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Les médecins exerçant dans le service des urgences d’une façon permanente ou non doivent prendre an charge des pathologies diversifiées et souvent complexes. Le pronostic vital laisse parfois peu de temps pour une analyse complète de la symptomatologie clinique. Ainsi dans de nombreux cas, des examens complémentaires justifiés ou non sont demandés surtout par les jeunes médecins pour plus de sécurité. Cette démarche excessive entraîne sûrement un surcoût de dépense de santé et peut être un raisonnement erroné.

MATERIEL ET METHODE

:

Il s’agit d’une étude prospective réalisée dans le service des urgences aux cours de l’année 2003, composée de 2 parties :

 Analyser l apport de 3 examens les plus demandes aux urgences à Savoir radiographie du thorax, électrocardiogramme, enzymes cardiaques.

 Évaluer l’intérêt diagnostique de NT-pro BNP dans les dyspnées aigues au service des urgences.

DISCUSSION :

La prescription d’un examen paraclinique est un art difficile qui requiert un savoir-faire qui ne doit rien à l’intuition ni aux rituels. Dans le cadre particulier de l’urgence, la prescription – plus que dans d’autres domaines – doit répondre à des impératifs de moyens et non de résultats. L’objectif de la prescription doit être clair. Un marqueur biologique est utile en urgence si une question urgente concernant la maladie ou le malade mérite d’être posée et si le marqueur y répond de façon performante.

Il n’a pas d’intérêt si la question est mal posée, si l’examen demande n’est pas adapté ou si la réponse apportée était évidente. En effet, un examen complémentaire ne donne pas de bonne réponse à une question mal posée ou s’il n’est pas adapté à la question, et n’offre qu’une réponse inutile à une question qui ne se pose pas.

CONCLUSION :

Le bilan complémentaire aux urgences doit permettre d’améliorer le diagnostic, de préciser le terrain et/ou de stratifier la gravité d’un malade.

le BNP permet d’améliorer la morbidité des patients admis pour dyspnée aiguë. Compte tenu de l’intérêt pronostique de la précocité du diagnostic d’ICA, le dosage rapide du BNP ou du NT-pro BNP devrait être accessible 24 heures sur 24 en urgence.

VII. Bibliographie :

【2】. Agence nationale d’accréditation et d’évaluation en santé. Les examens préopératoires systématiques.

Recommandations et références médicales. Paris: ANAES; Décembre 1998 (disponible sur http://www.anaes.fr). 【3】.Fontana RS, Sanderson DR, Woolner LB, Taylor WF, Miller WE, Muhm JR. Lung cancer screening: the Mayo program. J Occup Med 1986;28:746–750.

【4】.Henschke CI, McCauley DI, Yankelevitz DF, Naidich DP, McGuinness G, Miettinen OS, et al. Early lung cancer action project: overall design and findings from baseline screening. Lancet 1999;354:99–105.

【5】.Epler GR, McLoud TC, Gaensler EA, Mikus JP, Carrington CB. Normal chest roentgenograms in chronic diffuse infiltrative lung disease. N Engl J Med 1978;298:801– 809.

【6】.Gay J, Desnos M, Benoit P. L’électrocardiogramme. Paris: Frison-Roche; 1990.

【7】.Brody DA, Arzbaecher RC, Woolsey MD, Sato T. The normal atrial electrocardiogram; morphologic and quantitative variability in bipolar extremity leads. Am Heart J 1967;74: 4–12.

【8】. Herbert WH, Sobol BJ. Normal atrioventricular conduction times. Am J Med 1970;48:145–147. 【9】. Greene CR, Kellu JJ. Electrocardiogram of the healthy adult negro. Circulation 1959;20:906–909.

【10】. Bexton RS, Vallin HO, Camm AJ. Diurnal variation of the QT interval-influence of the autonomic nervous system.

Br Heart J 1986;55:253–258.

【11】. Koate P, Sylla M, Sankale M. De l’électrocardiogramme normal du Noir africain : constatations et hypothèses pathogéniques. Arch Mal Coeur 1972;65:1195–1207.

【12】. Hiss RG, Lamb LE, Allen MF. Electrocardiographic findings in 67 375 asymptomatic subjects. X Normal values. Am J Cardiol 1960;6:200–231.

【13】. Mimbs JW, De Mello V, Roberts R. The effect of respiration on normal and abnormal Q waves. Am Heart J 1977;94: 579–584.

【14】. Lloyd-Thomas HG. The effect of exercise on the electrocardiogram in healthy subjects. Br Heart J 1999;23: 260– 270.

【15】.Kemp GL, Ellstead MH. The significance of hyperventilative and orthostatic T-wave changes on the electrocardiogram. Arch Intern Med 1968;121:518–523.

【16】.Shaftel N, Selman D, Kuhn PH, Halpern A. Electrocardiographic changes produced by the Valsalva manoeuvre in healthy adults. Am J Cardiol 1960;5:473–546..

【17】. Ostrander LD, Weinstein BJ. Electrocardiographic changes after glucose ingestion.Circulation1964;30:6776. 【18】. Serradimigni A, Arnaud A, Bory M. Le syndrome du dos plat en cardiologie. Coeur Méd Interne 2003;9:69 74. 【35】. [1] Gottdiener JS, Arnold AM, Aurigemma GP, Polak JF, Tracy RP, Kitzman DW, et al. Predictors of congestive heart failure in the elderly: the cardiovascular health study. J Am Coll Cardiol 2000;35:1628–37.

【36】 Lien CT, Gillespie ND, Struthers AD, McMurdo ME. Heart failure in frail elderly patients: diagnostic difficulties, comorbidities, polypharmacy and treatment dilemmas. Eur J Heart Fail 2002;4:91–8.

【37 】Davis M, Espiner E, Richards G, Billings J, Town I, Neill A, et al. Plasma brain natriuretic peptide in assessment of acute dyspnoea. Lancet 1994;343:440–4.

【38】 Maisel AS, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 2002;347:161–7.

【39】Ray P, Arthaud M, Lefort Y, Birolleau S, Beigelman C, Riou B. Usefulness of Brain Natriuretic Peptide in elderly patients in acute dyspnea. Intensive Care Med 2004;30:2230–6.

【40 】Hood S, Taylor S, Roeves A, Crook AM, Tlusty P, Cohen J, et al. Are there age and sex differences in the investigation and treatment of heart failure? A population-based study. Br J Gen Pract 2000;50:559–63.

【41】 Marantz PR, Tobin JN, Derby CA, Cohen MV. Age-associated changes in diastolic filling: Doppler E/A is not associated with congestive heart failure in the elderly. South Med J 1994;87:728–35.

【42】 Hermann PG, Khan A, Kollman CE, Rojas KA, Carnody DP, Bodenheimer MM. Limited correlation of left ventricular end diastolic pressure with radiographic assessment of pulmonary hemodynamics. Radiology 1990;174:721–4. 【43】Collins SP, Ronan-Bentle S, Storrow AB. Diagnostic and prognostic usefulness of natriuretic peptides in emergency department patients with dyspnea. Ann Emerg Med 2003;41:532–45.

【44】Levin ER, Gardner DG, Samson WK. Natriuretic peptides. N Engl Med J 1998;339:321–8.

【45】Clerico A, Del Ry S, Maffei S, Prontera C, Emdin M, Giannessi D. The circulating levels of cardiac natriuretic hormones in healthy adults: effect of age and sex. Clin Chem Lab Med 2002;40:371–7.

【46】 Ray P, Arthaud M, Birolleau S, Isnard R, Lefort Y, Boddaert J, et al. Comparison of brain natriuretic peptide and pro-brain natriuretic peptide, in the diagnosis of cardiogenic pulmonary edema, in patients older than 65 years. J Am Geriatr Soc 2005;53:643–8.

【47】 Mc Cullough PA, Duc P, Omland T, McCord J, Nowak R, Hollander J, heart failure: an analysis from the Breathing not Properly Multinational study. Am J Kidney Dis 2003;41:571–9.

【48 】Ten Wolde M, Tulevski II, Muldez JW, Sohne M, Boomsma F, Mulder B, et al. Brain Natriuretic Peptide as a predictor of adverse outcomes in patients with pulmonary embolism. Circulation 2003;107:2082–4.

【49】de Lemos JA, Morrow DA, Gibson CM, Murphy SA, Sabatine MS, Rifai N, et al. The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes. N Engl J Med 2001;345:1014–21.

【50】Lainchbury JG, Campbell E, Frampton CM, Yandle TG, Nicholls MG, Richards AM. Brain natriuretic peptide and N-terminal brain natriuretic peptide in the diagnosis of heart failure in patients with acute shortness of breath. J Am Coll Cardiol 2003;42:728–35.

【51】 Cowie MR, Struthers AD, Wood DA, Coats AJ, Thompson SG, Poole-Wilson PA, et al. Value of natriuretic peptides in assessments of patients with possible new heart failure in primary care. Lancet 1997; 350:1347–50.

【52】Januzzi Jr. JL, Camargo CA, Anwaruddin S, Baggish AL, Chen AA, Krauser DG, et al. The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol 2005;95: 948–54.

【53】Maisel AS, Koon J, Krishnaswamy P, Kazenegra R, Clopton P, Gardetto N, et al. Utility of B-natriuretic peptide as a rapid, point-of-care test for screening patients undergoing echocardiography to determine left ventricular dysfunction. Am JHeart 2001;141:367–74.

【54】Lubien E, DeMaria A, Krishnaswamy P, Clopton P, Koon J, Kazanegra R, et al. Utility of B-type natriuretic peptide in detecting diastolic dysfunction. Circulation 2002;105:595–602.

【55】 Maeda K, Tsutamoto T, Wada A, Hisanaga T, Kinoshita M. Plasma brain natriuretic peptide as a biochemical marker of high-left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction. Am Heart J 1998;135:825–32.

【56】Cheng V, Kazanagra R, Garcia A, Lenert L, Krishnaswamy P, Gardetto N, et al. A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study. J Am Coll Cardiol 2001;37:386–91.

【57】 Wuerz RC, Meador SA. Effects of pre hospital medications on mortality and length of stay in congestive heart failure. Ann Emerg Med 1992;21: 669–74.

【58】 Ray P, Birolleau S, Lefort Y, Becquemin M-H, Beigelman C, Isnard R, et al. Acute respiratory failure in elderly patients: etiologic diagnostic and prognostic. Critical Care 2006 (sous presse).

【59】Cabanes L, Richaud-Thiriez B, Fulla Y, Heloire F, Vuillemard C, Weber S, et al. Brain natriuretic peptide blood levels in the differential diagnosis of dyspnea. Chest 2001;120:2047–50.

【60】 Morrison K, Harrison A, Krishnaswamy P, Kazanegra R, Clopton P, Maisel A. Utility of a rapid B-Natriuretic Peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea. J Am Coll Cardiol 2002;39:202–9.

【61】 Dao Q, Krishnaswamy P, Kazanegra R, Harrison A, Amirnovin R, Lenert L, et al. Utility of B-natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting. J Am Coll Cardiol 2001;37:379–85.

【62】 Logeart D, Saudubray C, Beyne P, Thabut G, Ennezat PV, Chavelas C, et al. Comparative value of Doppler echocardiography and B-type natriuretic peptide assay in the etiologic diagnosis of acute dyspnea. J Am Coll Cardiol 2002;40:1794–800.

【63】 Teboul A, Gaffinel A, Meune C, Greffet A, Sauval P, Carli P. Management of acute dyspnoea: use and feasibility of brain natriuretic peptide (BNP) assay in the prehospital setting. Resuscitation 2004;61:91–6.【64】 Silver MA, Maisel A, Yancy CW, McCullough PA, Burnett Jr. JC, Francis GS, et al. Monitoring, and therapeutic roles of natriuretic peptides in cardiovascular diseases. Congest Heart Fail 2004;5(Suppl 3):1–30.

【65】 Bayes-Genis A, Santalo-Bel M, Zapico-Muniz E, Lopez L, Cotes C,Bellido J, et al. N-terminal probrain natriuretic peptide (NT-proBNP)in the emergency diagnosis and in-hospital monitoring of patients with dyspnoea and ventriculardysfunction. Eur J Heart Fail 2004;6:301–8.

【66】Chenevier-Gobeaux C, Claessens YE, Voyer S, Desmoulins D, Ekindjian OG. Influence of renal function on N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients admitted for dyspnoea in the Emergency Department: Comparison with brain natriuretic peptide (BNP). Clin Chim Acta 2005;361:167–75.

【67】 Alibay Y, Beauchet A, El Mahmoud R, Schmitt C, Brun-Ney D, Benoit MO, et al. N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in assessment of acute dyspnea. Biomed Pharmacother 2005;59:20–4.

【68】Mueller T, Gegenhuber A, Poelz W, Haltmayer M. Diagnostic accuracy of B type natriuretic peptide and amino terminal proBNP in the emergency diagnosis of heart failure. Heart 2005;91:606–12.

【69】 Mueller C, Scholer A, Laule-Kilian K, Martina B, Schindler C, Buser P, et al. Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med 2004;350:647–54.

【70】 Maisel AS, Clopton P, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, et al. Impact of age, race, and sex on the ability of B-type natriuretic peptide to aid in the emergency diagnosis of heart failure: results from the Breathing Not Properly (BNP) multinational study. Am Heart J 2004;147:1078–84.

【71】 Mueller C, Laule-Kilian K, Scholer A, Frana B, Rodriguez D, Schindler C, et al. Use of B-type natriuretic peptide for the management of women with dyspnea. Am J Cardiol 2004;94:1510–4.

【72】 Mueller C, Laule-Kilian K, Scholer A, Nusbaumer C, Zeller T, Staub D, et al. B-type natriuretic peptide for acute dyspnea in patients with kidney disease: insights from a randomized comparison. Kidney Int 2005; 67:278–84.

【73】 McCullough PA, Nowak RM, McCord J, Hollander JE, Herrmann HC, Steg PG, et al. B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly Multinational Study. Circulation 2002;106:416–22.

【74】 Harrison A, Morrison LK, Krishnaswamy P, Clopton P, Maisel A. Btype natriuretic peptide predicts future cardiac events in patients presenting to the emergency department with dyspnea. Ann Emerg Med 2002; 39:131–8.

【75】 Logeart D, Thabut G, Jourdain P, Chavelas C, Beyne P, Beauvais F, et al. Predischarge B-type natriuretic peptide assay for identifying patients at high-risk of readmission after decompensated heart failure. J Am Coll Cardiol 2004;43:635– 41.

【76】 James SK, Lindahl B, Siegbahn A, Stridsberg M, Venge P, Armstrong P, et al. N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (GUSTO)-IV substudy. Circulation 2003;108:275–81.

【77】 Bassan R, Potsch A, Maisel A, Tura B, Villacorta H, Nogueira MV, et al. A.B-type natriuretic peptide: a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation. Eur Heart J 2005;26:234–40.

【78】 Kucher N, Printzen G, Goldhaber SZ. Prognostic role of brain natriuretic peptide in acute pulmonary embolism. Circulation 2003;107:2545–7.

【79】Pruszczyk P, Kostrubiec M, Bochowicz A, Styczynski G, Szulc M, Kurzyna, et al. N-terminal pro-brain natriuretic peptide in patients with acute pulmonary embolism. Eur Respir J 2003;22:649–53.

【80】Ray P, Maziere F, Medimagh S, Lefort Y, Arthaud A, Duguet A, et al. B-type natriuretic as a predictor of complicated pulmonary embolism in the elderly. Am J Emerg Med 2006 (in press).

【81】. Glauser MP. Pathophysiologic basis of sepsis : considerations for future strategies of intervention. Crit Care Med 2000 ; 2 (Suppl. 9) : 4-8.

【82】 Guilhot F. Hyperleucocytoses avec polynucléose neutrophile. In : Dreyfus B, Breton-Gorius J, Reyes F, Rochant H, Rosa J, Vernant JP, Eds. L’Hématologie. Paris : Flammarion Médecine- Sciences ; 2000. p. 567-8.

【83】 Chrousos GP, Loriaux DL, Gold PW. Mechanisms of physical and emotional stress. New York, NY : Plenum Press ;1988.

【84】 NaitoY, Fukata J,Tamai S, Seo N, NakaiY, Mori K, et al. Biphasic changes in hypothalamo-pituitary-adrenal axis function during the early recovery period after major abdominal surgery. J Clin Endocrinol Metab 2001 ; 73 : 111-7.

【85】 Thomsen SP, McMahon LJ, Nugent CA. Endogenous cortisol : a regulator of the number of lymphocytes in peripheral blood. Clin Immunol Immunopathol 1999 ; 17 : 506-14.

【86】 Wardlaw AJ. Eosinophils in the 1990s : new perspectives on their role in health and disease. Postgrad Med J 1994 ; 70 : 536-52.

【87】. Bass DA, Gonwa TA, Szejda P, Cousart MS, DeChatelet LR, McCall CE. Eosinopenia of acute infection : Production of eosinopenia by chemotactic factors of acute inflammation. J Clin Invest 2000 ; 65 : 1265-71.

【88】. Rumke CL. Statistically expected variability in differential leukocyte counting. In : Koepke JA, Ed. Differential leukocyte counting. Aspen : Collegian American Pathologists ; 1997. p. 39-45.

【89】Darko DF, Rose J, Gillin JC, Golshan S, Baird SM. Neutrophilia an lymphopenia in major mood disorders. Psychiatry Res 1998 ; 25 : 243-51.

【90】. Kikano GE, Stange KC, Flocke SA, Zyzanski SJ. Effect of the white blood count on the clinical management of the febrile infant. J Fam Pract 2001 ; 33 : 465-71.

91.AGENCE NATIONALE POUR LE DÉVELOPPEMENT DE L'ÉVALUATION MÉDICALE

【92】. Alpert J, Thygesen K. for the Joint European Society of Cardiology/American College of Cardiology committee. Myocardial infarction redefined.Aconsensusdocumentof the joint European Society of

Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J AmColl

Cardiol 2000; 36: 959-969

【93】.WuAH,AppleFS, GiblerWB,Jesse RL,WarshawMM,Valdes RJr. National Academy of Clinical Biochemistry Standards of Laboratory Practice: recommendations for the use of cardiac markers in coronary artery diseases.

Clin Chem 1999; 45: 1104-1121

【94】.Katus HA, Schoeppenthau M, Tanzeem A, Bauer HG, Saggau W, DiederichKWet al. Non-invasive assessment of perioperative myocardial cell damage by circulating cardiac troponin T. Br Heart J 1991; 65: 259-264

【95】. Adams JE, Sicard GA, Allen BT, Bridwell KH, Lenke LG, Davila-RomanVGet al. Diagnosis of perioperative myocardial infarction with measurement of cardiac troponin I. N Engl J Med 1994; 330: 670-674

【96】. Januzzi JL, Lewandrowski K, MacGillivray TE, Newell JB, Kathiresan S, Servoss S et al. A comparison of cardiac troponin T and creatine kinase-MB for patient evaluation after cardiac surgery. J AmColl Cardiol 2002; 39: 1518-1523

【97】.Bertinchant JP, Polge A, Mohty D, Nguyen-Ngoc-Lam R, Estorc J, Cohendy R, et al. Evaluation of incidence, clinical significance, and prognostic value of circulating cardiac troponin I and T elevation in hemodynamically stable patients with

suspected myocardial contusion after blunt chest trauma. J Trauma 2007;48:924—31.

【98】.GUSTO IIb. A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction. The Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO IIb) Angioplasty Substudy Investigators. N Engl J Med 1997 ; 336 : 1621-8.

【99】.SACKETT D, STRAUS S, RICHARDSON W, ROSENBERG W, HAYNES RB. Evidence-Based Medicine. Edinburgh, Scotland: Churchill Livingstone, 2000.

【100】.WANG K, ASINGER RW, MARRIOTT HJ. ST-segment elevation in conditions other than acute myocardial infarction. N Engl J Med 2003 ; 349 : 2128-35.

【101】.LOY CT, IRWIG L. Accuracy of diagnostic tests read with and without clinical information: a systematic review.

JAMA 2004 ; 292 : 1602-9.

【102】.DUNN PM, LEVINSON W. The lack of effect of clinical information on electrocardiographic diagnosis of acute myocardial infarction. Arch Intern Med 1990 ; 150 : 1917-9.

【103】. HATALA R, NORMAN GR, BROOKS LR. Impact of a clinical scenario on accuracy of electrocardiogram interpretation. J Gen Intern Med 1999 ; 14 : 126-9.

【104】.Turnbull JM, Buck C. The value of preoperative screening investigations in otherwise healthy patients. Arch Intern

Med 1997 ; 147 : 1101-5

【105】. Seymour DC, Pringler R, McLennan WJ. The role of the routine preoperative electrocardiogram in the elderly surgical patient. Age Ageing 1999 ; l2 : 97-104

【106】. Carliner NH, Fisher MK. Plotnick GD et al. The preoperative electrocardiogram as an indicator of risk in major non cardiac surgery. Can J Cardiol 1996 ; 2 : 134-7

【107】.Goldberger AL, O'Konski M. Utility of the routine electrocardiogram before surgery and on general hospital admission. Ann Intern Med 1999 ; 105 : 552-7

【108 】MC NAMARA R, ROUSSEAU E, SANDERS AB. Geriatric Emergency Medicine: a survey of practicing emergency physicians. Ann Emerg Med 2003 ; 21 : 796-800.

【109】.SINGAL BM, HEDGES JR, ROUSSEAU EW et al. Geriatric patient emergency visits Part 1: comparison o fvisits by geriatric and younger patients. Ann Emerg Med 2004 ; 21 : 802-7.

【110】PFITZENMEYER P. Le vieillard malade : particularités physiologiques, séméiologiques et psychologiques. La

Revue de Gériatrie 2003 ; 23 : 415-22.

【111】 LE CONTE PH, BARON D. Particularités séméiologiques de la personne âgée dans le service d’Accueil et d’Urgences. In : Actualités en Réanimation et Urgences, Paris : Arnette Blackwell 2002 : 445-74.

【112】Lacombe P, Quanadli S, Mesurolle B, Chagnon S, Subourg O, Schnyder P. Imagerie des traumatismes fermés du thorax. Encycl Méd Chir (Elsevier SAS, Paris), Radiodiagnostic – Coeur-Poumon, 32-386-A-10, 2003.

【113】. Wintermark M, Schnyder P. Imagerie des traumatismes fermés du thorax. J Radiol 2002;83:123-32.

【114】. Nourjah P. National hospital ambulatory medical care survey: 1997 emergency department summary. Advance Data form Vital and Health Statistics, National Center for Health Statistics, Hyattsville, Maryland 2004; 304: available from URL: http://www.cdcgov, nchswww, nchshome.htm.

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