Para a obtenção das evidências científicas publicadas, foi definida o acesso nas bases de dados PUBMED/MEDLINE, COCHRANE, CINAHL, por meio do Portal de Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
Os termos/descritores utilizados na busca dos artigos são padronizados pelo Medical Subject Heading (MESH), descritos a seguir:
- Adverse events AND epinephrine
- Adverse events AND epinephrine AND emergency treatment - Adverse events AND epinephrine AND safety
- Adverse events AND epinephrine AND Dose-Response Relationship, Drug
- Errors AND epinephrine
- Errors AND epinephrine AND treatment - Errors AND epinephrine AND safety
- Errors AND epinephrine AND Dose-Response Relationship, Drug
- Damage AND epinephrine AND emergency treatment - Damage AND epinephrine AND safety
- Damage AND epinephrine AND Dose-Response Relationship, Drug
- Adverse effects AND epinephrine
- Adverse effects AND epinephrine AND emergency treatment - Adverse effects AND epinephrine AND safety
- Adverse effects AND epinephrine AND Dose-Response Relationship, Drug
A partir da definição dos descritores e termos de busca, foi realizado teste na base de dados Pubmed, conforme demonstrado a seguir:
A busca foi realizada no período de 06 a 10 de agosto de 2012, conforme associações e filtros abaixo estabelecidos para a droga epinefrina, ao qual gerou as seguintes sintaxes de busca:
Quadro 1: Sintaxe de busca gerada pela própria base. Florianópolis, 2013.
Sintaxe de busca para o teste piloto com a droga adrenalina
Estu dos (adverse[All Fields] AND events[All Fields]) AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND (("2001/01/01"[PDAT]:"2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Clinical Trial, Phase III[ptyp] OR Clinical Trial, Phase IV[ptyp] OR Meta-Analysis[ptyp] OR Multicenter Study[ptyp] OR Randomized Controlled Trial[ptyp]) AND English[lang] AND ("adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "aged"[MeSH Terms] OR "young adult"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms] OR "middle aged"[MeSH Terms]))
101
(adverse[All Fields] AND events[All Fields]) AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND ("emergency treatment"[MeSH Terms] OR ("emergency"[All Fields] AND "treatment"[All Fields]) OR "emergency treatment"[All Fields] OR ("emergency"[All Fields] AND "care"[All Fields]) OR "emergency care"[All Fields] OR "emergency medical services"[MeSH Terms] OR ("emergency"[All Fields] AND "medical"[All Fields] AND "services"[All Fields]) OR "emergency medical services"[All Fields] OR ("emergency"[All Fields] AND "care"[All Fields])) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Clinical Trial, Phase III[ptyp] OR Clinical Trial, Phase IV[ptyp] OR Meta-Analysis[ptyp] OR Multicenter Study[ptyp] OR Randomized Controlled Trial[ptyp]) AND English[lang] AND ("adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]))
(adverse[All Fields] AND events[All Fields]) AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND ("safety"[MeSH Terms] OR "safety"[All Fields]) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Clinical Trial, Phase III[ptyp] OR Clinical Trial, Phase IV[ptyp] OR Meta-Analysis[ptyp] OR Multicenter Study[ptyp] OR Randomized Controlled Trial[ptyp]) AND English[lang] AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]))
20
(adverse[All Fields] AND events[All Fields]) AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND ("dose-response relationship, drug"[MeSH Terms] OR ("dose-response"[All Fields] AND "relationship"[All Fields] AND "drug"[All Fields]) OR "drug dose-response relationship"[All Fields] OR ("dose"[All Fields] AND "response"[All Fields] AND "relationship"[All Fields] AND "drug"[All Fields]) OR "dose response relationship, drug"[All Fields]) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Clinical Trial, Phase III[ptyp] OR Clinical Trial, Phase IV[ptyp] OR Meta-Analysis[ptyp] OR Multicenter Study[ptyp] OR Randomized Controlled Trial[ptyp]) AND English[lang] AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]).
10
errors[All Fields] AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase
I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Meta- Analysis[ptyp] OR Randomized Controlled Trial[ptyp] OR Clinical Trial, Phase III[ptyp] OR Multicenter Study[ptyp]) AND English[lang]) AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]))
errors[All Fields] AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND ("emergency treatment"[MeSH Terms] OR ("emergency"[All Fields] AND "treatment"[All Fields]) OR "emergency treatment"[All Fields] OR ("emergency"[All Fields] AND "care"[All Fields]) OR "emergency care"[All Fields] OR "emergency medical services"[MeSH Terms] OR ("emergency"[All Fields] AND "medical"[All Fields] AND "services"[All Fields]) OR "emergency medical services"[All Fields] OR ("emergency"[All Fields] AND "care"[All Fields])) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Meta-Analysis[ptyp] OR Randomized Controlled Trial[ptyp] OR Clinical Trial, Phase III[ptyp] OR Multicenter Study[ptyp]) AND English[lang] AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms]))
07
errors[All Fields] AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND ("safety"[MeSH Terms] OR "safety"[All Fields]) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Meta- Analysis[ptyp] OR Randomized Controlled Trial[ptyp] OR Clinical Trial, Phase III[ptyp] OR Multicenter Study[ptyp]) AND English[lang]) AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]))
errors[All Fields] AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND ("dose-response relationship, drug"[MeSH Terms] OR ("dose-response"[All Fields] AND "relationship"[All Fields] AND "drug"[All Fields]) OR "drug dose-response relationship"[All Fields] OR ("dose"[All Fields] AND "response"[All Fields] AND "relationship"[All Fields] AND "drug"[All Fields]) OR "dose response relationship, drug"[All Fields]) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Meta- Analysis[ptyp] OR Randomized Controlled Trial[ptyp] OR Clinical Trial, Phase III[ptyp] OR Multicenter Study[ptyp]) AND English[lang])AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]))
03
damage[All Fields] AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Meta- Analysis[ptyp] OR Randomized Controlled Trial[ptyp] OR Clinical Trial, Phase III[ptyp] OR Multicenter Study[ptyp]) AND English[lang])
40
damage[All Fields] AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND ("emergency treatment"[MeSH Terms] OR ("emergency"[All Fields] AND "treatment"[All Fields]) OR "emergency treatment"[All Fields] OR ("emergency"[All Fields] AND "care"[All Fields]) OR "emergency care"[All Fields] OR "emergency medical services"[MeSH Terms] OR ("emergency"[All Fields] AND "medical"[All Fields] AND "services"[All Fields]) OR "emergency medical services"[All Fields] OR ("emergency"[All Fields] AND "care"[All Fields])) AND
(("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Meta-Analysis[ptyp] OR Randomized Controlled Trial[ptyp] OR Clinical Trial, Phase III[ptyp] OR Multicenter Study[ptyp]) AND English[lang]) ]) AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]))
damage AND epinephrine AND safety Filters: Publication date from 2001/01/01 to 2011/12/31; Humans; Case Reports; Systematic Reviews; Comparative Study; Clinical Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Meta-Analysis; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; English
0
damage AND epinephrine AND Dose-Response Relationship, Filters: Publication date from 2001/01/01 to 2011/12/31; Humans; Case Reports; Systematic Reviews; Comparative Study; Clinical Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Meta-Analysis; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; English
0
("adverse effects"[Subheading] OR ("adverse"[All Fields] AND "effects"[All Fields]) OR "adverse effects"[All Fields]) AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Meta-Analysis[ptyp] OR Randomized Controlled Trial[ptyp] OR Clinical Trial, Phase III[ptyp] OR Multicenter Study[ptyp]) AND English[lang]) ]) AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]))
("adverse effects"[Subheading] OR ("adverse"[All Fields] AND "effects"[All Fields]) OR "adverse effects"[All Fields]) AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND ("emergency treatment"[MeSH Terms] OR ("emergency"[All Fields] AND "treatment"[All Fields]) OR "emergency treatment"[All Fields] OR ("emergency"[All Fields] AND "care"[All Fields]) OR "emergency care"[All Fields] OR "emergency medical services"[MeSH Terms] OR ("emergency"[All Fields] AND "medical"[All Fields] AND "services"[All Fields]) OR "emergency medical services"[All Fields] OR ("emergency"[All Fields] AND "care"[All Fields])) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Meta-Analysis[ptyp] OR Randomized Controlled Trial[ptyp] OR Clinical Trial, Phase III[ptyp] OR Multicenter Study[ptyp]) AND English[lang]) ]) AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]))
81
("adverse effects"[Subheading] OR ("adverse"[All Fields] AND "effects"[All Fields]) OR "adverse effects"[All Fields]) AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND ("safety"[MeSH Terms] OR "safety"[All Fields]) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Meta-Analysis[ptyp] OR Randomized Controlled Trial[ptyp] OR Clinical Trial, Phase III[ptyp] OR Multicenter Study[ptyp]) AND English[lang]) ]) AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]))
("adverse effects"[Subheading] OR ("adverse"[All Fields] AND "effects"[All Fields]) OR "adverse effects"[All Fields]) AND ("epinephrine"[MeSH Terms] OR "epinephrine"[All Fields]) AND ("dose-response relationship, drug"[MeSH Terms] OR ("dose-response"[All Fields] AND "relationship"[All Fields] AND "drug"[All Fields]) OR "drug dose-response relationship"[All Fields] OR ("dose"[All Fields] AND "response"[All Fields] AND "relationship"[All Fields] AND "drug"[All Fields]) OR "dose response relationship, drug"[All Fields]) AND (("2001/01/01"[PDAT] : "2011/12/31"[PDAT]) AND "humans"[MeSH Terms] AND (Case Reports[ptyp] OR systematic[sb] OR Comparative Study[ptyp] OR Clinical Trial[ptyp] OR Clinical Trial, Phase I[ptyp] OR Clinical Trial, Phase II[ptyp] OR Meta- Analysis[ptyp] OR Randomized Controlled Trial[ptyp] OR Clinical Trial, Phase III[ptyp] OR Multicenter Study[ptyp]) AND English[lang]) ]) AND ("adult"[MeSH Terms] OR "young adult"[MeSH Terms] OR "adult"[MeSH Terms:noexp] OR "middle aged"[MeSH Terms] OR "aged"[MeSH Terms] OR "aged, 80 and over"[MeSH Terms]))
62
O teste dos descritores realizado demonstrou que há estudos, num total de 1.317. A partir desta padronização de termos e descritores, a mesma estratégia foi utilizada para as drogas noradrenalina e vasopressina.