Voltage-gated calcium channel
The β and α2δ auxiliary subunits of voltage-gated calcium channel 1 (Cav1) are required for Th2-lymphocyte function and acute allergic airway inflammation
... Single-cell calcium imaging Cells were loaded with Fura-2 AM, as previously described, E2,E3 in culture medium containing 5% heat-inactivated FBS for 30 minutes at 37 ...
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Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of Ca(V)2.1 voltage-gated calcium channels.
... One key feature of G protein modulation of Ca V channels is its transient relief by a strong depolarizing prepulse. This phenomenon called facilitation is attributed to the dissociation of Gβγ dimers as channels undergo ...
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Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel
... modulate voltage dependent gating; profoundly influencing the time course and amplitudes of potassium currents during physiological processes such as action ...the voltage sensor, C-linker and ...
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Voltage-gated ion channels and gating modifier toxins.
... The Voltage-Gated Ion Channels Electrical signals control contraction of muscle, secretion of hormones, sensation of the environment, processing of information in the brain, and output from the brain to ...
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Voltage-Sensor Probes as efficient tools to screen for new modulators of voltage-gated sodium channels
... Management of pain is an essential aspect for the quality of life; however current therapies are frequently insufficient owing to severe side effects, or limited effectiveness. Therefore, the discovery of new analgesics ...
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Physiological involvement of presynaptic L-type voltage dependent calcium channels in GABA release of cerebellar molecular layer interneurons
... the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell- specific expression in the cerebellar ...
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Gene regulation by voltage-dependent calcium channels.
... above, Voltage-gated calcium channels and link with Ca 2 + -regulated transcription factors transcription factor activity was under the dependency of Ca 2 + -binding proteins such as ...L-type ...
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en fr Role of calcium-activated chloride channel TMEM16F in motricity and implication in amyotrophic lateral sclerosis Rôle du canal chlorure activé par le calcium TMEM16F dans la motricité et implication dans la sclérose latérale amyotrophique
... inhibition, voltage ramps were applied from -100 mV to + 40 mV to activate voltage-gated Ca 2+ current, ...- channel inhibitor, decreased both the outward and tail inward current amplitudes ...
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The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function
... the efficient firing of C-LTMRs and the subsequent release of glutamate, further amplified presynaptically by low-voltage- gated calcium entry. In a neuropathic states, a change in the ...
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en fr Modulation of type 1 Na+/H+ exchanger (NHE1) by Nav1.5 voltage-gated sodium channel : involvement in human breast cancer cells invasiveness Modulation de l'échangeur Na + /H + de type 1 (NHE1) par le canal sodique dépendant du voltage Na V 1.5 Implication dans l'invasivité de cellules cancéreuses mammaires humaines
... 133 sur 337 I. Techniques de culture cellulaire A. Lignées cellulaires Les cellules utilisées lors de cette étude sont toutes des lignées de cellules épithéliales mammaires humaines provenant de l’American Type Culture ...
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Proteolytic cleavage of the voltage-gated Ca2+ channel alpha2delta subunit: structural and functional features.
... 5. Bernstein GM, Jones OT. (2006) Kinetics of internalization and degradation of N-type voltage-gated calcium channels: Role of the α2/δ subunit. Cell Calcium (in press). 6. Brodbeck J, Davies ...
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Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism
... Because of the moderate peptides effects, we cannot be sure that the ligand/receptor is the major actor of signal transduction between S4 movement and pore opening in Na V channels. Other mechanisms such as the ...
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High Lateral Breakdown Voltage in Thin Channel AlGaN/GaN High Electron Mobility Transistors on AlN/Sapphire Templates
... high voltage. The thin channel structure shows a lateral BV that is slightly higher than 1000 V, which corresponds to a remarkable breakdown field above 5 ...high voltage demonstration on AlN-based ...
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Molecular Characterization of Voltage-Gated Sodium Channels and Their Relations with Paralytic Shellfish Toxin Bioaccumulation in the Pacific Oyster Crassostrea gigas
... DNA polymorphism analysis in C. gigas revealed that the 10 amino acids of the PST binding sites were strictly monomorphic, despite the high nucleotid polymorphism of CgNav1, similar to the global SNP level described for ...
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Introducing an alternative biophysical method to analyze direct G protein regulation of voltage-dependent calcium channels.
... Introduction of a novel method to study G protein regulation of Ca 2.2/ v β 3 channels We present a step by step illustration of the method we developed using a representative example of a Ca 2.2/ v β 3 current inhibited ...
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On The Pixel Level Estimation of Pinning Voltage, Pinned Photodiode Capacitance and Transfer Gate Channel Potential
... pinning voltage is different or not based on the “knee voltage criterion” used in ...injection voltage (as expected for a PN junction) and the ...
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Antibodies against the beta subunit of voltage-dependent calcium channels in Lambert-Eaton myasthenic syndrome
... mol. wt 58,000) are general targets of Lambert–Eaton myasthenic syndrome autoantibodies. Of 20 disease sera tested, 55% were able to immunoprecipitate 35 S-labeled â subunits. All five patients a ffected with small-cell ...
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Gated networks: an inventory
... 2.3 V ARIATIONS ON THE CENTRAL TENSOR The architecture outlined in Section 2.2.2 can be seen either as a particular way to parametrize the global 3-way tensor, introducing features into its internal structure, or as a ...
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The Calcium Phosphate−Calcium Carbonate System: Growth of Octacalcium Phosphate on Calcium Carbonates
... It is interesting to note that despite the fact the experiments lasted for relatively long time periods, there was no evidence for hydrolysis to HAP, suggesting stabilization of the unstable OCP by the carbonate ...
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Dual regulation of the native ClC-K2 chloride channel in the distal nephron by voltage and pH
... Current recordings Patch pipettes were pulled from Harvard Apparatus GC150T borosilicate glass (Phymep) by a P-97 puller (Sutter Instrument), coated with SYL GARD, and heat polished. Single-channel currents were ...
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