[PDF] Top 20 Pontin and reptin, two related ATPases with multiple roles in cancer.: Pontin and Reptin in cancer

... Pontin and Reptin are two related members of the AAA+ (ATPases associated with diverse cellular activities) superfamily sharing conserved Walker A and B motifs, ... Voir le document complet

... D299N and its effect on cell growth in HuH7 cells. A. Reptin D299N mutant interacts with Pontin and endogenous ...transduced with Flag-Reptin or Flag-Reptin ... Voir le document complet

... recently, pontin and reptin, two highly conserved members of the AAA+ family of ATPases (putative DNA helicases), initially named RUVBL1 and RUVBL2 after the bacterial ... Voir le document complet

... analogy with the two human Cu + -ATPases ATP7A and ATP7B, the functional differences between HMA6 and HMA8 might be related to distinct cellular ...Cu and a slow catalytic ... Voir le document complet

... correlates with the development of metastases and is negatively associated with disease-free and overall survival [ 49 ...role in melanoma invasion. Indeed, the silencing of integrin ... Voir le document complet

...  and ER  mRNAs in both neoplastic breast tissue and cell lines [52, ...exons and are usually coexpressed with the wild-type ER ...protein, and a 10-20-fold excess might be ... Voir le document complet

... deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...teaching and research institutions in France or abroad, or from public or private research ... Voir le document complet

... result in increased expression and membrane distribution of the GLUT1 glucose transporter (Barthel et al 1999, Wieman et al 2007, Wofford et al 2008), association of hexokinase I and II to the ... Voir le document complet

... h-incubation with Prop, cells showed a basal respiration and a mitochondria-governed ATP generation reduced by 35% and 33%, respectively, as compared to control (Figure 3A, ...decrease in both ... Voir le document complet

... tolerance in cancer The biological mechanisms that induce cancer cell plasticity upon drug treat- ment remain to be fully ...described in bacteria upon antibiotic ...engage in a ... Voir le document complet

... results in microthrombi due to platelet ...appear in approximately 15 ...model in which multiple primary tumors develop in the ...step and the presence of a thrombocytopenia due ... Voir le document complet

... expensive cancer treatments. The second and third funds—the “State Illness Assistance Fund” and the “Health Minister’s Cancer Fund” under the Rashtriya Arogya Nidhi (National Health Fund)—were ... Voir le document complet

... patients in LC4 who were younger and received more chemotherapy displayed the lowest recalibration RS and poor ...limitations and paths for future research can be outlined. The change ... Voir le document complet

... involved in neural development 23,24 (Table 1) and possibly morphogenesis, in spite of the lack of a lethal or abnormal phenotype in ALK- knock-out mice (Morris, personal communication, ... Voir le document complet

... pre-miRNA in the nucleus In human, primary transcripts are processed in the nucleus by a protein complex called microprocessor that is composed of the ribonuclease Drosha associated with its ... Voir le document complet

... metastases and from their corresponding primary tumors could represent global predisposition to complete some, but not all, steps of the metastatic cascade; this allows fully competent variants to arise through ... Voir le document complet

... Chapter Six reviews ptychography (and its Fourier dual), presents an experimental setup for automated mitoses detection in a desktop microscope, and details an exper- [r] ... Voir le document complet

... or in combinations, in order to reduce the probability of resistance emergence and reduce side-effects on healthy cells ...studied in [46, 47] using ordinary differential systems which give a ... Voir le document complet

... by cancer cells to provide macromolecules is glutaminolysis, which generates reductive equivalents such as NADPH by replenishing the TCA cycle [ 4 ...acid in the sense that, under normal conditions, it can ... Voir le document complet

... pathways. In this context, KIAA1199 is transcriptionally induced by NF-kB proteins in transformed keratinocytes as well as in breast cancer- derived cells (Figure 3) ...BCL-3 in ... Voir le document complet