[PDF] Top 20 Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease
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Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease
... Introduction The global epidemic of obesity poses drastic threats to public health systems because of the increasing incidence of its related ...lack of physical activity ... Voir le document complet
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Relevance of Endoplasmic Reticulum Stress Cell Signaling in Liver Cold Ischemia Reperfusion Injury
... storage and consequently the activation of UPR is lower than when using UW [ 36 ...to the substitution of HES by PEG-35. Taking this into account and in view of the ... Voir le document complet
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Pathogenic role of IL-15 in non-alcoholic fatty liver disease
... proliferation, the biochemical and functional relationship between these two cytokines were examined in ...IL-2 and IL-15 signalling starts when the cytokines bind IL-2Rα or IL-15Rα, ... Voir le document complet
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Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease
... paradox of hepatic insulin resistance, which is also associated with obesity and T2DM, is still not fully ...explain the selective hepatic insulin resistance involve extrahepatic pathways from ... Voir le document complet
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en fr Progression and diagnostic methods in non-alcoholic fatty liver disease Progression et tests diagnostiques de la stéatose hépatique non alcoolique
... level of insulin resistance in patients with steatohep- atitis than in those with isolated steatosis ...indicative of insulin resistance worsening and a potential for progression from steatosis to ... Voir le document complet
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Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
... ED of VLDLR levels has been reported to be dependent on the activation of oxidative stress-induced nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in alcoholic liver ... Voir le document complet
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Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring
... expenditure and leptin sensitivity, further supporting a fundamental role for the XBP1 pathway in POMC neurons in the delete- rious metabolic effects of hypothalamic ER stress [ 15 ... Voir le document complet
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Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress
... explore the Wb-host interactions and the Wb- induced viral protection at the cellular and molecular levels [ 19 , 28 – 31 ...cultures and added to flasks of uninfected ... Voir le document complet
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Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites
... to the Nature Protocols from Wieckowski et al. 36 . The cell number and the cell lysis method were adapted for AML ...billion of MOLM14 cells were washed with PBS (with Ca2 + and ... Voir le document complet
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BAT3 Guides Misfolded Glycoproteins Out of the Endoplasmic Reticulum
... in the dislocation reaction when in close proximity to the ER membrane, because at least some of the Figure ...in the presence or absence of canine pancreatic microsomal ... Voir le document complet
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p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress
... IF and PLA. For IF of proteins, following seeding, transfection and treatment, cover- slips with cells were briefly washed with PBS and fixed with 4% PFA for 20 min at RT, washed again with ... Voir le document complet
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Evaluation of the endoplasmic reticulum-stress response in eIF2B-mutated lymphocytes and lymphoblasts from CACH/VWM patients.
... in the level of ATF4, CHOP, ASNS and GRP78 mRNAs was also observed, which was similar in normal and eIF2B-mutated EIL, confirming the comparable activation of the ... Voir le document complet
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Nonalcoholic fatty liver disease and obstructive sleep apnea
... (OSA) and more importantly its hallmark chronic intermittent hypoxia (CIH), are established factors in the pathogenesis and exacerbation of nonalcoholic fatty liver ... Voir le document complet
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A guide to assessing Endoplasmic Reticulum homeostasis and stress in mammalian systems
... if and how they deviate during ER stress, which could then be used as independent measures of ER ...As non-proteinaceous molecules, monitoring GSH and H 2 O 2 ER redox state and ... Voir le document complet
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Gene Expression of Protein Tyrosine Phosphatase 1B and Endoplasmic Reticulum Stress During Septic Shock
... on the cytoplasmic side of the endoplasmic reticulum (ER), is involved in the negative regulation of many cell pathways such as response to insulin or endothelial nitric ... Voir le document complet
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Degradation and folding of the asialoglycoprotein receptor in the endoplasmic reticulum
... This thesis discusses two aspects of the regulation of the secretory pathway in mammalian cells - the degradation and folding of proteins in the endoplasmic reticulum (ER)[r] ... Voir le document complet
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Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment.
... is the major cause of acute renal failure (ARF) ...establishment of blood flow is the best way to salvage organ after ischemic injury, but it may also cause reper- fusion ...bodies of ... Voir le document complet
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Reflux of Endoplasmic Reticulum proteins to the cytosol inactivates tumor suppressors
... in the cytosolic fraction after Tg treatment compared with ...in the cytosol (Table ...ER and lysosomal compartments. Moreover, 23 out of these 26 proteins were part of a unique ... Voir le document complet
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Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response
... relapsed disease in recent years (<20% event-free survival). At the genome level, the sole distinguishing feature of ES is the presence of the reciprocal EWS/ETS ... Voir le document complet
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Responses to Hypoxia and Endoplasmic Reticulum Stress Discriminate the Development of Vitreous and Floury Endosperms of Conventional Maize (Zea mays) Inbred Lines
... concerning the regulation of the expression of the three SUS isoforms, ...SUS2, and SUS-SH1. These three genes are highly expressed but sus1 and sus2 expressions are ... Voir le document complet
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