Intérêts et limites de l’observatoire REVELA13 pour la connaissance épidémiologique des tumeurs de vessie de la femme dans les Bouches-du-Rhône

Texte intégral

(1)Intérêts et limites de l’observatoire REVELA13 pour la connaissance épidémiologique des tumeurs de vessie de la femme dans les Bouches-du-Rhône Thomas Martin. To cite this version: Thomas Martin. Intérêts et limites de l’observatoire REVELA13 pour la connaissance épidémiologique des tumeurs de vessie de la femme dans les Bouches-du-Rhône. Sciences du Vivant [q-bio]. 2017. �dumas-01829627�. HAL Id: dumas-01829627 https://dumas.ccsd.cnrs.fr/dumas-01829627 Submitted on 4 Jul 2018. HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés..

(2) 1234563793

(3) 397 9 7953 595 22 7729 4 4

(4) 9 973

(5) 957 9977 9 9 9

(6)

(7) 9 27 97!97" "!#29$. %&'(. )5479234993 9

(8) 92373929 923 *+,%-./-.+10./(1 912359345 )5/27 95%!

(9) 7/%10 04 9

(10) 673825 9279:1; . . <=>?=@ABCD?EBF?GHBHBI=JAB>?BCKLHBJDCB IMNMOMHBPQRSTSURNUVWVSXYN /9

(11) 597 Z5[ 9 %!\79]. /27 95 9)597795^(0%_`. 97 /27 95 9)597795+&15 /27 95 9)597795(%1.+[5. 9 /27 95 9)597795,a,1)7 . )547 923 7797795 7797795 7797795 .

(12)

(13) Intérêts et limites de l'observatoire REVELA 13 pour la connaissance épidémiologique des tumeurs de vessie de la femme dans les Bouchesdu-Rhône.. T H È S E Présentée et publiquement soutenue devant LA FACULTÉ DE MÉDECINE DE MARSEILLE Le 5 Octobre 2017 Par Monsieur Thomas MARTIN Né le 3 mai 1982 à Orleans (45). Pour obtenir le grade de Docteur en Médecine D.E.S. de CHIRURGIE GÉNÉRALE Membres du Jury de la Thèse :. Monsieur le Professeur KARSENTY Gilles. Président. Monsieur le Professeur LECHEVALLIER Eric. Assesseur. Monsieur le Professeur BASTIDE Cyrille. Assesseur. Monsieur le Professeur AUQUIER Pascal. Assesseur.

(14)

(15)

(16)

(17)

(18)

(19)

(20)

(21)

(22)

(23)

(24)

(25)

(26)

(27)

(28)

(29)

(30)

(31)

(32)

(33) 23454367789 63 4

(34) 6. 23454367789 88

(35) 6.

(36) 234356734389.

(37) ! . " # $%& '%('%) '% )'*+,'*-.,'*/0 '*1 */ 2

(38) . ! 3" ! 4 # " ! 3 5"$%& '%6 0'%('%/ '** # '*7 '* / '*8'*)99'*+,'*(09:9'*;" '*1 '*< = '*-.,'*)'*> '*% '*8'*8 '* 1 */ ?2 @. %7 6 0##3 4 '# #" . '# "' # ' ' 2 8 ##!" 8 ' 3 # . ;-(; # '3 # -;@'3 # A3" A! 3 ; #'A" .#! 'A3" "! #! B8C 3 D 2- ##" .# .". #! ."2 8 % & # A #"' . # ! 2 8 A% ( / # !"."# '#! 3! # #" 5#B# E 2 0. .

(39) 2345689 4

(40) 3394353863486339963438

(41) 64 86

(42) 394 8553 34

(43) 6686

(44)

(45) 94 8643 84633

(46) 9433 23456 !833"96 33#$%$&'53("(643")8463283389*4 894353+858

(47) 943946

(48) 6,663943 6586

(49) 943

(50) 56

(51) 333

(52) ,348

(53) 643#$%$&'339458!3895

(54) 943534886234568

(55) 64 469 3 94394

(56) ,6!86

(57) 4

(58) 36

(59) 33

(60) 9434353

(61) 645

(62) 8434

(63) 86693 3 84656 34"3496

(64)

(65) 94 8566343

(66) 686

(67) 3

(68) 3353

(69) ,348

(70) 643 -3 43935333348396436

(71) 4853339448863, 65396 43 433

(72) 94394

(73)

(74) !939 8433396

(75) 94485

(76) 46,934"8 436 23456"96 338*#./0*64356

(77) 38#353453.669333/

(78) 86

(79) 189 363+(22

(80) 8389+4+858996343"-38*

(81) 4396

(82) 3943

(83) 94 86338394386 6 6586

(84) 33

(85) 686

(86) 3

(87) 33#$%$&' 23456".86433/44533/6#4665

(88) 8%684

(89) 9!338..24368863.87389 38.#4349($

(90) 948

(91) 64

(92) 9463866933435

(93) 868533 9394336338863 4

(94) 36

(95) 33 $ 63456"33,338 86338,33( 8633338696

(96) 3463844634"89

(97) 9496%

(98) 9837

(99) 9

(100) 94

(101) 93935493

(102) 6 993 354

(103) 86 84

(104) 6

(105) 6(83.363488 8

(106) 9

(107) 9463

(108) 94

(109) 686 396 634853345355333

(110) 98

(111) 5634 -33 39 85634

(112) 933 34

(113) 389 9333 335843

(114) 9,63486534863 8

(115) 936 8

(116) 633 39 83 8 843465638 8633

(117) 43 +66 39684868 863538 659

(118) 633!

(119) 933

(120) 43843 84653968

(121) 9

(122) 9435

(123) 948! " 864353933 6486396

(124) 6843 6433

(125) 6 "(89338:94.84

(126) 63968

(127) 9

(128) 94 46

(129) 63

(130) 6-3 33896"8,33( 863"26533"6333 34

(131) 396

(132) 35:9494886396

(133)

(134) 9

(135) 94

(136) 939 0. .

(137) 2345378983 8 2

(138) 5 58

(139) 58

(140) 35 58

(141) 38575 8388 9883

(142) 8

(143)

(144) 83 8. 8358 895

(145) 538333 53 538 985848

(146)

(147) 893

(148)

(149) 82 38 852

(150) 5 5893 5833

(151) 34538 858

(152) 88

(153) 883 858

(154) 53378

(155)

(156) 838 5 8 858

(157) 5 3838 8 8 87838335 9 855

(158) 8 ! 38895885888 8"87 858 3 5883 8

(159) 8385 5888

(160) 53885 4935. 8

(161) 83 948. 5338 883

(162)

(163) 83 9. 834

(164) 5 88838

(165) 5 #8983 85838383. 58 88

(166) 4

(167) 5 8

(168) 8 3 8 838

(169) 3953

(170)

(171) 538

(172) 8 53 8 88

(173) 8 8$4

(174) 5 8

(175) 8

(176) 5 83438

(177) 8

(178) 5

(179) 85 5

(180) 8 $53838 % 85 85345 89 8

(181) 83987 595 58883833

(182) 85 . 0. .

(183) . 23456869 3

(184) 69 . !" #$%%&$'(($)!!* +($(,-%,)(,.$(!)%')!* /0('!$!1'/ 23(4(!4!/5 / 3')($'((0(// 2 67!)%8#9#:;2/" /<'=#'$0.92/> / 67?(4/@ // -A%$%%&/B //%'%(7/B ///#'$$!()%7!)%/B //23!1'!25 //"<(%'&&%&A1'$'$22 /2 8!'!2* /23!1'!&!2* /2/#)%'%%2B /22+($(!%&%&A1'2C /2"D%!%)(!$%!%!$!%7!"@ /" <!('!!%*/ /* D%('!%*B %!!*C :!$!7)%!> :!$!0&'!>" :!$!.7'=>* 1.

(185) 2343567869

(186) . 77669 . 7766 6 65 6

(187) 9 53 !6 3735 ". 7766 " 6 # 6 $ 9 53 !6 58%6 $. 7766 $ &6548 &'2( )

(188) ## 6 385%7 6 *. 7766 * )9+69 6 568%7799786 67 69 ,

(189). 7766 448-6 2','.$ . 7766

(190) (8-6 6 976!67 /6996 2','.$ 0. 7766. (%5!56 6 6!76 6 %77369 7%7 7%!7/69 1 )73 2+6 (5786. 3. 7766 0 (%5!56 467 6!67 2559 6 )73 2+6 (5786 0#. 7766 3 69 6 9759%7 95 46 6 0. 7766 # 6 6 8%55692%7786 /69 69 2 7 8%7 6 ') 0". 7766 69 6 8%55692%7786 8%7 69 '9)7') 0$. 7766 " :; ) 6 659 /57869 69 , 43!7769 79 69 2 6 79 69 4435679. 655%569 '9) 95 235%6 "#"<"#* 0*. 7766 $ : 6 ) 69 , 43!7769 79 69 4435679 655%569 ') 69 2 95 . 235%6 "#"<"#* 0. 7766 * ,57869 69 : 6 ) 69 , 43!7769 79 69 4435679 655%569 '). 69 2 95 235%6 "#"<"#* 0

(191). 7766 '9!%79 3256!6769 6 4786786 69 878659 6 /6996 8-6= . 46!!6 95 235%6 "##0<"## 1 255 522%5 ):7: 6446849 7769 !%>679 ?@;. ) %76; ):2 6 :&3A 0. 7766

(192) 239!3 25%%8%6 436 (,$ 00. 7766 /9 4/%56 6 B2&: 8%786577 436 (,$ 3#. 7766 0 %6 474%5!%7 5%% 6 2%5 436 (,$ 3. 7766 3 %6 474%5!%7 2676 2%5 436 (,$ 3". 7766 "# %<+69%7756 2676 2%5 436 (,$ 3$. C. D D. 0. .

(193) 2345789.

(194) 5 8 9

(195) 45 9

(196) 588 34

(197) 534 5 4 38 5

(198) 4

(199) 85 8

(200) 34

(201). . . 0. .

(202) . . 3 4 6789 78

(203) 7 87 . 0. .

(204) 232356789 7

(205) 7887 23232378

(206) 799

(207) 89

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

(209) 2356783796

(210) 5 686 7986796

(211) 783 689379686 666 656 3 367

(212) 5367593686 3

(213) 56 3 6796865336395837 6367 8 6

(214) 66759

(215) 6 376! 6 635 3 6675"6 798679696#

(216) 6

(217) 5 3365378"696

(218) 5 7 6696# 366$ 2356783796

(219) 5 686 3

(220) 53 5

(221) 783 689379686 666 656 3 36837 3 358638 6

(222) 6%965

(223) 735686337576 5375

(224) 7 9

(225) 7

(226) "63869

(227) 696%8& "696753 6'88658696537 38(

(228) 686 65)3'* 36'+

(229) 766756356,69 56 39586 3 9

(230) 7

(231) 35

(232) 7

(233) 783 6865339'6

(234) 73 686-./86 3

(235) 53 5 869379686 66$ (77 798679665 3

(236) 53 5 89379686 66

(237) 75

(238) 566759

(239) . 786%86 8 6

(240) 667537)01!

(241) 03716 6

(242) 675!786%,65939768662 9

(243)

(244) 3756"6

(245) 75 6 379686 6 3733796' 67

(246) 68377 68 586 65 66 6733537593 9 6

(247) 85735

(248) 73 534 865./867

(249) 63% 93869379686 66 677675837 6./86 3

(250) 35

(251) 7

(252) 783 6 3 9665

(253) 7865/837 3

(254) 35

(255) 7

(256) 783 68 3

(257) 6$2653%87986796 6 6 65675837 638 6

(258) 5378"6 653%

(259) 53 5 6 . 6 665

(260) 675837 638&"687

(261) 86586

(262) 6778675' 6%965

(263) 7 86#

(264) 76678 "6

(265) 9 5 3 3#

(266) 69

(267) 6 (56

(268) 9 69379686 6665 6 "6675837

(269) 5" $'3):6$65, . 0. .

(270) 2334566789 9

(271)

(272) 6

(273) 76

(274) 4

(275) 4 . . !"#$"!%$"!&#!#$'$()&#!%#*&+#&+#+!&+#,$$-'(&& &./. . . 2334566789 9

(276)

(277) 6

(278) 76

(279) 4

(280) 4. . .!"#$"!%$"!&#!#$'$()&#!%#()"!0"'#+!&+#,$$-'(&& &./.1 . 0. .

(281) . !"#$"!%$"!&#!#$'$()&#!%#*'+!,&-*!",,./!&$#-!&- #+$$0'(&&&1231 4 2334566789 9

(282)

(283) 6

(284) 76

(285) 4

(286) 4. . 0. .

(287) 232323436789

(288)

(289). !" #$ % &' () *+ ,-*!! ( ( *+ , .!!/ - " 0) $ %% %%% *12 &0 *+ ,-*!! (0 *+ .!!/3 , 4! 5 , $, ."6 #$ 73 8 &91, /0. : "4 !" #$ % &( *+ ,-*!! '' *+ , .!!/ " 0' "4 $ %% %%% *12 &0 *+ ,-*!! 0 *+ , .!!/3 , 4! 5 , $, !, #$ 78 &91, /0 . ; $" - !," $! , $, "," , $,4 780. ; ", ,- " 1 ,- !, * ,- ."! , $,$ $< $" 6 , !," = , 1 , 780. ; $", $,, #$ % !" = : % = &' ((( *+ ,-*!! ) )( *+ , .!!/3 ( % = ( & % *+ ,-*!! % '%( *+ , .!!/3 :) ( = &(' ' *+ ,-*!! % % *+ , .!!/ 78 &91, /0.

(290). 0. .

(291) 34343454789

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

(293) . U!:P&'!:' $%5N9OPNQ R%SS'T 8'SS'T "%N9O R%SS'T 8'SS'T "%N9O ! "#$ ! "#$ ! "#$ ! "#$ ! "#$ ! "#$ ( ( ) ( * ) + , ) + + . ( / , / / + 0 + ( 1 , ( . / ( ) 1 . ( , / / ) ( ( ) , + . 2 1 ) * .,+ $%!&' ..*(21 .0,0 ( /+(/ (,1 .1./+0 +,2 (+1// 1,/ ./**+ .,. 1 /-.. /,* 345%6'7 -.2 /,1 ..+21 *,) (10- -,+ ..+* .,) -00/ /,0 859!:'7 +1-+ .-,0 / ;<=>;?@A<B?CD?EDFGH=ICDJK?CK.)))))L?MFB?CBG . 3456748

(294) 4 7 677 7 7 64 46 8 47 7 7 7 4 67 7 7

(295) 87 7 7 47 . V5QW9O'!:'7X7Z79! V5QW9O'!:'7X7[79!T V5QW9O'!:'7X7Y79!T R%SS'T 8'SS'T "%N9O R%SS'T 8'SS'T "%N9O R%SS'T 8'SS'T "%N9O ! ! ! ! ! ! ! ! !. $%!&' /12-0- 01//- ((.2+* 201./( .+*+)- *0-)/0 .).*-.1 ().((- .(.+0-+ 345%6'7 +*((( /22(0 ./-+0) /1+)++ 0)*)( (/++)/ (*+/*0 .)0)+/ -+2(0+ 859!:'7 02)) .1.0 +..0 .+-.. (*+) /((). /*-(+ 10/. (-.2). . 3456748

(296) 4 7 64 4677 7 4 8 47 7 7 7 4 67 7 7

(297) 87 7 7 47. 00. .

(298) 34345489

(299)

(300)

(301) . . !""!#"$#%&#"" !!"'()*)+,-./012"2 3#--432#"-567"#!809#" :43"#""%82##"2##""*"#4;"+3" #3&<#-#32#<<2"23"/(8 3"(#&:22!""(%"#""&#"(2 <#2&#2&3+4"=<":2#<32&#3:3/# 2#4>#"+"-:#34>#"/#"4# "::"-&>#"":4#"":3%82##"* %""%2#-0 OPQRSTUVWSUXVYTSUSQZ[[TVWSQP[QSUWS\SVVXS ,-43 b82##"2##""*"#4;" 983" e"::"#&:22!"" e"::"f"#""&#" e"::"-&>#" 2#4>#"#"4# <#2&#2&3#"4# b82##"*f""f2#- cdgc#"#"". ]XVYTSVUS^PRX_V `a) cd .a) `a) ` cd '() cd cd. ?9@A

(302) 9 BC89

(303)

(304)

(305)

(306) DEE 9EA

(307) 9E

(308)

(309) F

(310)

(311)

(312)

(313)

(314) A9 G9D H . I%!""!(-"2:(" #"3"2#""23" 2!"+,-)/0J%4 -432(4:":::0182##" "!#""3"8"#4;"#":-0 OPQRSTUVWSUXVYTSVTVhSQRiVjPXV[Z[USQZ[[TVWSQP[QSUWS\SVVXS ,-432 b82##""!#""3"+&#""f2#-/ k4:": k:: ?9@A

(315) 9 KC89

(316)

(317)

(318) L

(319) HM9EDE

(320) DEE 9EA

(321) 9E

(322)

(323) F

(324)

(325) N. . 01. .

(326) . . 343454347898. 3434543434 7898

(327) 8 . !!"#!$"%&"$'$"' ! ' !$%(!)!*+,%! ")"-%!%)./01*+23*,% ! ")"-"$!/+24+,%! ")"-#!!5.3067$#$! ' !$%(!)!8+,%$ $#.906!!%!&" 1::5%;<%"&"' $<<$&"1=:>5#$!#'$! !!"' "?""!@$%!$! !A%"!%)$%! '"!%"""!./067$-"!$!"$!$("!!%" &"%%#)$''"!!%)$!!&"!'&"B !!#.306C!"" !%## 8'$"2&"&"("!! !B"""! !!""/'$"2&"./06' !D$<'%$ % %!!?"!""!@$)"!&""' "$(!;$!'"$ ! )"$(!;$!"$' "$!!%"!)"$$!% ./06 !!&" !%$!$"%!)!" $(#'%#$%"!%)E!;!"$$"$$$$%$ '#)$!%"%"!$/+B4+!!#'#.9D/06F' "! '-'$&"' "&" $(!%!#!!$$"$$!"!!) $("!!%";G$%!$%!$!!#9HI+B J+./06:"$$!D!)!/+,%%"$!K"'"-KBC!!% ""#"$)"!'' !#$%(; %./06 (L%"!M!"!%!"!#%%"&"%%#)$''"!! %)1%(!)!8+,%!$928!")!$(L%(!)!3*,'A/*! %(L5.306C!!!""""?""!&"'$"#$)#%%#)$''"!! %)&"("!! !B"".9406'#)!!'$L"! ! <! %(!' "%!"'%!$(!%!$ $#%"!%)./D3067$ "!""$!$(' !%'%(%%(L"%! $$"!$!%)./06(L%"$#$!#$$ ")$$'#&"./06 01. .

(328) 3434543454 7898

(329) 8

(330)

(331) . !"#"$%%&%'()$!&$'$' $*'&&$'*+(,-(.$&'$*&!' %$$'$"&$/""*/!%'&'( $"(,#!%$*'(&&$'*01$%&%2 ,'33$&$$!'$*'(&&$'*-4045 &.6$"/"%!*$$""/"%*& $%"!&!789:;<=>?0:@2405?AB>4?A0C*$%''"% &"&$!$*'&&$'*+$'"$ '"&%%*&"'D$#"$'(.!&" !&$'$*%$%>4EA0. . 34345454FG H

(332) I HJKH

(333)

(334) HJJLL8MGN8KN JH OJ

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

(336) 3434545434 7898

(337)

(338)

(339) 99

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

(341) 3457879 7 45

(342) 944997557944977

(343) 4455994459 4 5 4 459945 !"879 7 454 5 #$44454

(344) 495494

(345) 5%479& '94 #(49449

(346) 47&849 9 #) 7 9

(347) 45

(348) &49545*7+79,4"-.$/

(349) 470/"$14 99*7 +79,4"5579477

(350) 42 !"879 7 45459945 #/5449,7 4*3454575

(351) 4 795 784459&7 9

(352) 64

(353) &7 4 #)9

(354) 49 &5797'455&48&454 57957

(355) 474944975

(356) 78

(357) 4 787 #(49 44975

(358) 44549' 4

(359) 7 8 &

(360) 44 7 4 #/4959

(361) 4&8459457479 5

(362) 54975

(363) 4

(364) &'5

(365) 4745994 0,7%4799&455

(366) 495

(367) 4577&5'5

(368) 4977

(369) 45 4559944559 4994545957+45

(370) 45

(371) 495

(372) 479&45 4

(373) 457977 & 474

(374) 45

(375) 4998445977 &547949 45 4

(376) 45

(377) 4:

(378) &'5;37 79

(379) 477 &

(380) 45$/94949 45-+45$5. <%44. %451-$<279+4

(381) 4==:=49915 3

(382) 459>98445$/ 499454992 79

(383) 5%4459847575

(384) 4 45

(385) 4845544&549 49 49 4=4 757984797 977849<45(7 ?@A5 & 779 49 4:;:34 ;357&

(386) 4.91"99454=2;B945 9

(387) 45,45

(388) 47. &7 4%4 45 4<45(7 1<(?@AC9.::3249+4

(389) 47945

(390) 484554

(391) 944559944145 &49 494 935454599

(392) 52;D944 5 9 95

(393) '4%4 9

(394) 494

(395) 457945

(396) 48455449& 7

(397) 4>99847575 10,45)EF<29*75

(398) 944559944& 749 7. 49

(399) 54919* 93

(400) 7

(401) 459847575275%449459 %4=75%9 & &

(402) &7&5 1;:3C=@>92; "9984775

(403) 4 4

(404) 484554&999 7& &49949$/

(405) 7959 4

(406) &7 449 9

(407) 7957& 9/"0".05457&

(408) 4:.91"99454=2;G 01. .

(409) 3434546489

(410)

(411) . !"#$%!#!$!&'"()'*%*&+(&(%,!&%"$*&&!$*. -#$%!")",!)!".&!)!&$#&$")./0123)'!&'!)(%!) %%&%&(.)&$"4)!+(&*)#&#$#"$&*+&5)#./0301267 ",!))(.*''"!&$#&$")."#%8-*'!(.($ 9!&'"*&&)*&% '#"&%*&%#%%&%)$#&$")./83:26;<"#%(+#&%,! '*=*"' )8&9=$()#&(%#<*)#&#"*#%,! >?@AB0%CDAB8E#!+&%"#%#!$'%<%(#!F$#"$&*+5&>'#""#&%&% )!"#$%.%()#$(%=#%*&E%&%"#&"#%!&",!#$$"!))(.*''"!&$#&$") .6G#!%"(%!)*&%$'&)#&%&($#"#.#&%)$*&-""$ '"()'*%*&+(&(%,!$*-#$%!")",!)!".&!)$#&$"). /03830126. . 343454H4I

(412) J

(413) . . 7*%-&*&%'#(+#!F-#$#!$#&$").6K&,! *&%*&%*!$(,!*>L#%*MNO&%"PN0%1N0E3'"*<#<&% $#!)#*&)"F'*%*&#!%#<#$3#!F$#"$&*+5&/83:2%)!"4'"*%$%!" )*%"*+5&/83:38823-'"(&%&%'#"$*&%"!&##)'!#.#&$( #!)#+&*%$%!&*&<*&&!"./83Q267"%#")#!)#+&*%$$ 9#-3 &*%#&%$#!)#-"(,!&$)&-$%*&!"&#"<##.$,! "#&%$*&-*&)!%*"%'""+&)%!!").3'*!""#%%"!& F'$#%*&/826 . 01. .

(414) 3434546489

(415) 9

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

(417) 99

(418) 9R. <%-'2%#!'(-/&' '&%-#)&('0/%-%!+F'+) &K'(-%/&' '&%-(!&%#(/-#(CC% 2#!%/&-$%&'-0/% --(#'"-.+-/&,%/%$=/#&#'(C%$%,%--'%.#%++/+%- -0/ C%/-%-1# &#'(C%-"*'$%&C(S$%-5,%#/&'-0/%&%+!'2%-!'C".36873747T789:; < F'+) &K'(-%/&' '&%1'2%#!'(* &-'!'&%$/%.UVWXYZ[Y[\]^W]_\]Z[`Xa\5%-!+ $%/b'DC%'2%#!'(* &-'!'&%+*+/-&"* $/% /C($% *&D-+%* +/$'-C%6T: !(/#) !$%-K(%-%$"C'0/%-#(CC%+=?>A*!%(c+%# #%&$%,%--'%%-!$%*/'- +(>!%C*-+%*+/-2&"0/%CC%!$'>(-!'0/"68:;. . . . 34345464d4 e

(419) 9 f

(420) g

(421) h P9. <%-* !'%!-!&'!"-* &#A#+(*)(-*) C'$%.+(>!%&C%7>%!+iA+!*&'#'* +%C%! /!'+'-"*(/&!&'!%&/+AC*)(C%(//%+%/#"C'%7-(!*+/-.&'-0/%$%$",%+(**%&/ # #%&$%,%--'%0/%+*(*/+!'(>""&+%7!(/!#(CC%+%-$'F"!'0/%-$%!A*%3!&'!"- * &*'(>+'!K(%/+(>#(/&-1jkl8;4m9nopq78;r9B3;r56374789:;< *'(>+'!K(%= *+/-+=@ss%t&#%$%*/'-+%uG/'3r88; 01. .

(422) 3434546489

(423)

(424)

(425)

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

(427) RS S T

(428) . G(&( !*$&(%!+88,(!!"!&!U(%!%& (!&44!*$&(%!+!%,(!+!(%' (! +(!&$ &%!+!'!,(!&!!#$!,($ 8!+$(!98%8!$%!U(%/!#$!& 44$ !+! &$*8/!+!*%(!!#89(4/!+!'$ +!%(9/!+!'$4!(!+!48%$(!-0/!N23!! . 01. .

(429) . 34345489

(430)

(431)

(432)

(433)

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

(435) 346789 4

(436)

(437) 6 9

(438) 9

(439) 69996

(440) 49 46 9

(441) 994 9 99!6

(442) 4!9 !969646 7"494!98!#9#!89

(443) 9 46 69 #9 8979"4999996 !$!6

(444) 49%&'477 7

(445) 6#'

(446)

(447) 6

(448) ! 79 474789#9 !6

(449) 49

(450) 76 6

(451) 9

(452) 699

(453) 9!

(454) 69#776499 7"49 #9#!89

(455) 9 46 69 #98979&9

(456)

(457) 699(499!767699 4769 996

(458) 49 46 9# 6 76

(459) 969#4 69 #98979 89#99 9 7

(460)

(461) 7"49 8! !7687

(462) 976878

(463) & 9999 796! 996

(464) 76796 7996 9"499

(465) 9 89 6

(466) 96#97697

(467) 64 76 7 9 94 !"4969

(468) 6

(469) 6# 69 9 # 69 #7 6

(470) 7%& . #7! 969#9

(471) 97

(472) 796694 76 7 9

(473) 96 9) !

(474) 6#! 69#9

(475) 74 9* 999#9+

(476) ,69 9 74 9*'

(477) 9-

(478) 4 7. 9/'

(479) 7769#'469 #7! 969# 6 76

(480) 969#4 69 #989790' 4 9!4#9

(481) 6996# 6 6!9 7 9 8 6#9

(482) 48

(483) 7 ' 7 9 & 1676796"49 99 69 #98979 976

(484) 624

(485) !7 4(

(486) 6#94(

(487) 74 6

(488) 94( 9*999"49 9*9

(489) 9%%. 3 4 4 4 4 4 4 4 4 4 4 4. 4 4 4 01. .

(490) 23436789

(491)

(492) 7 8 8 . !""##$#!!%&'""('")'# #'(*+,-./0(*+,1-'"1.""/!'#2%!$'"34 %%#"#'5#!$!'"!6'"37#$'"8'"9'0!"6!":4; '$!$'!"23<%$#'#'"'"!''!"'"# 0%81%"#!!%&1=!>1=#'!!%&?,65-"'20(% 42@:4ABC"!1"":D$'"@:EAB . FGGHIJJKKKLMNOGPHNQMRPSNSTUVPLWTXJVPYUMGVPZRPMZWNOWPVMJNVGUWSPMJSPZVPMPN[Z\VNOWUX . . ]78 ^_` 8a b8 ] ba8 b b789

(493)

(494) b 8b 8 4c2d e$#'!""37fE1%'"1!""#$3B:!" '"B.'"g"%"5='8"!6'5''"'"" h!"%#!%'$=&##0"%#"#'#$'"2!"ij!%"! !""#j""'"$!"('"'"6'"'!"'1#%!"' #$'"'@:k1:f1:DAB +"%"!6'"'#%!"l+-+B 00. .

(495) 345689 4

(496) 4

(497) 4 64464 444

(498) 45

(499) 4

(500) 854 4 46 8

(501) 585

(502) 8548484346

(503) 4 644 644 564 4 88 544 468

(504) 8 4848544

(505) 84 5

(506)

(507) 4 68 44

(508) 484464

(509) 6456456 5 5

(510) 64 856 4 844 44

(511) 64

(512) 44

(513) 6

(514)

(515) 85

(516) 4!4 44"5 84#8 46

(517)

(518) 8$56 64%"#$&!4 9 4

(519)

(520) 88'

(521) 88 4!48448

(522) 8854564%(3)&!5$68644

(523) 84*

(524) +4 86

(525) 8%$,-.&!5)6

(526) 44

(527) .86

(528) 8 , 4%).,&!484486

(529)

(530) !/ 3484 4 48

(531) 4

(532) 406

(533) 6484464

(534) 64654

(535) 44486

(536)

(537) 06

(538) 65 4

(539) 64 88 4564 54 44 +%# )#& 8 948566 44

(540) +64)4*4

(541)

(542)

(543) 548

(544) 44

(545) 5465 +644

(546) 6446 449 8

(547)

(548)

(549) 54418 4 43*8 %1#3&8564

(550) 46 4 44

(551) 86

(552)

(553) 6 4646 44 54

(554) 5

(555) 8544468 4

(556) 84

(557) 54*4

(558) 4

(559) 8542345!467 . #4*

(560) +44564 4464

(561) 484644

(562)

(563) 8 4 44 6

(564) 44

(565) 8546

(566) 6464

(567) 64 856464

(568) 45

(569) 466

(570) 8 64.4