[PDF] Top 20 Hepatitis C virus entry: molecular mechanisms and targets for antiviral therapy.
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Hepatitis C virus entry: molecular mechanisms and targets for antiviral therapy.
... attachment and entry is a major target of adaptive host cell ...system and induce the production of ...exhibit antiviral activity in vitro and are defined as virus-neutralizing ... Voir le document complet
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Hepatitis C virus entry into hepatocytes: molecular mechanisms and targets for antiviral therapies.
... archive for the deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...teaching and research institutions in France or abroad, or from public or private ... Voir le document complet
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EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
... homeostasis, and tumorigenesis 31 ...polarity and motility 32 ...HCV entry factor complexes and membrane ...HCV entry suggesting that EGFR plays a key role in the HCV entry ... Voir le document complet
32
Host–virus interactions during hepatitis C virus infection : a complex and dynamic molecular biosystem
... cirrhosis and hepatocellular carcinoma (HCC) ...diagnostic and prognostic markers, and the absence of broadly effective treatment ...combination therapy with modified interferons (pegylated), ... Voir le document complet
13
Cholesterol uptake and hepatitis C virus entry.
... alpha and ribavirin has markedly improved the treatment outcome, viral resistance and adverse effects still remain important ...HCV entry is the first step of virus- hepatocyte interaction ... Voir le document complet
9
Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses
... fever virus (YFV) vaccine 17D stands as a “gold standard” for a successful ...mouse and chicken embryo tissues. Despite its immense success, the molecular determinants for virulence ... Voir le document complet
16
Hepatitis C virus entry.
... of hepatitis C virus entry for pathogenesis of liver disease and antiviral therapy ...Conclusions and perspectives 1. Discovery and characterization of ... Voir le document complet
42
Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals
... at entry factors have a higher genetic barrier for resistance, as the targets are not encoded by highly mutable viral ...genomes. Entry inhibitors also act synergistically with DAAs [53, 54], ... Voir le document complet
20
CD81-receptor associations-impact for hepatitis C virus entry and antiviral therapies
... Conclusions and Perspectives TEMs play a role in membrane compartmentalization leading to coupling and/or regulating molecular machinery and signaling pathways in a tissue specific ...HCV ... Voir le document complet
19
Genotype 1 hepatitis C virus envelope features that determine antiviral response assessed through optimal covariance networks
... combined antiviral therapy of pegylated alfa-interferon and ribavarin for hepatitis C virus (HCV) infection may be linked to mutations in the viral envelope gene E1E2 (env), ... Voir le document complet
10
Hepatitis B virus resistance to antiviral drugs: where are we going?
... infected and exposed to the risk of developing severe complications including cirrhosis and hepatocellular ...chronic hepatitis B has been made during the last decade with the development of ... Voir le document complet
8
Hepatitis C virus-related vasculitis
... cryoproteins and cold ...II and type III cryoglobulins are classified as mixed cryoglobulins (MC) because they include two types of Ig (usually IgG and ...chronic hepatitis C virus ... Voir le document complet
19
Hepatitis C virus infection and chronic kidney disease: Time for reappraisal
... seropositivity and an increased incidence of CKD (defined by the incidence of stages 3-5 CKD or ...estimate for adjusted hazard ratio was ...having and/or developing CKD compared to uninfected ... Voir le document complet
31
Effet antiviral des interférons sur le virus BK
... 6 I. INTRODUCTION Le virus BK est un pathogène ubiquiste. Il établit une infection persistante asymptomatique dans les voies rénales de 80% de la population humaine. Son pouvoir pathogène se manifeste ... Voir le document complet
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Hepatitis C virus core protein targets 4E-BP1 expression and phosphorylation and potentiates Myc-induced liver carcinogenesis in transgenic mice
... carcinogenesis and thus subsequent oncogenic alterations were required to drive ...progression and was required for cancer cell survival in Myc-dependent tumor initiation and maintenance ... Voir le document complet
16
Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes using monoclonal antibodies.
... archive for the deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...teaching and research institutions in France or abroad, or from public or private ... Voir le document complet
18
Hepatitis E Virus
... Rodentia and Soricomorpha, and HEV-C2 infects hosts of the order Carnivora ...small virus with a positive-sense, single-stranded, ...required for HEV replication; these are methyltransferase, ... Voir le document complet
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Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients.
... Karine Lacombe, Joël Gozlan, Anders Boyd, Pierre-Yves Boelle, Philippe Bonnard, Jean-Michel Molina, Patrick Miailhes, Caroline Lascoux-Combe,. Lawrence Serfaty, Fabien Zoulim, et al[r] ... Voir le document complet
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Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.
... of Hepatitis C Virus Cell Entry Factors Mediate Escape from Neutralizing Antibodies Article Type: Basic - Liver/Pancreas/Biliary Section/Category: Human Research - Human Material Corresponding ... Voir le document complet
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Un double effet antiviral des IFITM sur les virus enveloppés
... LIENS D’INTÉRÊT Les auteurs déclarent n’avoir aucun lien d’intérêt concernant les données publiées dans cet article. > Au cours d’une infection virale, le virus, « parasite » intracellulaire obligatoire, se ... Voir le document complet
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