&" +!).)!3" -**%&)" 06" -3)!;-)!,2" )$%" %'7*%&&!.," -,(" ,/34%-*" 4.3-4!F-)!.," .5" 3%44" 3634%" !,$!0!).*" @BI3!7I_{" -,(" 06" *%7*%&&!,2"}

74/*!7.)%,36" +-*J%*&" -,(" @DAB" $-&" ,%2-)!;%" %55%3)&" .," !'"()" %'7*%&&!.,8" 9," -((!)!.," @DAB" &/77.*)&" -3)!;-)!.," .5" +-4%" &7%3!5!3" 2%,%" *(+$,-./ ?%,3%" )$%&%" (-)-" &/22%&)" )$-)" @DAB" &!2,-4!,2" )$*./2$" A@B" *%3%7).*" !&" *%1/!*%(" 5.*" 7*.7%*" +-4%"2%*+"3%44"(!55%*%,)!-)!.,8" " " " " " " " " " "

" !!"

KLMNO>HPADPQPN#" "

9" -+" %'7*%&&!,2" +6" 2*-)!)/(%" )." )$%" (!*%3).*" .5" +6" )$%&!&" A*8" R*!2!))%" R.!F%)= R.,$./*%" -,(" 3.=(!*%3).*" .5" +6" )$%&!&" A*8" S*-,3!&" @./4-)" 5.*" -33%7)!,2" +%" !," 6./*"4-0"-,("2/!(!,2"+%").")$!&":.*J8"9"-77*%3!-)%"6./*"J!,("3.=.7%*-)!.,<":$!3$" %,-04%("+%")."3.+74%)%"+6"@$A"(%2*%%8"A*8"R*!2!))%"R.!F%)"9"$-;%",.)"5.*2.))%," )$%"0%2!,,!,2"(-6&".5"+6"@$A":$%,"6./"$%47%("+%"!,"2%))!,2"LTOUV"*%&!(%,3%8" "

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

!!!" ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' (')*)+,-.*'./+0'1234'.2'56'7!5(86999:' " " " " " " " " " " " " " " " "

!

!

!

!

!

$.2,*!&4!)&#$*#$+!

$-;<*'2='&2>.*>.0'

'

'

?-@*'A2:'

'

!;0.3-,.9999999999999999999999999999999999('

'

!,4>21<*)@*B*>.9999999999999999999999999999(('

'

C*)+,-.+2>99999999999999999999999999999999::(((' ' $-;<*'2=',2>.*>.099999999999999999999999999999(D' ' 8+0.'2='=+@E3*0999999999999999999999999999:::::::::::::D(((' ' 8+0.'2='7+@E3*0'2='F-F*3'->)'0EFF<*B*>.-<')-.-99999999999:G' ' 8+0.'2='$-;<*0999999999999999999999999999999:::::G(' ' !;;3*H+-.+2>0'2='@*>*0'->)'.*3B09999999999999999999G((' '

&/-F.*3'I:''

I:I'(>.32)E,.+2>99999999999999999999999999999:I' I:J:'#2B-.+,'#*K'C+==*3*>.+-.+2>99999999999999999999:B' I8B8I8I"V*699999999999999999999999999999::::::::::::::B" I8B8I8B"V*6"P'7*%&&!.,99999999999999999999999999::X" I8B8I8Y"VTZ"K3)!;-)!.,"-,("T%2/4-)!.,9999999999999:::::::::::::::::X" I8B8I8X"V*6"S/,3)!.,999999999999999999999999:::::::::::::["

;" " I:J:J:'#2K'L99999999999999999999999999999999:\' I:J:M:I'"+F2.*>.+-<'?3+B23)+-<'@2>-)'->)'$*0.+0'723B-.+2>' 99999999999999999999999999999999999999:I]' I8B8Y8B"V%*).4!"3%44&"-,("#%&)!&"3.*(&"L.+7-*)+%,)&89999999^^8888II" I8B8Y8Y"#%&)!&"R4..("_-&3/4-)/*%999999999999999999:^^8888IB" I8B8Y8X"H%6(!2"L%44&9999999999999999999999999:^^^8IB" I:M'N*>*0'+>H2<H*)'+>'5-<*'#2B-.+,'&*<<'7-.*'?32@3-B9999:^^^8IX' I8Y8I">#I^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^88IX" I8Y8B"VS=I`NTaKI^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^8Ia" I8Y8Y"KQ?^^^^^^^^^^^^^^^^^^^^^^^^^^^^^8^^^^^8I[" " I:O'N*>*0'+>H2<H*)'+>'7*B-<*'#2B-.+,'&*<<'7-.*'?32@3-B99::

!!!"

!"_' I8X8I"T&7.I^^^^^^^^^^^^^^^^^^^^^^^^^^^^88^88^^^8Ib" I8X8B">,)X^^^^^^^^^^^^^^^^^^^^^^^^^^^^^8^8^^^8Ic" I8X8Y">,)X<"T&7.I"-,(">,)`R=3-)%,!,"&!2,-44!,2^^^^^^^^^88^^^8B]" I8X8X"S.'4B^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^88^^^8BI" I8X8a"A%;%4.7+%,)".5"Q-++-4!-,"O;-*6"-,("V./*3%".5"D*-,/4.&-"L%44&" ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^BX" " I:P'N*>*'!>.-@2>+0B0'23'5+0Q*KF3*00+2>'->)'#*K'%*H*30-<9::^^^B\' ' I:R'N*3B'&*<<'#*K'C+==*3*>.+-.+2>9999999999999999::

!!!

#$

_' I:R:I'732B'#F*,+=+,-.+2>'.2'&2<2>+S-.+2>999999999999:

!!!

#$

_' I:R:J'&/->@*'+>'N*>*.+,'5-,/+>*3T'2>'!33+H-<'+>.2'N*>+.-<'%+)@*0' ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^888^^^8YI" I:R:M'N*3B'&*<<'5-<*'7-.*999999999999999999999

!!!

#%

_' I8[8Y8I"A-F4^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^8^^^8YX" I8[8Y8B"N-,.&Y^^^^^^^^^^^^^^^^^^^^^^^^^^^^88^^^8Ya" I8[8Y8Y"N-,.&B^^^^^^^^^^^^^^^^^^^^^^^^^^^^88^^^8Ya"

I8[8Y8X"_-&-`Q;$^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^8Ya" I8[8Y8a"R-&.,/34!,"B^^^^^^^^^^^^^^^^^^^^^^88^^^^^^8Y[" I8[8Y8["P7!2%,%)!3"T%2/4-)!.,^^^^^^^^^^^^^^^^^^^^^^^88Y[" " " I:U'(BF23.->.'#.*F0'CE3+>@'5-<*'N*3B'&*<<'7-.*'?32@3-B99999Y\' I:U:I'5+.2.+,'!33*0.99999999999999999999999999:::::Y\' I:U:J'5*+20+0'(>/+;+.+2>9999999999999999999999::::::::::X]' " I:U:M'%*@E<-.+2>'2='?<E3+F2.*>,T'CE3+>@'VB;3T2@*>*0+0999999XX' I8\8Y8I"O3)=X^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^XX" I8\8Y8B"V.'B^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^8Xa" I8\8Y8Y"N-,.2^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^8X[" I8\8Y8X"L.+0!,%("-3)!.,".5"O3)X<"V.'B"-,("N-,.2"-,(")$%!*"*.4%"!," " A!55%*%,)!-)!,2"2%*+"3%44&^^^^88^^^^^^^^^^^^^^^^^8X[" " I:U:O'N*3B'&*<<'!F2F.20+0'W?32@3-BB*)'&*<<'C*-./X99999999:Xb' " " I:Y'723B-.+2>'2='N*3B'&*<<'$EB2309999999999999::9999::a]' I:Y:I'&(#'723B-.+2>^^^^^^^^^^^^^^^^^^^^^^^^^^^^8a]' "

I:L'?NCJ'?-./1-T9999999999999999999999999:

aX

'

I:L:I'7-..T'!,+)0'->)'?/20F/2<+F-0*'V>STB*0999999999999:aX' I:L:J'&ZG'V>STB*0'->)'!3-,/+)2>+,'!,+)999999999999999aa' I:L:M'?320.-@<->)+>'723B-.+2>^^^^^^^^^^^^^^^^^^^^^88a\' I:L:O'?320.->2+)'%*,*F.230^^^^^^^^^^^^^^^^^^^^8^^^88ac' I:L:P'8Q?NC#'->)'[Q?NC#\'$12'V>STB*0'(>H2<H*)'+>'?NCJ'723B-.+2>' ^^^^^^^^^^^^^^^^^^^88^^^^^^^^^^^^^^^^^^^^8ac' I8c8a8I"H=@DAV^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^88[]" I8c8a8B"?=@DAV^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^88[I" I:I]'?320.-@<->)+>'CJ'W?NCJX'->)'+.0'C+==*3*>.'%2<*09999999::[I'

;!!" " "

I:II'?NCJ'->)'VB;3T2>+,'C*H*<2FB*>.\'+>,<E)+>@'&2>.3+;E.+2>''

2='BT'N32EF9999999:::99999999999:999999:

[X

'

I:II:I'?NCJ'#+@>-<<+>@'->)'B-+>.*>->,*'2='./*'#2KL'*KF3*00+2>'-=.*3'' )21>'3*@E<-.+2>''2=''''''#3T'VKF3*00+2>99999:99:999999:[X' I:II:J ?NCJ'0+@>-<<+>@'->)'0E;,*<<E<-3'<2,-<+S-.+2>'2='#2KL'*KF3*00+2>

'

99999999999999999999999999999999::

[a

'

I:IJ'Z;^*,.+H*'2='./+0'_2349999999999999999999999:9[b'

'

&/-F.*3'J:'%*0E<.09999999999999999999999999:

\]

'

J:I (>.32)E,.+2>^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^8\]' J:J Q-,/&3*!7)^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^\B' J:M N*>*3-<')+0,E00+2>^^^^^^^^^^^^^^^^^^^^^^^^^^88I]]' B8X ?*30F*,.+H*099999999999999999999999999999::I]X" J:P "@/04!3-)!.,"B"^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^8I]['

'

%*=*3*>,*0

^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^888II\" ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' "

8(#$'Z7'7(N`%V#' " 7+@E3*'I:'O;%*;!%:".5"&%'"(%)%*+!,-)!.,"!,"+!3%^^^^^^^^88^^^^^^^^]Y" ' 7+@E3*'J:'?/+-,"T=&7.,(!,"7*.)%!,&8"^^^^^^^^^^^^^^^^^^88^^^^I\" " 7+@E3*'M:'S.44!3/4-*"(%;%4.7+%,)"!,"+-++-4!-,".;-*6^^^^^^^^^^^^^BY' ' 7+@E3*' O:'#$%"+./&%")%&)!&="-,(".;-*6=(%)%*+!,!,2"7-)$:-6&"-,(")$%!*"+/)/-4" -,)-2.,!&+8"^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^B[" "

7+@E3*' P:'Q./&%" @DL" .,).2%,68" A%;%4.7+%,)-4" )!+!,2" .5" @DL" &7%3!5!3-)!.,<" +!2*-)!.,<" 7*.4!5%*-)!.,<"-7.7).&!&<"3.4.,!F-)!.,".5")$%"2%,!)-4"*!(2%&<"2%,%)!3"*%7*.2*-++!,2<"d= 3$*.+.&.+%"-3)!;!)6"-,("&%'/-4"(!55%*%,)!-)!.,888888888888888888888888888888888888888888888888888888888888Bc" "

7+@E3*' R:'A!55%*%,)" 7$-&%&" .5" 3%44" 3634%" -,(" 3.**%&7.,(!,2" L634!,&<" LAM&" -,(" )$%!*"!,$!0!).*"7*.)%!,&^^^^8^^^^^^^^^^^^^^^^^^^^^88Yb"

'

7+@E3*' U:' #%+7.*-4" %'7*%&&!.," .5" 74/*!7.)%,36" 3.*%" 2%,%&" (/*!,2" +./&%" %+0*6.,!3"(%;%4.7+%,)^^^^^^^^^^^8^^^^^^^^^^^8^^88XY"

'

7+@E3*'Y:'A%;%4.7+%,)-4".*!2!,".5"$/+-,")67%"99"#DL#^88^^^^^^^^^8^^88aI" '

7+@E3*' L:' #$%" 7*.&)-,.!(" 0!.&6,)$%&!&" 7-)$:-68" LOd<" 3634..'62%,-&%e" @DPV<" 7*.&)-24-,(!," P" &6,)$-&%e" @DAV<" 7*.&)-24-,(!," A" &6,)$-&%e" @DSV<" 7*.&)-24-,(!," S" &6,)$-&%e"@D9V<"7*.&)-3634!,"&6,)$-&%e"#dV<")$*.+0.'-,%"&6,)$-&%8888888888888888888888888888a["

'

7+@E3*' I]:'@*.&)-,.!(&" -,(" )$%!*" *%3%7).*&" -,(" )!&&/%&" .*" 3%44/4-*" 7*.3%&&%&" !," :$!3$")$%6"-*%"!,;.4;%(^^^^^^^^^^^^^^^^8^^^^^^^^^ab" '

7+@E3*'II:'Q-!,)%,-,3%".5"V.'c"%'7*%&&!.,"06"@.&!)!;%"5%%(0-3J"4..7&^^^8^[Y" "

7+@E3*' IJ:'Q.(%4"5.*")$%"*%2/4-)!.,".5"VOdc"36).74-&+!3"*%)%,)!.,"-,(",/34%-*" 4.3-4!F-)!.,")$*./2$"-3)!;-)!.,".5"@DAB`@MK"7-)$:-6^^^^8^^^^[["

!'" ""

7+@E3*' IM:' T.4%" .5" @DAB" !," 3.,)*.4" .5" +-4%" 2%*+" 3%44" 7*.4!5%*-)!.," -,(" (!55%*%,)!-)!.,"!,"%+0*6.,!3"+./&%")%&)!&^^^^^^^^^^^^^^I]X' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' ' '

8+0.'2='7+@E3*0'2='?-F*3'->)'#EFF<*B*>.-<'C-.-' '

7+@E3*' I:" @DAB" &!2,-4!,2" 3.,)*.4&" )$%" 2%*+4!,%" 7*.4!5%*-)!.," !," )$%" %+0*6.,!3" )%&)!&^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^8\X" "

7+@E3*' J:' @DAB" *%2/4-)%&" )$%" 3%44" 3634%" 7BIL!7I_{" !,$!0!).*" ).:-*(&" )$%" +!).)!3"}

-**%&)^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^\[" " 7+@E3*'M:'@DAB"*%2/4-)%&")$%"%'7*%&&!.,".5"74/*!7.)%,36^^^^^^^^^^^88\\" " 7+@E3*'O:'@DAB"3.,)*!0/)%&").")$%"+-4%"2%*+"3%44"(!55%*%,)!-)!.,^^^^^^^\b" " 7+@E3*'P:'#$%"@DAB"*%3%7).*"!&"%'7*%&&%("!,")$%"+-4%"2%*+4!,%"-,("5/,3)!.,&")." 3.,)*.4"7*.4!5%*-)!.,"-,("(!55%*%,)!-)!.,".5")$%"2%*+4!,%^^^^^^8\c" ' 7+@E3*'#I:'V.+-)!3"3%44&"(!55%*%,)!-)%",.*+-446"!,"+-4%"0123456,=`="2.,-(&^cI" " 7+@E3*'#J:'V.+-)!3"-,("2%*+"3%44&"7$%,.)67%"!&",.*+-4"!,"03456,313/-,("" 23456,313/2.,-(&8"^^^^^^^^^^^^^^^^^^^^^^^^^^8cB" " 7+@E3*'#M:'@*.4!5%*-)!.,".5"&.+-)!3"3%44&"!&",.)"-55%3)%("!,"0123456,313/-,("" 78-313/2.,-(&8"^^^^^^^^^^^^^^^^^^^^^^^^^^^^cY" " 7+@E3*'#O:'@DAB"&!2,-4!,2"*%2/4-)%&"2%*+"3%44=&7%3!5!3"-,("3%44"3634%"2%,%&^cX" 7+@E3*:'#P:'@4/*!7.)%,)"+-*J%*&"-*%"%'7*%&&%("!,")$%",/34%/&".5")$%"2%*+4!,%"!," 0123456,313/-&"!,">#"2.,-(&8"^^^^^^^^^^^^^^^^^^^^^ca" ' 7+@E3*:'#R:'K(+!,!&)*-)!.,".5")$%"A@B"-,)-2.,!&)"LKZI]X\I"+!+!3J%(")$%"4.&&".5" @DAB"&!2,-44!,2"-)"PIY8a"^^^^^^^^^^^^^^^^^^^^^^^c[' ' 7+@E3*:'%H1'I:'@-)$:-6".5"7*.&)-,.!("0!.&6,)$%&!&"-,("&!2,-4!,28"^^^^^8I]b" ' 7+@E3*:'%H1'J:'Q.(%4"5.*")$%"*.4%".5"@DAB"&!2,-4!,2"!,"V%*).4!"3%44"-,("2%*+"3%44" (!55%*%,)!-)!.,"!,")$%"+-4%"%+0*6.,!3"2.,-(8"^^^^^^^^8III' '

'!" "" 8+0.'2='$-;<*0' ' $-;<*' I:' L%44" 3634%" -,(" 3%44" 7*.4!5%*-)!.," 2%,%&" /7=" -,(" (.:,*%2/4-)%(" !," IY8a(73"H`?=@2(&"+/)-,)"*%4-)!;%").":!4(=)67%")%&)%&8"^^^8^^8'\a' ' $-;<*' J:' D%*+"3%44&"-,("74/*!7.)%,36"2%,%&"/7="-,("(.:,*%2/4-)%("!,' IY8a(73" H`?=@2(&"+/)-,)"*%4-)!;%").":!4(=)67%")%&)%&8"^^^^^^^^88^^88\a" ' $-;<*'#I:'D%,%&"(!55%*%,)!-446"%'7*%&&%("!,"+/)-,)"3.+7-*%(").":!4(")67%"PIY8a" )%&)%&8"H!,J"5.*".,4!,%"%'3%4")-04%8" C$))7G``:::80!.4.2!&)&83.+`AP_fQ.;!%&`AP_I]YX]b`AP_I]YX]b#-04%VI8'4&E" " $-;<*'#J:'K,)!0.(!%&"/&%("!,"9++/,.54/.*%&3%,3%"-,(">%&)%*,"04.))!,28'9:8c\' ' $-;<*'#M:'O4!2.,/34%.)!(%&"/&%("5.*"1@LT."^^^^^^^^^^^^^^^^^^^cb' ' ' ' ' '

'

'

'

'

'

'

'

'

'

'

'

!;;3*H+-.+2>0'

' ' #3Ta#%6' ' #*KQ)*.*3B+>+>@'3*@+2>'6' #7QI' ' ' #.*32+)2@*>+,'=-,.23'I' A%P!I' ' AE,<*-3'%*,*F.23'#E;=-B+<TP'N32EF'!'5*B;*3I' _$I' ' ' _+<B0b'.EB2E3'I' #2KLa#ZGL' ' #3T';2KQ,2>.-+>+>@'@*>*'L' !5[' ' ' !>.+Q5E<<*3+->'/23B2>*' 5([' ' ' 5E<<*3+->Q+>/+;+.+>@'/23B2>*' 5+0' ' ' 5E<<*3+->'+>/+;+.+>@'0E;0.->,*' 5(7' ' ' 5E<<*3+->'+>/+;+.+>@'=-,.23' ?NCJ' ' ' ?320.-@<->)+>'CJ' A3];I'' ' AE,<*-3'3*,*F.23'0E;=-B+<T']\'@32EF'"\'B*B;*3'I' C-KI' C20-@*Q0*>0+.+H*'0*K'3*H*30-<\'-)3*>-<'/TF2F<-0+-',3+.+,-<' 3*@+2>\'2>',/32B202B*'G\'@*>*'I' C5%$I' ' C2E;<*0*K'->)'B-;QMQ3*<-.*)'.3->0,3+F.+2>'=-,.23'I' 7N7L' ' ' 7+;32;<-0.'@321./'=-,.23'L' 7ZNJ' ' ' c73+*>)'2='N-.-Ib'.TF*'J' 7ZG8J' ' 7234/*-)';2K'8J' N!$!O' ' N!$!Q;+>)+>@'F32.*+>'O' %#?ZI' ' %Q0F2>)+>'/2B2<2@E*'I' _A$O'' ' _+>@<*00Q3*<-.*)'55$D'+>.*@3-.+2>'0+.*'O' A[%I' ' ' AE,<*-3'/23B2>*'3*,*F.23' C//' ' ' C*0*3.'[*)@*/2@' N-))OPN' ' N321./'-33*0.'->)'CA!')-B-@*Q+>)E,+;<*'@-BB-'@*>*' #+KI' ' ' #(G'/2B*2;2K'I' dB^)I-' ' dEB2>^+')2B-+>Q,2>.-+>+>@'F32.*+>'I!' 8/KL' ' ' 8+B'/2B*2;2K'F32.*+>'L' eC5M!' ' <T0+>*'WeXQ0F*,+=+,')*B*./T<-0*'M!' C#C' ' ' C+023)*30'2='0*K')*H*<2FB*>.'' #ZG' ' ' #%6Q3*<-.*)'[5N';2K' [5N' ' ' [+@/'B2;+<+.T'@32EF''

'!!!" " A8#' ' ' AE,<*-3'<2,-<+S-.+2>'0+@>-<' ,-5' ' ' &-<B2)E<+>' )F,' ' ' C-T0'F20.',2+.EB' #?I' ' ' #F*,+=+,+.T'F32.*+>I' ,!5?' ' ' &T,<+,'-)*>20+>*'B2>2F/20F/-.*' ?e!' ' ' ?32.*+>'4+>-0*'!' 5!?e'' ' 5+.2@*>Q-,.+H-.*)'F32.*+>'4+>-0*' "R' ' ' &PU"8aRd' &C' ' ' &-BF2B*<+,')T0F<-0+-' Z)0' ' ' Z))'0*K' $V#&Z'' ' $*0.+0'0F*,+=+,'*>/->,*3'2='#2KL',23*'*<*B*>.' $V#' ' ' $*0.+0'0F*,+=+,'*>/->,*3'2='#2KL' 8Q?@)0' ' 8+F2,-<+>Q.TF*'F320.-@<->)+>'C'0T>./-0*' [Q?@)0' ' /*B-.2F2+*.+,'Q.TF*'F320.-@<->)+>'C'0T>./-0*' &[(?' ' ' &/32B-.+>'+BBE>2F3*,+F+.-.+2>' ?CN7' ' ' ?<-.*<*.')*3+H*)'@321./'=-,.23' 8[' ' ' 8E.*+>+S+>@'/23B2>*' ?-.,/I' ' ?-.,/*)'/2B2<2@'I' (A8#M' ' ' (>0E<+>Q<+4*'@321./'=-,.23'M' CC#' ' ' C*>T0QC3-0/'0T>)32B*' e$#' ' ' eQ<T0+>*\'$Q.T320+>*\'#Q0*3+>*' 7$fQ7I' ' 7E0/+Q.-3-SE'=-,.23'I' ?5C#' ' ' ?*30+0.*>.'5E<<*3+->'CE,.'#T>)32B*' $#?I' ' ' $/32B;20F2>)+>'.TF*I'F32.*+>' &$AA"' ' g'Q,-.*>+>' "?V#' '"<*F/-32F/+B20+0aF.20+0a*F+,->./E0'+>H*30E0'0T>)32B*' 70.' 72<<+0.-.+>' C##' C20-@*'0*>0+.+H*'0*K'3*H*30-<' ?N&0' ?3+B23)+-<'@*3B',*<<0' "<+BFI' "Q<TBF/2,T.*'+>)E,*)'B-.E3-.+2>'F32.*+>I' $N7Q"' $3->0=23B+>@'@321./'=-,.23Qg' "5?0' "2>*'B23F/2@*>*.+,'F32.*+>0' #5!C' C3202F/+<-'52./*30'-@-+>0.')*,-F*>.-F<*@+,'

e8' e+.'<+@->)' #&7' #.*B',*<<'=-,.23' &Qe($' &T.24+>*'e+.'<+@->)\'?32.2QZ>,2@*>*'?32.*+>'W%*,*F.23'' =23'#&7X' 5N7' 5-0.',*<<'@321./'=-,.23' ?V&!5QI' ?<-.*<*.'*>)2./*<+-<',*<<'-)/*0+2>'B2<*,E<*QI' $>-F' $+00E*'>2>Q0F*,+=+,'-<4-<+>*'F/20F/-.*' ##V!I' #.-@*'#F*,+=+,'VB;3T2>+,'!>.+@*>QI' N,>-I' N*3B',*<<'>E,<*-3'->.+@*>'I' C-S<' C*<*.*)'+>'-S220F*3B+-'<+4*' N,<' N*3B',*<<Q<*00' V%%Q"' V0.32@*>'3*<-.*)'3*,*F.23Qg' 5H/' 52E0*'H-0-'/2B2<2@' A->20JaM' A->20'/2B2<2@'JaM' %!' %*.+>2+,'-,+)' !<)/' !<)*/T)*')*/T)32@*>-0*'W*>STB*0'=-B+<TX' #.3-Y' #.+BE<-.*)';T'%*.+>2+,'!,+)'@*>*'Y' D!C' D+.-B+>'!')*=+,+*>.' #T,FM' 0T>-F.2>*B-<',2BF<*K'F32.*+>'M' CB,I' CA!'B*+2.+,'3*,2B;+>-0*'I' Z,.O' Z,.-B*3Q;+>)+>@'.3->0,3+F.+2>'=-,.23'O' ?2EP=I' ?Z`',<-00'P'/2B*2;2K'I' &6?JR"I' &T.2,/32B*'?OP]\'=-B+<T'JR\'0E;=-B+<T'"\'F2<TF*F.+)*'I' $`AV8' $*3B+>-<')*2KT>E,<*2.+)T<'.3->0=*3-0*'W$)$X')`$?'A+,4Q V>)'8-;*<+>@' VN' VB;3T2>+,'@*3B',*<<0' V#&0' VB;3T2>+,'0.*B',*<<0' C>B.' CA!'B*./T<.3->=*3-0*' &Ce' &T,<+>Q)*F*>)*>.'4+>-0*' %"' %*.+>2;<-0.2B-' &)4>I;' &T,<+>')*F*>)*>.'4+>-0*'+>/+;+.23'I"' CACI' C*-)'*>)'/2B2<2@I' (&5' (>>*3',*<<'B-00'

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eC-' e+<2'C-<.2>0' &%$[J' &/*B2-..3-,.->.'%*,*F.23Q/2B2<2@2E0'B2<*,E<*' *KF3*00*)'2>'$/J',*<<0' 70/%' 72<<+,<*'0.+BE<-.+>@'/23B2>*'3*,*F.23' 8/%' 8E.*+>+S+>@'/23B2>*' (BFQ"' (BF23.+>Qg' C)KO' CV!C'W!0FQN<EQ!<-Q!0FX';2K'F2<TF*F.+)*'O' V)`' ' ' PQ*./T>T<QJhQ)*2KTE3+)+>*' F[M' ' ' F/20F/2Q[+0.2>*'[M' 5T;<I'' ' 5T*<2;<-0.20+0'H+3-<'2>,2@*>*'/2B2<2@Q<+4*'I' V3;;O'' ' V3T./32;<-0.+,'<*E4*B+-'H+3-<'2>,2@*>*'/2B2<2@'O'

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

!

!

!

!

!

!

"#$%&'()$"&#!

!

!

!

!

!

!

" I"

&/-F.*3'I:'

I:I:'(>.32)E,.+2>

" " #$%" 4!5%" .5" +/4)!3%44/4-*" .*2-,!&+" &)-*)&" 5*.+" -" (!74.!(" 3%44<" )$%" 5%*)!4!F%(" %22" 3-44%(" F62.)%8" 9)" !&" 5.*+%(" 06" )$%" 5/&!.," .5" ):." $-74.!(" 3%44&<" )$%" ..36)%" -,(" &7%*+-).F.-<" -4&." 3-44%(" 2-+%)%&8" g62.)%" 7-&&%&" )$*./2$" -" &%*!%&" .5" 3$-,2%&" )." (%;%4.7"!,)."-,"-(/4)8"9,"0!=&%'/-4".*2-,!&+&"%-3$"!,(!;!(/-4".*2-,!&+"!&"%!)$%*" +-4%" .*" 5%+-4%" -,(" /7.," +-)/*!)6" :!44" 7*.(/3%" 2-+%)%&<" &7%*+-).F.-" -,(" ..36)%&"*%&7%3)!;%468"9,"+-++-4&"%;%*6"!,(!;!(/-4".*2-,!&+"!,$%*!)&"-,"d".*"-"Z" &%'"3$*.+.&.+%"5*.+"5-)$%*"-,("-,"d"&%'"3$*.+.&.+%"5*.+"+.)$%*8"9,")$!&":-6" -,"%+0*6.")$-)"!,$%*!)&"dZ"&%'"3$*.+.&.+%&":!44"(%;%4.7"-&"-"+-4%":$%*%-&"-," %+0*6." :!)$" dd" &%'" 3$*.+.&.+%&" :!44" (%;%4.7" -&" -" 5%+-4%8" Q-4%" -,(" 5%+-4%" 2-+%)%&" 3-**6" 2%,%)!3" !,5.*+-)!.," )$-)" !&" %'7*%&&%(" (/*!,2" )$%" 4!5%" .5" -," .*2-,!&+"-,("!&")*-,&+!))%("5*.+"2%,%*-)!.,")."2%,%*-)!.,8""

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a(73" -,(" IB8a(73" !," +!3%" -,(" 0%):%%," [=b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

" B" I:J:'#2B-.+,'#*K'C*.*3B+>-.+2>

'

"

I:J:I:I:'#%6'

V*6" C&%'" (%)%*+!,!,2" *%2!.," .," Z" 3$*.+.&.+%E" !&" )$%" 5!*&)" +%+0%*" .5" )$%" VOd" CVTZ=*%4-)%("?QD"0.'E"5-+!46<"-"5-+!46".5")*-,&3*!7)!.,"5-3).*&"5./,(")$*./2$./)" )$%" -,!+-4" J!,2(.+8" VOd" 5-+!46" !&" 3$-*-3)%*!F%(" 06" )$%" 7*%&%,3%" .5" -" ANK= 0!,(!,2" $!2$" +.0!4!)6" 2*./7" C?QDE" (.+-!,8" #$%&%" VOd" 7*.)%!,&" 74-6" -" 3%,)*-4" *.4%" !," +-,6" 7*.3%&&%&" !,34/(!,2" %+0*6.2%,%&!&" -,(" (%;%4.7+%,)" .5" .*2-,&" CR.:4%&"%)"-48<"B]]]E8"#$%"?QD"(.+-!,"!&"$!2$46"3.,&%*;%("-+.,2"&7%3!%&"-,("!&" )$%" &!)%" .5" -4+.&)" -44" +!&&%,&%" +/)-)!.,&8" #$!&" (.+-!," -4&." 7*.;!(%&" ,/34%-*" !+7.*)"-,("ANK"0%,(!,2"C?-*4%6"%)"-48<"B]]YE8"#$%"?QD"(.+-!,"+%(!-)%&"ANK= 0!,(!,2" .5" VTZ" -,(" VOd" 7*.)%!,&" )." *%2/4-)%" )-*2%)" 2%,%&" CR%*2&)*.+" %)" -48<" B]]]E8"#$%"?QD"(.+-!,"!&"3*/3!-4"5.*")$%"5/,3)!.,".5"VTZ"-,("VOdc<"-&"!,"$/+-," dZ" 5%+-4%&h" +/)-)!.,&" -*%" 5./,(" %&&%,)!-446" !," )$!&" (.+-!," C?-*4%6" -,(" D..(5%44.:<" IccXE8" VTZ" !&" -" ,/34%-*" 7*.)%!," -,(" ):." ,/34%-*" 4.3-4!F-)!.," &!2,-4" CNHVE" +.)!5&" -*%" 4.3-)%(" .," !)&" ?QD" (.+-!," )$-)" 3-," !,(%7%,(%,)46" (!*%3)" )$%" !+7.*)" .5" 7*.)%!,&" !," )." ,/34%/&8" #$%&%" NHV" +.)!5&" 4!%" -)" %-3$" %,(" .5" ?QD" (.+-!,<"CN"-,("L")%*+!,!E"C@./4-)"%)"-48<"Iccae"V/(0%3J"-,("V3$%*%*<"Icc\E8"#$%" N=)%*+!,-4<" -" 0!7-*)!)%" NHV" !,)%*-3)&" :!)$" 3-4+.(/4!," C3-QEC?-,.;%*" %)" -48<" B]]cE" :$!4%" L=)%*+!,-4" NHV" !,)%*-3)&" :!)$" !+7.*)!,=i" C,/34%-*" !+7.*)" 5-3).*E" CS.*:..("%)"-48<"B]]IE"-,("&/77.*)"!,"4.3-4!F-)!.,".5"VTZ"7*.)%!,"!,")$%",/34%/&" .5" @*%=V%*).4!" 3%44&" C?-,4%6" %)" -48<" B]]]E8" K)" )$%" L=)%*+!,-4" %,(<" +./&%" VTZ" 7*.)%!,"$-&"-"24/)-+!,%"*!3$"*%2!.,"%')%,(%("$-45".5")$%"7*.)%!,8"#$!&"24/)-+!,%" *!3$"(.+-!,"$-&"!+7.*)-,)"*.4%"!,"+./&%"+-4%"&%'"(%)%*+!,-)!.,<"-&"dd"%+0*6." )*-,&2%,!3" .5" !"#" 3.,&)*/3)" )$-)" %,3.(%" 7*.)%!,&" 4-3J!,2" )$%" 24/)-+!,%" *!3$" *%2!.,":%*%"/,-04%")."%55%3)"+-4%"&%'"(%)%*+!,-)!.,"CR.:4%&"%)"-48<"IcccE8" " " " " " " "

" Y"

' '

7+@E3*'I:'ZH*3H+*1'2='0*K')*.*3B+>-.+2>'+>'B+,*:""

L$*.,.4.2!3-4" 54.:" .5" %-*46" +./&%" &%'" (!55%*%,)!-)!.,e" )$%" 2*%6" -*%-" !,(!3-)%&" )$%" 7%*!.(" .5" &%'" (%)%*+!,-)!.,8"A/*!,2"+./&%"%+0*6.2%,%&!&<"0!=7.)%,)!-4"2.,-(&"C6%44.:E"-*!&%"5*.+")$%"2%,!)-4" *!(2%&" 06" I]8a(738" 9," &.+-)!3" 3%44&" .5" dZ" 2%,!)-4" *!(2%&<" !"#" %'7*%&&!.," C&$.:," !," (-*J" 04/%" 0%,%-)$")$%"&3$%+-)!3E"&)-*)&"-)"I]8a(73<"*%-3$%&"-"7%-J"-)"II8a(73"-,(")$%,":-,%&"06"IB8a"(738" K"5%:"$./*&"4-)%*<"!$%&"%'7*%&&!.,"C&$.:,"!,"4!2$)"04/%"0%,%-)$")$%"&3$%+-)!3E"!&"/7*%2/4-)%(")." !,(/3%" (!55%*%,)!-)!.," .5" V%*).4!" 3%44&8" !$%&" %'7*%&&!.," 7%-J&" -)" II8a=IB8a" (73<" 3.,)!,/%&" )." 0%" %'7*%&&%("7.&),-)-446"-,("!&"&/77.*)%("06"&%;%*-4"7.&!)!;%=5%%(0-3J"4..7&"C!,34/(!,2"SDSc"-,(" 7*.&)-24-,(!,"ABE<"-,("VOdc"&/0&%1/%,)46"-3)!;-)%&"+-,6"+-4%=&7%3!5!3"2%,%&<"!,34/(!,2"9:;8"K)" IB8a" (73<" )%&)!&" 3.*(&" $-;%" 5.*+%(<" -,(" +.*7$.4.2!3-4" (!55%*%,3%&" 0%):%%," )%&)!&" C04/%E" -,(" .;-*6" C7!,JE" -*%" %;!(%,)8" 9," )$%" -0&%,3%" .5" VTZ<" 2%,%&" )$-)" -*%" -4*%-(6" %'7*%&&%(" !," /,(!55%*%,)!-)%(" 2.,-(&" .5" 0.)$" &%'%&" &/3$" -&" <+'=/-,(/>,8$?" CL$-&&.)" %)" -48<" B]IBE" -,(" @$%A-" -*%"%'7*%&&%("!,"-"5%+-4%=&7%3!5!3"+-,,%*"-,("!,(/3%".;-*!-,"(%;%4.7+%,)<"-&"3$-*-3)%*!F%("06" )$%" %'7*%&&!.," .5" 5.44!&)-)!," -,(" +-,6" .)$%*" .;-*6=&7%3!5!3" 2%,%&8" !;;3*H+-.+2>0i" 9:;<" -,)!= Qj44%*!-,"$.*+.,%e"(73<"(-6&"7.&)"3.!)/+e"SDSc<"5!0*.04-&)"2*.:)$"5-3).*"ce"SOdHB<"5.*J$%-("0.'" HBe" @DAB<" 7*.&)-24-,(!," ABe" TV@OI<" T=&7.,(!," Ie" VOdc<" VTZ" 0.'" 3.,)-!,!,2" 2%,%" ce" VTZ<" &%'= (%)%*+!,!,2" *%2!.," .," )$%" 3$*.+.&.+%" Ze" >N#X<" :!,24%&&=)67%" QQ#_" !,)%2*-)!.," &!)%" 5-+!46<" +%+0%*"X"CM-&$!+-(-"-,("M..7+-,<"B]I]E8'

' '

" X" I:J:I:J'!"#'VKF3*00+2>'

"

P'7*%&&!.," .5" !"#" %!)$%*" 5*.+" Z" 3$*.+.&.+%" .*" 5*.+" %3).7!3" )*-,&2%,%" (!*%3)&" )%&)!&"5.*+-)!.,"5*.+"*/(!+%,)-*6"2.,-(8"!"#"!&"3.,&!(%*%("-&"-"2%,%)!3"&:!)3$")." (%)%*+!,%")$%"5-)%".5")$%"0!7.)%,)!-4"2.,-(G")$%"!,)*.(/3)!.,".5"!"#"!,"dd"+./&%" %+0*6."!&"&/55!3!%,)")."!,(/3%")%&)!&"(!55%*%,)!-)!.,"CM..7+-,"%)"-48<"IccIE8"" 9," +!3%" !"#" !&" %'7*%&&%(" !," &.+-)!3" 3%44&" .5" dZ" 2%,!)-4" *!(2%&" C7*%=V%*).4!" -,(" V%*).4!" 3%44&E" 5.*" -" &$.*)" )!+%" :!,(.:" 5!*&)" (%)%3)-04%" -)" I]8a(73" C(-6&" 7.&)" 3.!)/+E<" *%-3$%&" )." 7%-J" -)" II8a(73" -,(" (%34!,%&" /7" )." IB8a(73" C?-3J%*" %)" -48<" Iccae" M..7+-," %)" -48<" Icc]E8" #$%" %'7*%&&!.," .5" !"#" !,!)!-)%&" !," )$%" 3%,)*%" .5" +./&%"2%,!)-4"*!(2%")$%,"%')%,(&")."0.)$"7.4%&".;%*"&%;%*-4"$./*&"CR/44%W.&"-,(" M..7+-,<"B]]IE8"A/*-)!.,".5"!"#"%'7*%&&!.,";-*!%&"0%):%%,"&7%3!%&<"-&"!,"2.-)&" -,(" $/+-,&" !>B" 2%,%" %'7*%&&!.," 3.,)!,/%&" (/*!,2" 2%&)-)!.,-4" 7%*!.(" -,(" !&" %;%," .0&%*;%(" -5)%*" 0!*)$" C?-,4%6" %)" -48<" B]]]e" @-,,%)!%*" %)" -48<" B]][E8" #$%" %'7*%&&!.," .5" !"#" 4%-(&" )." )$%" /7=*%2/4-)!.," .5" !$%&<" -" )*-,&3*!7)!.," 5-3).*" )$-)" 7*.+.)%&")%&)!&"(!55%*%,)!-)!.,"!,"dZ"0!7.)%,)!-4"2.,-(&"CV%J!(."%)"-48<"B]]XE8"#$%" .;%*;!%:" .5" !"#" %'7*%&&!.," -,(" &%'" (%)%*+!,-)!.," !," +!3%" !&" &$.:," !," S!28" I" CM-&$!+-(-"-,("M..7+-,<"B]I]E8" " ' I:J:I:M'!"#'!,.+H-.+2>'->)'%*@E<-.+2>' " 9,")$%"/,(!55%*%,)!-)%("2.,-(<"!"#"2%,%"!&"-3)!;-)%("06"&)%*.!(.2%,!3"5-3).*"I"CVS= IE<" -" 3.+7.,%,)" .5" )$%" ,/34%-*" *%3%7).*&" 5-+!46" )$-)" 0!,(&" &7%3!5!3-446" )." )$%" N?TI"C,/34%-*"$.*+.,%"*%3%7).*E"&!)%"CV%J!(."-,("H.;%44=R-(2%<"B]]bE8"?/+-," !>B" 7*.+.)%*" $-&" ):." V@I" C&7%3!5!3!)6" 7*.)%!,I=)*-,&3*!7)!.," 5-3).*E" 0!,(!,2" &!)%&" )$-)" *%2/4-)%" !>B" %'7*%&&!.," CA%&34.F%-/'" %)" -48<" IccbE8" ?/+-," VTZ" 7*.+.)%*"*%&7.,(&")."3KQ@"(%7%,(-,)"@MK"7$.&7$.*64-)!.,")$*./2$"VS=I"-,(" V7I" &!)%&8" Q/)-)!.," .5" N?TI" &!)%" *%(/3%&" 7*.+.)%*" -3)!;!)6" 06" \]k" $.:%;%*" -((!)!.,-4" +/)-)!.," .5" V7I" &!)%&" *%(/3%&" 7*.+.)%*" -3)!;!)6" 06" ,%-*46" c]k<" !,(!3-)!,2" )$-)" 7*.'!+-4" N?TI" -,(" V7I" &!)%&" -*%" %&&%,)!-4" 5.*" )*-,&3*!7)!.,-4" -3)!;!)6".5"$/+-,"!>B"2%,%"C(%"V-,)-"R-*0-*-"%)"-48<"B]]IE8""

" a"

$.+.4.2E"-&"!,"<'?/CDEF!G=,/44"+./&%"dZ"2.,-(&"VTZ"7*.)%!,"4%;%4"&!2,!5!3-,)46" (%3*%-&%(" 7%*" 3%44" -&" :%44" -&" ,/+0%*" .5" VTZ" %'7*%&&!,2" 3%44&" *%(/3%(" (/%" )." (%3*%-&%" !," 7*.4!5%*-)!.," .5" 3.%4.+!3" %7!)$%4!-4" 3%44&" 06" II8a(738" 9," -((!)!.," V%*).4!"3%44"(!55%*%,)!-)!.,":-&"04.3J%("!,"dZ"<'?/CDEF!G=,/44"+./&%"2.,-(&"(/%" )."4.&&".5"!$%&"-,("@5H&"%'7*%&&!.,8"?.:%;%*"!,"I%/JKJ$/2.,-("3/4)/*%&"-((!)!.," .5" *%3.+0!,-,)" S25c" *%&3/%(" )$%" +/)-,)" 7$%,.)67%" 06" %,$-,3!,2" V%*).4!" 3%44" (!55%*%,)!-)!.,"CR*-(5.*("%)"-48<"B]]cE8" #$%"7.463.+7"2*./7"7*.)%!,"LRdB"C3$*.+.0.'"$.+.4.2"Be"-4&."J,.:,"QYYE"!&" !,;.4;%(" !," )$%" *%2/4-)!.," .5" !"#" 2%,%" %'7*%&&!.," -,(" )%&)!&" (!55%*%,)!-)!.,8" 9," LM%-313_{" MO" 2.,-(&" )$%" %'7*%&&!.," .5" !"#<" !$%&" -,(" .)$%*" +-4%" 5-)%" 2%,%&" :-&"} -55%3)%(8" >$%," LM%-" MO" +!3%" :%*%" 3*.&&%(" :!)$" )*-,&2%,!3" +!3%" (!&74-6!,2" 5.*3%("%'7*%&&!.,".5"!"#".*"!$%&<":$!3$"*%&3/%("+-4%")."5%+-4%"&%'"*%;%*&-4"0/)" )%&)!&"*%+-!,%("$67.74-&)!3<"!,(!3-)!,2")$-)")$%"&!F%"-,(")$%"&%'".5")$%"2.,-("-*%" (%)%*+!,%("06"(!55%*%,)"&%)&".5"LRdB")-*2%)"2%,%&"CM-).$=S/J/!"%)"-48<"B]IBE8" DK#KX" -,(" !)&" 3.=5-3).*" SODB" -*%" *%1/!*%(" 5.*" *%2/4-)!.," .5" !"#" -,(" +./&%" 2.,-(-4" (!55%*%,)!-)!.," !," 0.)$" &%'%&8" ?.+.F62./&" +/)-)!.,&" !," N('(=" .*" @$5-" 3-/&%" 2.,-(-4" -0,.*+-4!)!%&" !," +./&%" %+0*6." .5" 0.)$" &%'%&" C#%;.&!-," %)" -48<" B]]BE8" #$%" )*-,&3*!7)" 4%;%4" .5" !"#/&!2,!5!3-,)46" *%(/3%(" !," dZ" @$5-/313_{" 2.,-(&" -)"} )$%")!+%"CII8a(73E":$%,"!"#"%'7*%&&!.,"4%;%4"*%-3$%&"!)&"7%-J"CQ-,/64.;"%)"-48<" B]]\e"#%;.&!-,"%)"-48<"B]]BE8"#$%"2%,%&"*%1/!*%("5.*",.*+-4"V%*).4!"3%44"5/,3)!.,&" &/3$" -&" !$%&<" Q/44%*!-," !,$!0!)!,2" &/0&)-,3%" COK,E<" A%&%*)" ?%(2%$.2" C7;;E" -,(" H%6(!2" 3%44" 0!.&6,)$%)!3" %,F6+%&" :%*%" ,.)" %'7*%&&%(" !," dZ" @$5-/ 313"_2.,-(&" :$%*%-&".;-*6"(%;%4.7+%,)"2%,%"<+'=":-&"%'7*%&&%("%3).7!3-446" C#%;.&!-,"%)" -48<"B]]BE8""

#$%" )*-,&3*!7)!.," 5-3).*&" V!'I" -,(" V!'X" 7-*)!3!7-)%" !," +-4%" 2.,-(-4" (!55%*%,)!-)!.," 06" *%2/4-)!,2" !"#" %'7*%&&!.," -,(" 06" !,(/3!,2" 2.,-(-4" 7*%3/*&.*" 3%44" 5.*+-)!.,8" H.&&" .5" 0.)$" !K%?" -,(" !K%=/ C,.)" .,46" .,%E" *%&/4)%(" !," -" +-4%" )." 5%+-4%"&%'"*%;%*&-4":!)$"5-!4/*%"!,"!"#"-3)!;-)!.,8"A%3*%-&%"!,"2.,-(-4"7*%3/*&.*" 3%44" 5.*+-)!.," :!)$" *%(/3%(" 2.,-(-4" &!F%" :-&" .0&%*;%(" !," +/)-,)" %+0*6.&" .5" 0.)$" &%'%&" -,(" 5.*3%(" !"#" )*-,&2%,%" %'7*%&&!.," !," dZ" !K%?" -,(" !K%=" +/)-,)" 2.,-(&" *%&3/%(" )%&)!3/4-*" (%;%4.7+%,)8" V!'I" -,(" V!'X" -3)" )$*./2$" ):." (.:,&)*%-+" )-*2%)&" @$5-" -,(" !H3?" !," 2.,-(-4" (%;%4.7+%,)" CS/W!+.)." %)" -48<" B]IYE8""

" ["

Q!).2%,=-3)!;-)%(" 7*.)%!," J!,-&%" CQK@ME" &!2,-4!,2" !&" *%1/!*%(" 5.*" +-4%" &%'" (%)%*+!,-)!.," !," +./&%<" -&" $.+.F62./&" +/)-)!.," !," O(8PQ=313_{" 3-/&%(" dZ"} 2.,-(-4" &%'" *%;%*&-4" !," La\RH`[m" CR[E" 2%,%)!3" 0-3J2*./,(<" (/%" )." 5-!4/*%" !," +%&.,%7$*!3" 3%44" +!2*-)!.," -,(" *%(/3)!.," !," !"#" %'7*%&&!.,8" N.*+-446" Q-7YJX" -3)!;-)%&" @Yb" !," )$%" 3.%4.+!3" *%2!.," .5" )$%" dZ" 2.,-(&" -)" II8a(73" )." 7*.+.)%" 2.,-(-4"&.+-)!3"3%44"7*.4!5%*-)!.,"-,("*%2/4-)!.,".5"!"#"%'7*%&&!.,"CR.2-,!"%)"-48<" B]]cE8"N(66=RN"C2*.:)$"-**%&)"-,("ANK"(-+-2%E"2%,%"!&"%'7*%&&%("!,"&.+-)!3" 3%44&".5"(%;%4.7!,2"2.,-(&".5"0.)$"&%'%&"-)"I]8a(73"0/)"+-!,)-!,%("!,"dZ"2.,-(&" 5*.+" I]8a=IB8a(73" C>-**" %)" -48<" B]IBE8" D-((XaD" !&" %&&%,)!-4" 5.*" 7*!+-*6" &%'" (%)%*+!,-)!.,<" +-4%" 5%*)!4!)6" -,(" )%&)!&" (%;%4.7+%,)" Cm.$,%," %)" -48<" B]IYE8" D-((XaD" 7.&!)!;%46" *%2/4-)%&" Q-7YJX" +%(!-)%(" @Yb" QK@M" &!2,-4!,2" !," dZ" %+0*6.,!3" 2.,-(-4" &.+-)!3" 3%44&" -&" *%1/!*%+%,)" 5.*" )%&)!&" (%)%*+!,-)!.,8" Q!3%" 4-3J!,2"N(66=RN"-4&."%'$!0!)"dZ"2.,-(-4"&%'"*%;%*&-4"3-/&%("06"(!&*/7)!.,".5"!"#" %'7*%&&!.," -&" !," O(8PQ=313_{" 2.,-(&8" D-((XaD" -,(" Q-7YJX" 2%,%)!3-446" !,)%*-3)"} (/*!,2" &%'" (%)%*+!,-)!.,<" -,(" )*-,&2%,!3" .;%*%'7*%&&!.," .5" O(8PQ=" *%&3/%&" 2.,-(-4"(%5%3)&"!,"N(66=RN313_{"(%5!3!%,)"%+0*6.&"C>-**"%)"-48<"B]IBE8"?!&).,%"(%=} +%)$64-)!.," $-&" !+7.*)-,)" *.4%&" !," +-++-4!-," &%'" (%)%*+!,-)!.," -,(" 2%,%" %'7*%&&!.,<" -&" S:T6?(1E6:P(" 2%,%" (!*%3)46" -,(" 7.&!)!;%46" 3.,)*.4&" !"#" %'7*%&&!.,8"9,"dZ"+!3%"$.+.F62./&"+/)-,)".5"?YMc"(%+%)$64-&%"m+W(I-<"+-4%" )."5%+-4%"&%'"*%;%*&-4"!&".0&%*;%("CM/*.J!"%)"-48<"B]IYE8" " " " I:J:I:O'#3T'7E>,.+2>' " #$%"7*.3%&&".5"V%'"(%)%*+!,-)!.,"!,"+-++-4&"&)-*)&"(/*!,2"%+0*6.,!3"4!5%8"#$%" 3$.!3%" .5" +-4%" .*" 5%+-4%" &%'" (%)%*+!,-)!.," 5-)%" (%7%,(&" /7.," )$%" 7*%&%,3%" .5" )$%"2%,%"!"#<"4.3-)%(".,")$%"Z"3$*.+.&.+%"CM..7+-,"%)"-48<"IccIE8"9,"+!3%"!"#" 2%,%"!&"%'7*%&&%("-)"-"&)-2%".5"+-4%"2.,-(-4"(%;%4.7+%,)<":$!3$"!&"(%4%)%("!,"dZ" 5%+-4%"+!3%"+/)-,)"5.*"F6#U/!,(!3-)!,2"!)&"*.4%"!,")%&)!&"(%)%*+!,-)!.,"CD/00-6"%)" -48<"Icc]E8"#$%"Z"&7%3!5!3",%:"!(%,)!5!%("2%,%"!&"3.,&%*;%("-+.,2"-":!(%"*-,2%".5" +-++-4&"!,34/(!,2"$/+-,&"-,("%,3.(%&"-"7*.)%!,":!)$"3.,&%*;%("ANK=0!,(!,2" +.)!5" 7*%&%,)" !," )$%" ,/34%-*" ?QDI" -,(" ?QDB" CV!,34-!*" %)" -48<" Icc]E8" !>B/

" \"

!(%,)!5!3-)!.," -&" -" 2%,%" *%&7.,&!04%" 5.*" !,!)!-)!,2" +-4%" &%'" (%)%*+!,-)!.," :-&" *%7.*)%(" !," 7-)!%,)&" :$%*%" +/)-)!.,&" !," !>B" *%&/4)%(" !," X[" dZ" 5%+-4%" &%'" *%;%*&-4&"CR%*)-"%)"-48<"Icc]E8"#$%"4.&&".5"5/,3)!.,".5"!>B"!,"$/+-,&"!&"-&&.3!-)%(" :!)$"&%'"*%;%*&-4"CA.+%,!3%"%)"-48<"B]]XE8"!"#"J,.3J"./)"+!3%"$-("5%+-4%"%')%*,-4" -,(" !,)%*,-4" 2%,!)-4!-<" 5%+-4%" 4%;%4" .5" 04..(" )%&).&)%*.,%<" &$.:%(" %&)*./&" 3634%" -,(" 7%*5.*+%(" 3.7/4-).*6" 0%$-;!.*" -&" 5%+-4%&" 0/)" !,5%*)!4%" .*" *%(/3%(" 5%*)!4!)6" CM-)." %)" -48<" B]IYE8" #$%" )*-,&2%,!3" !"#" %'7*%&&!.," !," 3$*.+.&.+-446" dd" 5%+-4%" *%&/4)%("!,"(%;%4.7+%,)".5"+-4%"+./&%"CM..7+-,"%)"-48<"IccIE8"K5)%*"%'7*%&&!.," .5" !"#<" )$%" %-*4!%&)" !(%,)!5!%(" 3$-,2%" .0&%*;%(" !," dZ" 2%,!)-4" *!(2%&<" !&" )$%" +-4%" &7%3!5!3" 7*.4!5%*-)!.," .5" 3.%4.+!3" %7!)$%4!-4" 3%44&<" :$!3$" !&" ,.)" (%)%3)%(<" !," dd" 2%,!)-4"*!(2%&"CV3$+-$4"%)"-48<"B]]]E8"K)")$%"+.4%3/4-*"4%;%4<")$%"7*!+-*6"5/,3)!.," .5"V*6"!&")."!,!)!-)%"!$%&/2%,%"%'7*%&&!.,")."7*.+.)%"V%*).4!"3%44"5-)%8"K,6"(%4-6%(" .*" *%(/3%(" !"#" %'7*%&&!.," 3-," 3-/&%" dZ" &%'" *%;%*&-4" 06" 5-!4/*%" )." 0..&)" !$%&" %'7*%&&!.,"CK40*%3$)"-,("P!3$%*<"B]]IE8" " " " I:J:J:'#2KL' "

!VW&/ CV*6" 0.'" 3.,)-!,!,2" 2%,%" cE/ !&" -" 2%,%" 4.3-)%(" .," )$%" 4.,2" -*+" C1E" .5" 3$*.+.&.+%" I\" CI\1BX8YE" !," $/+-,&" )$-)" 74-6&" !+7.*)-,)" *.4%&" !," )$%" ,.*+-4" &J%4%)-4" (%;%4.7+%,)" -,(" +-4%" &%'" (%)%*+!,-)!.,8" !VW&" $%)%*.F62./&" +/)-)!.,&" (%;%4.7" !,)." &J%4%)-4" +-45.*+-)!.," &6,(*.+%" 3-44%(" 3-+7.+%4!3" (6&74-&!-" CLAECR!" %)" -48<" B]]IE" -,(" \ak" dZ" 7-)!%,)&" %'$!0!)" +-4%" )." 5%+-4%" &%'" *%;%*&-4" !," $/+-,&"CQ-,&./*"%)"-48<"Iccae">-2,%*"%)"-48<"IccXE8"#$%",/44"+/)-)!.,".5"+./&%" !$%&"3-/&%&"+-4%")."5%+-4%"&%'"*%;%*&-4"CR-**!.,/%;."%)"-48<"B]][e"L$-0.!&&!%*"%)" -48<" B]]XE" $.:%;%*" )$%" +./&%" $%)%*.F62./&" !$%&" +/)-)!.," 3-/&%&" &J%4%)-4" -0,.*+-4!)!%&"0/)"(.",.)"(%;%4.7"!,)."dZ"&%'"*%;%*&-48"#$%"&J%4%)-4"-0,.*+-4!)!%&" .0&%*;%("!,"!$%&D13_{"+!3%"*%&%+04%").")$-)".5"LA"7-)!%,)&"CL-+7.+%4!3"A6&74-&!-E"} -,(" -*%" 3-/&%(" 06" (%4-6%(" .*" (%5%3)!;%" 7*%" 3-*)!4-2!,./&" 3.,(%,&-)!.,8" S/*)$%*+.*%"7*%+-)/*%"+!,%*-4!F-)!.,".0&%*;%("!,"+-,6"0.,%&"!&"3.,&%1/%,3%".5" -44%4%" !,&/55!3!%,36" .5" !$%&" %'7*%&&!.," CR!" %)" -48<" B]]IE8" !$%&" 2-!," .5" 5/,3)!.," %'7%*!+%,)&"!,"+!3%<"$-;%"*%7.*)%("&%'"*%;%*&-4"5*.+"5%+-4%")."+-4%"!,"dd"2.,-(&" C_!(-4" %)" -48<" B]]IE8" N.)" .,46" )$%" 7*%&%,3%" 0/)" -4&." &/55!3!%,)" !$%&" %'7*%&&!.," !&"

" b" *%1/!*%(" 5.*" ,.*+-4" (%;%4.7+%,)" -,(" +-4%" &%'" (!55%*%,)!-)!.,8" dd" %+0*6.&" :!)$" !$%&"/7&)*%-+"!,&%*)!.,"+/)-)!.,"Cdd".(&`lE"(%;%4.7"-&"&)%*!4%"dd"+-4%&":!)$./)" 7*%&%,3%".5"!"#8"!$%&"%'7*%&&!.,":-&"/7*%2/4-)%("-,("+-!,)-!,%("!,")$%&%"dd".(&`l_" &)%*!4%"+-4%&"CR!&$.7"%)"-48<"B]]]E8"n!,"-,("R!&$.7&"&$.:%(")$-)"!,"Z"3$*.+.&.+-4" !"#"+/)-)%("CdZo_{<"pcJ0"!"#"+/)-)!.,".,"Z"3$*.+.&.+%E"%+0*6.&<":$%,"!$%&":-&"}

+/)-)!.,-446" -,(" $%)%*.F62./&46" -3)!;-)%(" C!$%&" dZo_{.(&`lE" C.(&q" .((" &%'E<" !)"}

7*.(/3%("5%*)!4%"+-4%&"0/)":!)$")%&)!&"&+-44%*"!,"&!F%"-,("!**%2/4-*")%&)!&"&7%3!5!3" ;-&3/4-*!F-)!.,8"#$%&%"+-4%&":%*%"5%*)!4%"!,")$%"0%2!,,!,2"0/)"5%*)!4!)6":-&"4.&)"/7" )."&!'"+.,)$&<"&/22%&)!,2"!,&/55!3!%,)"!$%&"%'7*%&&!.,8">$%,"!$%&"%'7*%&&!.,":-&" !,3*%-&%(" :!)$" $.+.F62./&" -3)!;-)!.," 3.,(!)!.," CdZo_{.(&`.(&E<" &7%*+-).2%,!3"}

(%5%3)&":%*%"*%&3/%(":!)$"2-!,".5"5%*)!4!)6"-,(",.*+-4")%&)!&";-&3/4-)/*%"Cn!,"-,(" R!&$.7<"B]]aE8"

#$%" +!3%" 3.,(!)!.,-4" V%*).4!" +/)-,)" .5" !$%&" 06" IX8](73" )$-)" $-;%" ,.*+-4" %+0*6.,!3" )%&)!&" (%;%4.7+%,)" -,(" -*%" !,!)!-446" 5%*)!4%<" (!&74-6" (6&5/,3)!.,-4" &7%*+-).2%,%&!&" -,(" 0%3.+%" &)%*!4%" -5)%*" a+.,)$&8" >$%," )$!&" !$%&" 3.,(!)!.,-4" +/)-)!.,":-&"2%,%*-)%(".,"!$%)D13_{"+/)-,)"0-3J2*./,(<")$%"(!55%*%,)!-)!.,".5")%&)!&"} 3.*(&"!,)."&%+!,!5%*./&")/0/4%&"3%-&%("-5)%*"@["(-6"C7q7.&),-)-4E":$!4%".,"!$%)313_" +/)-,)" 0-3J2*./,(" )$%" )%&)!&" 3.*(" (!55%*%,)!-)!.," 3%-&%(" -5)%*" @]" -,(" 7*.(/3%(" 3.+74%)%"7*!+-*6"!,5%*)!4!)6<"!,(!3-)!,2")$-)"V.'b"3.+7%,&-)%&"5.*")$%"-0&%,3%".5" V.'c"(/*!,2"%+0*6.,!3")%&)!&"(!55%*%,)!-)!.,8"9,"-((!)!.,"!$%)<"!$%&"(./04%"+/)-,)" )%&)%&" &$.:" /7*%2/4-)!.," .5" %-*46" .;-*6=&7%3!5!3" +-*J%*&" -,(" (.:,*%2/4-)!.," .5" V%*).4!" !,)%*3%44/4-*" W/,3)!.,&" 06" Ia8a(73" 0/)" &)!44" ;%*6" 4.:" 4%;%4&" .5" 9:;" 3-/&%" 3.+74%)%" *%2*%&&!.," .5" )$%" Q/44%*!-," (/3)" :!)$" *%(/3%(" 7%,%)*-,3%8" #$%*%5.*%" )%&)!&" 3.*(" (!55%*%,)!-)!.," 06" IX8](73" !&" !,(%7%,(%,)" .5" V.'c" -,(" )$-)" V.'c" !," 3.,3%*)" :!)$" V.'b" !&" %&&%,)!-4" 5.*" )$%" +-!,)%,-,3%" .5" )%&)!3/4-*" 5/,3)!.," CR-**!.,/%;."%)"-48<"B]]cE8"

R%5.*%")$%"%'7*%&&!.,".5"!"#1!>B<"!$%&1!VW&"!&"%'7*%&&%("-)"4.:"4%;%4"!,"0.)$"dd" -,("dZ"2%,!)-4"*!(2%&"!,"+!3%"-,("$/+-,"%+0*6.&"*%&7%3)!;%46"CQ.*-!&"(-"V!4;-"%)" -48<"Icc[-E8"U7.,"%'7*%&&!.,".5"!"#<"!$%&"%'7*%&&!.,"!&"!,3*%-&%("!,"7*%=V%*).4!"-,(" V%*).4!"3%44&".5"dZ"2.,-(&"CV%J!(."%)"-48<"B]]XE8"9,"+!3%<")$%"-0!4!)6".5"!"#")."!,(/3%" )%&)!&" (%;%4.7+%,)" !&" 4!+!)%(" )." -77*.'!+-)%46" II8](73" )." II8Ba(73<" -" )!+%" :!,(.:" .5" .,46" [" $./*&" -5)%*" )$%" .,&%)" .5" !"#" %'7*%&&!.," !," ,.*+-4" dZ" 2.,-(&8"" A%4-6%("!"#"-3)!;-)!.,"C-5)%*"II8Y(73E"(.%&",.)"!,!)!-)%"!$%&"%'7*%&&!.,"*%&/4)!,2"

" c"

!," .;-*!-," (%;%4.7+%,)" C?!*-+-)&/" %)" -48<" B]]cE8" 9," +!3%<" !"#" 3..7%*-)%" :!)$" &)%*.!(.2%,!3" 5-3).*" I" CVS=IE" )." !,!)!-)%" )$%" %'7*%&&!.," .5" !$%&" )$*./2$" )$%!*" 0!,(!,2" )." )$%" 2.,-(" &7%3!5!3" %,$-,3%*" .5" )$%" !$%&" 2%,%" C#PVLO=)%&)!&=" &7%3!5!3" %,$-,3%*" .5" !$%&" 3.*%" %4%+%,)E" CV%J!(." -,(" H.;%44=R-(2%<" B]]bE8" L$*.+-)!," !++/,.7*%3!7!)-)!.,"CL?9@E"-&&-6&"&$.:%(")$-)"V*6"-,("V5=I"(!*%3)46"0!,("&%;%*-4" &!)%&" :!)$!," #PV" C)%&)!&" &7%3!5!3" %,$-,3%*" .5" !$%&E" -,(" +/)-)!.," !," )$%&%" &!)%&" (%3*%-&%(" )$%" %,$-,3%*" -3)!;!)6" &/22%&)!,2" )$-)" V*6" -,(" V5=?" &6,%*2!&)!3-446" /7*%2/4-)%")$%"%,$-,3%*".5"!$%&"CV%J!(."-,("H.;%44=R-(2%<"B]]cE8"!$%&"%'7*%&&!.," -5)%*" )$%" (.:,*%2/4-)!.," .5" !"#" &/22%&)&" )$-)" !$%&" !&" -04%" )." &/&)-!," !)&" .:," %'7*%&&!.,".,3%"!,!)!-)%("CM-&$!+-(-"-,("M..7+-,<"B]I]E8"9,(%%(<"!$%&"3*%-)%&"-" 5%%(" 5.*:-*(" 7-)$:-6<" !,)%*-3)!,2" :!)$" V5=I" -,(" 0!,(!,2" )." #PVLO" !," .*(%*" )." +-!,)-!,"!)&".:,"%'7*%&&!.,"CV%J!(."-,("H.;%44=R-(2%<"B]]bE8"

O)$%*"5-3).*&"-*%"-4&."&/22%&)%("5.*"!$%&"-3)!;-)!.,"-&"P3).7!3"-3)!;-)!.,".5"V.'c"!," dd" <'?X/ !$%&F51D_{" )*-,&2%,!3" +!3%" !,(/3%&" 5%+-4%" =).=" +-4%" &%'" *%;%*&-4" !," -(/4)"} &)-2%8" 9,!)!-446" )$%&%" )*-,&2%,!3" dd" <'?X/ !$%&F51D_{" +!3%" (!&74-6" .;.)%&)!&"} (!55%*%,)!-)!.," :!)$" )%&)!3/4-*" 3%,)*-4" *%2!.," -,(" .,%" .*" 0.)$" .;-*!-," 7.4%&<" &/22%&)!,2" )$-)" >)IG" V.'c" !&" ,.)" -&" %55!3!%,)" -&" V*6" )." !,(/3%" +-4%" (%;%4.7+%,)8" #$%" 3%44&" .5" .;-*!-," *%2!.," .5" .;.)%&)!&" /,(%*2." -7.7).&!&" (/*!,2" 4-)%" %+0*6.2%,%&!&"4%-(!,2")."3.+74%)%"5%+-4%"=).="+-4%"&%'"*%;%*&-4".5")$%")*-,&2%,!3" +!3%"-)"0!*)$"CD*%2.!*%"%)"-48<"B]IIE8"

V.'c" -4&." +-J%&" 7.&!)!;%" 5%%(0-3J" 4..7" )." S25c" C5!0*.04-&)" 2*.:)$" 5-3).*" cE" )." +-!,)-!," !)&" %'7*%&&!.," CM!+" %)" -48<" B]][0E8" #$%" -&&%&&+%,)" .5" @5H&313_{/ +/)-,)"} 2.,-(&" !,(!3-)%&" )$-)" !$%&" !,!)!-4" %'7*%&&!.," -,(" /7*%2/4-)!.," :-&" ,.*+-4" 0%):%%,"II8a(73=IB8](73"0/)"06"IB8a(73"V%*).4!"7*%3/*&.*"3%44&"(!(",.)".*2-,!F%" !,).")%&)!&"3.*("&)*/3)/*%&<"!,(!3-)!,2")$-)"S25c"!&"*%1/!*%("5.*"+-!,)%,-,3%".5"V.'c" %'7*%&&!.,"!,"V%*).4!"7*%3/*&.*"3%44&"CM!+"%)"-48<"B]][0E8"@5H&"%'7*%&&!.,"4!J%"V*6" -,("V.'c<"!,!)!-)%&"!,"-":-;%"7-))%*,"!,"3%,)%*"F.,%".5"2.,-("-,("%'7-,(&")."7.4%&" .5" 2.,-(8" 95" )$!&" 3%,)%*" F.,%" .5" dZ" 2.,-(" !&" *%+.;%(" 0%5.*%" %'7-,&!.," .5" S25c" &!2,-4&<")$%"7.4%"*%2!.,&".5"2.,-(&":!44"0%"/,-04%")."5.*+")%&)!&"3.*(&"C?!*-+-)&/" %)"-48<"B]I]E8"

VOdc"7*.)%!,"!&"-"+%+0%*".5")$%"VOd"5-+!46".5")*-,&3*!7)!.,"5-3).*&8"VOdc"7*.)%!," !&" !,;.4;%(" !," )$%" -3)!;-)!.," .5" &%;%*-4" (!*%3)" )-*2%)" 2%,%&" )$-)" -*%" J,.:," )." 7-*)!3!7-)%"!,")%&)!3/4-*"(%;%4.7+%,)"&/3$"-&"9:;/CA%"V-,)-"R-*0-*-"%)"-48<"IccbEU/

" I]"

7;;/CL4-*J" %)" -48<" B]]]E" -,(" 03456," C>!4$%4+" %)" -48<" B]]\E8" VOdc" $-*0./*&" -" &%'= &7%3!5!3" &/03%44/4-*" )*-,&4.3-)!.," 5*.+" )$%" 36).74-&+" )." )$%" ,/34%/&" !," +-4%" 2%,!)-4" *!(2%" 3%44&" -)" )$%" )!+%" .5" )%&)!&" (!55%*%,)!-)!.," )." !,(/3%" KQ?" %'7*%&&!.," CA%" V-,)-" R-*0-*-" %)" -48<" Iccbe" (%" V-,)-" R-*0-*-" %)" -48<" B]]]e" D-&3-" %)" -48<" B]]BE8" #$%" !+7.*)-,3%" .5" VOdc" &$/))4!,2" 5.*" !)&" 5/,3)!.," 3-," 0%" &%%," 5*.+" )$%" %'7%*!+%,)<" :$%," VOdc" ,/34%-*" %'7.*)" :-&" !,$!0!)%(" 06" 4%7).+63!," R" C,/34%-*" %'7.*)" !,$!0!).*E" !," )$%" +./&%" 3/4)/*%(" dd" 2.,-(&<" !)" !,(/3%(" -" &%'" *%;%*&-4" 7$%,.)67%"3$-*-3)%*!F%("06",/34%-*"VOdc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

9,&/4!,"*%3%7).*"C9NVTE"-,(")$%"9DS")67%"9"*%3%7).*"C9DSITE"&!2,-4!,2"!&"%&&%,)!-4" 5.*" -(*%,.2%,!)-4" (%;%4.7+%,)" -,(" 7*!+-*6" &%'" (%)%*+!,-)!.," .5" 0.)$" 2.,-(&8" L.,&)!)/)!;%"-04-)!.,".5"K+,"Y/K5H?""&!2,-4!,2"*%&/4)%("!,"*%(/3%("7*.4!5%*-)!.,"*-)%" .5" &.+-)!3" 7*.2%,!).*" 3%44&" !," 2.,-(&" .5" 0.)$" &%'%&" 7*!.*" )." &%'" (%)%*+!,-)!.,8" L.,&%1/%,)46"%+0*6.&"4-3J!,2"5/,3)!.,-4"!,&/4!,`9DS"&!2,-4!,2"%'$!0!)"3.+74%)%" -2%,%&!&".5")$%"-(*%,-4"3.*)%'<"%+0*6.,!3"dZ"2.,-(-4"&%'"*%;%*&-4"(/%")."(%4-6%(" !"#" /7*%2/4-)!.," -,(" (%4-6" !," .;-*!-," (!55%*%,)!-)!.,8" #$%" K+,"Y/ K5H?"" +/)-,)" 2.,-(&" !**%&7%3)!;%" .5" 2%,%)!3" &%'" *%+-!,%(" !," -," %')%,(%(" /,(!55%*%,)!-)%(" &)-)%"5!,-446".;-*!-,"(!55%*%,)!-)!.,"7*.2*-+"!,!)!-)%("-)"-*./,("I[8a(73"C@!)%))!" %)"-48<"B]IYE8"

9," 0!7.)%,)!-4" 2.,-(-4" 7*!+.*(!-<" 4!,%-2%" &7%3!5!3" 2%,%&" -*%" &%'" &7%3!5!3-446" (%74%)%(" -,(" %,*!3$%(8" V%'/-446" /,(!55%*%,)" 2%*+" 3%44" -,(" &/77.*)!,2" 3%44" 7*.2%,!).*&"&$.:"4!,%-2%"7*!+!,2<":$%*%"2%*+"3%44"7*.2%,!).*&"-*%"7*!+%(":!)$" -" 0!-&" ).:-*(&" )$%" +-4%" 5-)%<" !," 3.,)*-&)" &/77.*)!,2" 3%44&" -*%" 7*!+%(" :!)$" -" 5%+-4%" 0!-&<" !,(!3-)!,2" )$-)" *.0/&)" *%7*%&&!.," 7*.2*-+" !&" !,;.4;%(" !," )$%"