[PDF] Top 20 Development and application of fast NMR methods for the study of protein structure and dynamics

... as the folding of proteins or the equilibration of binding interactions, requires experimental methods that yield in- formation at both atomic-level resolution and at high ... Voir le document complet

... years, NMR spectroscopy has become the technique of choice to obtain atomic-resolution information for IDPs, and to extract useful information on the structural ensemble that ... Voir le document complet

... in the ability of proteins to exchange between different con- formational states, that may be involved in different stages of a functional ...Spectroscopic methods, such as solution-state ... Voir le document complet

... Despite the continual increase in both available computational power and efficiency of contemporary algorithms, the simulation of slow motions in proteins involving stochastic ... Voir le document complet

... relationship portrayed in Figure 2-7b represents the assumed relationship between dependent design tasks in Browning's (1998) project model... 100% Percent of downstream ta[r] ... Voir le document complet

... In-situ NMR illumination and time-efficient NMR experiments Our portable laser illumination device allowed us to perform a large set of 2D and 3D correlation experiments on a single ... Voir le document complet

... (Chang and Snyder 1978) to name a ....these The drug-molecule binding was characterized to such an extent that the radio-labelled variants of drugs are used for diagnosis of ... Voir le document complet

... 1.3.5. NMR Imaging Studies NMR imaging (NMRI) has been used to study the matrix systems for more than a decade as NMRI can provide cross-sectional images from inside solid ...observe ... Voir le document complet

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... potential. The wall was set to a fixed buffer distance of 2.5 Å outside the specified radius of 12 ...probe the role of the size of the radius ...molecular ... Voir le document complet

... 31 and magnesium-aluminosilicates 32 ), and both in different proportions 34 .... For all studied compositions, Si–O–Al, Si–O–Na, and Si– O–Mg were hardly distinguishable, mostly because ... Voir le document complet

... Most of the local structural variations in the loop regions in NMR ensembles do not correlate to their local structural differences at structurally equivalent positions in homologous proteins ... Voir le document complet

... In the past few decades, large galaxy redshift surveys have revealed structures on ever- increasing ...scales. The largest coherent structures found are superclusters, collections of thousands ... Voir le document complet

... main methods employed by climatologists are the analysis of observations and the modelling of the physical laws (processes) that determine the ...in the ... Voir le document complet

... conditions, ioeo, mortar bar expansion test, wetting and drying, and freezing and thawing testso The thin sections or polished surfaces can be prepared and examined with the petrographic[r] ... Voir le document complet

... validation The method was validated according to the AFNOR regulation XP T 90-210 ...points. The compounds are quantified using the relation between the analyte response and that ... Voir le document complet

... Evaluation of washing methods. Variable volumes of warm PBS and number of washes were tested to assess contamination from residual growth media after its removal by pipetting: a single ... Voir le document complet

... 2 and 3) The simplest way to describe the changes in cell dynamics is to follow the total cell num- ber along ...time. The natural associated mathematical formalism is the ... Voir le document complet

... problem of vesicles at equilibrium (equilibrium shapes) is now fairly understood ...[4]. The study of vesicles under non-equilibrium conditions has constituted a major focus in recent years: ... Voir le document complet

... Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous ... Voir le document complet